KEGG   ENZYME: 2.7.6.2Help
Entry
EC 2.7.6.2                  Enzyme                                 
Name thiamine diphosphokinase;
thiamin kinase;
thiamine pyrophosphokinase;
ATP:thiamin pyrophosphotransferase;
thiamin pyrophosphokinase;
thiamin pyrophosphotransferase;
thiaminokinase;
thiamin:ATP pyrophosphotransferase;
TPTase
Class Transferases;
Transferring phosphorus-containing groups;
Diphosphotransferases
BRITE hierarchy
Sysname ATP:thiamine diphosphotransferase
Reaction(IUBMB) ATP + thiamine = AMP + thiamine diphosphate [RN:R00619]
Reaction(KEGG) R00619;
(other) R00616
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Substrate ATP [CPD:C00002];
thiamine [CPD:C00378]
Product AMP [CPD:C00020];
thiamine diphosphate [CPD:C00068]
Pathway PATH: ec00730  Thiamine metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00949  thiamine pyrophosphokinase
Genes HSA: 27010(TPK1)
PTR: 463818(TPK1)
MCC: 706237(TPK1)
MMU: 29807(Tpk1)
RNO: 680668(Tpk1)
CFA: 475515(TPK1)
BTA: 788066(TPK1)
ECB: 100058622
MDO: 100013205 100017303
OAA: 100075492
GGA: 420780(TPK1)
TGU: 100220081
XTR: 549924(tpk1)
DRE: 450054
SPU: 764757
DME: Dmel_CG14721
DPO: Dpse_GA13203
NVE: NEMVE_v1g230649
OSA: 4326818(Os01g0931400) 4338566(Os05g0367400)
CME: CMH016C
SCE: YOR143C(THI80)
KLA: KLLA0B03784g KLLA0E03190g
PIC: PICST_46967(TNR3) PICST_59866(THI80)
CGR: CAGL0I07117g
YLI: YALI0E21351g
SPO: SPAC6F12.05c(tnr3)
MGR: MGG_09347
ANI: AN9488.2
AFM: AFUA_7G05410
DDI: DDBDRAFT_0189361
EHI: EHI_148290
TET: TTHERM_00391440
TVA: TVAG_096630
LPN: lpg2497
LPF: lpl2418
LPP: lpp2564
LPC: LPC_1977
FTU: FTT_1316c
FTF: FTF1316c
FTW: FTW_1482
FTL: FTL_1477
FTH: FTH_1431
FTN: FTN_0662
DNO: DNO_0090
BPM: BURPS1710b_0775
HPY: HP1291
HPA: HPAG1_1222
HAC: Hac_0207
DBA: Dbac_3421
DAT: HRM2_18060(thiN)
SAT: SYN_01522
RLE: RL4610
BBK: BARBAKC583_0128(thiN)
JAN: Jann_3176
RDE: RD1_1915(thiN)
GOX: GOX0109
GBE: GbCGDNIH1_0611
BSU: BSU15800(thiN)
BAN: BA3997
BAR: GBAA3997
BAA: BA_4467
BAT: BAS3710
BAH: BAMEG_0634
BAI: BAA_4021
BCE: BC3857
BCA: BCE_3901
BCZ: BCZK3618
BCR: BCAH187_A3907
BCB: BCB4264_A3958
BCU: BCAH820_3873
BCG: BCG9842_B1285
BCQ: BCQ_3644
BCX: BCA_3959
BCY: Bcer98_2511
BTK: BT9727_3600
BTL: BALH_3490
BWE: BcerKBAB4_3682
BLI: BL02306(thiN)
BLD: BLi01801(yloS)
BAY: RBAM_015630(thiN)
BPU: BPUM_1479(yloS)
OIH: OB1512
GKA: GK1179
GTN: GTNG_1032
GWC: GWCH70_1070
AFL: Aflv_1783
SAC: SACOL1236
SAA: SAUSA300_1116
SHA: SH1692
SSP: SSP1549
LMO: lmo1817
LMF: LMOf2365_1845
LMH: LMHCC_0740
LMC: Lm4b_01833
LIN: lin1931
LWE: lwe1836
LSP: Bsph_1496
ESI: Exig_1919
EAT: EAT1b_2875
PJD: Pjdr2_2646
LLC: LACR_2014
LLM: llmg_2013(thiN)
SPZ: M5005_Spy_0225
SPM: spyM18_0249
SPG: SpyM3_0193
SPS: SPs0198
SPH: MGAS10270_Spy0225
SPI: MGAS10750_Spy0220
SPJ: MGAS2096_Spy0243
SPK: MGAS9429_Spy0227
SPF: SpyM50204(thiN)
SPA: M6_Spy0257
SPB: M28_Spy0219
SPN: SP_1982
SPD: SPD_1779
SPR: spr1796
SPW: SPCG_1945
SPV: SPH_2123
SAG: SAG1775
SAN: gbs1818
SAK: SAK_1797
SMU: SMU.353
STC: str1796
STL: stu1796
STE: STER_1768
SSA: SSA_2118
SSU: SSU05_1992
SSV: SSU98_1997
SGO: SGO_0199
SEZ: Sez_0261(thiN)
SUB: SUB1639(thiN)
LPL: lp_1622
LAC: LBA1314
LSA: LSA0695
LSL: LSL_0618
LBR: LVIS_0959
LCA: LSEI_1619
LCB: LCABL_18340(thiN)
LRE: Lreu_1166
LRH: LGG_01664(thiN)
LRL: LC705_01645(thiN)
PPE: PEPE_0835
EFA: EF3117
OOE: OEOE_0791
LME: LEUM_1508
CAC: CAC1731
CPE: CPE1735
CPF: CPF_1988
CPR: CPR_1706
CTC: CTC01228
CNO: NT01CX_2236
CTH: Cthe_0577
CDF: CD2574
CBO: CBO2501
CBA: CLB_2374
CBH: CLC_2356
CBY: CLM_2801
CBL: CLK_1883
CBK: CLL_A1224
CBB: CLD_2136
CBI: CLJ_B2731
CBT: CLH_1175
CBF: CLI_2562
CBE: Cbei_1154
CKL: CKL_1378
CKR: CKR_1274
CPY: Cphy_2483
CCE: Ccel_1538
AMT: Amet_2776
AOE: Clos_1437
STH: STH1052
SWO: Swol_2104
ATE: Athe_1805
DSY: DSY2682
DRM: Dred_3202
PTH: PTH_0604(THI80)
FMA: FMG_0671
EEL: EUBELI_00919
ERE: EUBREC_2336
TTE: TTE1497(thi80)
TEX: Teth514_1746
TPD: Teth39_1310
CHY: CHY_0231
CSC: Csac_2348
NTH: Nther_0627
HOR: Hore_10040
CCU: Ccur_09380
BTH: BT_2397
FJO: Fjoh_2175
FNU: FN0890
LBA: Lebu_2170
RRS: RoseRS_3933
RCA: Rcas_3607
HAU: Haur_2676
TMA: TM0888
TPT: Tpet_0039
TME: Tmel_0036
FNO: Fnod_0949
PMO: Pmob_1363
DTH: DICTH_1158
DTU: Dtur_1262
Taxonomy
Structures PDB: 1IG0  1IG3  2F17  2G9Z  2HH9  2OMK  
Reference
  Authors
  Title
  Journal
 1
Leuthardt, F. and Nielsen, H.
Phosphorylation biologique de la thiamine.
Helv. Chim. Acta 35 (1952) 1196-1209.
Reference
  Authors
  Title

  Journal
 2
Shimazono, N., Mano, Y., Tanaka, R. and Kajiro, Y.
Mechanism of transpyrophosphorylation with thiamine
pyrophosphokinase.
J. Biochem. (Tokyo) 46 (1959) 959-961.
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:14934742]
STEYN-PARVE EP.
Partial purification and properties of thiaminokinase from yeast.
Biochim. Biophys. Acta. 8 (1952) 310-24.
Saccharomyces cerevisiae [GN:sce]
Other DBs ExplorEnz - The Enzyme Database: 2.7.6.2
IUBMB Enzyme Nomenclature: 2.7.6.2
ExPASy - ENZYME nomenclature database: 2.7.6.2
BRENDA, the Enzyme Database: 2.7.6.2
CAS: 9026-24-8
DBGET integrated database retrieval system