KEGG   ENZYME: 2.7.11.8Help
Entry
EC 2.7.11.8                 Enzyme                                 

Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
History
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K08290  
Fas-activated serine/threonine kinase
Genes
HSA: 
10922(FASTK)
PTR: 
472626(FASTK)
PPS: 
100978359(FASTK)
GGO: 
101150125(FASTK)
PON: 
100171584(FASTK)
MCC: 
714020(FASTK)
MCF: 
MMU: 
66587(Fastk)
RNO: 
296741(Fastk)
CGE: 
100762130(Fastk)
HGL: 
101707658(Fastk)
TUP: 
102498075(FASTK)
CFA: 
482802(FASTK)
AML: 
100482824(FASTK)
FCA: 
101082140(FASTK)
PTG: 
102956491(FASTK)
BTA: 
509781(FASTK)
BOM: 
102266409(FASTK)
PHD: 
102321141(FASTK)
CHX: 
102186744(FASTK)
SSC: 
100233181(FASTK)
CFR: 
102523278(FASTK)
BACU: 
103019324(FASTK)
LVE: 
103084660(FASTK)
ECB: 
100063473(FASTK)
MYB: 
102254535(FASTK)
MYD: 
102755949(FASTK)
PALE: 
102878349(FASTK)
GGA: 
426636(FASTK)
MGP: 
FAB: 
101814009(FASTK)
PHI: 
102100505(FASTK)
FPG: 
101913183(FASTK)
FCH: 
102058389(FASTK)
CLV: 
102096109(FASTK)
ASN: 
102382446(FASTK)
AMJ: 
102570632(FASTK)
CMY: 
102940414(FASTK)
DRE: 
564534(fastk)
MZE: 
XMA: 
LCM: 
102349276(FASTK)
CMK: 
103190094(fastk)
 » show all
Taxonomy
Reference
1  [PMID:7544399]
  Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
  Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
  Journal
J. Exp. Med. 182 (1995) 865-74.
  Organism
Homo sapiens
  Sequence
[hsa:10922]
Reference
2  [PMID:15572676]
  Authors
Li W, Simarro M, Kedersha N, Anderson P.
  Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
  Journal
Mol. Cell. Biol. 24 (2004) 10718-32.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
170347-50-9

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