KEGG   ENZYME: 2.7.11.21Help
Entry
EC 2.7.11.21                Enzyme                                 
Name
polo kinase;
Cdc5;
Cdc5p;
Plk;
PLK;
Plk1;
Plo1;
POLO kinase;
polo serine-threonine kinase;
polo-like kinase;
polo-like kinase 1;
serine/threonine-specific Drosophila kinase polo;
STK21
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (spindle-pole-dependent)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
Orthology
K06631  
polo-like kinase 1
K06660  
cell cycle serine/threonine-protein kinase CDC5/MSD2
K08861  
polo-like kinase 2
K08862  
polo-like kinase 3
K08863  
polo-like kinase 4
Genes
HSA: 
10733(PLK4) 10769(PLK2) 1263(PLK3) 5347(PLK1)
PTR: 
453991(PLK1) 456546(PLK3) 461480(PLK4) 461861(PLK2)
PPS: 
100968426(PLK2) 100973032(PLK3) 100985260(PLK4) 100992499(PLK1)
GGO: 
101132540(PLK2) 101142495(PLK1) 101143772(PLK3) 101145407(PLK4)
PON: 
100174060(PLK2) 100294540(PLK4) 100433480(PLK3) 100437332(PLK1)
MCC: 
697686(PLK1) 704071(PLK3) 708835(PLK2) 710233(PLK4)
MMU: 
12795(Plk3) 18817(Plk1) 20620(Plk2) 20873(Plk4)
RNO: 
25515(Plk1) 310344(Plk4) 58936(Plk3) 83722(Plk2)
CFA: 
475380(PLK3) 476087(PLK4) 478063(PLK2) 489971(PLK1)
AML: 
FCA: 
101086791(PLK4) 101088599(PLK3) 101092083(PLK2) 101098508(PLK1)
BTA: 
504282(PLK3) 514405(PLK4) 538238(PLK1) 539449(PLK2)
SSC: 
100517044(PLK4) 396953(PLK1) 397250(PLK3) 397251(PLK2)
ECB: 
100051484 100063593(PLK4) 100065793(PLK3)
MDO: 
100010836(PLK4) 100024987 100027403 100032162
SHR: 
100914691(PLK2) 100917173(PLK3) 100928146(PLK4) 100930498(PLK1)
OAA: 
100073533(PLK1) 100075832 100091573
GGA: 
416575(PLK1) 424586(PLK3) 427150(PLK2)
MGP: 
100539569(PLK1) 100545840(PLK3) 100548694(PLK4) 100551083
TGU: 
100221236(PLK3) 100221581(PLK1) 100231503(PLK2) 100231569(PLK4)
ACS: 
100553693 100557501(plk4) 100558384(plk1) 100559459(plk3)
XLA: 
379122(plk2) 379315(MGC53542) 380481(plk1) 398770(plk4)
XTR: 
100038180(plk4) 100125189(plk2) 407937(plk1) 448451(plk3)
DRE: 
100148413(plk2a) 280649(plk1) 334202(plk3) 368390(plk4) 565576(plk2b)
TRU: 
101066743 101069402 101072492 101075724
OLA: 
101155385 101161450 101166557 101170155
BFO: 
BRAFLDRAFT_247541 BRAFLDRAFT_256673 BRAFLDRAFT_258514
CIN: 
100177145 100177586
SPU: 
579629 584420 589028 753995
DME: 
Dmel_CG12306(polo) Dmel_CG7186(SAK)
DPO: 
Dpse_GA11545 Dpse_GA20166 Dpse_GA25172
DAN: 
Dana_GF10050 Dana_GF10707
DER: 
Dere_GG13228 Dere_GG16099
DPE: 
Dper_GL11903 Dper_GL25129 Dper_GL25881
DSE: 
Dsec_GM22133 Dsec_GM22270
DSI: 
Dsim_GD12112 Dsim_GD14871
DWI: 
Dwil_GK17233 Dwil_GK17621
DYA: 
Dyak_GE19659 Dyak_GE22325
DGR: 
Dgri_GH14380 Dgri_GH16744
DMO: 
Dmoj_GI11323 Dmoj_GI13469
DVI: 
Dvir_GJ11579 Dvir_GJ11832
AGA: 
AgaP_AGAP004239 AgaP_AGAP012499
AAG: 
AaeL_AAEL009360 AaeL_AAEL013390
CQU: 
CpipJ_CPIJ004252 CpipJ_CPIJ006236
AME: 
413261(polo) 550739(SAK)
NVI: 
100115256(Plk4) 100118436(Plk3)
TCA: 
660822(polo) 663303
API: 
100168700 100571755
PHU: 
Phum_PHUM087560 Phum_PHUM252390 Phum_PHUM611910
ISC: 
IscW_ISCW020269
CEL: 
CELE_C14B9.4(plk-1) CELE_F55G1.8(plk-3) CELE_F59E12.2(zyg-1) CELE_Y71F9B.7(plk-2)
CBR: 
CBG02462(Cbr-zyg-1) CBG04120(Cbr-plk-2) CBG09233(Cbr-plk-1)
BMY: 
Bm1_11620 Bm1_12980 Bm1_14075
TSP: 
Tsp_02561 Tsp_04548
SMM: 
Smp_009600 Smp_079410
NVE: 
NEMVE_v1g128941 NEMVE_v1g230033 NEMVE_v1g246408
HMG: 
100205568 100206873
TAD: 
TRIADDRAFT_30306 TRIADDRAFT_50801
AQU: 
100638798 100641743
RCU: 
RCOM_1340560
CRE: 
CHLREDRAFT_115581
VCN: 
VOLCADRAFT_69399
OLU: 
OSTLU_30992
OTA: 
Ot04g00800
CME: 
CME146C
SCE: 
YMR001C(CDC5)
AGO: 
AGOS_ACL006W
KLA: 
KLLA0C06138g
LTH: 
KLTH0C10912g
PPA: 
PAS_chr3_0243
VPO: 
Kpol_1037p20
ZRO: 
ZYRO0C07480g
CGR: 
CAGL0J11638g
DHA: 
DEHA2F09966g
PIC: 
PICST_68049(CDC5)
PGU: 
PGUG_04276
LEL: 
LELG_01370
CAL: 
CaO19.13431(CDC5) CaO19.6010(CDC5)
CTP: 
CTRG_04398
CDU: 
CD36_00900
YLI: 
YALI0D26015g
CLU: 
CLUG_01461
TML: 
GSTUM_00008436001
SPO: 
SPAC23C11.16(plo1)
CNE: 
CNK02500
CNB: 
CNBK1050
CGI: 
CGB_K1340C
LBC: 
LACBIDRAFT_191474
CCI: 
CC1G_07437
SCM: 
SCHCODRAFT_17460
MGL: 
MGL_2936
PGR: 
PGTG_19329
ECU: 
ECU01_0630
EIN: 
Eint_010510
EHE: 
EHEL_010500
NCE: 
NCER_100270
MBR: 
MONBRDRAFT_39338
NGR: 
NAEGRDRAFT_29554 NAEGRDRAFT_53552 NAEGRDRAFT_63986
DDI: 
DDB_G0274503(plk)
DPP: 
DICPUDRAFT_98258
EHI: 
EHI_008410(114.t00009)
EDI: 
EDI_061560
TET: 
TTHERM_00191790 TTHERM_01076980 TTHERM_01443850
PTM: 
GSPATT00006256001 GSPATT00009060001 GSPATT00022475001 GSPATT00026684001 GSPATT00028443001 GSPATT00031090001 GSPATT00036333001
TBR: 
Tb927.7.6310(Tb07.2F2.640)
TCR: 
506513.160 508917.10
LMA: 
LMJF_17_0790
LIF: 
LINJ_17_0770
LDO: 
LDBPK_170770
LMI: 
LMXM_17_0790
LBZ: 
LBRM_17_0690
GLA: 
GL50803_104150
TVA: 
TVAG_003370 TVAG_039910 TVAG_088660 TVAG_496190
PTI: 
PHATR_10628
TPS: 
THAPSDRAFT_33979
PIF: 
PITG_10092
 » show all
Taxonomy
Reference
1  [PMID:1660828]
  Authors
Llamazares S, Moreira A, Tavares A, Girdham C, Spruce BA, Gonzalez C, Karess RE, Glover DM, Sunkel CE.
  Title
polo encodes a protein kinase homolog required for mitosis in Drosophila.
  Journal
Genes. Dev. 5 (1991) 2153-65.
Reference
2  [PMID:7790358]
  Authors
Golsteyn RM, Mundt KE, Fry AM, Nigg EA.
  Title
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
  Journal
J. Cell. Biol. 129 (1995) 1617-28.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:12186944]
  Authors
Mulvihill DP, Hyams JS.
  Title
Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint.
  Journal
J. Cell. Sci. 115 (2002) 3575-86.
  Organism
Schizosaccharomyces pombe [GN:spo]
Reference
4  [PMID:14654016]
  Authors
Ohkura H.
  Title
Phosphorylation: polo kinase joins an elite club.
  Journal
Curr. Biol. 13 (2003) R912-4.
  Organism
Homo sapiens [GN:hsa], Saccharomyces cerevisiae [GN:sce]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
149433-93-2
DBGET integrated database retrieval system