KEGG   ENZYME: 2.7.11.24Help
Entry
EC 2.7.11.24                Enzyme                                 

Name
mitogen-activated protein kinase;
c-Jun N-terminal kinase;
Dp38;
ERK;
ERK1;
ERK2;
extracellular signal-regulated kinase;
JNK;
JNK3alpha1;
LeMPK3;
MAP kinase;
MAP-2 kinase;
MAPK;
MBP kinase I;
MBP kinase II;
microtubule-associated protein 2 kinase;
microtubule-associated protein kinase;
myelin basic protein kinase;
p38delta;
p38-2;
p42 mitogen-activated protein kinase;
p42mapk;
PMK-1;
PMK-2;
PMK-3;
pp42;
pp44mapk;
p44mpk;
SAPK;
STK26;
stress-activated protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.24 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04371  
mitogen-activated protein kinase 1/3
K04440  
c-Jun N-terminal kinase
K04441  
p38 MAP kinase
K04464  
mitogen-activated protein kinase 7
K04468  
nemo like kinase
K06855  
mitogen-activated protein kinase 4/6
K08293  
mitogen-activated protein kinase
K14512  
mitogen-activated protein kinase 6
Genes
HSA: 
1432(MAPK14) 225689(MAPK15) 51701(NLK) 5594(MAPK1) 5595(MAPK3) 5596(MAPK4) 5597(MAPK6) 5598(MAPK7) 5599(MAPK8) 5600(MAPK11) 5601(MAPK9) 5602(MAPK10) 5603(MAPK13) 6300(MAPK12)
PTR: 
450161(MAPK14) 450445(MAPK8) 453439(MAPK6) 454037(MAPK3) 454499(MAPK7) 458680(MAPK1) 461358(MAPK10) 462336(MAPK9) 462644(MAPK13) 468536(MAPK4) 739132(NLK) 746712(MAPK15) 747077(MAPK12)
PPS: 
100967254(MAPK7) 100972270(MAPK15) 100979222(NLK) 100979542(MAPK3) 100980937(MAPK11) 100981268(MAPK12) 100982480(MAPK8) 100982544(MAPK13) 100983649(MAPK14) 100984173(MAPK10) 100988980(MAPK6) 100989422(MAPK4) 100990080(MAPK9) 100995567(MAPK1)
GGO: 
101124033(MAPK8) 101129084(MAPK15) 101134492(MAPK12) 101134843(MAPK11) 101135988(MAPK3) 101137450(MAPK7) 101138810(NLK) 101140164 101143697(MAPK6) 101148438(MAPK13) 101151665(MAPK4) 101152026(MAPK9) 101152640(MAPK14)
PON: 
100169740(MAPK1) 100173242(MAPK6) 100174482(MAPK10) 100431824(MAPK3) 100437263(MAPK12) 100437341(NLK) 100437424(MAPK8) 100438440 100440111(MAPK15) 100449269(MAPK14) 100449853(MAPK13) 100451029(MAPK7) 100459133(MAPK9)
MCC: 
677693(NLK) 694444(MAPK6) 694998(MAPK6) 698569(MAPK1) 699736(MAPK10) 700969(MAPK4) 702837(MAPK7) 708938(MAPK3) 711115(MAPK8) 715745(MAPK12) 715794(MAPK11) 718976 719085
MCF: 
MMU: 
18099(Nlk) 19094(Mapk11) 225724(Mapk4) 23939(Mapk7) 26413(Mapk1) 26414(Mapk10) 26415(Mapk13) 26416(Mapk14) 26417(Mapk3) 26419(Mapk8) 26420(Mapk9) 29857(Mapk12) 332110(Mapk15) 50772(Mapk6)
RNO: 
100912585 114509(Mapk7) 116554(Mapk8) 116590(Mapk1) 25272(Mapk10) 286997(Mapk15) 29513(Mapk13) 497961(Nlk) 50658(Mapk9) 50689(Mapk3) 54268(Mapk4) 58840(Mapk6) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CGE: 
HGL: 
101698286(Mapk9) 101700449(Mapk6) 101700581(Mapk4) 101701893(Nlk) 101702687(Mapk3) 101705370(Mapk11) 101706002(Mapk12) 101706099(Mapk1) 101712538(Mapk15) 101712980(Mapk10) 101715259(Mapk8) 101715692(Mapk14) 101726391(Mapk7)
TUP: 
102468920 102472233(MAPK8) 102475335(MAPK7) 102475730(MAPK10) 102475742(MAPK4) 102481241(MAPK13) 102483057(MAPK3) 102487603(MAPK11) 102494380(MAPK15) 102495693(MAPK14) 102496009(MAPK6) 102496453(MAPK1) 102497095(MAPK9) 102501733(MAPK12)
CFA: 
100855877(MAPK3) 403856(MAPK14) 474652(MAPK9) 477575(MAPK1) 477746(MAPK8) 478311(MAPK6) 478464(MAPK10) 479790(MAPK3) 482080(MAPK15) 489532(MAPK7) 491160(NLK) 491690(MAPK4) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML: 
FCA: 
101080751(NLK) 101081149(MAPK12) 101081396(MAPK11) 101084765(MAPK9) 101087614(MAPK1) 101087958(MAPK3) 101091310(MAPK8) 101091508(MAPK15) 101092057(MAPK4) 101093275(MAPK6) 101097357(MAPK7) 101101135(MAPK14) 101101463(MAPK10)
BTA: 
327672(MAPK1) 507204(NLK) 512125(MAPK15) 512943(MAPK12) 529183(MAPK4) 531391(MAPK3) 534125(MAPK9) 534492(MAPK14) 535327(MAPK13) 537631(MAPK10) 537703(MAPK7) 538094(MAPK6) 539941(MAPK8) 618906(MAPK11)
BOM: 
102266282(MAPK4) 102266960(MAPK9) 102271030(MAPK13) 102271320(MAPK14) 102272368(MAPK3) 102272421(MAPK10) 102274050(NLK) 102274306(MAPK6) 102277976(MAPK8) 102278560(MAPK7) 102285026(MAPK15) 102285848(MAPK12)
PHD: 
102321680(MAPK13) 102322031(MAPK14) 102323252(MAPK9) 102324617(NLK) 102326136 102329495(MAPK4) 102331873(MAPK12) 102334117(MAPK8) 102335953(MAPK7) 102338495(MAPK6) 102342433(MAPK3) 102344390(MAPK10)
CHX: 
100860996(MAPK13) 100861087(MAPK8) 102169187(MAPK6) 102170408(MAPK9) 102180534(MAPK7) 102182774(MAPK10) 102183251 102184020(MAPK4) 102186040(MAPK1) 102188824(MAPK3) 102189174(MAPK14) 102190163(NLK)
SSC: 
100153927(MAPK1) 100156630(MAPK14) 100511657(NLK) 100521736(MAPK10) 100523414(MAPK4) 100620270 102164433 396609(MAPK9) 396610(MAPK8) 396833(MAPK6) 445013(MAPK3) 574062(MAPK12)
CFR: 
102503577(MAPK8) 102509244 102509448(MAPK10) 102511078(MAPK14) 102511298(MAPK13) 102515487(MAPK6) 102516847(MAPK12) 102517586(MAPK1) 102518561(MAPK9) 102518663(MAPK4) 102519162(NLK) 102519781(MAPK11) 102521659(MAPK3) 102522626(MAPK15) 102524416
ECB: 
100051798(MAPK8) 100052608(MAPK10) 100053916(MAPK4) 100055006(MAPK6) 100056239(MAPK12) 100056278(MAPK11) 100057701(MAPK1) 100057961(MAPK9) 100058876(NLK) 100063532(MAPK14) 100066173(MAPK3) 100073174(MAPK7) 100146864(MAPK15)
MYB: 
102245641(MAPK1) 102245831(MAPK7) 102246292(MAPK8) 102246580(NLK) 102248097 102249806(MAPK6) 102254628(MAPK12) 102255250(MAPK3) 102259698(MAPK4) 102259984(MAPK9) 102263026(MAPK10)
MDO: 
SHR: 
100913231(MAPK1) 100917749(MAPK7) 100919388(MAPK15) 100919999(MAPK4) 100924267(MAPK9) 100925013(MAPK14) 100925447(MAPK13) 100928480(MAPK10) 100928564(NLK) 100928729(MAPK12) 100930815(MAPK8) 100931440(MAPK6) 100934330(MAPK3)
OAA: 
GGA: 
100858386 373953(MAPK1) 395983(MAPK9) 415419(MAPK6) 417669(NLK) 417739(MAPK11) 421183(MAPK14) 422592(MAPK10) 423778(MAPK8) 426292(MAPK15) 769763(MAPK12) 771145(MAPK13)
MGP: 
TGU: 
100217568(NLK) 100218485 100218726(MAPK6) 100220802(MAPK1) 100220867(MAPK8) 100223519(MAPK10) 100225101(MAPK11) 100225285(MAPK9) 100227852 100227993(MAPK12) 100229840(MAPK4)
FAB: 
101806540 101806829(MAPK6) 101807358(MAPK12) 101809052(MAPK10) 101811957(MAPK15) 101814783(MAPK11) 101815088(MAPK1) 101817298(NLK) 101817339(MAPK8) 101817434(MAPK13) 101817836(MAPK4) 101819306(MAPK9) 101819980(MAPK14)
PHI: 
102099139(MAPK6) 102099159(MAPK10) 102102818(MAPK1) 102104312(MAPK15) 102106744(MAPK9) 102108455(NLK) 102109820(MAPK11) 102110009(MAPK12) 102110807(MAPK13) 102111004(MAPK14) 102111242 102114247(MAPK4) 102114724(MAPK8)
APLA: 
101789910(MAPK4) 101791119(MAPK15) 101792057(MAPK11) 101793591(MAPK12) 101793594(MAPK8) 101797936(MAPK6) 101799011(MAPK9) 101799776(MAPK10) 101800319(MAPK1) 101802116(MAPK13) 101804891(NLK) 101805023(MAPK14)
FPG: 
101912679 101914611(MAPK1) 101915038(MAPK15) 101915315(NLK) 101917138(MAPK10) 101918008(MAPK4) 101919216(MAPK6) 101920170(MAPK12) 101920353(MAPK11) 101921076(MAPK9) 101921635(MAPK14) 101922433(MAPK13) 101924129(MAPK8)
FCH: 
102047380(MAPK8) 102048221(MAPK1) 102051874(MAPK12) 102052038(MAPK11) 102053335(MAPK6) 102053931(NLK) 102054176(MAPK10) 102054359(MAPK13) 102055655(MAPK15) 102055660(MAPK9) 102057908(MAPK4) 102059377(MAPK14)
CLV: 
102084319 102084879(MAPK1) 102085027(MAPK9) 102085840(MAPK10) 102086843(NLK) 102087983(MAPK8) 102089738(MAPK14) 102089969 102090037(MAPK13) 102090861(MAPK12) 102094655(MAPK4)
ASN: 
102374196(MAPK12) 102374345(MAPK4) 102374542(MAPK10) 102375835(MAPK11) 102375954(MAPK13) 102376040(MAPK9) 102376154(MAPK8) 102376541(MAPK14) 102376659(NLK) 102376690(MAPK1) 102381114(MAPK6) 102386241
PSS: 
102445212(NLK) 102445557(MAPK6) 102448785(MAPK14) 102450501 102452788(MAPK4) 102453224(MAPK9) 102453948(MAPK1) 102455939(MAPK13) 102459702(MAPK8) 102460734(MAPK10) 102460982 102462429(MAPK11) 102462672(MAPK12) 102463278(MAPK7)
ACS: 
XLA: 
100329215(p38-beta) 379876(mapk8) 379992(mapk14) 397785(mapk1-b) 398295(nlk.2) 398592(mapk12) 398985(mapk1-a) 414522(nlk) 446599(mapk7) 494669(mapk11) 734485(mapk15) 735153
XTR: 
100101766(mapk11) 100144638(nlk) 100144684(nlk.2) 100144715(mapk13) 100145045(mapk12) 100145558(mapk15) 100170194(mapk8) 100494114(mapk6) 100498202 448296(mapk14) 549834(mapk12) 549881(mapk1) 779515(mapk10) 779785(mapk7)
DRE: 
100002318(mapk13) 100149273(mapk9) 266756(mapk14b) 30681(mapk12a) 360144(mapk1) 399480(mapk3) 405892(nlk1) 406782(mapk4) 415185(mapk11) 541323(mapk7) 553780(mapk15) 557810(mapk12b) 562552(fc89f08) 562720(mapk8a) 563460(nlk2) 565830(mapk6) 569698(mapk10) 65236(mapk8b) 65237(mapk14a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
100184138 778596(erk1/2) 778597(erk5) 778660(jnk) 778685(nemo-like) 778927(p38) 778965(erk3/4)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408917(erk7) 409286(bsk) 409523(rl) 410956(nmo) 411915(p38b)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0218.3(pmk-1) CELE_B0478.1(jnk-1) CELE_C05D10.2(C05D10.2) CELE_F42G8.3(pmk-2) CELE_F42G8.4(pmk-3) CELE_F43C1.2(mpk-1) CELE_W06F12.1(lit-1)
CBR: 
CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1) CBG05733(Cbr-jnk-1) CBG18286(Cbr-lit-1) CBG21144 CBG21247(Cbr-mpk-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G01560(MPK11) AT1G07880(ATMPK13) AT1G10210(MPK1) AT1G59580(MPK2) AT2G18170(MPK7) AT2G43790(MPK6) AT2G46070(MPK12) AT3G45640(MPK3) AT3G59790(MPK10) AT4G01370(MPK4) AT4G11330(MPK5) AT4G36450(MPK14)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0002s03340g(POPTRDRAFT_643073) POPTR_0002s16400g(POPTRDRAFT_816604) POPTR_0005s12140g POPTR_0005s25270g(POPTRDRAFT_801509) POPTR_0007s00930g(POPTRDRAFT_718188) POPTR_0009s07050g(POPTRDRAFT_833180) POPTR_791419 POPTR_813465
VVI: 
SLY: 
100736474(MAPK6) 100736510(MAPK8) 100736512(MPK9) 100736513(MAPK4) 100736536(MAPK7) 543792(mpka1;1) 543879(MPK2) 543880(MPK3)
SOT: 
OSA: 
DOSA: 
Os02t0148100-01(Os02g0148100) Os03t0285800-01(Os03g0285800) Os06t0154500-01(Os06g0154500) Os06t0699400-01(Os06g0699400) Os08t0157000-00(Os08g0157000) Os10t0533600-01(Os10g0533600)
BDI: 
100834779(MPK6) 100837420(MPK3) 100839224(MPK11) 100839537(MPK14) 100841616(MPK7-1) 100846323
SBI: 
SORBI_01g030680(SORBIDRAFT_01g030680) SORBI_04g003480(SORBIDRAFT_04g003480) SORBI_07g003810(SORBIDRAFT_07g003810) SORBI_10g003810(SORBIDRAFT_10g003810) SORBI_10g028780(SORBIDRAFT_10g028780)
ZMA: 
100283121(pco133201) 100286386(MPK7) 100381337 542144(simk1) 542594(gpm355)
SITA: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
CME: 
CCP: 
SCE: 
YBL016W(FUS3) YGR040W(KSS1) YHR030C(SLT2) YKL161C(KDX1) YLR113W(HOG1) YPR054W(SMK1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A02120(NCAS0A02120) NCAS_0A06680(NCAS0A06680) NCAS_0A11020(NCAS0A11020) NCAS_0B05560(NCAS0B05560) NCAS_0C03380(NCAS0C03380)
NDI: 
NDAI_0A05280(NDAI0A05280) NDAI_0B02900(NDAI0B02900) NDAI_0D01620(NDAI0D01620) NDAI_0D04050(NDAI0D04050) NDAI_0G02700(NDAI0G02700)
TPF: 
TPHA_0A01630(TPHA0A01630) TPHA_0B02440(TPHA0B02440) TPHA_0C02880(TPHA0C02880) TPHA_0J00630(TPHA0J00630) TPHA_0M01500(TPHA0M01500)
TBL: 
TBLA_0A06670(TBLA0A06670) TBLA_0A08430(TBLA0A08430) TBLA_0A08810(TBLA0A08810) TBLA_0A10420(TBLA0A10420) TBLA_0H01330(TBLA0H01330)
TDL: 
TDEL_0B04490(TDEL0B04490) TDEL_0C04800(TDEL0C04800) TDEL_0D02650(TDEL0D02650) TDEL_0E03520(TDEL0E03520) TDEL_0F04290(TDEL0F04290)
KAF: 
KAFR_0B02980(KAFR0B02980) KAFR_0C02840(KAFR0C02840) KAFR_0E01810(KAFR0E01810) KAFR_0F03900(KAFR0F03900) KAFR_0H01040(KAFR0H01040)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.10404(ERK1) CaO19.2886(ERK1) CaO19.460(CEK2) CaO19.7208(CSK1) CaO19.7523(MKC1) CaO19.8091(CEK2) CaO19.8514(HOG1) CaO19.895(HOG1)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1044194 AOR_1_332184(AO090009000199) AOR_1_692154(AO090003000402)
ANG: 
ANI_1_1286014(An01g09520) ANI_1_1432074(An08g10670) ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_08980(erkB)
EHI: 
EHI_073650(67.t00005) EHI_194420(46.t00053)
EDI: 
ACAN: 
PFA: 
PF11_0147(map-2) PF14_0294(PfMAP1)
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_IV005520(23.m06268)
BEQ: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:2842341]
  Authors
Ray LB, Sturgill TW.
  Title
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.
  Journal
J. Biol. Chem. 263 (1988) 12721-7.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:1657919]
  Authors
Rossomando AJ, Sanghera JS, Marsden LA, Weber MJ, Pelech SL, Sturgill TW.
  Title
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
  Journal
J. Biol. Chem. 266 (1991) 20270-5.
  Organism
Mus musculus [GN:mmu], Xenopus laevis [GN:xla]
Reference
3  [PMID:1321146]
  Authors
Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG.
  Title
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
  Journal
J. Biol. Chem. 267 (1992) 14373-81.
  Organism
Xenopus laevis [GN:xla]
Reference
4  [PMID:9235954]
  Authors
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS.
  Title
p38-2, a novel mitogen-activated protein kinase with distinct properties.
  Journal
J. Biol. Chem. 272 (1997) 19509-17.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:5600]
Reference
5  [PMID:10715136]
  Authors
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P.
  Title
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
  Journal
Biochemistry. 39 (2000) 3141-8.
  Organism
Homo sapiens [GN:hsa]
  Sequence
[hsa:5602]
Reference
6  [PMID:15187187]
  Authors
Roux PP, Blenis J.
  Title
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
  Journal
Microbiol. Mol. Biol. Rev. 68 (2004) 320-44.
  Organism
Saccharomyces cerevisiae [GN:sce], mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system