KEGG   ENZYME: 2.7.11.16Help
Entry
EC 2.7.11.16                Enzyme                                 

Name
G-protein-coupled receptor kinase;
G protein-coupled receptor kinase;
GPCR kinase;
GPCRK;
GRK4;
GRK5;
GRK6;
STK16
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[G-protein-coupled receptor] phosphotransferase
Reaction(IUBMB)
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
Substrate
ATP [CPD:C00002];
[G-protein-coupled receptor]
Product
ADP [CPD:C00008];
[G-protein-coupled receptor] phosphate
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, beta-adrenergic-receptor kinase).
History
EC 2.7.11.16 created 2005
Orthology
K08291  
G protein-coupled receptor kinase
Genes
HSA: 
2868(GRK4) 2869(GRK5) 2870(GRK6)
PTR: 
461082(GRK4) 466217(GRK5) 471760(GRK6)
PPS: 
100972068(GRK6) 100972921(GRK4) 100975050(GRK5)
GGO: 
101125204(GRK6) 101142802(GRK5) 101148767(GRK4)
PON: 
100171722(GRK5) 100433745(GRK6)
NLE: 
100592067(GRK6) 100593251(GRK5) 100595255(GRK4)
MCC: 
MCF: 
102115240(GRK4) 102128844(GRK6) 102132362(GRK5)
CJC: 
100400573(GRK5) 100403264(GRK6) 100403887(GRK4)
MMU: 
14772(Grk4) 14773(Grk5) 26385(Grk6)
RNO: 
59075(Grk5) 59076(Grk6) 59077(Grk4)
CGE: 
100767022(Grk4) 100771151(Grk5) 103161260(Grk6)
NGI: 
103729285(Grk5) 103732366(Grk6) 103741150(Grk4)
HGL: 
101718249(Grk6) 101718850(Grk5) 101720649(Grk4)
OCU: 
TUP: 
102474598(GRK6) 102480420(GRK4) 102485965(GRK5)
CFA: 
100684653(GRK6) 479075(GRK4) 486915(GRK5)
AML: 
UMR: 
103657694(GRK5) 103664442(GRK6) 103676663(GRK4)
FCA: 
101086226(GRK4) 101087379(GRK6) 101089047(GRK5)
PTG: 
102955344(GRK4) 102962153(GRK5) 102968971(GRK6)
BTA: 
281801(GRK5) 512489(GRK4) 521413(GRK6)
BOM: 
102271649(GRK6) 102272970(GRK5) 102283303(GRK4)
PHD: 
102321739(GRK6) 102336686(GRK4) 102338691(GRK5)
CHX: 
102183500(GRK4) 102186301(GRK6) 102190578(GRK5)
OAS: 
SSC: 
100152937(GRK5) 100519668(GRK4)
CFR: 
BACU: 
103005786(GRK5) 103011898(GRK4) 103017883(GRK6)
LVE: 
ECB: 
100053624(GRK4) 100065919(GRK5) 100068570(GRK6)
MYB: 
102246592(GRK5) 102255277(GRK6) 102260906(GRK4)
MYD: 
102757801(GRK6) 102758601(GRK5) 102762532(GRK4)
PALE: 
102877766(GRK5) 102881935(GRK6) 102893603(GRK4)
MDO: 
100021366(GRK4) 100026232(GRK5) 100031943(GRK6)
SHR: 
100915281(GRK5) 100921906(GRK6) 100931079(GRK4)
OAA: 
100074050(GRK4) 100084269(GRK5) 100084380(GRK6)
GGA: 
416361(GRK6) 422879(GRK4) 423929(GRK5)
MGP: 
APLA: 
101794252(GRK5) 101798639(GRK6) 101798987(GRK4)
TGU: 
100227306(GRK5) 100229994(GRK6) 100232432(GRK4)
FAB: 
101807573(GRK4) 101814948(GRK5) 101818256(GRK6)
PHI: 
102106169(GRK5) 102110063(GRK4) 102110395(GRK6)
FPG: 
FCH: 
CLV: 
102084153(GRK6) 102091969(GRK4) 102093957(GRK5)
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
446831(grk4-a) 447337(grk6) 474158(grk4-b)
XTR: 
100379796(grk6) 100497344 448587(grk4) 550070(grk5)
DRE: 
100330963(grk4) 560761(grk4) 560806(grk5) 561288(grk6) 567452(grk5l)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103177327(grk6) 103186330(grk4) 103186576(grk5)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
AME: 
410632(Gprk2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG01947(Cbr-grk-1)
BMY: 
LOA: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:8288567]
  Authors
Kunapuli P, Onorato JJ, Hosey MM, Benovic JL.
  Title
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
  Journal
J. Biol. Chem. 269 (1994) 1099-105.
Reference
2  [PMID:8120045]
  Authors
Premont RT, Koch WJ, Inglese J, Lefkowitz RJ.
  Title
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
  Journal
J. Biol. Chem. 269 (1994) 6832-41.
  Sequence
[bta:281801]
Reference
3  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends. Pharmacol. Sci. 24 (2003) 626-33.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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