KEGG   ENZYME: 2.7.7.31Help
Entry
EC 2.7.7.31                 Enzyme                                 
Name
DNA nucleotidylexotransferase;
terminal deoxyribonucleotidyltransferase;
terminal addition enzyme;
addase;
deoxynucleotidyl terminal transferase;
deoxyribonucleic acid nucleotidyltransferase;
deoxyribonucleic nucleotidyltransferase;
terminal deoxynucleotide transferase;
TdT
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
nucleoside-triphosphate:DNA deoxynucleotidylexotransferase
Reaction(IUBMB)
deoxynucleoside triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Reaction(KEGG)
Substrate
deoxynucleoside triphosphate [CPD:C00677];
DNAn [CPD:C00039]
Product
diphosphate [CPD:C00013];
DNAn+1 [CPD:C00039]
Comment
Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or deoxyribo-.
Orthology
K00977  
DNA nucleotidylexotransferase
Genes
HSA: 
1791(DNTT)
PTR: 
466167(DNTT)
PPS: 
100976638(DNTT)
GGO: 
101139353(DNTT)
PON: 
100457001(DNTT)
MCC: 
704482(DNTT)
MMU: 
21673(Dntt)
RNO: 
294051(Dntt)
CFA: 
486815(DNTT)
AML: 
FCA: 
101097099(DNTT)
BTA: 
281120(DNTT)
SSC: 
100518694
ECB: 
100061113(DNTT)
MDO: 
554183(DNTT)
SHR: 
100932555(DNTT)
OAA: 
100074260
GGA: 
396351(DNTT)
TGU: 
100220809(DNTT)
ACS: 
100561065
XLA: 
378525(dntt)
XTR: 
100495475
DRE: 
544653(dntt)
TRU: 
445927(tdt)
OLA: 
101161827
SPU: 
591373
 » show all
Taxonomy
Reference
1  [PMID:5543689]
  Authors
Chang LM, Bollum FJ.
  Title
Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase.
  Journal
J. Biol. Chem. 246 (1971) 909-16.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:4288534]
  Authors
Gottesman ME, Canellakis ES.
  Title
The terminal nucleotidyltransferases of calf thymus nuclei.
  Journal
J. Biol. Chem. 241 (1966) 4339-52.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:14459258]
  Authors
KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES.
  Title
Studies on the incorporation of deoxyribonucleic acid.
  Journal
Biochim. Biophys. Acta. 55 (1962) 639-50.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-67-2
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