KEGG   ENZYME: 2.7.11.7Help
Entry
EC 2.7.11.7                 Enzyme                                 

Name
myosin-heavy-chain kinase;
ATP:myosin-heavy-chain O-phosphotransferase;
calmodulin-dependent myosin heavy chain kinase;
MHCK;
MIHC kinase;
myosin heavy chain kinase;
myosin I heavy-chain kinase;
myosin II heavy-chain kinase;
[myosin-heavy-chain] kinase;
myosin heavy chain kinase A;
STK6
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[myosin heavy-chain] O-phosphotransferase
Reaction(IUBMB)
ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate
Reaction(KEGG)
(other) R04023
Show
Substrate
ATP [CPD:C00002];
[myosin heavy-chain]
Product
ADP [CPD:C00008];
myosin heavy-chain phosphate [CPD:C03874]
Comment
The enzyme from Dictyostelium sp. (slime moulds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor. While the enzyme from some species is activated by actin, in other cases Ca2+/calmodulin are required for activity.
History
EC 2.7.11.7 created 1990 as EC 2.7.1.129, transferred 2005 to EC 2.7.11.7
Orthology
K08240  
myosin-heavy-chain kinase
Genes
TBR: 
Tb927.4.4970(Tb04.3M17.320) Tb927.8.7450(Tb08.10K10.110)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
Taxonomy
Reference
1  [PMID:3027076]
  Authors
Cote GP, Bukiejko U.
  Title
Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum.
  Journal
J. Biol. Chem. 262 (1987) 1065-72.
Reference
2  [PMID:6309772]
  Authors
Hammer JA 3rd, Albanesi JP, Korn ED.
  Title
Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii.
  Journal
J. Biol. Chem. 258 (1983) 10168-75.
Reference
3  [PMID:2822719]
  Authors
Rieker JP, Swanljung-Collins H, Collins JH.
  Title
Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border.
  Journal
J. Biol. Chem. 262 (1987) 15262-8.
Reference
4  [PMID:2549052]
  Authors
Ravid S, Spudich JA.
  Title
Myosin heavy chain kinase from developed Dictyostelium cells. Purification and characterization.
  Journal
J. Biol. Chem. 264 (1989) 15144-50.
Reference
5  [PMID:2168881]
  Authors
Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED.
  Title
Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides.
  Journal
J. Biol. Chem. 265 (1990) 16138-44.
Reference
6  [PMID:1321427]
  Authors
Ravid S, Spudich JA.
  Title
Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 5877-81.
Reference
7  [PMID:7822274]
  Authors
Futey LM, Medley QG, Cote GP, Egelhoff TT.
  Title
Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins.
  Journal
J. Biol. Chem. 270 (1995) 523-9.
  Sequence
Reference
8  [PMID:9539704]
  Authors
Szczepanowska J, Ramachandran U, Herring CJ, Gruschus JM, Qin J, Korn ED, Brzeska H.
  Title
Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 4146-51.
Reference
9  [PMID:15545285]
  Authors
Egelhoff TT, Croft D, Steimle PA.
  Title
Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly.
  Journal
J. Biol. Chem. 280 (2005) 2879-87.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
64763-54-8

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