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Entry
EC 2.7.7.10                 Enzyme                                 
Name UTP---hexose-1-phosphate uridylyltransferase;
galactose-1-phosphate uridylyltransferase;
galactose 1-phosphate uridylyltransferase;
alpha-D-galactose 1-phosphate uridylyltransferase;
galactose 1-phosphate uridyltransferase;
UDPgalactose pyrophosphorylase;
uridine diphosphate galactose pyrophosphorylase;
uridine diphosphogalactose pyrophosphorylase
Class Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname UTP:alpha-D-hexose-1-phosphate uridylyltransferase
Reaction(IUBMB) UTP + alpha-D-galactose 1-phosphate = diphosphate + UDP-galactose
[RN:R00502]
Reaction(KEGG) R00502
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Substrate UTP [CPD:C00075];
alpha-D-galactose 1-phosphate [CPD:C00446]
Product diphosphate [CPD:C00013];
UDP-galactose [CPD:C00052]
Comment alpha-D-Glucose 1-phosphate can also act as acceptor, but more
slowly.
Pathway PATH: ec00052  Galactose metabolism
PATH: ec00520  Amino sugar and nucleotide sugar metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00964  galactose-1-phosphate uridylyltransferase
Genes ATH: AT5G18200
OSA: 4342514(Os07g0171200)
CME: CMQ030C
MGR: MGG_05098
ANI: AN6182.2
AFM: AFUA_2G11560
AOR: AO090026000490
CNE: CNM00620
DDI: DDBDRAFT_0204814
ECK: EC55989_0737(galT)
ECQ: ECED1_0719(galT)
ECR: ECIAI1_0726(galT)
ECT: ECIAI39_0726(galT)
ECZ: ECS88_0774(galT)
EBR: ECB_00711(galT)
EFE: EFER_2351(galT)
VCM: VCM66_1536(galT)
VCJ: VCD_002780
VFI: VF_A0353(galT)
VFM: VFMJ11_A0391(galT)
TBD: Tbd_0601
GSU: GSU3256(galT)
GME: Gmet_3176
PCA: Pcar_2956(galT)
BHA: BH1109(galT)
BLI: BL00193(galT)
BLD: BLi04284(galT)
SSP: SSP0631
ESI: Exig_0379
LLA: L0027(galT)
LLC: LACR_2243
LLM: llmg_1726 llmg_2234(galT)
SPN: SP_1829 SP_1852
SPV: SPH_1968(galT)
SMU: SMU.887(galT)
STC: str1401(galT)
STL: stu1401(galT)
STE: STER_1370
SSA: SSA_1009(galT)
SSU: SSU05_0361
SSV: SSU98_0352
SGO: SGO_0933(galT)
SEZ: Sez_1742(galT)
LPL: lp_3480(galT)
LJO: LJ0860
LBR: LVIS_1902
LCA: LSEI_0666
LGA: LGAS_1321
PPE: PEPE_0208
EFA: EF1071(galT)
OOE: OEOE_0303
LME: LEUM_0884 LEUM_1067
CAC: CAC2961(galT)
CPE: CPE1346(galT)
CPR: CPR_1346
CTC: CTC00864
TTE: TTE1929
MTU: Rv0618(galTa) Rv0619(galTb)
MRA: MRA_0627(galTa) MRA_0628(galTb)
MBO: Mb0635(galT)
MBB: BCG_0665(galT)
MPA: MAP4071(galT)
MAV: MAV_4565(galT)
MSM: MSMEG_3691(galT)
MUL: MUL_0691(galT)
CDI: DIP1014(galT)
CJK: jk0290(galT)
SCO: SCO3138(galT)
SMA: SAV_3576(galT)
CMI: CMM_2518(galT)
AAU: AAur_1280(galT)
RSA: RSal33209_3055
SEN: SACE_0764(galT)
BLO: BL1643(galT2)
SRU: SRU_1285(galT)
FNU: FN2108
RBA: RB6656(galT)
TTH: TT_P0071
TTJ: TTHB114
SAF: SULAZ_1597(galT)
DTH: DICTH_1069(galT)
MAC: MA3680
MBA: Mbar_A0295
MMA: MM_0586
MBU: Mbur_0434
PFU: PF0441
TKO: TK1828
TSI: TSIB_0579
RCI: RCIX1322(galT)
PAI: PAE1184
TPE: Tpen_0250
Taxonomy
Structures PDB: 1GUP  1GUQ  1HXP  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13549431]
ISSELBACHER KJ.
A mammalian uridinediphosphate galactose pyrophosphorylase.
J. Biol. Chem. 232 (1958) 429-44.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:13115434]
KALCKAR HM.
The role of phosphoglycosyl compounds in the biosynthesis of
nucleosides and nucleotides.
Biochim. Biophys. Acta. 12 (1953) 250-64.
Saccharomyces fragilis
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:500588]
Lee L, Kimura A, Tochikura T.
Purification and properties of UDP-glucose (UDP-galactose)
pyrophosphorylase from Bifidobacterium bifidum.
J. Biochem. (Tokyo). 86 (1979) 923-8.
Bifidobacterium bifidum
Reference
  Authors
  Title

  Journal
  Organism
 4  [PMID:6304512]
Lobelle-Rich PA, Reeves RE.
Separation and characterization of two UTP-utilizing hexose
phosphate uridylyltransferases from Entamoeba histolytica.
Mol. Biochem. Parasitol. 7 (1983) 173-82.
Entamoeba histolytica [GN:ehi]
Other DBs ExplorEnz - The Enzyme Database: 2.7.7.10
IUBMB Enzyme Nomenclature: 2.7.7.10
ExPASy - ENZYME nomenclature database: 2.7.7.10
BRENDA, the Enzyme Database: 2.7.7.10
CAS: 9016-11-9
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