KEGG   ENZYME: 2.7.7.1Help
Entry
EC 2.7.7.1                  Enzyme                                 
Name nicotinamide-nucleotide adenylyltransferase;
NAD+ pyrophosphorylase;
adenosine triphosphate-nicotinamide mononucleotide transadenylase;
ATP:NMN adenylyltransferase;
diphosphopyridine nucleotide pyrophosphorylase;
nicotinamide adenine dinucleotide pyrophosphorylase;
nicotinamide mononucleotide adenylyltransferase;
NMN adenylyltransferase
Class Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname ATP:nicotinamide-nucleotide adenylyltransferase
Reaction(IUBMB) ATP + nicotinamide ribonucleotide = diphosphate + NAD+ [RN:R00137]
Reaction(KEGG) R00137;
(other) R03005
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Substrate ATP [CPD:C00002];
nicotinamide ribonucleotide [CPD:C00455]
Product diphosphate [CPD:C00013];
NAD+ [CPD:C00003]
Comment Nicotinate nucleotide can also act as acceptor. See also EC 2.7.7.18
nicotinate-nucleotide adenylyltransferase.
Pathway PATH: ec00760  Nicotinate and nicotinamide metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00952  nicotinamide-nucleotide adenylyltransferase
Genes HSA: 23057(NMNAT2) 349565(NMNAT3) 64802(NMNAT1)
PTR: 460735(NMNAT3) 743583(NMNAT2) 749401(NMNAT1)
MCC: 715614(NMNAT3) 717648 722599
MMU: 226518(Nmnat2) 66454(Nmnat1) 74080(Nmnat3)
RNO: 289095(Nmnat2) 298653(Nmnat1)
CFA: 477091(NMNAT3) 479601(NMNAT1) 610576(NMNAT2)
BTA: 511042(NMNAT2) 518138(NMNAT3) 522863(NMNAT1)
ECB: 100055391 100057371 100146546
MDO: 100018288 100024807
OAA: 100073858 100076457
GGA: 419446(NMNAT1) 424820(NMNAT3) 771393(NMNAT2)
TGU: 100218081 100224396
XTR: 100124800(nmnat2)
DRE: 336257(nmnat2) 572070(CH73-170L17.1)
BFO: BRAFLDRAFT_247568
CIN: 100178979 100181507
SPU: 577778
DPO: Dpse_GA26603
DER: Dere_GG11340
DPE: Dper_GL24404
DSI: Dsim_GD21151
DYA: Dyak_GE23535
DGR: Dgri_GH19439
AGA: AgaP_AGAP009544
AAG: AaeL_AAEL007908
CQU: CpipJ_CPIJ015320
NVI: 100121756
API: 100168929
ISC: IscW_ISCW008048
CBR: CBG16194
BMY: Bm1_39780
SMM: Smp_123490
NVE: NEMVE_v1g159188
HMG: 100214495
TAD: TRIADDRAFT_28369
POP: POPTR_812149 POPTR_893025
RCU: RCOM_0521840
VVI: 100251521
OSA: 4331124(Os02g0814900)
SBI: SORBI_04g036990(SORBIDRAFT_04g036990)
ZMA: 100284011
PPP: PHYPADRAFT_93376
CRE: CHLREDRAFT_102803
CME: CMF018C
SCE: YGR010W(NMA2) YLR328W(NMA1)
AGO: AGOS_AGR022C
KLA: KLLA0C18051g
LTH: KLTH0E08756g
DHA: DEHA0C12639g
PIC: PICST_86133(NMA1)
PPA: PAS_chr1-4_0181
VPO: Kpol_1025p28
LEL: LELG_00028
ZRO: ZYRO0G11154g
CAL: CaO19.7499
CTP: CTRG_01044
CDU: CD36_25480
CGR: CAGL0A01023g
YLI: YALI0E25652g
SPO: SPAC806.06c
NCR: NCU04019
FGR: FG09476.1
ANI: AN1745.2
AFM: AFUA_6G08870
AOR: AO090001000561
ANG: An11g06610
AFV: AFLA_128650
PCS: Pc12g08660
NFI: NFIA_054520
CIM: CIMG_01346
URE: UREG_01169
SSL: SS1G_02223
BFU: BC1G_04324
LBC: LACBIDRAFT_249182
MGL: MGL_2248
MBR: MONBRDRAFT_27368
DDI: DDB_0233076
EHI: EHI_084990
EDI: EDI_323960
GLA: GL50803_92618
ECO: b4390(nadR)
ECJ: JW5800(nadR)
ECD: ECDH10B_4548(nadR)
EBW: BWG_4082(nadR)
ECE: Z5991(nadR)
ECS: ECs5348
ECF: ECH74115_5904(nadR)
ETW: ECSP_5472(nadR)
ECG: E2348C_4688(nadR)
ECC: c5475(nadR)
ECI: UTI89_C5161(nadR)
ECP: ECP_4774
ECV: APECO1_1991(nadR)
ECW: EcE24377A_4989(nadR)
ECX: EcHS_A4625(nadR)
ECM: EcSMS35_4939(nadR)
ECY: ECSE_4665
ECL: EcolC_3666
ECK: EC55989_5052(nadR)
ECQ: ECED1_5261(nadR)
ECR: ECIAI1_4613(nadR)
ECT: ECIAI39_4922(nadR)
ECZ: ECS88_5071(nadR)
EUM: ECUMN_5014(nadR)
ELF: LF82_1438(nadR)
EBL: B21_04231(nadR)
EBD: ECBD_3630
EBR: ECB_04266(nadR)
EOH: ECO103_5251(nadR)
EOI: ECO111_5251(nadR)
EOJ: ECO26_5596(nadR)
EFE: EFER_4487(nadR)
STY: STY4927(nadR)
STT: t4619(nadR)
SPT: SPA4390(nadR)
SEK: SSPA4075
SPQ: SPAB_05758
SEI: SPC_4713(nadR)
SEC: SC4425(nadR)
SEH: SeHA_C4990
SEE: SNSL254_A4938
SEW: SeSA_A4831
SEA: SeAg_B4904
SED: SeD_A4992
SEG: SG4402(nadR)
SET: SEN4336(nadR)
SES: SARI_03003
STM: STM4580.S(nadR)
YPE: YPO0444(nadR)
YPM: YP_3738(nadR)
YPA: YPA_3840
YPN: YPN_0315
YPG: YpAngola_A0824
YPP: YPDSF_3190
YPS: YPTB0588(nadR)
YPI: YpsIP31758_3491
YPY: YPK_3620
YPB: YPTS_0610
YEN: YE0580(b4390)
SFL: SF4422(nadR)
SFX: S4693(nadR)
SFV: SFV_4424(nadR)
SSN: SSON_4540(nadR)
SBO: SBO_4453(nadR)
SBC: SbBS512_E4937(nadR)
SDY: SDY_4651(nadR)
ECA: ECA0463(nadR)
PCT: PC1_0448
PWA: Pecwa_0545
ETA: ETA_06740(nadR)
PLU: plu0553(nadR)
PAY: PAU_00522(nadR)
ENT: Ent638_0549
ESA: ESA_03362
CTU: Ctu_06040(nadR)
KPN: KPN_04845(nadR)
KPE: KPK_4769(nadR)
KPU: KP1_0806(nadR)
CKO: CKO_03396
SPE: Spro_0668
PMR: PMI2505(nadR)
DDA: Dd703_3471
DDC: Dd586_0485
DZE: Dd1591_3590
HIN: HI0763(nadR)
HIT: NTHI0923(nadR)
HIQ: CGSHiGG_07310
HAP: HAPS_1974(nadR)
HSO: HS_0087(nadR)
HSM: HSM_1981
PMU: PM1387(nadR)
MSU: MS0169(nadR)
APL: APL_0046(nadR)
APJ: APJL_0047(nadR)
APA: APP7_0046
ASU: Asuc_0487
AAP: NT05HA_1755
AAT: D11S_0576
XCC: XCC3446
XCB: XC_0718
XCA: xccb100_0750(nadM)
XCV: XCV0734
XAC: XAC0673
XOO: XOO3948
XOM: XOO_3725
XOP: PXO_04292
SML: Smlt0261
PAR: Psyc_1913(nadR)
PCR: Pcryo_2058 Pcryo_2204
PRW: PsycPRwf_1851 PsycPRwf_2213
ACI: ACIAD2606
ACB: A1S_2547
ABM: ABSDF0924
ABY: ABAYE0916
FTU: FTT_0386(nadM)
FTF: FTF0386(nadM)
FTW: FTW_1688
FTL: FTL_0452
FTH: FTH_0449
FTA: FTA_0479
FTM: FTM_0541
FTN: FTN_0483
FPH: Fphi_0367
HCH: HCH_06993
CSA: Csal_1837
DNO: DNO_0139
RSO: RS05360(RSp0835)
RME: Rmet_5104
BVI: Bcep1808_5372
BUR: Bcep18194_B0825
BCN: Bcen_3479
BCH: Bcen2424_4887
BCM: Bcenmc03_5399
BCJ: BCAM2080
BAM: Bamb_4267
BAC: BamMC406_4793
PNA: Pnap_3717
AAV: Aave_0974
AJS: Ajs_0701
VEI: Veis_4845
DAC: Daci_5608
DIA: Dtpsy_0679
VAP: Vapar_6285
CTT: CtCNB1_0648
DAL: Dalk_3061
SAT: SYN_00623
SFU: Sfum_3306
MES: Meso_3455(nadD)
BMB: BruAb1_1821(nadD)
BMS: BR1842(nadD)
BBE: BBR47_15280(nadR)
LLA: L0242(nadR)
LLC: LACR_2249
LLM: llmg_2241(nadR)
STC: str0429(nadR)
STL: stu0429(nadR)
STE: STER_0466
SSA: SSA_2195(nadR)
SSV: SSU98_1978
SGO: SGO_1997(nadR)
OOE: OEOE_0896
LME: LEUM_1517
MTU: Rv0212c(nadR)
MTC: MT0222
MRA: MRA_0220(nadR)
MBO: Mb0218c(nadR)
MBB: BCG_0249c(nadR)
MBT: JTY_0218(nadR)
MMI: MMAR_2965(nadR)
ROP: ROP_15930
SGR: SGR_5731
ART: Arth_0694
ACH: Achl_2567
LBI: LEPBI_I2702
LBF: LBF_2620(nadR)
BHY: BHWA1_02421(nadR)
CPI: Cpin_0606 Cpin_5743
FNU: FN1132
LBA: Lebu_1786 Lebu_1936
STR: Sterm_3133
OTE: Oter_2174
SYN: slr0787
SYC: syc1306_c
SYF: Synpcc7942_0205
GVI: glr1660
DRA: DR_2428
DGE: Dgeo_0228 Dgeo_1324
DDR: Deide_20050
MJA: MJ0541
MFE: Mefer_0787
MVU: Metvu_1233
MMP: MMP1578
MMQ: MmarC5_1831
MMX: MmarC6_1092
MMZ: MmarC7_0825
MAE: Maeo_0254
MVN: Mevan_0890
MAC: MA3731
MBA: Mbar_A0256
MMA: MM_0626
MBU: Mbur_2370
MTP: Mthe_0206
MHU: Mhun_2915
MLA: Mlab_0767 Mlab_1019
MEM: Memar_1582
MBN: Mboo_1731
MPL: Mpal_2201
MPD: MCP_2311
MTH: MTH150
MST: Msp_0435
MSI: Msm_0129
AFU: AF1488 AF2315
HAL: VNG0301C
HSL: OE1462R
HMA: rrnAC1913(nadM)
HWA: HQ1164A(nadR)
NPH: NP0310A(nadM1_2) NP0908A(nadM1_1)
HLA: Hlac_1037
HUT: Huta_2898
HMU: Hmuk_3200
TAC: Ta0774
TVO: TVN0845
PTO: PTO0129
PHO: PH0464
PAB: PAB1318
PFU: PF0458
TKO: TK0067
TON: TON_1164
TGA: TGAM_1162(nadM)
TSI: TSIB_1082
RCI: RCIX2287(nadR)
APE: APE_0513.1(nadM) APE_1986.1(nadM)
SMR: Smar_0936 Smar_1488
IHO: Igni_0948
DKA: DKAM_0759 DKAM_0869 DKAM_1286
HBU: Hbut_1560
SSO: SSO0255
STO: ST0302 ST0648
SAI: Saci_0300(nadM) Saci_0720
SIS: LS215_1994
SIA: M1425_1885
SIM: M1627_1962
SID: M164_1892
SIY: YG5714_1961
SIN: YN1551_0959
MSE: Msed_0004
PAI: PAE1438 PAE2259
PIS: Pisl_0898 Pisl_1561
PCL: Pcal_0794 Pcal_1625
PAS: Pars_0405 Pars_1824
CMA: Cmaq_0276 Cmaq_1647
TNE: Tneu_0591 Tneu_1430
TPE: Tpen_0576 Tpen_0898
NMR: Nmar_0960 Nmar_1732
NEQ: NEQ367
KCR: Kcr_1597
Taxonomy
Structures PDB: 1EJ2  1GZU  1HYB  1KKU  1KQN  1KQO  1KR2  1M8F  1M8G  1M8J  
     1M8K  2QJO  2QJT  2R5W  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:13684981]
ATKINSON MR, JACKSON JF, MORTON RK.
Nicotinamide mononucleotide adenylyltransferase of pig-liver nuclei.
The effects of nicotinamide mononucleotide concentration and pH on
dinucleotide synthesis.
Biochem. J. 80 (1961) 318-23.
Sus scofa [GN:ssc]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4291828]
Dahmen W, Webb B, Preiss J.
The deamido-diphosphopyridine nucleotide and diphosphopyridine
nucleotide pyrophosphorylases of Escherichia coli and yeast.
Arch. Biochem. Biophys. 120 (1967) 440-50.
Saccharomyces cerevisiae [GN:sce], Escherichia coli [GN:eco]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:14861199]
KORNBERG A, PRICER WE Jr.
Enzymatic cleavage of diphosphopyridine nucleotide with radioactive
pyrophosphate.
J. Biol. Chem. 191 (1951) 535-41.
Saccharomyces cerevisiae [GN:sce]
Other DBs ExplorEnz - The Enzyme Database: 2.7.7.1
IUBMB Enzyme Nomenclature: 2.7.7.1
ExPASy - ENZYME nomenclature database: 2.7.7.1
BRENDA, the Enzyme Database: 2.7.7.1
CAS: 9032-70-6
DBGET integrated database retrieval system