KEGG   ENZYME: 2.7.11.30Help
Entry
EC 2.7.11.30                Enzyme                                 
Name
receptor protein serine/threonine kinase;
activin receptor kinase;
receptor type I serine/threonine protein kinase;
receptor type II serine/threonine protein kinase;
STK13;
TGF-beta kinase;
receptor serine/threonine protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[receptor-protein] phosphotransferase
Reaction(IUBMB)
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[receptor-protein]
Product
ADP [CPD:C00008];
[receptor-protein] phosphate
Comment
The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
Orthology
K04388  
TGF-beta receptor type-2
K04670  
activin receptor type-2A
K04671  
bone morphogenetic protein receptor type-2
K04672  
anti-mullerian hormone receptor type-2
K04673  
bone morphogenetic protein receptor type-1A
K04674  
TGF-beta receptor type-1
K04675  
activin receptor type-1
K13567  
activin receptor type-1B
K13568  
activin receptor type-1C
K13578  
bone morphogenetic protein receptor type-1B
K13594  
activin receptor-like kinase 1
K13596  
activin receptor type-2B
Genes
HSA: 
130399(ACVR1C) 269(AMHR2) 657(BMPR1A) 658(BMPR1B) 659(BMPR2) 7046(TGFBR1) 7048(TGFBR2) 90(ACVR1) 91(ACVR1B) 92(ACVR2A) 93(ACVR2B) 94(ACVRL1)
PTR: 
450572(BMPR1A) 451910(ACVRL1) 451911(ACVR1B) 459646(ACVR2A) 459885(BMPR2) 460243(TGFBR2) 460271(ACVR2B) 461683(BMPR1B) 467005(AMHR2) 470564(ACVR1C) 470565(ACVR1) 472992(TGFBR1)
PPS: 
100967435(ACVR1) 100968350(ACVR1C) 100973488(BMPR1A) 100978253(ACVR1B) 100978576(ACVRL1) 100978909(ACVR2A) 100984463(TGFBR1) 100984661(AMHR2) 100985497(TGFBR2) 100987362(BMPR2) 100991587(BMPR1B) 100993873(ACVR2B)
GGO: 
101124161(ACVR1) 101126947(ACVR2A) 101127602(BMPR1B) 101128510(TGFBR1) 101135109(BMPR1A) 101146131(TGFBR2) 101147417(ACVRL1) 101147783(ACVR1B) 101149682(AMHR2) 101152104 101153315(ACVR2B) 101153902
PON: 
100172614(ACVRL1) 100173725(ACVR1B) 100435220(ACVR2A) 100441106(AMHR2) 100441517(BMPR2) 100444576(BMPR1B) 100450136(BMPR1A) 100450864(TGFBR1) 100455362(ACVR1C) 100455728(ACVR1) 100456564(ACVR2B) 100459236(TGFBR2)
MCC: 
696071(ACVR2B) 696471(ACVRL1) 696587(ACVR1B) 696898(BMPR1A) 697826(ACVR1C) 697935(ACVR1) 702822(AMHR2) 703088(TGFBR2) 704088(BMPR2) 705474(BMPR1B) 707017(ACVR2A) 714952(TGFBR1)
MMU: 
110542(Amhr2) 11477(Acvr1) 11479(Acvr1b) 11480(Acvr2a) 11481(Acvr2b) 11482(Acvrl1) 12166(Bmpr1a) 12167(Bmpr1b) 12168(Bmpr2) 21812(Tgfbr1) 21813(Tgfbr2) 269275(Acvr1c)
RNO: 
140590(Bmpr2) 245921(Acvr1c) 25237(Acvrl1) 25366(Acvr2b) 29263(Acvr2a) 29381(Acvr1b) 29530(Amhr2) 29591(Tgfbr1) 310914(Bmpr1b) 79558(Acvr1) 81507(Bmpr1a) 81810(Tgfbr2)
CFA: 
476140(ACVR2A) 477039(TGFBR2) 477603(ACVRL1) 478484(BMPR1B) 478757(ACVR1) 478875(BMPR2) 481628(TGFBR1) 485590(ACVR2B) 486506(AMHR2) 486537(ACVR1B) 488361(ACVR1C) 489077(BMPR1A)
AML: 
100467049(BMPR1B) 100472026 100472999(BMPR1A) 100475241(AMHR2) 100475698 100476073(ACVR1C) 100476325(ACVR1) 100477787 100482103(ACVR1B) 100482358(ACVRL1) 100482939(TGFBR2) 100483427(BMPR2)
FCA: 
101082489(BMPR1B) 101085902(AMHR2) 101086087(ACVR2B) 101089548(BMPR1A) 101091037(ACVR1C) 101091298(ACVR1) 101091725(TGFBR2) 101094057(TGFBR1) 101096338(BMPR2) 101097406(ACVRL1) 101097654(ACVR1B) 101097750(ACVR2A)
BTA: 
281598(ACVR2A) 282131(ACVR2B) 282382(TGFBR1) 338068(ACVR1) 404101(BMPR1A) 407127(BMPR2) 407128(BMPR1B) 514963(AMHR2) 534536(ACVRL1) 535376(TGFBR2) 536380(ACVR1C) 539315(ACVR1B)
SSC: 
100038019 100127483(BMPR2) 100152307(ACVR1) 100152462(ACVR1B) 100153279(ACVRL1) 100154297(AMHR2) 100156756(ACVR1C) 100169652(BMPR1A) 396665(TGFBR1) 396691(BMPR1B) 397282(ACVR2A) 448845(ACVR2B)
ECB: 
100033860(TGFBR2) 100034117(ALK5) 100049823(ACVR2A) 100050899(ACVR1) 100053554 100053588(ACVR2B) 100059573(ACVR1C) 100061313(ACVRL1) 100062619(ACVR1B) 100063905(AMHR2) 100064367(BMPR1A) 100067195
MDO: 
100011507 100016370(BMPR1B) 100018756 100018765 100021309(ACVR1C) 100021438 100026839(BMPR1A) 100029516 100031897(TGFBR2)
SHR: 
100913352(TGFBR2) 100913438(ACVRL1) 100913702(ACVR1B) 100913844(TGFBR1) 100918537(ACVR2A) 100920492(BMPR1B) 100925781(BMPR2) 100928279(ACVR1) 100928319(BMPR1A) 100929763(AMHR2) 100931037(ACVR1C) 100933894(ACVR2B)
OAA: 
100076965(TGFBR2) 100077006(ACVR1) 100077247 100077843(BMPR1A) 100081575(ACVR1C) 100085680 100086574 100089503 100092358
GGA: 
100857446 374094(TGFBR1) 374147(BMPR2) 374213(ACVR2B) 395246(ACVR1) 396030(BMPR1B) 396308(BMPR1A) 396324(ACVR2A) 396399(TGFBR2) 424261 424325(ACVR1C) 768878(ACVR1B)
MGP: 
100543302 100543917 100544085 100545173 100545739 100546861 100548397 100548990 100549829 100551416
TGU: 
100218713(BMPR1B) 100220619(TGFBR2) 100220695(ACVR1B) 100223148(BMPR1A) 100224301(ACVR2A) 100224677 100227149(BMPR2) 100230545(ACVR1) 100230911 100230960(ACVR2B) 100232553(ACVR1C)
ACS: 
100552477 100552899 100553122 100553521(bmpr2) 100553556 100554151 100554341 100556560 100561841(bmpr1a) 100562173 100565604 100566944
XLA: 
397711 397712(bmpr1a) 397859(xstk2) 397981(bmpr2) 399083(acvr1-a) 399103(acvr1-b) 399283(acvr2a) 399295(tgfbr1) 399454(acvr1b) 495087
XTR: 
100216172(acvr2a) 100487430 100487548(acvr1c) 100488582 100494339(bmpr2) 448641(acvr2b) 548715(tgfbr1) 550111(acvr1) 733849(acvr1b) 734017(bmpr1a) 780089(bmpr1b)
DRE: 
100149664(bmpr1bb) 30183(acvr1b) 30457(acvr2b) 30615(acvr1l) 30739(tgfbr2) 30742(bmpr1ba) 447846(bmpr1ab) 553359(acvr2aa) 555655(bmpr2b) 560446 560578(tgfbr1a) 562822(bmpr2a) 58145(bmpr1aa) 792928(tgfbr1b)
TRU: 
101062282 101062677 101063689 101064229 101064978 101067920 101069199 101069366 101072160 101075765 101078818
OLA: 
100049489(acvr2) 101158075 101161926 101167856 101169384 101170689 101171086 101171650 101171991 101173751 101173900 101174785
BFO: 
BRAFLDRAFT_213409 BRAFLDRAFT_221588 BRAFLDRAFT_59353
CIN: 
778776(tgfbr-ia) 778778(tgfbr-iib)
SPU: 
580712 586095 590282 592872
DME: 
Dmel_CG1891(sax)
DPO: 
Dpse_GA15112
DAN: 
Dana_GF13635 Dana_GF24409
DER: 
Dere_GG23304
DPE: 
Dper_GL10841
DSE: 
Dsec_GM20983
DSI: 
Dsim_GD10510 Dsim_GD15359
DWI: 
Dwil_GK18023 Dwil_GK22220
DYA: 
Dyak_GE19150 Dyak_GE20653
DGR: 
Dgri_GH20320 Dgri_GH24979
DMO: 
Dmoj_GI11419 Dmoj_GI19992
DVI: 
Dvir_GJ13615 Dvir_GJ21241
AGA: 
AgaP_AGAP005567 AgaP_AGAP007729
AAG: 
AaeL_AAEL004165 AaeL_AAEL012152
CQU: 
CpipJ_CPIJ004526 CpipJ_CPIJ014117
AME: 
413895(wit) 725711(sax)
NVI: 
100119760(Sax) 100121252(wit)
TCA: 
658545(sax) 663692(wit)
PHU: 
Phum_PHUM551530
ISC: 
IscW_ISCW011054 IscW_ISCW020983
TSP: 
Tsp_06484
SMM: 
Smp_049760 Smp_080120.2
NVE: 
NEMVE_v1g104199 NEMVE_v1g178197
HMG: 
100210091 100212672
AQU: 
100637532
 » show all
Taxonomy
Reference
1  [PMID:8047140]
  Authors
Wrana JL, Attisano L, Wieser R, Ventura F, Massague J.
  Title
Mechanism of activation of the TGF-beta receptor.
  Journal
Nature. 370 (1994) 341-7.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:10733523]
  Authors
Massague J, Chen YG.
  Title
Controlling TGF-beta signaling.
  Journal
Genes. Dev. 14 (2000) 627-44.
  Organism
Caenorhabditis elegans [GN:cel], mammalian
Reference
3  [PMID:9153220]
  Authors
de Caestecker MP, Hemmati P, Larisch-Bloch S, Ajmera R, Roberts AB, Lechleider RJ.
  Title
Characterization of functional domains within Smad4/DPC4.
  Journal
J. Biol. Chem. 272 (1997) 13690-6.
  Organism
Caenorhabditis elegans [GN:cel]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system