KEGG   ENZYME: 2.7.11.27Help
Entry
EC 2.7.11.27                Enzyme                                 

Name
[acetyl-CoA carboxylase] kinase;
acetyl coenzyme A carboxylase kinase (phosphorylating);
acetyl-CoA carboxylase bound kinase;
acetyl-CoA carboxylase kinase;
acetyl-CoA carboxylase kinase (cAMP-independent);
acetyl-CoA carboxylase kinase 2;
acetyl-CoA carboxylase kinase-2;
acetyl-CoA carboxylase kinase-3 (AMP-activated);
acetyl-coenzyme A carboxylase kinase;
ACK2;
ACK3;
AMPK;
I-peptide kinase;
STK5
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[acetyl-CoA carboxylase] phosphotransferase
Reaction(IUBMB)
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate [RN:R03272]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[acetyl-CoA carboxylase] [CPD:C01139]
Product
ADP [CPD:C00008];
[acetyl-CoA carboxylase] phosphate [CPD:C01247]
Comment
Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form [5]. Phosphorylates serine residues.
History
EC 2.7.11.27 created 1990 as EC 2.7.1.128 (EC 2.7.1.111 created 1984, incorporated 1992), transferred 2005 to EC 2.7.11.27
Reference
1  [PMID:2879833]
  Authors
Jamil H, Madsen NB.
  Title
Phosphorylation state of acetyl-coenzyme A carboxylase. I. Linear inverse relationship to activity ratios at different citrate concentrations.
  Journal
J. Biol. Chem. 262 (1987) 630-7.
Reference
2  [PMID:6120170]
  Authors
Lent B, Kim KH.
  Title
Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase.
  Journal
J. Biol. Chem. 257 (1982) 1897-901.
Reference
3  [PMID:6146523]
  Authors
Munday MR, Hardie DG.
  Title
Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity.
  Journal
Eur. J. Biochem. 141 (1984) 617-27.
Reference
4  [PMID:7907095]
  Authors
Mohamed AH, Huang WY, Huang W, Venkatachalam KV, Wakil SJ.
  Title
Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver.
  Journal
J. Biol. Chem. 269 (1994) 6859-65.
Reference
5  [PMID:9475166]
  Authors
Heesom KJ, Moule SK, Denton RM.
  Title
Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase.
  Journal
FEBS. Lett. 422 (1998) 43-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77000-06-7

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