KEGG   ENZYME: 2.7.11.3Help
Entry
EC 2.7.11.3                 Enzyme                                 

Name
dephospho-[reductase kinase] kinase;
AMP-activated kinase;
AMP-activated protein kinase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase kinase;
hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating);
reductase kinase;
reductase kinase kinase;
STK30
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} phosphotransferase
Reaction(IUBMB)
ATP + dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} = ADP + {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} [RN:R04589]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
dephospho-{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase}
Product
ADP [CPD:C00008];
{[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase}
Comment
The enzyme is activated by AMP and is specific for its substrate. Phosphorylates and activates EC 2.7.11.31, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase, that has been inactivated by EC 3.1.3.16, protein-serine/threonine phosphatase.
History
EC 2.7.11.3 created 1984 as EC 2.7.1.110, transferred 2005 to EC 2.7.11.3
Reference
1  [PMID:291971]
  Authors
Beg ZH, Stonik JA, Brewer HB Jr.
  Title
Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 4375-9.
Reference
2  [PMID:666819]
  Authors
Ingebritsen TS, Lee HS, Parker RA, Gibson DM.
  Title
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation.
  Journal
Biochem. Biophys. Res. Commun. 81 (1978) 1268-77.
Reference
3  [PMID:3155737]
  Authors
Beg ZH, Stonik JA, Brewer HB Jr.
  Title
Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase.
  Journal
J. Biol. Chem. 260 (1985) 1682-7.
Reference
4  [PMID:2369897]
  Authors
Clarke PR, Hardie DG.
  Title
Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.
  Journal
EMBO. J. 9 (1990) 2439-46.
Reference
5  [PMID:8415689]
  Authors
Sato R, Goldstein JL, Brown MS.
  Title
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 9261-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
72060-33-4

DBGET integrated database retrieval system