KEGG   ENZYME: 2.7.11.4Help
Entry
EC 2.7.11.4                 Enzyme                                 

Name
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase;
BCK;
BCKD kinase;
BCODH kinase;
branched-chain alpha-ketoacid dehydrogenase kinase;
branched-chain 2-oxo acid dehydrogenase kinase;
branched-chain keto acid dehydrogenase kinase;
branched-chain oxo acid dehydrogenase kinase (phosphorylating);
STK2
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphotransferase
Reaction(IUBMB)
ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
Reaction(KEGG)
(other) R03516
Show
Substrate
ATP [CPD:C00002];
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)]
Product
ADP [CPD:C00008];
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate
Comment
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the branched-chain 2-oxoacid dehydrogenase complex. Phosphorylation inactivates EC 1.2.4.4, 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).
Orthology
K00905  
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase
Genes
HSA: 
10295(BCKDK)
PTR: 
741960(BCKDK)
PPS: 
100988171(BCKDK)
GGO: 
101150693(BCKDK)
PON: 
100435349(BCKDK)
MCC: 
712985(BCKDK)
MCF: 
102135926(BCKDK)
MMU: 
12041(Bckdk)
RNO: 
29603(Bckdk)
CGE: 
HGL: 
101715390(Bckdk)
TUP: 
102488075(BCKDK)
CFA: 
479776(BCKDK)
AML: 
FCA: 
101089414(BCKDK)
BTA: 
505005(BCKDK)
BOM: 
102272790(BCKDK)
PHD: 
102327700(BCKDK)
CHX: 
102178232(BCKDK)
SSC: 
100522544(BCKDK)
CFR: 
102514896(BCKDK)
ECB: 
100063321(BCKDK)
MYB: 
102256163(BCKDK)
SHR: 
100930326(BCKDK)
OAA: 
PHI: 
FPG: 
FCH: 
ASN: 
PSS: 
ACS: 
XLA: 
432076(bckdk)
XTR: 
100380070(bckdk)
DRE: 
282677(bckdk)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
SPU: 
574737(bckdk)
ISC: 
NVE: 
HMG: 
TAD: 
CSL: 
GSL: 
MBR: 
TGO: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:7142221]
  Authors
Paxton R, Harris RA.
  Title
Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation.
  Journal
J. Biol. Chem. 257 (1982) 14433-9.
  Organism
Oryctolagus cuniculus
Reference
2  [PMID:10903321]
  Authors
Wynn RM, Chuang JL, Cote CD, Chuang DT.
  Title
Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase.
  Journal
J. Biol. Chem. 275 (2000) 30512-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:12189132]
  Authors
Chuang JL, Wynn RM, Chuang DT.
  Title
The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase.
  Journal
J. Biol. Chem. 277 (2002) 36905-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:9344245]
  Authors
Popov KM, Hawes JW, Harris RA.
  Title
Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases.
  Journal
Adv. Second. Messenger. Phosphoprotein. Res. 31 (1997) 105-11.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
82391-38-6

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