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Entry
EC 2.7.11.24                Enzyme                                 

Name
mitogen-activated protein kinase;
c-Jun N-terminal kinase;
Dp38;
ERK;
ERK1;
ERK2;
extracellular signal-regulated kinase;
JNK;
JNK3alpha1;
LeMPK3;
MAP kinase;
MAP-2 kinase;
MAPK;
MBP kinase I;
MBP kinase II;
microtubule-associated protein 2 kinase;
microtubule-associated protein kinase;
myelin basic protein kinase;
p38delta;
p38-2;
p42 mitogen-activated protein kinase;
p42mapk;
PMK-1;
PMK-2;
PMK-3;
pp42;
pp44mapk;
p44mpk;
SAPK;
STK26;
stress-activated protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.24 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04371  
mitogen-activated protein kinase 1/3
K04440  
c-Jun N-terminal kinase
K04441  
p38 MAP kinase
K04464  
mitogen-activated protein kinase 7
K04468  
nemo like kinase
K06855  
mitogen-activated protein kinase 4/6
K08293  
sporulation-specific mitogen-activated protein kinase SMK1 
K14512  
mitogen-activated protein kinase 6
K19603  
mitogen-activated protein kinase 15
K20535  
mitogen-activated protein kinase 1/2
K20536  
mitogen-activated protein kinase 3
K20537  
mitogen-activated protein kinase 7/14
K20538  
mitogen-activated protein kinase 8
K20600  
mitogen-activated protein kinase 4
Genes
HSA: 
1432(MAPK14) 225689(MAPK15) 51701(NLK) 5594(MAPK1) 5595(MAPK3) 5596(MAPK4) 5597(MAPK6) 5598(MAPK7) 5599(MAPK8) 5600(MAPK11) 5601(MAPK9) 5602(MAPK10) 5603(MAPK13) 6300(MAPK12)
PTR: 
104003820(MAPK11) 450161(MAPK14) 450445(MAPK8) 453439(MAPK6) 454037(MAPK3) 454499(MAPK7) 458680(MAPK1) 461358(MAPK10) 462336(MAPK9) 462644(MAPK13) 468536(MAPK4) 739132(NLK) 746712(MAPK15) 747077(MAPK12)
PPS: 
100967254(MAPK7) 100972270(MAPK15) 100979222(NLK) 100979542(MAPK3) 100980937(MAPK11) 100981268(MAPK12) 100982480(MAPK8) 100982544(MAPK13) 100983649(MAPK14) 100984173(MAPK10) 100988980(MAPK6) 100989422(MAPK4) 100990080(MAPK9) 100995567(MAPK1)
GGO: 
101124033(MAPK8) 101129084(MAPK15) 101133141(MAPK10) 101134492(MAPK12) 101134843(MAPK11) 101135988(MAPK3) 101137450(MAPK7) 101138810(NLK) 101140164(MAPK1) 101143697(MAPK6) 101148438(MAPK13) 101151665(MAPK4) 101152026(MAPK9) 101152640(MAPK14)
PON: 
100169740(MAPK1) 100173242(MAPK6) 100174482(MAPK10) 100431824(MAPK3) 100437263(MAPK12) 100437341(NLK) 100437424(MAPK8) 100438440 100440111(MAPK15) 100449269(MAPK14) 100449853(MAPK13) 100451029(MAPK7) 100459133(MAPK9)
NLE: 
100580599(MAPK12) 100581677(MAPK9) 100584480(MAPK3) 100589036(MAPK11) 100593682(MAPK6) 100593981(NLK) 100595369(MAPK13) 100597336(MAPK4) 100598787(MAPK7) 100600225(MAPK14) 100600574(MAPK1) 100602081(MAPK10) 100605285(MAPK8) 100606092(MAPK15)
MCC: 
100428659(MAPK15) 677693(NLK) 694998(MAPK6) 698569(MAPK1) 699736(MAPK10) 700969(MAPK4) 702837(MAPK7) 708938(MAPK3) 711115(MAPK8) 715745(MAPK12) 715782(MAPK9) 715794(MAPK11) 718976(MAPK14) 719085(MAPK13)
MCF: 
101865361(NLK) 101867305(MAPK12) 101867352(MAPK13) 101925732(MAPK6) 101926770(MAPK14) 102114808(MAPK4) 102116996(MAPK3) 102118497(MAPK9) 102121272(MAPK10) 102126339(MAPK8) 102129135(MAPK15) 102133212(MAPK7) 102134421(MAPK11) 102145011(MAPK1)
CSAB: 
103215844(MAPK8) 103221595(MAPK13) 103221596(MAPK14) 103222420(MAPK4) 103222941(MAPK1) 103223551(MAPK11) 103223553(MAPK12) 103230532(MAPK3) 103235918(MAPK10) 103237579(MAPK15) 103242509(MAPK7) 103242604(NLK) 103245120(MAPK9) 103245614(MAPK6)
RRO: 
104660707(MAPK7) 104660767(MAPK12) 104660769(MAPK11) 104660910(MAPK6) 104668007(MAPK10) 104669360(NLK) 104672911(MAPK4) 104676194(MAPK9) 104676897(MAPK1) 104678447(MAPK8) 104679800(MAPK15) 104681150(MAPK3) 104682867(MAPK14) 104682868(MAPK13)
RBB: 
108516767(MAPK7) 108517508 108521141(MAPK10) 108523695(MAPK3) 108528326(MAPK14) 108528327(MAPK13) 108533130(MAPK4) 108536070(MAPK1) 108536642(MAPK15) 108537794(MAPK8) 108538201(MAPK6) 108539403(MAPK12) 108539422(MAPK11) 108539940(NLK)
CJC: 
100387686(MAPK9) 100390109(MAPK10) 100392721(MAPK8) 100396611(MAPK11) 100396967(MAPK12) 100400023(MAPK7) 100400700(MAPK1) 100404377(MAPK14) 100404815(MAPK3) 100405093(MAPK13) 100407752(MAPK15) 100407964(MAPK4) 100414864(NLK) 100415140(MAPK6)
SBQ: 
101027742(MAPK9) 101030594(MAPK6) 101030709(MAPK15) 101034504(MAPK4) 101037444(MAPK14) 101038546(MAPK3) 101039160(MAPK8) 101040899(MAPK12) 101042695(NLK) 101043202(MAPK1) 101044137(MAPK13) 101048066(MAPK10) 101050659(MAPK7) 101052690(MAPK11)
MMU: 
18099(Nlk) 19094(Mapk11) 225724(Mapk4) 23939(Mapk7) 26413(Mapk1) 26414(Mapk10) 26415(Mapk13) 26416(Mapk14) 26417(Mapk3) 26419(Mapk8) 26420(Mapk9) 29857(Mapk12) 332110(Mapk15) 50772(Mapk6)
RNO: 
100912585 114509(Mapk7) 116554(Mapk8) 116590(Mapk1) 25272(Mapk10) 286997(Mapk15) 29513(Mapk13) 497961(Nlk) 50658(Mapk9) 50689(Mapk3) 54268(Mapk4) 58840(Mapk6) 60352(Mapk12) 689314(Mapk11) 81649(Mapk14)
CGE: 
100689104(Mapk14) 100753149(Mapk3) 100754042(Mapk12) 100754361(Mapk10) 100758520(Mapk7) 100758872(Mapk15) 100759172(Mapk11) 100759514(Mapk1) 100763519(Mapk13) 100764603(Mapk6) 100764964(Mapk9) 100768473(Nlk) 100771734(Mapk8) 100771894(Mapk4)
NGI: 
103724495(Nlk) 103726390(Mapk3) 103728439(Mapk7) 103731405(Mapk6) 103735023(Mapk8) 103735280(Mapk15) 103735473(Mapk12) 103735474(Mapk11) 103739659(Mapk13) 103739660(Mapk14) 103741442(Mapk1) 103748163(Mapk4) 103748972(Mapk10) 103749366(Mapk9)
HGL: 
101698286(Mapk9) 101700449(Mapk6) 101700581(Mapk4) 101701893(Nlk) 101702687(Mapk3) 101705370(Mapk11) 101706002(Mapk12) 101706099(Mapk1) 101712538(Mapk15) 101712980(Mapk10) 101715259(Mapk8) 101715692(Mapk13) 101726391(Mapk7) 106007524(Mapk14)
CCAN: 
109680014(Mapk4) 109683259(Mapk3) 109684381(Mapk1) 109685285(Mapk6) 109686728(Mapk9) 109686738 109689849(Mapk14) 109689865(Mapk13) 109690805(Mapk15) 109697389(Mapk11) 109697648(Mapk12) 109698362(Nlk) 109699716(Mapk7) 109703004
OCU: 
100337999(MAPK10) 100338535(MAPK7) 100338634(MAPK15) 100341695(MAPK14) 100342664(MAPK9) 100343055(MAPK4) 100344161(MAPK13) 100346929(MAPK8) 100347345(MAPK1) 100348561(MAPK3) 100348930(NLK) 100350614(MAPK12) 100356648(MAPK6) 103346035(MAPK11)
TUP: 
102468920(NLK) 102472233(MAPK8) 102475335(MAPK7) 102475730(MAPK10) 102475742(MAPK4) 102481241(MAPK13) 102483057(MAPK3) 102487603(MAPK11) 102494380(MAPK15) 102495693(MAPK14) 102496009(MAPK6) 102496453(MAPK1) 102497095(MAPK9) 102501733(MAPK12)
CFA: 
100855877(MAPK3) 403856(MAPK14) 474652(MAPK9) 477575(MAPK1) 477746(MAPK8) 478311(MAPK6) 478464(MAPK10) 482080(MAPK15) 489532(MAPK7) 491160(NLK) 491690(MAPK4) 607019(MAPK11) 607023(MAPK12) 612821(MAPK13)
AML: 
100465223(MAPK13) 100465476(MAPK14) 100465770(MAPK6) 100467560(MAPK4) 100469296(NLK) 100470035(MAPK1) 100470193(MAPK7) 100472388(MAPK3) 100477600(MAPK9) 100477951(MAPK10) 100480235(MAPK12) 100480483(MAPK11) 100482196(MAPK8) 100482855(MAPK15)
UMR: 
103656711(MAPK15) 103657827(MAPK3) 103658546(MAPK7) 103664250(MAPK4) 103665451(MAPK14) 103665538(MAPK13) 103667237(NLK) 103667893(MAPK8) 103669286(MAPK1) 103674004(MAPK11) 103674115(MAPK12) 103676754(MAPK6) 103676947(MAPK10) 103679990(MAPK9)
FCA: 
101080751(NLK) 101084765(MAPK9) 101087614(MAPK1) 101087958(MAPK3) 101091310(MAPK8) 101091508(MAPK15) 101091536(MAPK13) 101092057(MAPK4) 101093275(MAPK6) 101097357(MAPK7) 101101135(MAPK14) 101101463(MAPK10) 105260786(MAPK11)
PTG: 
102950636(NLK) 102950880(MAPK8) 102957425(MAPK15) 102959159(MAPK10) 102960306(MAPK12) 102960590(MAPK11) 102960964(MAPK3) 102963096(MAPK9) 102964803(MAPK7) 102964841(MAPK1) 102965196(MAPK6) 102966349(MAPK4) 102968191(MAPK13) 102968482(MAPK14)
AJU: 
106967248(MAPK6) 106969232(MAPK3) 106969894(MAPK9) 106970668(MAPK10) 106972759(MAPK14) 106972806(MAPK13) 106974962(MAPK4) 106981402(MAPK7) 106983267(NLK) 106987071(MAPK15) 106987636(MAPK12) 106987637(MAPK11) 106989581(MAPK8) 106990008(MAPK1)
BTA: 
327672(MAPK1) 507204(NLK) 512125(MAPK15) 512943(MAPK12) 529183(MAPK4) 531391(MAPK3) 534125(MAPK9) 534492(MAPK14) 535327(MAPK13) 537631(MAPK10) 537703(MAPK7) 538094(MAPK6) 539941(MAPK8) 618906(MAPK11)
BOM: 
102266282(MAPK4) 102266960(MAPK9) 102271030(MAPK13) 102271320(MAPK14) 102272368(MAPK3) 102272421(MAPK10) 102274050(NLK) 102274306(MAPK6) 102277976(MAPK8) 102278560(MAPK7) 102284931(MAPK1) 102285026(MAPK15) 102285848(MAPK12) 106701244(MAPK11)
BIU: 
109553773(MAPK8) 109560650(MAPK10) 109561331(MAPK9) 109568414(MAPK15) 109574074(NLK) 109574161(MAPK7) 109577010(MAPK14) 109577419(MAPK13) 109577974(MAPK4) 109578667(MAPK3)
PHD: 
102321680(MAPK13) 102322031(MAPK14) 102323252(MAPK9) 102324617(NLK) 102326136 102329495(MAPK4) 102331873(MAPK12) 102334117(MAPK8) 102335953(MAPK7) 102338495(MAPK6) 102342433(MAPK3) 102344390(MAPK10)
CHX: 
100860996(MAPK13) 100861087(MAPK8) 102169187(MAPK6) 102170408(MAPK9) 102180534(MAPK7) 102180926(MAPK12) 102182774(MAPK10) 102183251(MAPK15) 102184020(MAPK4) 102184510(MAPK11) 102186040(MAPK1) 102188824(MAPK3) 102189174(MAPK14) 102190163(NLK)
OAS: 
100194428(MAPK13) 100217411(MAPK14) 101103076(NLK) 101103324(MAPK6) 101110073(MAPK7) 101112234(MAPK15) 101112939(MAPK4) 101115485(MAPK1) 101115956(MAPK12) 101116201(MAPK8) 101116223 101120665(MAPK10) 101120826(MAPK9) 101123008(MAPK3)
SSC: 
100153927(MAPK1) 100155841(MAPK13) 100156630(MAPK14) 100511657(NLK) 100521736(MAPK10) 100523414(MAPK4) 102164433(MAPK7) 110260411(MAPK15) 396609(MAPK9) 396610(MAPK8) 396833(MAPK6) 445013(MAPK3) 574062(MAPK12)
CFR: 
102503577(MAPK8) 102509244 102509448(MAPK10) 102511078(MAPK14) 102511298(MAPK13) 102515487(MAPK6) 102516847(MAPK12) 102517586(MAPK1) 102518561(MAPK9) 102518663(MAPK4) 102519162(NLK) 102519781(MAPK11) 102521659(MAPK3) 102522626(MAPK15) 102524416 106729653
CDK: 
105086622(MAPK6) 105088250(NLK) 105090355(MAPK11) 105090356(MAPK12) 105091591(MAPK10) 105094659(MAPK8) 105095214(MAPK1) 105100603(MAPK7) 105100625(MAPK9) 105101337(MAPK13) 105101338(MAPK14) 105102769(MAPK3) 105103420(MAPK4) 105105682(MAPK15)
BACU: 
102997603(MAPK8) 102999619(MAPK1) 102999798 102999884(MAPK7) 102999887(MAPK6) 103002378(MAPK13) 103002389(NLK) 103002590(MAPK3) 103005755(MAPK15) 103007019(MAPK9) 103008537(MAPK14) 103008728(MAPK10) 103009561(MAPK11) 103009947(MAPK12) 103019117(MAPK4)
LVE: 
103070260(MAPK1) 103075265(NLK) 103075543(MAPK3) 103077215(MAPK15) 103077530(MAPK12) 103078049(MAPK14) 103078710(MAPK13) 103078792(MAPK10) 103080813(MAPK7) 103083209(MAPK11) 103083820(MAPK6) 103084630(MAPK8) 103085294(MAPK4) 103087676(MAPK9)
ECB: 
100051798(MAPK8) 100052608(MAPK10) 100053916(MAPK4) 100055006(MAPK6) 100056239(MAPK12) 100056278(MAPK11) 100057701(MAPK1) 100057961(MAPK9) 100058876(NLK) 100063532(MAPK14) 100066173(MAPK3) 100073174(MAPK7) 100146864(MAPK15)
EPZ: 
103547261(MAPK3) 103548458(MAPK6) 103549414(MAPK8) 103553980(MAPK10) 103555963(NLK) 103559485(MAPK12) 103559491(MAPK11) 103562408(MAPK1) 103563198(MAPK13) 103564504(MAPK4) 103565534(MAPK14) 103567629(MAPK9)
EAI: 
106824547(MAPK14) 106824582(MAPK13) 106831384(MAPK8) 106834752(MAPK4) 106837144(MAPK6) 106837912(MAPK7) 106839421(MAPK10) 106841849(MAPK15) 106843729(MAPK9) 106844594(NLK) 106845632(MAPK3) 106846005(MAPK12) 106846006(MAPK11) 106848262(MAPK1)
MYB: 
102245641(MAPK1) 102245831(MAPK7) 102246292(MAPK8) 102246580(NLK) 102248097(MAPK14) 102249806(MAPK6) 102254628(MAPK12) 102254920(MAPK11) 102255250(MAPK3) 102259698(MAPK4) 102259984(MAPK9) 102263026(MAPK10) 106723559(MAPK13)
MYD: 
102751471(MAPK6) 102755728(MAPK14) 102756012(MAPK13) 102760175(NLK) 102761596(MAPK4) 102764416(MAPK8) 102769037(MAPK1) 102769984(MAPK7) 102770021(MAPK12) 102770309(MAPK11) 102772062(MAPK9) 102774243(MAPK15) 102775211(MAPK3) 102775351
HAI: 
109373584(MAPK4) 109377280(MAPK7) 109377948 109385136(NLK) 109385803(MAPK3) 109390849(MAPK15) 109392215(MAPK8) 109392748(MAPK9) 109394140 109394195(MAPK6) 109394900(MAPK1) 109395979(MAPK14) 109395980(MAPK13) 109396629(MAPK12) 109396630(MAPK11)
RSS: 
PALE: 
102877720(MAPK13) 102881922(MAPK6) 102883986(MAPK15) 102885064(MAPK10) 102885749(MAPK3) 102888602(MAPK11) 102888845(MAPK12) 102890689(MAPK9) 102890853(NLK) 102892777(MAPK8) 102895102(MAPK4) 102895390(MAPK1) 102895900(MAPK14) 102897014(MAPK7)
LAV: 
100654943(MAPK9) 100656926(MAPK13) 100658240(MAPK3) 100660657(MAPK4) 100661039(MAPK12) 100665157(MAPK1) 100668196(NLK) 100671508(MAPK6) 100671889(MAPK7) 100673331(MAPK14) 100673395(MAPK10) 100674229(MAPK8)
MDO: 
100010279(MAPK12) 100010891(MAPK11) 100012916(MAPK3) 100015101(MAPK4) 100016316(MAPK7) 100016623(MAPK15) 100019356(NLK) 100026324(MAPK14) 100026361(MAPK6) 100028089(MAPK9) 100028096(MAPK1) 100028821(MAPK13) 100618895(MAPK10)
SHR: 
100913231(MAPK1) 100917749(MAPK7) 100919388(MAPK15) 100919999(MAPK4) 100924267(MAPK9) 100925013(MAPK14) 100925447(MAPK13) 100928480(MAPK10) 100928564(NLK) 100928729(MAPK12) 100928990(MAPK11) 100930815(MAPK8) 100931440(MAPK6) 100934330(MAPK3)
OAA: 
GGA: 
100858386 373953(MAPK1) 395983(MAPK9) 415419(MAPK6) 417669(NLK) 417739(MAPK11) 421183(MAPK14) 422592(MAPK10) 423778(MAPK8) 426292(MAPK15) 769763(MAPK12) 771145(MAPK13)
MGP: 
100540259(MAPK12) 100540416(MAPK11) 100541011(MAPK9) 100542628(MAPK10) 100543845(MAPK1) 100546825(NLK) 100546983(MAPK13) 100547553(MAPK15) 100547737(MAPK8) 100548558(MAPK6) 104916721(MAPK7)
CJO: 
107306769 107307520(MAPK7) 107308531 107308592(MAPK11) 107310653(MAPK15) 107313439(MAPK10) 107315851(MAPK8) 107318686(MAPK6) 107320159(MAPK9) 107321038(MAPK1) 107322736(NLK) 107324607(MAPK13) 107324616(MAPK14)
APLA: 
101789910(MAPK4) 101791119(MAPK15) 101792057(MAPK11) 101793591(MAPK12) 101793594(MAPK8) 101797936(MAPK6) 101799011(MAPK9) 101799776(MAPK10) 101800319(MAPK1) 101802116(MAPK13) 101804891(NLK) 101805023(MAPK14)
ACYG: 
106032805(MAPK9) 106033660(MAPK6) 106037349(MAPK4) 106040461 106040490 106041872(MAPK10) 106043757(NLK) 106046149(MAPK14) 106046150(MAPK13) 106047189(MAPK8) 106048745(MAPK15)
TGU: 
100217568(NLK) 100218726(MAPK6) 100220802(MAPK1) 100220867(MAPK8) 100223519(MAPK10) 100225101(MAPK11) 100225285(MAPK9) 100227852(MAPK14) 100227993(MAPK12) 100229840(MAPK4) 105758887(MAPK13) 105759043(MAPK15)
GFR: 
102033058(NLK) 102035183(MAPK4) 102036009(MAPK8) 102038706(MAPK15) 102038787(MAPK11) 102040487(MAPK6) 102042160(MAPK13) 102043222(MAPK9) 102043401(MAPK1) 102043521(MAPK12) 102043776(MAPK10) 102044158(MAPK14)
FAB: 
101806540 101806829(MAPK6) 101807358(MAPK12) 101809052(MAPK10) 101811957(MAPK15) 101814783(MAPK11) 101815088(MAPK1) 101817298(NLK) 101817339(MAPK8) 101817434(MAPK13) 101817836(MAPK4) 101819306(MAPK9) 101819980(MAPK14)
PHI: 
102099139(MAPK6) 102099159(MAPK10) 102102818(MAPK1) 102104312(MAPK15) 102106744(MAPK9) 102108455(NLK) 102109820(MAPK11) 102110009(MAPK12) 102110807(MAPK13) 102111004(MAPK14) 102111242(MAPK7) 102114247(MAPK4) 102114724(MAPK8)
PMAJ: 
107198287(MAPK4) 107200084(MAPK15) 107203419(MAPK10) 107204408(MAPK12) 107204409(MAPK11) 107206805(MAPK8) 107209402(MAPK6) 107210724(MAPK9) 107212813(NLK) 107214801(MAPK13) 107214802(MAPK14)
CCW: 
104684015(MAPK6) 104684206(MAPK15) 104686785(MAPK4) 104686831 104686906 104688782(MAPK1) 104689594(MAPK9) 104691151(NLK) 104692399(MAPK14) 104692401 104696634(MAPK8) 104697227(MAPK10)
FPG: 
101912679 101914611(MAPK1) 101915038(MAPK15) 101915315(NLK) 101917138(MAPK10) 101918008(MAPK4) 101919216(MAPK6) 101920170(MAPK12) 101920353(MAPK11) 101921076(MAPK9) 101921635(MAPK14) 101922433(MAPK13) 101924129(MAPK8)
FCH: 
102047380(MAPK8) 102048221(MAPK1) 102051874(MAPK12) 102052038(MAPK11) 102053335(MAPK6) 102053931(NLK) 102054176(MAPK10) 102054359(MAPK13) 102055655(MAPK15) 102055660(MAPK9) 102057908(MAPK4) 102059377(MAPK14)
CLV: 
102084319(MAPK15) 102084879(MAPK1) 102085027(MAPK9) 102085840(MAPK10) 102086843(NLK) 102087983(MAPK8) 102089738(MAPK14) 102089969(MAPK6) 102090037(MAPK13) 102090861(MAPK12) 102094655(MAPK4) 102097012
AAM: 
106482075(MAPK15) 106482177 106486864(MAPK1) 106487858(MAPK13) 106487877(MAPK14) 106493457(MAPK9) 106494874 106495922(MAPK12) 106495935(MAPK11) 106496528(MAPK6) 106496655(MAPK10) 106497812(MAPK8) 106498756(NLK)
ASN: 
102374196(MAPK12) 102374345(MAPK4) 102374542(MAPK10) 102375835(MAPK11) 102375954(MAPK13) 102376040(MAPK9) 102376154(MAPK8) 102376541(MAPK14) 102376659(NLK) 102376690(MAPK1) 102378924 102381114(MAPK6) 102385946(MAPK15) 102386241(MAPK7)
AMJ: 
102559907(MAPK15) 102561718(MAPK1) 102563128(MAPK6) 102565670(MAPK14) 102566087(MAPK10) 102570366(MAPK8) 102570628(MAPK9) 102571177(MAPK11) 102571419(MAPK12) 102575019(NLK) 102575816(MAPK4) 102577139(MAPK7) 106736779(MAPK13) 106737342
PSS: 
102445212(NLK) 102445557(MAPK6) 102448785(MAPK14) 102450501 102452788(MAPK4) 102453224(MAPK9) 102453948(MAPK1) 102455939(MAPK13) 102459702(MAPK8) 102460734(MAPK10) 102460982(MAPK15) 102462429(MAPK11) 102462672(MAPK12) 102463278(MAPK7)
CMY: 
102932835(MAPK10) 102934812(MAPK9) 102934859(MAPK14) 102935187(MAPK8) 102935899(MAPK15) 102938087(MAPK11) 102938366 102939637(MAPK6) 102940215(MAPK12) 102941338(MAPK13) 102942218(MAPK1) 102944975(MAPK4) 102946225(NLK)
CPIC: 
101931056(MAPK8) 101932787(MAPK7) 101936664(MAPK1) 101936886(MAPK10) 101937531(MAPK3) 101946382 101946576(MAPK15) 101946632(MAPK13) 101947220(MAPK4) 101948074(MAPK6) 101948637(MAPK14) 101950703(NLK) 101952286(MAPK12) 101952425(MAPK9) 101952546(MAPK11)
ACS: 
100553469(mapk4) 100553854(mapk7) 100555877(mapk1) 100558211(mapk10) 100560802(nlk) 100561204(mapk6) 100561907(mapk8) 100562588(mapk15) 100563538(mapk12) 100563731(mapk11) 100565814(mapk9) 100566699(mapk3) 100567479(mapk13) 100567618 100567676(mapk14)
PVT: 
110073473(MAPK9) 110077208(MAPK6) 110079793(MAPK14) 110079814(MAPK13) 110081803(MAPK3) 110081806 110084829(MAPK15) 110085327(MAPK10) 110086378(MAPK7) 110087777(MAPK8) 110088439(NLK) 110088632(MAPK4) 110088651(MAPK1) 110089644 110089645
PBI: 
103049456(MAPK10) 103052089(MAPK7) 103052178(MAPK1) 103053438(MAPK14) 103053984(MAPK6) 103053997(MAPK13) 103056455 103059169(MAPK3) 103059296(MAPK9) 103059532(NLK) 103060145(MAPK4) 103060996(MAPK8) 103063187(MAPK12) 103063888(MAPK11) 103067037 103067978 103068196
GJA: 
XLA: 
100329215(p38-beta) 108703801 108704101 108707338(mapk4.S) 108708144 108709347 108711159 108711387(mapk6.L) 108711504 108712920(mapk6.S) 108715909 108718592(mapk4.L) 379876(mapk8.L) 379992(mapk14.S) 397785(mapk1.L) 398295(nlk.2.S) 398499(mapk10.L) 398592(mapk12.S) 398985(mapk1.S) 414522(nlk.L) 446599(mapk7.L) 494669(mapk11.S) 734485(mapk15.L) 735153(LOC100145045.L)
XTR: 
100101766(mapk11) 100144638(nlk) 100144684(nlk.2) 100144715(mapk13) 100145045(mapk12) 100145558(mapk15) 100170194(mapk8) 100494114(mapk6) 100498202(mapk4) 448296(mapk14) 549834(mapk12) 549881(mapk1) 779515(mapk10) 779785(mapk7)
NPR: 
DRE: 
100002318(mapk13) 100149273(mapk9) 266756(mapk14b) 30681(mapk12a) 360144(mapk1) 399480(mapk3) 405892(nlk1) 406782(mapk4) 415185(mapk11) 541323(mapk7) 553780(mapk15) 557810(mapk12b) 562552(zgc:171775) 562720(mapk8a) 563460(nlk2) 565830(mapk6) 569698(mapk10) 65236(mapk8b) 65237(mapk14a)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102345149(MAPK6) 102346493(MAPK4) 102349570(MAPK15) 102351693(MAPK9) 102351958(MAPK10) 102352356(NLK) 102353948 102354316(MAPK11) 102354774(MAPK12) 102355992(MAPK1) 102357573(MAPK8) 102358042(MAPK14) 102358623(MAPK7)
CMK: 
103176608 103177012(mapk11) 103177013(mapk12) 103179134(mapk14) 103179136 103179665(mapk15) 103180867(mapk10) 103183358(nlk) 103183732(mapk9) 103185857(mapk8) 103186853(mapk6) 103187338(mapk4) 103188576(mapk1)
BFO: 
CIN: 
100184138 778596(erk1/2) 778597(erk5) 778660(jnk) 778685(nemo-like) 778927(p38) 778965(erk3/4)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD14046(Dsim_GD14046) Dsimw501_GD16072(Dsim_GD16072) Dsimw501_GD18318(Dsim_GD18318) Dsimw501_GD18319(Dsim_GD18319) Dsimw501_GD22289(Dsim_GD22289) Dsimw501_GD23919(Dsim_GD23919)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408917(erk7) 409286(bsk) 409523(rl) 410956(nmo) 411915(p38b)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
API: 
DNX: 
PHU: 
DPX: 
ISC: 
TUT: 
CEL: 
CELE_B0218.3(pmk-1) CELE_B0478.1(jnk-1) CELE_C04G6.1(mpk-2) CELE_C05D10.2(C05D10.2) CELE_F42G8.3(pmk-2) CELE_F42G8.4(pmk-3) CELE_F43C1.2(mpk-1) CELE_T07A9.3(kgb-1) CELE_W06F12.1(lit-1) CELE_ZC416.4(kgb-2)
CBR: 
CBG01553(Cbr-pmk-3) CBG01554(Cbr-pmk-2) CBG01555(Cbr-pmk-1) CBG02327(Cbr-mpk-2) CBG05733(Cbr-jnk-1) CBG18286(Cbr-lit-1) CBG21144 CBG21247(Cbr-mpk-1)
NAI: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G01560(MPK11) AT1G07880(ATMPK13) AT1G10210(MPK1) AT1G18150(ATMPK8) AT1G59580(MPK2) AT2G18170(MPK7) AT2G43790(MPK6) AT2G46070(MPK12) AT3G45640(MPK3) AT3G59790(MPK10) AT4G01370(MPK4) AT4G11330(MPK5) AT4G36450(MPK14)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0322829.1(Lj0g3v0322829.1) Lj0g3v0325839.1(Lj0g3v0325839.1) Lj0g3v0325839.2(Lj0g3v0325839.2) Lj0g3v0325839.3(Lj0g3v0325839.3) Lj1g3v2742300.1(Lj1g3v2742300.1) Lj2g3v0690050.1(Lj2g3v0690050.1) Lj3g3v3087330.1(Lj3g3v3087330.1) Lj4g3v0510080.1(Lj4g3v0510080.1) Lj4g3v0510090.1(Lj4g3v0510090.1) Lj4g3v0510120.1(Lj4g3v0510120.1) Lj4g3v2604390.1(Lj4g3v2604390.1) Lj4g3v2604390.2(Lj4g3v2604390.2) Lj4g3v3114640.1(Lj4g3v3114640.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s27860g(POPTRDRAFT_797776) POPTR_0002s03340g(POPTRDRAFT_643073) POPTR_0002s16400g(POPTRDRAFT_816604) POPTR_0005s12140g POPTR_0005s25270g(POPTRDRAFT_801509) POPTR_0007s00930g(POPTRDRAFT_718188) POPTR_0007s13370g(POPTRDRAFT_655357) POPTR_0009s07050g(POPTRDRAFT_833180) POPTR_0010s12240g(POPTRDRAFT_726880) POPTR_0012s04590g(POPTRDRAFT_806337) POPTR_0017s04290g(POPTRDRAFT_735966)
VVI: 
SLY: 
100534642(MAPK5) 100736510(MAPK8) 100736512(MPK9) 100736513(MAPK4) 100736539(MAPK16) 543792(mpka1;1) 543879(MPK2) 543880(MPK3)
SPEN: 
SOT: 
CANN: 
NTA: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
4328297(MAP3) 4332475(BIMK1) 4340170(MAPK6) 4341956(MAP2) 4344698(MPK2) 4349225(MPK6)
DOSA: 
Os02t0135200-00(Os02g0135200) Os02t0148100-01(Os02g0148100) Os03t0285800-01(Os03g0285800) Os06t0154500-01(Os06g0154500) Os06t0699400-01(Os06g0699400) Os08t0157000-00(Os08g0157000) Os10t0533600-01(Os10g0533600)
OBR: 
BDI: 
100834779(MPK6) 100837420(MPK3) 100839224(MPK11) 100839537(MPK14) 100841616(MPK7-1)
ATS: 
SBI: 
ZMA: 
100272353(gpm443) 100283121(pco133201) 100285952(cl9707_1a) 100286386(MPK7) 100381337 103639280(gpm355) 103641278 541618(mpk2) 542144(simk1)
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
MNG: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
SCE: 
YBL016W(FUS3) YGR040W(KSS1) YHR030C(SLT2) YLR113W(HOG1) YPR054W(SMK1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A02120(NCAS0A02120) NCAS_0A06680(NCAS0A06680) NCAS_0A11020(NCAS0A11020) NCAS_0B05560(NCAS0B05560) NCAS_0C03380(NCAS0C03380)
NDI: 
NDAI_0A05280(NDAI0A05280) NDAI_0B02900(NDAI0B02900) NDAI_0D01620(NDAI0D01620) NDAI_0D04050(NDAI0D04050) NDAI_0G02700(NDAI0G02700)
TPF: 
TPHA_0A01630(TPHA0A01630) TPHA_0B02440(TPHA0B02440) TPHA_0C02880(TPHA0C02880) TPHA_0J00630(TPHA0J00630) TPHA_0M01500(TPHA0M01500)
TBL: 
TBLA_0A06670(TBLA0A06670) TBLA_0A08430(TBLA0A08430) TBLA_0A08810(TBLA0A08810) TBLA_0A10420(TBLA0A10420) TBLA_0H01330(TBLA0H01330)
TDL: 
TDEL_0B04490(TDEL0B04490) TDEL_0C04800(TDEL0C04800) TDEL_0D02650(TDEL0D02650) TDEL_0E03520(TDEL0E03520) TDEL_0F04290(TDEL0F04290)
KAF: 
KAFR_0B02980(KAFR0B02980) KAFR_0C02840(KAFR0C02840) KAFR_0E01810(KAFR0E01810) KAFR_0F03900(KAFR0F03900) KAFR_0H01040(KAFR0H01040)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NCU02393(mak-2) NCU07024(os-2)
NTE: 
NEUTE1DRAFT117829(NEUTE1DRAFT_117829) NEUTE1DRAFT121521(NEUTE1DRAFT_121521)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
FVR: 
FOX: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
PLJ: 
VAL: 
VDA: 
CFJ: 
ELA: 
PFY: 
SSL: 
BFU: 
MBE: 
PSCO: 
GLZ: 
ANI: 
AFM: 
AOR: 
AOR_1_1044194 AOR_1_1150114(AO090701000642) AOR_1_332184(AO090009000199) AOR_1_692154(AO090003000402) AOR_1_816084(AO090020000466)
ANG: 
ANI_1_1286014(An01g09520) ANI_1_1432074(An08g10670) ANI_1_492064(An07g03980) ANI_1_826074(An08g05850)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
TVS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT115254(AGABI1DRAFT_115254) AGABI1DRAFT22411(AGABI1DRAFT_22411) AGABI1DRAFT86785(AGABI1DRAFT_86785)
ABV: 
AGABI2DRAFT194216(AGABI2DRAFT_194216) AGABI2DRAFT195979(AGABI2DRAFT_195979) AGABI2DRAFT41003(AGABI2DRAFT_41003)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_01227(erkA) DFA_08980(erkB)
EHI: 
EHI_073650(67.t00005) EHI_194420(46.t00053)
EDI: 
EIV: 
ACAN: 
PFA: 
PF11_0147(map-2) PF14_0294(PfMAP1)
PFD: 
PFH: 
PYO: 
PCB: 
PCHAS_091060(PC001036.02.0) PCHAS_101410(PC000139.04.0)
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
TOT: 
BEQ: 
BBO: 
BBOV_IV005520(23.m06268) BBOV_IV010480(23.m06413)
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
SMIN: 
v1.2.002243.t1(symbB.v1.2.002243.t1) v1.2.021115.t1(symbB.v1.2.021115.t1) v1.2.021115.t2(symbB.v1.2.021115.t2) v1.2.032039.t1(symbB.v1.2.032039.t1) v1.2.033826.t1(symbB.v1.2.033826.t1)
PTI: 
FCY: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:2842341]
  Authors
Ray LB, Sturgill TW.
  Title
Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells.
  Journal
J. Biol. Chem. 263 (1988) 12721-7.
Reference
2  [PMID:1657919]
  Authors
Rossomando AJ, Sanghera JS, Marsden LA, Weber MJ, Pelech SL, Sturgill TW.
  Title
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.
  Journal
J. Biol. Chem. 266 (1991) 20270-5.
Reference
3  [PMID:1321146]
  Authors
Seger R, Ahn NG, Posada J, Munar ES, Jensen AM, Cooper JA, Cobb MH, Krebs EG.
  Title
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
  Journal
J. Biol. Chem. 267 (1992) 14373-81.
Reference
4  [PMID:9235954]
  Authors
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS.
  Title
p38-2, a novel mitogen-activated protein kinase with distinct properties.
  Journal
J. Biol. Chem. 272 (1997) 19509-17.
  Sequence
[hsa:5600]
Reference
5  [PMID:10715136]
  Authors
Lisnock J, Griffin P, Calaycay J, Frantz B, Parsons J, O'Keefe SJ, LoGrasso P.
  Title
Activation of JNK3 alpha 1 requires both MKK4 and MKK7: kinetic characterization of in vitro phosphorylated JNK3 alpha 1.
  Journal
Biochemistry. 39 (2000) 3141-8.
  Sequence
[hsa:5602]
Reference
6  [PMID:15187187]
  Authors
Roux PP, Blenis J.
  Title
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions.
  Journal
Microbiol. Mol. Biol. Rev. 68 (2004) 320-44.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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