KEGG   ENZYME: 2.7.11.20Help
Entry
EC 2.7.11.20                Enzyme                                 

Name
elongation factor 2 kinase;
Ca/CaM-kinase III;
calmodulin-dependent protein kinase III;
CaM kinase III;
eEF2 kinase;
eEF2K;
EF2K;
STK19
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[elongation factor 2] phosphotransferase
Reaction(IUBMB)
ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate
Substrate
ATP [CPD:C00002];
[elongation factor 2]
Product
ADP [CPD:C00008];
[elongation factor 2] phosphate
Comment
Requires Ca2+ and calmodulin for activity. The enzyme can also be phosphorylated by the catalytic subunit of EC 2.7.11.11, cAMP-dependent protein kinase. Elongation factor 2 is phosphorylated in several cell types in response to various growth factors, hormones and other stimuli that raise intracellular Ca2+ [1,2].
History
EC 2.7.11.20 created 2005
Orthology
K08292  
elongation factor 2 kinase
Genes
HSA: 
PTR: 
454350(EEF2K)
PPS: 
100974702(EEF2K)
GGO: 
101135987(EEF2K)
PON: 
100457763(EEF2K)
NLE: 
100591954(EEF2K)
MCC: 
698604(EEF2K)
MCF: 
102136849(EEF2K)
CJC: 
100390187(EEF2K)
MMU: 
13631(Eef2k)
RNO: 
25435(Eef2k)
CGE: 
100765385(Eef2k)
HGL: 
101709310(Eef2k)
TUP: 
102470788(EEF2K)
CFA: 
479812(EEF2K)
AML: 
100482707(EEF2K)
UMR: 
103668877(EEF2K)
FCA: 
101101433(EEF2K)
PTG: 
102960729(EEF2K)
BTA: 
521730(EEF2K)
BOM: 
102283488(EEF2K)
PHD: 
102324564(EEF2K)
CHX: 
102168229(EEF2K)
OAS: 
101103447(EEF2K)
SSC: 
100523723(EEF2K)
CFR: 
102515399(EEF2K)
BACU: 
102997361(EEF2K)
LVE: 
103084838(EEF2K)
ECB: 
100058387(EEF2K)
MYB: 
MYD: 
102761531(EEF2K)
PALE: 
102897678(EEF2K)
MDO: 
100019979(EEF2K)
SHR: 
100917051(EEF2K)
OAA: 
100077045(EEF2K)
GGA: 
416619(EEF2K)
MGP: 
100547079(EEF2K)
APLA: 
101798747(EEF2K)
TGU: 
100226037(EEF2K)
FAB: 
101818070(EEF2K)
PHI: 
102109650(EEF2K)
FPG: 
101920273(EEF2K)
FCH: 
102054348(EEF2K)
CLV: 
102091136(EEF2K)
ASN: 
102383218(EEF2K)
AMJ: 
102562118(EEF2K)
PSS: 
102444339(EEF2K)
CMY: 
102948272(EEF2K)
ACS: 
100568209(eef2k)
PBI: 
103061498(EEF2K)
XTR: 
100145184(eef2k)
DRE: 
437013(eef2k)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103178713(eef2k)
BFO: 
CIN: 
SPU: 
583067(eef2k)
ISC: 
CEL: 
CBR: 
CBG21103(Cbr-efk-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
LBC: 
PGR: 
DPP: 
ACAN: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:8514778]
  Authors
Mitsui K, Brady M, Palfrey HC, Nairn AC.
  Title
Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas.
  Journal
J. Biol. Chem. 268 (1993) 13422-33.
  Sequence
[rno:25435]
Reference
2  [PMID:1372803]
  Authors
Hincke MT, Nairn AC.
  Title
Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini.
  Journal
Biochem. J. 282 ( Pt 3) (1992) 877-82.
Reference
3  [PMID:11500363]
  Authors
Knebel A, Morrice N, Cohen P.
  Title
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
  Journal
EMBO. J. 20 (2001) 4360-9.
  Sequence
Reference
4  [PMID:15158453]
  Authors
Sans MD, Xie Q, Williams JA.
  Title
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
  Journal
Biochem. Biophys. Res. Commun. 319 (2004) 144-51.
Reference
5  [PMID:14709557]
  Authors
Browne GJ, Finn SG, Proud CG.
  Title
Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398.
  Journal
J. Biol. Chem. 279 (2004) 12220-31.
  Sequence
Reference
6  [PMID:11904175]
  Authors
Ryazanov AG.
  Title
Elongation factor-2 kinase and its newly discovered relatives.
  Journal
FEBS. Lett. 514 (2002) 26-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116283-83-1

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