KEGG   ENZYME: 2.7.11.15Help
Entry
EC 2.7.11.15                Enzyme                                 

Name
beta-adrenergic-receptor kinase;
ATP:beta-adrenergic-receptor phosphotransferase;
[beta-adrenergic-receptor] kinase;
beta-adrenergic receptor-specific kinase;
beta-AR kinase;
beta-ARK;
beta-ARK 1;
beta-ARK 2;
beta-receptor kinase;
GRK2;
GRK3;
beta-adrenergic-receptor kinase (phosphorylating);
beta2ARK;
betaARK1;
beta-adrenoceptor kinase;
beta-adrenoceptor kinase 1;
beta-adrenoceptor kinase 2;
ADRBK1;
BARK1;
adrenergic receptor kinase;
STK15
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[beta-adrenergic receptor] phosphotransferase
Reaction(IUBMB)
ATP + [beta-adrenergic receptor] = ADP + phospho-[beta-adrenergic receptor] [RN:R03274]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[beta-adrenergic receptor] [CPD:C01141]
Product
ADP [CPD:C00008];
phospho-beta-adrenergic receptor [CPD:C04141]
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
History
EC 2.7.11.15 created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15
Orthology
K00910  
beta-adrenergic-receptor kinase
Genes
HSA: 
156(ADRBK1) 157(ADRBK2)
PTR: 
100614029(ADRBK2) 451363(ADRBK1)
PPS: 
100984800(ADRBK2) 100991802(ADRBK1)
GGO: 
101140574(ADRBK1) 101148325(ADRBK2)
PON: 
100454669(ADRBK2) 100461893(ADRBK1)
MCC: 
714510(ADRBK2) 721754(ADRBK1)
MCF: 
102141861(ADRBK1) 102141926(ADRBK2)
MMU: 
110355(Adrbk1)
RNO: 
25238(Adrbk1) 25372(Adrbk2)
CGE: 
100761290(Adrbk2) 100762552(Adrbk1)
HGL: 
101708742(Adrbk2) 101708906(Adrbk1)
TUP: 
102482004(ADRBK1) 102499442(ADRBK2)
CFA: 
483701(ADRBK1) 486327(ADRBK2)
AML: 
FCA: 
101090393(ADRBK2) 101101082(ADRBK1)
PTG: 
102957039(ADRBK2) 102970752(ADRBK1)
BTA: 
282136(ADRBK2) 282682(ADRBK1)
BOM: 
102286310(ADRBK1) 102288247(ADRBK2)
PHD: 
102322462(ADRBK2) 102323551(ADRBK1)
CHX: 
102180735(ADRBK1) 102185296(ADRBK2)
OAS: 
101108265(ADRBK1) 101117366(ADRBK2)
SSC: 
100156449(ADRBK2) 100513842(ADRBK1)
CFR: 
102505202(ADRBK2) 102523137(ADRBK1)
BACU: 
103005732(ADRBK2) 103015958 103019615(ADRBK1)
LVE: 
103073421(ADRBK2) 103076247(ADRBK1)
ECB: 
100059001(ADRBK1) 100065495(ADRBK2)
MYB: 
102243341(ADRBK1) 102248143(ADRBK2)
MYD: 
102761774(ADRBK2) 102764962(ADRBK1)
PALE: 
102881239(ADRBK2) 102893733(ADRBK1)
MDO: 
100009844(ADRBK2)
SHR: 
100913578(ADRBK2)
OAA: 
GGA: 
416904(ADRBK2) 426000(ADRBK1)
MGP: 
TGU: 
100217970(ADRBK2) 100227701(ADRBK1)
FAB: 
101810197(ADRBK2) 101811193(ADRBK1)
PHI: 
102108753(ADRBK2) 102114443(ADRBK1)
APLA: 
101801089(ADRBK1) 101802877(ADRBK2)
FPG: 
101911656(ADRBK1) 101916842(ADRBK2)
FCH: 
102048951(ADRBK2) 102058946(ADRBK1)
CLV: 
102092240(ADRBK1) 102096658(ADRBK2)
ASN: 
102367979(ADRBK1) 102378654(ADRBK2)
AMJ: 
102563874(ADRBK2) 102566517(ADRBK1)
PSS: 
102443539(ADRBK1) 102454375(ADRBK2)
CMY: 
102946005(ADRBK2) 102947181(ADRBK1)
ACS: 
100555775(adrbk1)
PBI: 
103064129(ADRBK1) 103066055(ADRBK2)
XTR: 
100379889(adrbk2)
DRE: 
569403(adrbk2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362780(ADRBK1) 102365333(ADRBK2)
CMK: 
BFO: 
CIN: 
100184862(adrbk2)
SPU: 
100888242(adrbk2)
DME: 
DAN: 
DER: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413197(Gprk1)
NVI: 
TCA: 
BMOR: 
API: 
100166085(Gprk1)
PHU: 
ISC: 
CEL: 
CBR: 
CBG15249(Cbr-grk-2)
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
100638292(Adrbk1)
MBR: 
PTI: 
TPS: 
PIF: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:3036840]
  Authors
Benovic JL, Mayor F Jr, Staniszewski C, Lefkowitz RJ, Caron MG
  Title
Purification and characterization of the beta-adrenergic receptor kinase.
  Journal
J. Biol. Chem. 262 (1987) 9026-32.
  Organism
Bos taurus
Reference
2  [PMID:8394172]
  Authors
Kim CM, Dion SB, Onorato JJ, Benovic JL.
  Title
Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.
  Journal
Receptor. 3 (1993) 39-55.
  Organism
Bos taurus
Reference
3  [PMID:9349395]
  Authors
Laugwitz KL, Kronsbein K, Schmitt M, Hoffmann K, Seyfarth M, Schomig A, Ungerer M.
  Title
Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes.
  Journal
Cardiovasc. Res. 35 (1997) 324-33.
  Organism
Rattus norvegicus, hamster
Reference
4  [PMID:7559596]
  Authors
Ferguson SS, Menard L, Barak LS, Koch WJ, Colapietro AM, Caron MG.
  Title
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
  Journal
J. Biol. Chem. 270 (1995) 24782-9.
  Organism
Bos taurus
Reference
5  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends. Pharmacol. Sci. 24 (2003) 626-33.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
102925-39-3

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