KEGG   ENZYME: 2.7.7.43Help
Entry
EC 2.7.7.43                 Enzyme                                 
Name N-acylneuraminate cytidylyltransferase;
CMP-sialate pyrophosphorylase;
CMP-sialate synthase;
cytidine 5'-monophosphosialic acid synthetase;
CMP-Neu5Ac synthetase;
CMP-NeuAc synthetase;
acylneuraminate cytidyltransferase;
CMP-N-acetylneuraminate synthetase;
CMP-N-acetylneuraminate synthase;
CMP-N-acetylneuraminic acid synthase;
CMP-NANA synthetase;
CMP-sialate synthetase;
CMP-sialic synthetase;
cytidine 5'-monophospho-N-acetylneuraminic acid synthetase;
cytidine 5-monophosphate N-acetylneuraminic acid synthetase;
cytidine monophosphosialic acid synthetase;
cytidine monophosphoacetylneuraminic synthetase;
cytidine monophosphosialate pyrophosphorylase;
cytidine monophosphosialate synthetase;
acetylneuraminate cytidylyltransferase
Class Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname CTP:N-acylneuraminate cytidylyltransferase
Reaction(IUBMB) CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate
[RN:R02599]
Reaction(KEGG) R02599 > R01117 R04215
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Substrate CTP [CPD:C00063];
N-acylneuraminate [CPD:C00591]
Product diphosphate [CPD:C00013];
CMP-N-acylneuraminate [CPD:C01064]
Comment Acts on N-acetyl- and N-glycolyl- derivatives.
Pathway PATH: ec00520  Amino sugar and nucleotide sugar metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K00983  N-acylneuraminate cytidylyltransferase
Genes HSA: 55907(CMAS)
PTR: 465340(CMAS)
MCC: 706604(CMAS)
MMU: 12764(Cmas)
RNO: 312826(Cmas)
CFA: 477673(CMAS)
BTA: 533483(CMAS)
ECB: 100064384
MDO: 100010366
GGA: 418199(CMAS)
TGU: 100225966
XTR: 100036739(cmas)
DRE: 561018(cmas)
BFO: BRAFLDRAFT_115660
CIN: 100101814(cmas)
SPU: 588508(cmas)
DME: Dmel_CG32220(Csas)
DAN: Dana_GF10834
DER: Dere_GG13354
DPE: Dper_GL11892
DSE: Dsec_GM14951
DSI: Dsim_GD12235
DYA: Dyak_GE22447
DGR: Dgri_GH14727
DMO: Dmoj_GI13380
AGA: AgaP_AGAP004527
AAG: AaeL_AAEL012868
CQU: CpipJ_CPIJ000558
TCA: 656718
ISC: IscW_ISCW021121
ECI: UTI89_C3371(neuA)
ECV: APECO1_3472(neuA)
ECM: EcSMS35_3231(neuA)
ECK: EC55989_2294
ECT: ECIAI39_3442(neuA)
ECZ: ECS88_3329(neuA)
PWA: Pecwa_3030
EIC: NT01EI_1317
ETR: ETAE_1208(neuA)
HIN: HI1279(neuA)
HIT: NTHI1891(siaB)
HIP: CGSHiEE_04135
HIQ: CGSHiGG_01585
HDU: HD0685(neuA)
HAP: HAPS_0040(neuA)
HSO: HS_0700(neuA) HS_0706(neuA)
HSM: HSM_1117
PMU: PM0187(neuA)
VVU: VV1_0803
VVY: VV0316
VPA: VP0203
VHA: VIBHAR_00677
VEX: VEA_001797
VFI: VF_0147(neuA)
VFM: VFMJ11_0173(pseF)
VSA: VSAL_I3012(neuA)
PPR: PBPRA2709
PPW: PputW619_3709
PFL: PFL_1623
PFO: Pfl01_1521
PSA: PST_3838
PAR: Psyc_0656(neuA2)
ABM: ABSDF0073
ABC: ACICU_00077
SDN: Sden_1288
SAZ: Sama_2336
SBM: Shew185_2981
SBN: Sbal195_3125
SPC: Sputcn32_2627
SSE: Ssed_3104
SPL: Spea_0052
SHN: Shewana3_1309
SHW: Sputw3181_1380
SWD: Swoo_1578
SWP: swp_1562
ILO: IL0554
CPS: CPS_2094
PAT: Patl_3078
AMC: MADE_02898
TTU: TERTU_1306
LPN: lpg0751(neuA)
LPF: lpl0788(neuA)
LPP: lpp0817(neuA)
LPC: LPC_2541(neuA)
FPH: Fphi_1170
TCX: Tcr_1455
AEH: Mlg_2324
HNA: Hneap_0634
HCH: HCH_04832
MMW: Mmwyl1_3562
AHA: AHA_4178
ASA: ASA_0150(neuA)
NME: NMB0069(siaB)
NMC: NMC0053(siaB)
NMN: NMCC_0077(siaB)
CVI: CV_4028(neuA)
BPH: Bphy_3009
BPT: Bpet2304(neuA)
VEI: Veis_4851
NEU: NE1569(neuA1)
NET: Neut_1548
NMU: Nmul_A0410
MMB: Mmol_1722
MEI: Msip34_0132
HPY: HP0326
HPA: HPAG1_0329 HPAG1_0330
HPS: HPSH_01690 HPSH_01695
HPG: HPG27_307(neuA-1) HPG27_308(neuA-2)
HPP: HPP12_0323 HPP12_0324
HHE: HH0900(neuA)
HAC: Hac_0994(neuA_fragment_2) Hac_0995(neuA_fragment_1)
     Hac_1269(neuA)
WSU: WS2106
TDN: Suden_0599
CJE: Cj1143(neuA1) Cj1311(pseF) Cj1331(ptmB)
CJR: CJE1506(neuA) CJE1520(ptmB)
CJJ: CJJ81176_1161 CJJ81176_1328(neuA)
CJU: C8J_1244(neuA2) C8J_1333
CJD: JJD26997_0378(ptmB) JJD26997_0406
CFF: CFF8240_1549
CCV: CCV52592_0562
CCO: CCC13826_2299
CLA: Cla_1229(ptmB) Cla_1320(pseF)
ABU: Abu_2245(neuA)
SDL: Sdel_2210
NAM: NAMH_1607
GSU: GSU1972
GUR: Gura_4089
GLO: Glov_3400
DVL: Dvul_2588
DVM: DvMF_1844
DDE: Dde_3257
DMA: DMR_24560
DSA: Desal_0579 Desal_3632
DBA: Dbac_0364
DRT: Dret_0620
BBA: Bd1686(neuA)
DAL: Dalk_1671
DAT: HRM2_36850(neuA)
RLG: Rleg_0443
RHI: NGR_b09470(rkpN)
BJA: blr5972(neuA)
RPB: RPB_1536
RPE: RPE_4239
NWI: Nwi_2397
MCH: Mchl_3990
PDE: Pden_0087
SAL: Sala_1578
RCE: RC1_3768(neuA)
MGM: Mmc1_0559 Mmc1_2414
BPU: BPUM_1898(neuA)
GKA: GK3120
LSP: Bsph_1166
BBE: BBR47_53230
SAG: SAG1158(neuA)
SAN: gbs1233(neuA)
SAK: SAK_1247(neuA)
SSU: SSU05_0581
SSV: SSU98_0585
SSB: SSUBM407_1277(neuA)
SSI: SSU0538(neuA)
SSS: SSUSC84_0520(neuA)
CNO: NT01CX_1783
CTH: Cthe_2639
CBL: CLK_2102
CBK: CLL_A1539
CBB: CLD_1850
CBT: CLH_1451
CBF: CLI_2773
CKL: CKL_2466(neuA)
CKR: CKR_2180
DSY: DSY3307
DAU: Daud_0021
ERE: EUBREC_3248
MTA: Moth_0758
JDE: Jden_0844
ELE: Elen_2424
LIL: LA1605(neuA1) LA1615(neuA2)
LIC: LIC12167 LIC12177(neuA)
BVU: BVU_2660 BVU_4039
SRU: SRU_0608
CHU: CHU_2761(kdsB)
DFE: Dfer_3365
PHE: Phep_3941
GFO: GFO_0572(neuA) GFO_2023(neuA)
FJO: Fjoh_0307
FPS: FP1257(neuA)
SYW: SYNW0398 SYNW0444
SYD: Syncc9605_2217
SYE: Syncc9902_0462
SYG: sync_0170(neuA-1) sync_0182(neuA-2)
CYT: cce_0338
CYP: PCC8801_0292
CYN: Cyan7425_4941
CYH: Cyan8802_0292
PMI: PMT9312_1349
PMB: A9601_13421
PMF: P9303_01151
PMG: P9301_14131
PMH: P9215_14461 P9215_14631
PMJ: P9211_12421 P9211_12871
PME: NATL1_08741
CTE: CT1153(neuA)
CPC: Cpar_1098
CCH: Cag_1132
CPH: Cpha266_1514
CLI: Clim_1387 Clim_1883
PVI: Cvib_0927
PPH: Ppha_0534 Ppha_1484
PAA: Paes_1024
PMX: PERMA_1622
TNP: Tnap_0416
TYE: THEYE_A0482
MAE: Maeo_0417
MAC: MA3766(neuA)
MHU: Mhun_3094
HWA: HQ3518A(neuA)
HMU: Hmuk_1467
Taxonomy
Structures PDB: 1EYR  1EZI  1QWJ  3EWI  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:4288894]
Kean EL, Roseman S.
The sialic acids. X. Purification and properties of cytidine
5'-monophosphosialic acid synthetase.
J. Biol. Chem. 241 (1966) 5643-50.
Sus scofa [GN:ssc], Neisseria meningitidis, Ovis aries
Other DBs ExplorEnz - The Enzyme Database: 2.7.7.43
IUBMB Enzyme Nomenclature: 2.7.7.43
ExPASy - ENZYME nomenclature database: 2.7.7.43
BRENDA, the Enzyme Database: 2.7.7.43
CAS: 9067-82-7
DBGET integrated database retrieval system