KEGG   ENZYME: 2.7.11.9Help
Entry
EC 2.7.11.9                 Enzyme                                 

Name
Goodpasture-antigen-binding protein kinase;
GPBPK;
GPBP kinase;
STK11;
Goodpasture antigen-binding protein kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[Goodpasture antigen-binding protein] phosphotransferase
Reaction(IUBMB)
ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein]
Reaction(KEGG)
(other) R00162
Show
Substrate
ATP [CPD:C00002];
[Goodpasture antigen-binding protein]
Product
ADP [CPD:C00008];
[Goodpasture antigen-binding phosphoprotein]
Comment
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
History
EC 2.7.11.9 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Reference
1  [PMID:10212244]
  Authors
Raya A, Revert F, Navarro S, Saus J.
  Title
Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen.
  Journal
J. Biol. Chem. 274 (1999) 12642-9.
  Organism
Homo sapiens
Reference
2  [PMID:11007769]
  Authors
Raya A, Revert-Ros F, Martinez-Martinez P, Navarro S, Rosello E, Vieites B, Granero F, Forteza J, Saus J.
  Title
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis.
  Journal
J. Biol. Chem. 275 (2000) 40392-9.
  Organism
Homo sapiens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
230316-19-5

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