KEGG   ENZYME: 2.7.11.20Help
Entry
EC 2.7.11.20                Enzyme                                 
Name
elongation factor 2 kinase;
Ca/CaM-kinase III;
calmodulin-dependent protein kinase III;
CaM kinase III;
eEF2 kinase;
eEF2K;
EF2K;
STK19
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[elongation factor 2] phosphotransferase
Reaction(IUBMB)
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
Substrate
ATP [CPD:C00002];
[elongation factor 2]
Product
ADP [CPD:C00008];
[elongation factor 2] phosphate
Comment
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
Orthology
K08292  
elongation factor 2 kinase
Genes
HSA: 
PTR: 
454350(EEF2K)
PPS: 
100974702(EEF2K)
GGO: 
101135987(EEF2K)
PON: 
100457763(EEF2K)
MCC: 
698604(EEF2K)
MMU: 
13631(Eef2k)
RNO: 
25435(Eef2k)
CFA: 
479812(EEF2K)
AML: 
100482707(EEF2K)
FCA: 
101101433(EEF2K)
BTA: 
521730(EEF2K)
SSC: 
100523723(EEF2K)
ECB: 
100058387(EEF2K)
MDO: 
100019979(EEF2K)
SHR: 
100917051(EEF2K)
OAA: 
100077045
GGA: 
416619(EEF2K)
MGP: 
100547079(EEF2K)
TGU: 
100226037(EEF2K)
ACS: 
100568209(eef2k)
XTR: 
100145184(eef2k)
DRE: 
437013(eef2k)
OLA: 
101158311
BFO: 
BRAFLDRAFT_126072
CIN: 
100186164
SPU: 
583067(eef2k)
ISC: 
IscW_ISCW010824
CEL: 
CELE_F42A10.4(efk-1)
CBR: 
CBG21103(Cbr-efk-1)
BMY: 
Bm1_35010
TSP: 
Tsp_07620
SMM: 
Smp_072980
NVE: 
NEMVE_v1g118107
HMG: 
100208670
TAD: 
TRIADDRAFT_33592
AQU: 
100639147
CRE: 
CHLREDRAFT_192430(SSA16)
VCN: 
VOLCADRAFT_33453(ssa16)
PTI: 
PHATRDRAFT_34488
TPS: 
THAPSDRAFT_261433
 » show all
Taxonomy
Reference
1  [PMID:8514778]
  Authors
Mitsui K, Brady M, Palfrey HC, Nairn AC.
  Title
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas.
  Journal
J. Biol. Chem. 268 (1993) 13422-33.
  Organism
Oryctolagus cuniculus, Rattus norvegicus [GN:rno]
Reference
2  [PMID:1372803]
  Authors
Hincke MT, Nairn AC.
  Title
Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini.
  Journal
Biochem. J. 282 ( Pt 3) (1992) 877-82.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:11500363]
  Authors
Knebel A, Morrice N, Cohen P.
  Title
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
  Journal
EMBO. J. 20 (2001) 4360-9.
  Organism
Homo sapiens [GN:hsa]
Reference
4  [PMID:15158453]
  Authors
Sans MD, Xie Q, Williams JA.
  Title
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
  Journal
Biochem. Biophys. Res. Commun. 319 (2004) 144-51.
  Organism
Rattus norvegicus [GN:rno]
Reference
5  [PMID:14709557]
  Authors
Browne GJ, Finn SG, Proud CG.
  Title
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
  Journal
J. Biol. Chem. 279 (2004) 12220-31.
  Organism
Homo sapiens [GN:hsa]
Reference
6  [PMID:11904175]
  Authors
Ryazanov AG.
  Title
Elongation factor-2 kinase and its newly discovered relatives.
  Journal
FEBS. Lett. 514 (2002) 26-9.
  Organism
Caenorhabditis elegans [GN:cel]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116283-83-1
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