KEGG   ENZYME: 2.7.2.2Help
Entry
EC 2.7.2.2                  Enzyme                                 
Name carbamate kinase;
CKase ;
carbamoyl phosphokinase;
carbamyl phosphokinase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
BRITE hierarchy
Sysname ATP:carbamate phosphotransferase
Reaction(IUBMB) ATP + NH3 + CO2 = ADP + carbamoyl phosphate [RN:R00150]
Reaction(KEGG) R00150;
(other) R01395
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Substrate ATP [CPD:C00002];
NH3 [CPD:C00014];
CO2 [CPD:C00011]
Product ADP [CPD:C00008];
carbamoyl phosphate [CPD:C00169]
Pathway PATH: ec00230  Purine metabolism
PATH: ec00330  Arginine and proline metabolism
PATH: ec00910  Nitrogen metabolism
Orthology KO: K00926  carbamate kinase
Genes GLA: GL50803_16453
TVA: TVAG_261970
ECO: b0323(yahI) b0521(ybcF) b2874(yqeA)
ECJ: JW0315(yahI) JW0510(ybcF) JW2842(yqeA)
ECD: ECDH10B_0477(ybcF) ECDH10B_3049(yqeA)
EBW: BWG_0396(ybcF) BWG_2600(yqeA)
ECE: Z0412(yahI) Z0676(arcC) Z4213(yqeA)
ECS: ECs0372 ECs0583 ECs3747
ECF: ECH74115_0388 ECH74115_0622(arcC) ECH74115_4164
ETW: ECSP_0379(yahI) ECSP_0595(ybcF) ECSP_3844(yqeA)
ECG: E2348C_0285(yahI) E2348C_0454(ybcF) E2348C_3126(yqeA)
     E2348C_4138
ECC: c0444 c0635(arcC) c3452(yqeA) c4764 c5349
ECI: UTI89_C0352(yahI) UTI89_C0549(arcC) UTI89_C3259(yqeA)
     UTI89_C4405 UTI89_C4856
ECP: ECP_0399 ECP_0581 ECP_2868 ECP_4034 ECP_4499
ECV: APECO1_1494(arcC) APECO1_1668(yahI) APECO1_2143 APECO1_2636
     APECO1_3652(yqeA)
ECW: EcE24377A_0341 EcE24377A_0559(arcC) EcE24377A_3199
ECX: EcHS_A0383 EcHS_A0595(arcC) EcHS_A3034
ECM: EcSMS35_0353 EcSMS35_0566(arcC) EcSMS35_3007 EcSMS35_4199
ECY: ECSE_0343 ECSE_0546 ECSE_3138
ECL: EcolC_0834 EcolC_3101 EcolC_3300
ECK: EC55989_0325(yahI) EC55989_0535(ybcF) EC55989_3161(yqeA)
ECQ: ECED1_0352(yahI) ECED1_0540(ybcF) ECED1_3334(yqeA) ECED1_4522
     ECED1_5104(arcC)
ECR: ECIAI1_0320(yahI) ECIAI1_0523(ybcF) ECIAI1_2994(yqeA)
ECT: ECIAI39_0364(yahI) ECIAI39_0484(ybcF) ECIAI39_3289(yqeA)
     ECIAI39_4724(arcC)
ECZ: ECS88_0331(yahI) ECS88_0520(ybcF) ECS88_3153(yqeA) ECS88_4269
EUM: ECUMN_0361(yahI) ECUMN_0561(ybcF) ECUMN_3217(yqeA)
ELF: LF82_2518(yahI) LF82_2569(ybcF) LF82_3644(yqeA) LF82_p591
     LF82_p716
EBL: B21_00282(yahI) B21_00476(ybcF) B21_02669(yqeA)
     B21_03661(ybl185)
EBD: ECBD_0863 ECBD_3137 ECBD_3334 ECBD_4205
EBR: ECB_00278(yahI) ECB_00471(arcC) ECB_02707(yqeA) ECB_03712
EOH: ECO103_0300(yahI) ECO103_0493(ybcF) ECO103_3449(yqeA)
EOI: ECO111_0357(yahI) ECO111_0553(ybcF) ECO111_3612(yqeA)
EOJ: ECO26_0357(yahI) ECO26_0554(ybcF) ECO26_3963(yqeA)
EFE: EFER_0421(yahI) EFER_0561(ybcF) EFER_4331(arcC)
STY: STY0580(arcC) STY4804
STT: t2329(arcC) t4500
SPT: SPA2191(arcC) SPA4266
SEK: SSPA2037 SSPA3963
SPQ: SPAB_03032 SPAB_05621
SEI: SPC_0546(arcC) SPC_4598
SEC: SC0571(arcC) SC4320(arcC)
SEH: SeHA_C0640(arcC) SeHA_C4868(arcC)
SEE: SNSL254_A0585(arcC) SNSL254_A4813(arcC)
SEW: SeSA_A4720(arcC)
SEA: SeAg_B0578(arcC) SeAg_B4750(arcC)
SED: SeD_A0580(arcC) SeD_A4849(arcC)
SEG: SG0544(arcC) SG4291
SET: SEN0513(arcC) SEN4217
SES: SARI_03185
STM: STM0532(arcC) STM4466
SFL: SF0452(arcC)
SFX: S0460(arcC)
SFV: SFV_0479(arcC)
SSN: SSON_0310(yahI) SSON_0497(arcC) SSON_3025(yqeA)
SBO: SBO_3110(yqeA)
ENT: Ent638_0451 Ent638_3141
ESA: ESA_03476
CTU: Ctu_04910(arcC)
KPU: KP1_1378(arcC)
CKO: CKO_03556 CKO_04293
SPE: Spro_3187
PMR: PMI2199(arcC)
EIC: NT01EI_3529
ETR: ETAE_3174(yqeA)
HIN: HI0595(arcC)
HIT: NTHI0734(arcC)
HIP: CGSHiEE_09190
HIQ: CGSHiGG_06295
APL: APL_1318(arcC)
APJ: APJL_1332(arcC)
APA: APP7_1369
AAP: NT05HA_2159
AAT: D11S_0083
VSP: VS_2925 VS_II1517
VFI: VF_A1146(ybcF)
VFM: VFMJ11_A1243
PPR: PBPRA0476 PBPRA1990 PBPRB1784 PBPRB1918
PAE: PA5173(arcC)
PAU: PA14_68350(arcC)
PAP: PSPA7_5913(arcC)
PAG: PLES_55651(arcC)
PPU: PP_0999(arcC)
PPF: Pput_1036
PPG: PputGB1_0998
PPW: PputW619_4225
PSB: Psyr_2686
PFL: PFL_4637(arcC)
PFO: Pfl01_4388
PFS: PFLU4893
PEN: PSEEN4430(arcC)
PMY: Pmen_1106
PSA: PST_0674(arcC-1) PST_3980(arcC-2)
SHL: Shal_0639 Shal_0688
HCH: HCH_05488(arcC)
AHA: AHA_2165(arcC-1) AHA_4092(arcC-2)
ASA: ASA_0223(arcC)
TAU: Tola_2457
DNO: DNO_1073(arcC)
CVI: CV_3780(arcC)
LHK: LHK_02732(arcC-2)
BMA: BMA1147(arcC)
BMV: BMASAVP1_A1587(arcC)
BML: BMA10229_A0246(arcC)
BMN: BMA10247_0913(arcC)
BPS: BPSL1745(arcC)
BPM: BURPS1710b_2126(arcC)
BPL: BURPS1106A_1984(arcC)
BPD: BURPS668_1966(arcC)
BPR: GBP346_A2010(arcC)
BTE: BTH_I2386(arcC)
BAC: BamMC406_4539
BXE: Bxe_A1875 Bxe_C0748
BPH: Bphy_6441
BPY: Bphyt_5577
MMS: mma_1119(arcC1) mma_3569(arcC2)
GSU: GSU2487(arcC)
GME: Gmet_2786
DBA: Dbac_2177
SAT: SYN_01213
SFU: Sfum_0047
MES: Meso_2239 Meso_3874
PLA: Plav_1145
SME: SMa0697(arcC)
SMD: Smed_5204
REC: RHECIAT_CH0000126(arcC)
OAN: Oant_4648
CAK: Caul_2963
DSH: Dshi_0434(arcC)
BCE: BC0409
BCA: BCE_0475(arcC)
BCB: BCB4264_A0423(arcC)
BCU: BCAH820_0410(arcC)
BCG: BCG9842_B4895(arcC)
BCY: Bcer98_0351
BTK: BT9727_0344(arcC)
BTL: BALH_0366(arcC)
BLI: BL01102 BL01916(arcC)
BLD: BLi01134 BLi04166
SAU: SA1013 SA2425(arcC)
SAV: SAV1170 SAV2632(arcC)
SAW: SAHV_1160 SAHV_2616(arcC)
SAM: MW1051 MW2553(arcC)
SAR: SAR1143 SAR2711(arcC)
SAS: SAS1103 SAS2518
SAC: SACOL1182(arcC1) SACOL2654(arcC2)
SAB: SAB1034 SAB2507c(arcC)
SAA: SAUSA300_0061(arcC) SAUSA300_1063(arcC) SAUSA300_2567(arcC)
SAX: USA300HOU_0066(arcC1) USA300HOU_1107(arcC2)
     USA300HOU_2632(arcC3)
SAO: SAOUHSC_01129 SAOUHSC_02965
SAJ: SaurJH9_1228 SaurJH9_2656
SAH: SaurJH1_1253 SaurJH1_2712
SAE: NWMN_1079(arcC) NWMN_2531(arcC)
SAD: SAAV_1138(arcC1) SAAV_2701(arcC2)
SEP: SE0102 SE0228
SER: SERP2352(arcC)
SHA: SH0259
SCA: Sca_2049(arcC) Sca_2252(arcC)
LMO: lmo0039
LMF: LMOf2365_0048(arcC)
LMC: Lm4b_00048
LSP: Bsph_2904
EAT: EAT1b_1474
BBE: BBR47_45090
LLA: L0112(arcC3) L92850(arcC2) L93826(arcC1)
LLK: LLKF_1859(arcC) LLKF_2219(arcC) LLKF_2220(arcC)
LLC: LACR_2318 LACR_2319
LLM: llmg_2309(arcC2) llmg_2310(arcC1)
SPY: SPy_1541(arcC)
SPZ: M5005_Spy_1270(arcC)
SPM: spyM18_1558
SPG: SpyM3_1191(arcC)
SPS: SPs0671
SPH: MGAS10270_Spy1285(arcC)
SPI: MGAS10750_Spy1377(arcC)
SPJ: MGAS2096_Spy1289(arcC)
SPK: MGAS9429_Spy1264(arcC)
SPF: SpyM50582(arcC)
SPA: M6_Spy1291
SPB: M28_Spy1208(arcC)
SOZ: Spy49_1192c(arcC)
SPN: SP_2151
SPD: SPD_1977(arcC)
SPR: spr1958(arcC)
SPW: SPCG_2120(arcC)
SPX: SPG_2090
SNE: SPN23F_21820(arcC)
SPV: SPH_2342(arcC)
SNM: SP70585_2277(arcC)
SJJ: SPJ_2175(arcC)
SPP: SPP_2201(arcC)
SNT: SPT_2162(arcC)
SAG: SAG2125(arcC-1) SAG2167(arcC-2)
SAN: gbs2084 gbs2126
SAK: SAK_2064(arcC) SAK_2125(arcC)
SMU: SMU.265(arcC)
SSA: SSA_0739(arcC)
SSU: SSU05_0627
SSV: SSU98_0626
SSB: SSUBM407_1239(arcC)
SSI: SSU0583(arcC)
SSS: SSUSC84_0558(arcC)
SGO: SGO_1591(arcC)
SEQ: SZO_14190
SEZ: Sez_0573(arcC)
SEU: SEQ_0602
SUB: SUB1324(arcC)
SDS: SDEG_1542(arcC)
LSA: LSA0071 LSA0372(arcC)
LBR: LVIS_2023 LVIS_2207
LRE: Lreu_0426
LRF: LAR_0420
LFE: LAF_0299
PPE: PEPE_0192 PEPE_1630
EFA: EF0106(arcC-1) EF0386(arcC-2) EF0735(arcC-3) EF2575(arcC-4)
CPE: CPE0171(arcC)
CPF: CPF_0164(arcC)
CPR: CPR_0160(arcC)
CTC: CTC02524
CBO: CBO2594(arcC)
CBA: CLB_2535(arcC)
CBH: CLC_2466(arcC)
CBY: CLM_2901(arcC)
CBL: CLK_1979(arcC)
CBK: CLL_A0624(arcC)
CBB: CLD_1971(arcC)
CBI: CLJ_B2824(arcC)
CBT: CLH_0585(arcC)
CBF: CLI_2657(arcC)
CBE: Cbei_1969
CPY: Cphy_3101
AMT: Amet_4607
AOE: Clos_2181
VPR: Vpar_1269
HMO: HM1_2643(arcC)
FMA: FMG_1016
APR: Apre_0029 Apre_1429
EEL: EUBELI_00708
ERE: EUBREC_2604
TTE: TTE0533(arcC)
TEX: Teth514_0485
TPD: Teth39_1747
MTA: Moth_1948 Moth_2117
CPO: COPRO5265_1087(arcC)
HOR: Hore_06680
MPN: MPN307(arcC)
MPE: MYPE6100(arcC)
MMY: MSC_0700(arcC) MSC_0864(arcC) MSC_0877(arcC)
MCP: MCAP_0651(arcC)
MAT: MARTH_orf130(arcC)
MHO: MHO_0630(arcC)
MVA: Mvan_1389
AAU: AAur_pTC10213
BCV: Bcav_0583
PAC: PPA0585
NCA: Noca_1504 Noca_2426
SRO: Sros_2798 Sros_6542
CAI: Caci_1878
RXY: Rxyl_2848
CCU: Ccur_06560
SHI: Shel_00850 Shel_02380 Shel_12560
APV: Apar_0242
ELE: Elen_0673 Elen_0679 Elen_1947
BTU: BT0843A
BHR: BH0843A
BDU: BDU_857(arcC)
TDE: TDE2476(arcC)
BHY: BHWA1_00063(arcC)
ABA: Acid345_1820
STR: Sterm_0787 Sterm_1665 Sterm_3444
SMF: Smon_0183
TAI: Taci_0269
SYN: sll0573(arcC)
CYP: PCC8801_2359
CYH: Cyan8802_2409
TRO: trd_0571(arcC)
TLE: Tlet_0827
TME: Tmel_1927
TAF: THA_1104(arcC)
FNO: Fnod_1788
PMO: Pmob_0069
KOL: Kole_1432
MEM: Memar_0247
HAL: VNG6316G(arcC)
HSL: OE5206R(arcC)
TAC: Ta1350m
TVO: TVN0259
PTO: PTO0590
PHO: PH1282
PAB: PAB0593(cpa)
PFU: PF0676
TKO: TK2158
TON: TON_1502
TGA: TGAM_0120(cpkA)
TSI: TSIB_1834
APE: APE_1968
SMR: Smar_0235
DKA: DKAM_0008
HBU: Hbut_0269
PAI: PAE1552
PIS: Pisl_1620
PCL: Pcal_0529
PAS: Pars_0659
CMA: Cmaq_1838
TNE: Tneu_0645
TPE: Tpen_0172
KCR: Kcr_1250
Taxonomy
Structures PDB: 1B7B  1E19  2E9Y  
Reference
  Authors
  Title
  Journal
 1  [PMID:4959296]
Bishop SH, Grisolia S.
Crystalline carbamate kinase.
Biochim. Biophys. Acta. 118 (1966) 211-5.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:5857367]
Davis RH.
Carbamyl phosphate synthesis in Neurospora crassa. I. Preliminary
characterization of arginine-specific carbamyl phosphokinase.
Biochim. Biophys. Acta. 107 (1965) 44-53.
Neurospora crassa [GN:ncr]
Reference
  Authors
  Title

  Journal
 3
Glasziou, K.T.
The metabolism of arginine in Serratia marcescens. II.
Carbamyladenosine diphosphate phosphoferase.
Aust. J. Biol. Sci. (1956) 253-262.
Reference
  Authors
  Title

  Journal
 4
Jones, M.E., Spector, L. and Lipmann, F.
Carbamyl phosphate, the carbamyl donor in enzymatic citrulline
synthesis.
J. Am. Chem. Soc. 77 (1955) 819-820.
Reference
  Authors
  Title


  Journal
  Organism
 5  [PMID:6895223]
Srivenugopal KS, Adiga PR.
Enzymic conversion of agmatine to putrescine in Lathyrus sativus
seedlings. Purification and properties of a multifunctional enzyme
(putrescine synthase).
J. Biol. Chem. 256 (1981) 9532-41.
Lathyrus sativus
Other DBs ExplorEnz - The Enzyme Database: 2.7.2.2
IUBMB Enzyme Nomenclature: 2.7.2.2
ExPASy - ENZYME nomenclature database: 2.7.2.2
BRENDA, the Enzyme Database: 2.7.2.2
CAS: 9026-69-1
DBGET integrated database retrieval system