KEGG   ENZYME: 2.7.3.2Help
Entry
EC 2.7.3.2                  Enzyme                                 

Name
creatine kinase;
ATP:creatine phosphotransferase;
CK;
MM-CK;
MB-CK;
BB-CK;
creatine phosphokinase;
creatine phosphotransferase;
phosphocreatine kinase;
adenosine triphosphate-creatine transphosphorylase;
Mi-CK;
CK-BB;
CK-MM;
CK-MB;
CKMiMi;
MiMi-CK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a nitrogenous group as acceptor
BRITE hierarchy
Sysname
ATP:creatine N-phosphotransferase
Reaction(IUBMB)
ATP + creatine = ADP + phosphocreatine [RN:R01881]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
creatine [CPD:C00300]
Product
ADP [CPD:C00008];
phosphocreatine [CPD:C02305]
Comment
N-Ethylglycocyamine can also act as acceptor.
History
EC 2.7.3.2 created 1961
Pathway
Arginine and proline metabolism
Metabolic pathways
Orthology
K00933  
creatine kinase
Genes
HSA: 
1152(CKB) 1158(CKM) 1159(CKMT1B) 1160(CKMT2) 548596(CKMT1A)
PTR: 
100608872 453185(CKB) 461770(CKMT2) 744935(CKM)
PPS: 
GGO: 
101125452(CKM) 101126518(CKMT2) 101143694(CKB) 101152129(CKMT1B)
PON: 
NLE: 
100579841(CKMT1A) 100580784(CKB) 100595118(CKM) 100596285(CKMT2)
MCC: 
711167(CKB) 711434(CKMT2) 712886
MCF: 
CJC: 
MMU: 
12709(Ckb) 12715(Ckm) 12716(Ckmt1) 76722(Ckmt2)
RNO: 
24264(Ckb) 24265(Ckm) 29593(Ckmt1b) 688698(Ckmt2)
CGE: 
100752172(Ckmt2) 100754659(Ckmt1b) 100754895(Ckm) 100774847(Ckb)
NGI: 
HGL: 
OCU: 
100009056(CKM) 100009085(CKB) 100302412(CKMT2) 100328683(CKMT1B)
TUP: 
102478248(CKMT2) 102481039(CKM) 102501342(CKB) 102503060(CKMT1B)
CFA: 
100855552(CKB) 476435(CKM) 478277(CKMT1B) 479163(CKMT2)
AML: 
UMR: 
FCA: 
101088213(CKMT2) 101095936(CKM) 101097983(CKMT1B) 101098237(CKB)
PTG: 
102950160(CKMT2) 102950440(CKM) 102965261(CKB) 102971492(CKMT1B)
BTA: 
100851864 281692(CKMT1B) 286822(CKM) 516210(CKB) 538944(CKMT2)
BOM: 
102269114(CKB) 102273174(CKMT2) 102279185(CKM) 102281409(CKMT1B)
PHD: 
CHX: 
102170262(CKM) 102171870(CKMT2) 102183273(CKMT1B)
OAS: 
SSC: 
100519994(CKMT1B) 100627332(CKB) 397264(CKM) 733602(CKMT2)
CFR: 
BACU: 
103002549(CKMT1B) 103003471(CKB) 103008202(CKM) 103019724(CKMT2)
LVE: 
103069811(CKMT2) 103077736(CKM) 103079457(CKMT1B) 103081944(CKB)
ECB: 
100055201(CKB) 100056283(CKMT1B) 100065641(CKM) 100073253(CKMT2)
MYB: 
102253413(CKB) 102255126(CKMT2) 102256170(CKM) 102258464(CKMT1B)
MYD: 
102751779(CKMT1B) 102755424(CKMT2) 102757599(CKM) 102768923(CKB)
PALE: 
102879754(CKMT2) 102880033(CKMT1B) 102881874(CKB) 102890804(CKM)
MDO: 
100011609(CKMT1B) 100012235(CKMT2) 100015112(CKM) 100017071(CKB)
SHR: 
100919833(CKMT2) 100920419(CKMT1B) 100921738(CKB) 100923163(CKM)
OAA: 
100076820(CKB) 100081308(CKMT2) 100082097(CKM) 100085972(CKMT1B)
GGA: 
374002(CKMT1A) 396248(CKB) 396507(CKM) 396508(CKMT2)
MGP: 
APLA: 
101793249(CKB) 101797300(CKMT2) 101805284(CKMT1B)
TGU: 
FAB: 
PHI: 
FPG: 
101919374(CKMT1B) 101919910(CKB) 101921119(CKM) 101924783(CKMT2)
FCH: 
102045686(CKM) 102048684(CKMT1B) 102059009(CKB) 102059596(CKMT2)
CLV: 
ASN: 
102369322(CKM) 102377457(CKMT2) 102384330(CKB) 102386529(CKMT1B)
AMJ: 
102561514(CKB) 102567141(CKM) 102570575(CKMT1B) 102571608(CKMT2)
PSS: 
102457144(CKB) 102459236(CKMT2)
CMY: 
102941582(CKMT2) 102943120(CKMT1B) 102943206(CKB) 102944467(CKM)
ACS: 
PBI: 
XLA: 
379216(ckmt1b-b) 379765(ckm) 380055(ckb) 380155(ckmt1b-a)
XTR: 
395000(ckmt1b) 395005(ckm) 733543(ckb)
DRE: 
140744(ckbb) 30095(ckma) 321892(ckmt1) 799492(ckmt2b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353273(CKM) 102356812(CKMT1B) 102360950(CKMT2) 102364298(CKB)
CMK: 
BFO: 
CIN: 
SPU: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
550932(Argk)
NVI: 
TCA: 
BMOR: 
692924(AK)
API: 
PHU: 
ISC: 
CBR: 
BMY: 
LOA: 
LGI: 
NVE: 
HMG: 
AQU: 
MBR: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
NSA: 
DPS: 
DAT: 
MXA: 
MFU: 
OPR: 
 » show all
Taxonomy
Reference
1  [PMID:13235819]
  Authors
ENNOR AH, ROSENBERG H, ARMSTRONG MD.
  Title
Specificity of creatine phosphokinase.
  Journal
Nature. 175 (1955) 120.
Reference
2  [PMID:5750168]
  Authors
Keutel HJ, Jacobs HK, Okabe K, Yue RH, Kuby SA.
  Title
Studies on adenosine triphosphate transphosphorylases. VII. Isolation of the crystalline adenosine triphosphate--creatine transphosphorylase from calf brain.
  Journal
Biochemistry. 7 (1968) 4283-90.
Reference
3  [PMID:13192073]
  Authors
KUBY SA, NODA L, LARDY HA.
  Title
Adenosinetriphosphate-creatine transphosphorylase. I. Isolation of the crystalline enzyme from rabbit muscle.
  Journal
J. Biol. Chem. 209 (1954) 191-201.
Reference
4
  Authors
Kuby, S.A. and Noltmann, E.A.
  Title
ATP-creatine transphosphorylase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 515-603.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9001-15-4

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