KEGG   ENZYME: 2.7.11.23Help
Entry
EC 2.7.11.23                Enzyme                                 
Name
[RNA-polymerase]-subunit kinase;
CTD kinase;
STK9
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[DNA-directed RNA polymerase] phosphotransferase
Reaction(IUBMB)
ATP + [DNA-directed RNA polymerase] = ADP + phospho-[DNA-directed RNA polymerase] [RN:R04358]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[DNA-directed RNA polymerase] [CPD:C03959]
Product
ADP [CPD:C00008];
phospho-[DNA-directed RNA polymerase] [CPD:C04395]
Comment
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
Orthology
K00916  
CTD kinase subunit alpha
K02087  
cyclin-dependent kinase 1
K02202  
cyclin-dependent kinase 7
K02208  
cyclin-dependent kinase 8/11
K02211  
cyclin-dependent kinase 9
K08819  
cyclin-dependent kinase 12/13
K15562  
serine/threonine-protein kinase BUR1
Genes
HSA: 
1022(CDK7) 1024(CDK8) 1025(CDK9) 23097(CDK19) 51755(CDK12) 8621(CDK13) 983(CDK1)
PTR: 
450481(CDK1) 452501(CDK8) 454630(CDK12) 462378(CDK7) 464755(CDK9) 736969(CDK13) 743086(CDK19)
PPS: 
100977722(CDK19) 100981400(CDK12) 100984451(CDK8) 100987832(CDK13) 100991412(CDK7) 100994414(CDK9) 100996071(CDK1)
GGO: 
101125559(CDK7) 101131389(CDK1) 101137348(CDK12) 101139311(CDK19) 101144006(CDK9) 101150971(CDK13) 101151398(CDK8)
PON: 
100172184(CDK1) 100172529(CDK12) 100431380(CDK19) 100438878(CDK9) 100443786(CDK8) 100444607(CDK13)
MCC: 
696733(CDK12) 698292 699269(CDK1) 699840(CDK9) 699871(CDK7) 709761(CDK8) 711379(CDK13)
MMU: 
107951(Cdk9) 12534(Cdk1) 12572(Cdk7) 264064(Cdk8) 69131(Cdk12) 69562(Cdk13) 78334(Cdk19)
RNO: 
171150(Cdk7) 192350(Cdk12) 306998(Cdk13) 309804(Cdk19) 362110(Cdk9) 498140(RGD1560888) 54237(Cdk1)
CFA: 
100855805 100856079 475874(CDK13) 486035(CDK8) 491027(CDK12) 608441(CDK7) 612317(CDK19)
AML: 
FCA: 
101083850(CDK19) 101086278(CDK8) 101086781(CDK7) 101090563(CDK12) 101097767(CDK9) 101098044(CDK13) 101101592
BTA: 
281061(CDK1) 507149(CDK8) 511147(CDK13) 511513(CDK12) 511802(CDK19) 515462(CDK7) 520580(CDK9)
SSC: 
100155762(CDK1) 100307051(CDK9) 100310797(CDK7) 100513815(CDK12) 100519067(CDK13)
ECB: 
100049964(CDK7) 100050819(CDK8) 100066791(CDK19) 100068316 100070437 100072299
MDO: 
100010850 100017594 100017606 100019463(CDK8) 100019498(CDK7) 100019938 100022235
SHR: 
100916129(CDK12) 100920167(CDK9) 100921796(CDK19) 100923056(CDK13) 100924163(CDK1) 100928365(CDK8) 100930055(CDK7)
OAA: 
100074988 100077655 100079814(CDK12) 100080299 100089343(CDK8) 100091817 100093399
GGA: 
396252(CDK1) 417226(CDK9) 420766(CDK13) 421756(CDK19) 428080(CDK8) 428306(CDK12) 771294(CDK7)
MGP: 
100540873 100541405 100543139 100543692 100549676
TGU: 
100218430(CDK1) 100220490(CDK9) 100221466(CDK8) 100221666(CDK12) 100226313(CDK19) 100229652(CDK13) 100230524(CDK7)
ACS: 
100553609 100554966 100557869 100558917 100560462 100562632 100565121
XLA: 
379785(cdk1-b) 380229(cdk9-b) 380246(cdk1-a) 380415(cdk19) 399461(cdk7) 447409(cdk8) 735101(cdk9-a)
XTR: 
100038049(cdk12) 100135368(cdk19) 100489599 394503(cdk1) 394856(cdk8) 448039(cdk9) 549973(cdk7)
DRE: 
100149670(cdk19) 100149834 321602(cdk9) 373868(cdk8) 405897(cdk7) 559027(cdk13) 80973(cdk1)
TRU: 
101062477 101063624 101064374 101070074 101073254 101075585
OLA: 
100049478(cdc2) 101155202 101158180 101162007 101169150 101169207 101170812
BFO: 
BRAFLDRAFT_114825 BRAFLDRAFT_118518 BRAFLDRAFT_174614 BRAFLDRAFT_259646 BRAFLDRAFT_265807
CIN: 
100177537 100181821 100182642
SPU: 
100894147 575965 584384 593706 764886
DME: 
Dmel_CG10572(Cdk8) Dmel_CG3319(Cdk7) Dmel_CG5179(Cdk9) Dmel_CG5363(cdc2) Dmel_CG7597(Cdk12)
DPO: 
Dpse_GA17354 Dpse_GA18713 Dpse_GA20468 Dpse_GA28311
DAN: 
Dana_GF10227 Dana_GF13008 Dana_GF14103 Dana_GF20951 Dana_GF23720
DER: 
Dere_GG14001 Dere_GG16193 Dere_GG18504 Dere_GG21780 Dere_GG23938
DPE: 
Dper_GL10467 Dper_GL11886 Dper_GL14332 Dper_GL19151 Dper_GL20758
DSE: 
Dsec_GM11695 Dsec_GM12652 Dsec_GM15631 Dsec_GM22376 Dsec_GM24836
DSI: 
Dsim_GD12888 Dsim_GD14967 Dsim_GD22264 Dsim_GD24595 Dsim_GD25120
DWI: 
Dwil_GK10332 Dwil_GK12315 Dwil_GK17904 Dwil_GK20415 Dwil_GK23499
DYA: 
Dyak_GE11856 Dyak_GE16821 Dyak_GE19764 Dyak_GE20297 Dyak_GE26009
DGR: 
Dgri_GH13856 Dgri_GH16743 Dgri_GH16999 Dgri_GH20336 Dgri_GH22186 Dgri_GH24366
DMO: 
Dmoj_GI11413 Dmoj_GI13468 Dmoj_GI15304 Dmoj_GI18275 Dmoj_GI20007
DVI: 
Dvir_GJ11831 Dvir_GJ13608 Dvir_GJ15416 Dvir_GJ16576 Dvir_GJ21256
AGA: 
AgaP_AGAP002646 AgaP_AGAP004780 AgaP_AGAP008541 AgaP_AGAP009459 AgaP_AGAP009936
AAG: 
AaeL_AAEL001038 AaeL_AAEL002395 AaeL_AAEL008621 AaeL_AAEL009364 AaeL_AAEL013002
CQU: 
CpipJ_CPIJ000891 CpipJ_CPIJ001155 CpipJ_CPIJ004253 CpipJ_CPIJ008862 CpipJ_CPIJ018296
AME: 
409590 409965 412339(Cdk7) 412560(Cdk9)
NVI: 
100113574(NV12115) 100114430(NV17938) 100116511(NV17198) 100116730(NV12113) 100116857(Cdk1) 100119419(NV16758) 100122290(NV11191) 100123058(NV12779)
TCA: 
655114 656189 660097 660461(cdk8) 664031
API: 
100164144 100164802 100165762 100167389 100167559 100168376 100168871
PHU: 
Phum_PHUM298010 Phum_PHUM399490 Phum_PHUM448370 Phum_PHUM500570
ISC: 
IscW_ISCW014734 IscW_ISCW018877 IscW_ISCW020730
CEL: 
CELE_F39H11.3(cdk-8) CELE_H25P06.2(cdk-9) CELE_T05G5.3(cdk-1) CELE_Y39G10AL.3(cdk-7)
CBR: 
CBG03876(Cbr-cdk-7) CBG10007(Cbr-cdk-1) CBG12346(Cbr-cdk-8) CBG15591 CBG18089 CBG20416(Cbr-cdk-9)
BMY: 
Bm1_01435 Bm1_14135 Bm1_20615 Bm1_33825 Bm1_46210
TSP: 
Tsp_01670 Tsp_02866 Tsp_07784
SMM: 
Smp_003000 Smp_094760 Smp_150040.2 Smp_156990
NVE: 
NEMVE_v1g130552 NEMVE_v1g228964 NEMVE_v1g246363
HMG: 
100203266 100205702 100215392(cdk9)
TAD: 
TRIADDRAFT_20854 TRIADDRAFT_23127 TRIADDRAFT_23304 TRIADDRAFT_32638 TRIADDRAFT_32711 TRIADDRAFT_55283
AQU: 
100632624 100632998 100636755 100638755 100641344
ATH: 
AT1G18040(CDKD1;3) AT1G66750(CAK4) AT1G73690(CDKD1;1) AT5G10270(CDKC;1) AT5G63610(CDKE;1)
ALY: 
ARALYDRAFT_472021(AT_CDCKD_3) ARALYDRAFT_475772(AT_CDKD_2) ARALYDRAFT_476509(AT_CDKD_1) ARALYDRAFT_487853(CDKC_1) ARALYDRAFT_919653 ARALYDRAFT_919823(CDKC_2)
GMX: 
100776618 100779413 100793565 100795971 100807993 100813433 100813673 100814263
MTR: 
MTR_2g020210 MTR_3g096960 MTR_7g114300 MTR_8g099770
CSV: 
101203984 101217645 101217952 101220936
RCU: 
RCOM_0243690 RCOM_0964880 RCOM_1312220 RCOM_1429130
POP: 
POPTR_420526 POPTR_560274 POPTR_569512 POPTR_640317 POPTR_757657 POPTR_834270
VVI: 
100240938 100244503 100247566 100249168 100253284 100263383
OSA: 
4325386 4325730 4338674 4338689 4349519
DOSA: 
Os01t0367700-01(Os01g0367700) Os01t0958000-01(Os01g0958000) Os05t0389700-01(Os05g0389700) Os10t0580300-01(Os10g0580300)
BDI: 
100825427 100833383 100835837 100843755
SBI: 
SORBI_01g009600(SORBIDRAFT_01g009600) SORBI_01g027690(SORBIDRAFT_01g027690) SORBI_03g014750(SORBIDRAFT_03g014750) SORBI_09g019250(SORBIDRAFT_09g019250) SORBI_09g019400(SORBIDRAFT_09g019400)
ZMA: 
100193551(AY106948) 100272776(pco075430a) 100274390 100279243 100284562(cl17437_1)
SMO: 
SELMODRAFT_100958(CDKD-1) SELMODRAFT_110606(CDKE-1) SELMODRAFT_122588(CDKD-2) SELMODRAFT_128208(CDKE-2) SELMODRAFT_169412(CDKC1-2)
PPP: 
PHYPADRAFT_112137 PHYPADRAFT_135647 PHYPADRAFT_161163 PHYPADRAFT_170206 PHYPADRAFT_184162 PHYPADRAFT_224823 PHYPADRAFT_73705
CRE: 
CHLREDRAFT_120881(CDKE1) CHLREDRAFT_137457(CDKD1) CHLREDRAFT_148395(CDKC1)
VCN: 
VOLCADRAFT_65162(cdkd1) VOLCADRAFT_68336(cdke1) VOLCADRAFT_82776(cdkc1)
OLU: 
OSTLU_17513 OSTLU_3057 OSTLU_35576
OTA: 
Ot01g04200(CDK-C) Ot07g01260(CDKD) Ot12g00510
CME: 
CMN139C CMQ195C
SCE: 
YDL108W(KIN28) YKL139W(CTK1) YPL042C(SSN3) YPR161C(SGV1)
AGO: 
AGOS_ABR177C AGOS_ADL283W AGOS_AFR205C AGOS_AGL249C
ERC: 
Ecym_2540 Ecym_3371 Ecym_6092 Ecym_7206
KLA: 
KLLA0D10527g KLLA0D11814g KLLA0E12145g KLLA0E14785g
LTH: 
KLTH0D04356g KLTH0E11396g KLTH0F09504g KLTH0F18458g
PPA: 
PAS_chr1-4_0305 PAS_chr2-1_0468 PAS_chr2-2_0041 PAS_chr3_0375
VPO: 
Kpol_1013p52 Kpol_1018p148 Kpol_1031p76 Kpol_534p14
ZRO: 
ZYRO0A07062g ZYRO0D01584g ZYRO0F08272g ZYRO0G20306g
CGR: 
CAGL0D02002g CAGL0H10318g CAGL0I08349g CAGL0L12650g
NCS: 
NCAS_0A04220(NCAS0A04220) NCAS_0A15040(NCAS0A15040) NCAS_0B06000(NCAS0B06000) NCAS_0C02390(NCAS0C02390)
NDI: 
NDAI_0B03310(NDAI0B03310) NDAI_0E01960(NDAI0E01960) NDAI_0E03080(NDAI0E03080) NDAI_0J00420(NDAI0J00420)
TPF: 
TPHA_0C04650(TPHA0C04650) TPHA_0G02800(TPHA0G02800) TPHA_0I03100(TPHA0I03100) TPHA_0L01350(TPHA0L01350)
TBL: 
TBLA_0A01580(TBLA0A01580) TBLA_0B09590(TBLA0B09590) TBLA_0H00370(TBLA0H00370) TBLA_0J00250(TBLA0J00250)
TDL: 
TDEL_0A02010(TDEL0A02010) TDEL_0B01470(TDEL0B01470) TDEL_0G02620(TDEL0G02620) TDEL_0H00560(TDEL0H00560)
KAF: 
KAFR_0A06790(KAFR0A06790) KAFR_0B00520(KAFR0B00520) KAFR_0D02900(KAFR0D02900) KAFR_0H01460(KAFR0H01460)
DHA: 
DEHA2C06358g DEHA2F08844g DEHA2G02266g DEHA2G21230g
PIC: 
PICST_54142(KIN28) PICST_5847(CRK1) PICST_77457(CTK1) PICST_89025(SSN3)
PGU: 
PGUG_00670 PGUG_01495 PGUG_02490 PGUG_05344
LEL: 
LELG_00602 LELG_00959 LELG_01034 LELG_02752
CAL: 
CaO19.11006(CRK1) CaO19.13619(KIN28) CaO19.1619(CTK1) CaO19.3524 CaO19.6239(KIN28) CaO19.794(SSN3) CaO19.8413(SSN3) CaO19.9187(CTK1)
CTP: 
CTRG_01578 CTRG_01634 CTRG_02406 CTRG_04213
CDU: 
CD36_06280 CD36_18910 CD36_19450(CRK1) CD36_82230
COT: 
CORT_0A06400 CORT_0A09350 CORT_0A10460 CORT_0C04520
YLI: 
YALI0B22528g YALI0C10967g YALI0D04334g YALI0D22935g
CLU: 
CLUG_01841 CLUG_02664 CLUG_02781 CLUG_05119
NCR: 
NCU03659 NCU06685 NCU07172
SMP: 
SMAC_02534 SMAC_04502 SMAC_06647 SMAC_12613
PAN: 
PODANSg235 PODANSg8354 PODANSg8403 PODANSg8989
TTT: 
THITE_2107486 THITE_2107586 THITE_2108493 THITE_2109238
MTM: 
MYCTH_2301244 MYCTH_2301373 MYCTH_2302277 MYCTH_2303023
MGR: 
MGG_07291 MGG_13401 MGG_13931
FGR: 
FG04484.1 FG06793.1 FG07409.1 FG07423.1
NHE: 
NECHADRAFT_48520 NECHADRAFT_63411 NECHADRAFT_71668 NECHADRAFT_95835
VAL: 
VDBG_00057 VDBG_02134 VDBG_04162 VDBG_04181
SSL: 
SS1G_00199 SS1G_01068 SS1G_06051 SS1G_07672
BFU: 
BC1G_01470 BC1G_02926 BC1G_06090 BC1G_13827
ANI: 
AN2489.2 AN8190.2 AN8285.2
NFI: 
NFIA_024670 NFIA_037540 NFIA_038950 NFIA_063290
AFM: 
AFUA_3G13990 AFUA_5G03160 AFUA_5G05510 AFUA_7G03720
AOR: 
AOR_1_1204184(AO090009000710) AOR_1_1272194(AO090012000729) AOR_1_1510014 AOR_1_848134(AO090102000520)
ANG: 
ANI_1_1480084(An09g05370) ANI_1_518154(An17g02320) ANI_1_570084(An09g04660)
AFV: 
AFLA_005900 AFLA_019840 AFLA_048030 AFLA_131040
ACT: 
ACLA_001990 ACLA_005400 ACLA_008810 ACLA_041380
PCS: 
Pc13g15460 Pc20g00540 Pc20g09050 Pc21g16250
CIM: 
CIMG_00063 CIMG_06354 CIMG_06521 CIMG_07467
CPW: 
CPC735_028650 CPC735_029990 CPC735_044430 CPC735_060640
PBL: 
PAAG_00829 PAAG_03996 PAAG_04341 PAAG_08700
URE: 
UREG_00175 UREG_03907 UREG_07806
ABE: 
ARB_00891 ARB_00952 ARB_02978 ARB_06874
TVE: 
TRV_00195 TRV_00732 TRV_03726 TRV_05964
AJE: 
HCAG_00490 HCAG_01109 HCAG_03109 HCAG_04046
PNO: 
SNOG_03503 SNOG_09406 SNOG_11252 SNOG_16136
PTE: 
PTT_00382 PTT_08758 PTT_10882 PTT_12614
ZTR: 
MYCGRDRAFT_45390(KIN28) MYCGRDRAFT_46259(BUR1) MYCGRDRAFT_65914(SSN3) MYCGRDRAFT_74961(LSK1)
TML: 
GSTUM_00005162001 GSTUM_00005403001 GSTUM_00011210001 GSTUM_00011694001
SPO: 
SPAC23H4.17c(srb10) SPAC2F3.15(lsk1) SPBC19F8.07(mcs6) SPBC32H8.10(cdk9)
CNE: 
CNI04290 CNM00930 CNN01700
CNB: 
CNBH4100 CNBM0820 CNBN1650
CGI: 
CGB_H5650W CGB_M1150C CGB_N2440W
PPL: 
POSPLDRAFT_24358 POSPLDRAFT_31174 POSPLDRAFT_93074
LBC: 
LACBIDRAFT_305450 LACBIDRAFT_319506
MPR: 
MPER_02035 MPER_06335 MPER_07452
CCI: 
CC1G_00997 CC1G_07887 CC1G_11325 CC1G_14638
SCM: 
SCHCODRAFT_15275 SCHCODRAFT_46333 SCHCODRAFT_58330 SCHCODRAFT_59968
UMA: 
UM03131.1 UM04902.1 UM04925.1 UM04950.1
MGL: 
MGL_1286 MGL_2835 MGL_3180
PGR: 
PGTG_15320
ECU: 
ECU02_1450
EIN: 
Eint_021410
EHE: 
EHEL_021380 EHEL_110840
NCE: 
NCER_101204
MBR: 
MONBRDRAFT_13866 MONBRDRAFT_2068 MONBRDRAFT_21735(Cdk7) MONBRDRAFT_33116
NGR: 
NAEGRDRAFT_2502 NAEGRDRAFT_53182 NAEGRDRAFT_70082
DDI: 
DDB_G0267442(cdk8) DDB_G0273207(cdk9-1) DDB_G0273721(cdk9-2) DDB_G0285417(cdk7)
DPP: 
DICPUDRAFT_157293 DICPUDRAFT_29225 DICPUDRAFT_58676
EHI: 
EHI_108670(170.t00025)
EDI: 
EDI_187190
PFA: 
PF10_0141
PFD: 
PFDG_00800
PFH: 
PFHG_04457
PYO: 
PY05139
PBE: 
PB001062.01.0
PKN: 
PKH_081440
PVX: 
PVX_094935
PCY: 
PCYB_082420
TAN: 
TA07000
TPV: 
TP01_0781
BBO: 
BBOV_IV010230(23.m05960)
CPV: 
cgd7_430
CHO: 
Chro.70056
TGO: 
TGME49_070330
TET: 
TTHERM_00011670
TVA: 
TVAG_311740
PTI: 
PHATRDRAFT_10160(CDKD1) PHATRDRAFT_10704(CDKC1) PHATRDRAFT_26925(CDKC2) PHATRDRAFT_51279(CDKA2)
TPS: 
THAPSDRAFT_14004 THAPSDRAFT_15887 THAPSDRAFT_33726 THAPS_35387(cdc2)
PIF: 
PITG_02446 PITG_07995 PITG_19235
 » show all
Taxonomy
Reference
1  [PMID:2657724]
  Authors
Lee JM, Greenleaf AL.
  Title
A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 3624-8.
  Organism
Saccharomyces cerevisiae [GN:sce]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122097-00-1
DBGET integrated database retrieval system