| Entry |
|
| Name |
[acetyl-CoA carboxylase] kinase;
acetyl coenzyme A carboxylase kinase (phosphorylating);
acetyl-CoA carboxylase bound kinase;
acetyl-CoA carboxylase kinase;
acetyl-CoA carboxylase kinase (cAMP-independent);
acetyl-CoA carboxylase kinase 2;
acetyl-CoA carboxylase kinase-2;
acetyl-CoA carboxylase kinase-3 (AMP-activated);
acetyl-coenzyme A carboxylase kinase;
ACK2;
ACK3;
AMPK;
I-peptide kinase;
STK5
|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
 |
| Sysname |
ATP:[acetyl-CoA carboxylase] phosphotransferase
|
| Reaction(IUBMB) |
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate [RN: R03272]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
ADP [CPD: C00008];
[acetyl-CoA carboxylase] phosphate [CPD: C01247]
|
| Comment |
Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form [5]. Phosphorylates serine residues.
|
| Reference |
|
| Authors |
Jamil H, Madsen NB. |
| Title |
Phosphorylation state of acetyl-coenzyme A carboxylase. I. Linear inverse relationship to activity ratios at different citrate concentrations. |
| Journal |
J. Biol. Chem. 262 (1987) 630-7. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Lent B, Kim KH. |
| Title |
Purification and properties of a kinase which phosphorylates and inactivates acetyl-CoA carboxylase. |
| Journal |
J. Biol. Chem. 257 (1982) 1897-901. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Munday MR, Hardie DG. |
| Title |
Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity. |
| Journal |
Eur. J. Biochem. 141 (1984) 617-27. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Mohamed AH, Huang WY, Huang W, Venkatachalam KV, Wakil SJ. |
| Title |
Isolation and characterization of a novel acetyl-CoA carboxylase kinase from rat liver. |
| Journal |
J. Biol. Chem. 269 (1994) 6859-65. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Heesom KJ, Moule SK, Denton RM. |
| Title |
Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase. |
| Journal |
FEBS. Lett. 422 (1998) 43-6. |
| Organism |
Rattus norvegicus [GN: rno] |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 77000-06-7 |