KEGG   ENZYME: 2.7.4.2Help
Entry
EC 2.7.4.2                  Enzyme                                 
Name phosphomevalonate kinase;
ATP:5-phosphomevalonate phosphotransferase;
5-phosphomevalonate kinase;
mevalonate phosphate kinase;
mevalonate-5-phosphate kinase;
mevalonic acid phosphate kinase
Class Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname ATP:(R)-5-phosphomevalonate phosphotransferase
Reaction(IUBMB) ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate
[RN:R03245]
Reaction(KEGG) R03245
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Substrate ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]
Product ADP [CPD:C00008];
(R)-5-diphosphomevalonate [CPD:C01143]
Pathway PATH: ec00900  Terpenoid backbone biosynthesis
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01066  Biosynthesis of alkaloids derived from terpenoid and
               polyketide
PATH: ec01070  Biosynthesis of plant hormones
PATH: ec01100  Metabolic pathways
Orthology KO: K00938  phosphomevalonate kinase
KO: K13273  phosphomevalonate kinase
Genes HSA: 10654(PMVK)
PTR: 457350(PMVK)
MCC: 717014(PMVK)
MMU: 68603(Pmvk)
RNO: 310645(Pmvk)
CFA: 612251(PMVK)
BTA: 513533(PMVK)
SSC: 100152301
ECB: 100062963
MDO: 100021196
XLA: 734816
DRE: 100003383
BFO: BRAFLDRAFT_114776 BRAFLDRAFT_289738
CIN: 100185100
DME: Dmel_CG10268
DPO: Dpse_GA10206
DAN: Dana_GF15482
DER: Dere_GG21619
DPE: Dper_GL25642
DSE: Dsec_GM16997
DSI: Dsim_GD13720 Dsim_GD21744
DYA: Dyak_GE12639
DGR: Dgri_GH13497
DMO: Dmoj_GI17248
AGA: AgaP_AGAP000338
AAG: AaeL_AAEL013814
CQU: CpipJ_CPIJ015413
AME: 725018
NVI: 100120840
TCA: 663114
API: 100163413(Acypi004503)
ISC: IscW_ISCW021370
CEL: F32D8.13
CBR: CBG09742
BMY: Bm1_05275
SMM: Smp_072460
NVE: NEMVE_v1g204629
HMG: 100204226
TAD: TRIADDRAFT_22239
ATH: AT1G31910
POP: POPTR_712033 POPTR_739979
RCU: RCOM_0699810
VVI: 100242124
OSA: 4332275(Os03g0253100)
SBI: SORBI_01g040900(SORBIDRAFT_01g040900)
ZMA: 100282968
PPP: PHYPADRAFT_184801
SCE: YMR220W(ERG8)
AGO: AGOS_AER354W
KLA: KLLA0C07084g
LTH: KLTH0D12672g
DHA: DEHA0G19569g
PIC: PICST_52257(ERG8)
PPA: PAS_chr2-2_0318
LEL: LELG_04217
ZRO: ZYRO0A06072g
CAL: CaO19.12076(ERG8) CaO19.4606(ERG8)
CTP: CTRG_00230
CDU: CD36_41760
CGR: CAGL0F03993g
YLI: YALI0E06193g
SPO: SPAC343.01c(erg8)
NCR: NCU08671
PAN: PODANSg342
MGR: MGG_05812
FGR: FG09764.1
ANI: AN2311.2
AFM: AFUA_5G10680
AOR: AO090010000471
ANG: An14g04010
AFV: AFLA_119540
PCS: Pc21g10310
NFI: NFIA_076530
CIM: CIMG_00714
URE: UREG_00705
SSL: SS1G_08637
BFU: BC1G_07491
CNE: CNM00100
CNB: CNBM0120
LBC: LACBIDRAFT_246613
UMA: UM00760.1
MGL: MGL_2793
MBR: MONBRDRAFT_27803
DDI: DDBDRAFT_0184512
TET: TTHERM_00371030
PTM: GSPATT00017224001
TBR: Tb09.160.3690
TCR: 507913.20 508277.140
LMA: LmjF15.1460
LIF: LinJ15.1420
LBZ: LbrM15_V2.1450
GLA: GL50803_16552
TVA: TVAG_128700
TPS: THAPSDRAFT_21866
TTU: TERTU_3246
MXA: MXAN_5017
SCL: sce4207
HOH: Hoch_3407
OIH: OB0227
SAU: SA0549(mvaK2)
SAV: SAV0592(mvaK2)
SAW: SAHV_0590(mvaK2)
SAM: MW0547(mvaK2)
SAR: SAR0598(mvaK2)
SAS: SAS0551
SAC: SACOL0638
SAB: SAB0542(mvaK2)
SAA: SAUSA300_0574
SAX: USA300HOU_0585(mvaK2)
SAO: SAOUHSC_00579
SAJ: SaurJH9_0615
SAH: SaurJH1_0630
SAE: NWMN_0555(mvaK2)
SAD: SAAV_0554
SEP: SE0363
SER: SERP0240
SHA: SH2400(mvaK2)
SSP: SSP2120
SCA: Sca_0246(mvaK2)
LMO: lmo0012
LMF: LMOf2365_0013
LMH: LMHCC_2651
LMC: Lm4b_00012
LIN: lin0012
LWE: lwe0013
LLA: L10014(yebA)
LLK: LLKF_0458(mvaK)
LLC: LACR_0456
LLM: llmg_0427
SPY: SPy_0878(mvaK2)
SPZ: M5005_Spy_0684(mvaK2)
SPM: spyM18_0939
SPG: SpyM3_0597(mvaK2)
SPS: SPs1256
SPH: MGAS10270_Spy0742(mvaK2)
SPI: MGAS10750_Spy0776(mvaK2)
SPJ: MGAS2096_Spy0755(mvaK2)
SPK: MGAS9429_Spy0739(mvaK2)
SPF: SpyM51124(mvaK2)
SPA: M6_Spy0701
SPB: M28_Spy0664(mvaK2)
SOZ: Spy49_0692(mvaK2)
SPN: SP_0383
SPD: SPD_0348(mvaK2)
SPR: spr0340(mvaK2)
SPW: SPCG_0378(mvaK2)
SPX: SPG_0348(mvaK2)
SNE: SPN23F_03550(mvaK2)
SPV: SPH_0490
SNM: SP70585_0454
SJJ: SPJ_0370
SPP: SPP_0421
SNT: SPT_0428
SAG: SAG1324
SAN: gbs1394
SAK: SAK_1355
SMU: SMU.938
STC: str0561(mvaK2)
STL: stu0561(mvaK2)
STE: STER_0600
SSA: SSA_0335(mvaK2)
SSU: SSU05_0291
SSV: SSU98_0287
SSB: SSUBM407_0262(mvaK2)
SSI: SSU0271(mvaK2)
SSS: SSUSC84_0260(mvaK2)
SGO: SGO_0241
SEQ: SZO_08850
SEZ: Sez_1082
SEU: SEQ_1106
SUB: SUB0767(mvaK2)
SDS: SDEG_0835(mvaK2)
LPL: lp_1733(mvaK2)
LPJ: JDM1_1456(mvaK2)
LJO: LJ1207
LJF: FI9785_973(pmvK)
LAC: LBA1169
LSA: LSA0906(mvaK2)
LSL: LSL_0683
LDB: Ldb0997(mvaK)
LBU: LBUL_0904
LBR: LVIS_0860
LCA: LSEI_1092
LCB: LCABL_12550(mvaK2)
LGA: LGAS_1035
LRE: Lreu_0913
LRF: LAR_0860
LHE: lhv_1277
LFE: LAF_1194
LRH: LGG_01061(mvaK2)
LRL: LC705_01132(mvaK2)
PPE: PEPE_0925
EFA: EF0902
OOE: OEOE_1102
LME: LEUM_1387
LCI: LCK_00621(yebA)
ACL: ACL_0798(mvaK2)
MUL: MUL_3523
MMI: MMAR_3215
CKP: ckrop_0028(mvaK2)
NFA: nfa22090
BBU: BB0687
BBZ: BbuZS7_0707
BGA: BG0710
BAF: BAPKO_0731
BTU: BT0687
BHR: BH0687
BDU: BDU_690
BRE: BRE_693
LBA: Lebu_1674
SMF: Smon_1122
SSO: SSO2988
STO: ST0978
SAI: Saci_1244
SIS: LS215_2536
SIA: M1425_2363
SIM: M1627_2441
SID: M164_2370
SIY: YG5714_2510
SIN: YN1551_0396
MSE: Msed_1575
Taxonomy
Structures PDB: 1K47  3CH4  3GON  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13801508]
BLOCH K, CHAYKIN S, PHILLIPS AH, DE WAARD A.
Mevalonic acid pyrophosphate and isopentenylpyrophosphate.
J. Biol. Chem. 234 (1959) 2595-604.
Rattus norvegicus [GN:rno], Saccharomyces cerevisiae [GN:sce]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:13662013]
HENNING U, MOSLEIN EM, LYNEN F.
Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic
acid by phosphomevalonic kinase.
Arch. Biochem. Biophys. 83 (1959) 259-67.
Saccharomyces cerevisiae [GN:sce]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:14416398]
LEVY HR, POPJAK G.
Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase
from liver.
Biochem. J. 75 (1960) 417-28.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 2.7.4.2
IUBMB Enzyme Nomenclature: 2.7.4.2
ExPASy - ENZYME nomenclature database: 2.7.4.2
BRENDA, the Enzyme Database: 2.7.4.2
CAS: 9026-46-4
DBGET integrated database retrieval system