KEGG   ENZYME: 2.7.7.48Help
Entry
EC 2.7.7.48                 Enzyme                                 
Name
RNA-directed RNA polymerase;
RNA nucleotidyltransferase (RNA-directed);
RNA nucleotidyltransferase (RNA-directed);
RNA-dependent ribonucleate nucleotidyltransferase;
3D polymerase;
PB1 proteins;
PB2 proteins;
phage f2 replicase;
polymerase L;
Q-beta replicase;
phage f2 replicase;
ribonucleic acid replicase;
ribonucleic acid-dependent ribonucleate nucleotidyltransferase;
ribonucleic acid-dependent ribonucleic acid polymerase;
ribonucleic replicase;
ribonucleic synthetase;
RNA replicase;
RNA synthetase;
RNA transcriptase;
RNA-dependent ribonucleate nucleotidyltransferase;
RDRP;
RNA-dependent RNA polymerase;
RNA-dependent RNA replicase;
transcriptase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Reaction(IUBMB)
nucleoside triphosphate + RNAn = diphosphate + RNAn+1 [RN:R00444]
Reaction(KEGG)
Substrate
nucleoside triphosphate [CPD:C00201];
RNAn [CPD:C00046]
Product
diphosphate [CPD:C00013];
RNAn+1 [CPD:C00046]
Comment
Catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. See also EC 2.7.7.6 DNA-directed RNA polymerase.
Pathway
Purine metabolism
Metabolic pathways
Orthology
K00985  
RNA-directed RNA polymerase
K11699  
RNA-dependent RNA polymerase 1
Genes
ATH: 
ALY: 
GMX: 
CSV: 
POP: 
POPTR_562705(RDR908) POPTR_591179(RDR909)
VVI: 
OSA: 
DOSA: 
Os01t0197900-01(Os01g0197900) Os01t0198000-01(Os01g0198000)
SBI: 
SORBI_03g002800(SORBIDRAFT_03g002800) SORBI_06g001590(SORBIDRAFT_06g001590)
SMO: 
PPP: 
PHYPADRAFT_169723(RDR1503)
NCR: 
NCU02178
SMP: 
SMAC_05269
PAN: 
PODANSg4487
MGR: 
MGG_02748
FGR: 
FG08716.1
NHE: 
NECHADRAFT_91974(RDR2103)
SSL: 
SS1G_13161
BFU: 
BC1G_15614
ANI: 
AN2717.2 AN4790.2
NFI: 
NFIA_070460
AFM: 
AFUA_3G06790 AFUA_5G09430
AOR: 
AOR_1_558084(AO090020000318)
ANG: 
ANI_1_2480094(An11g09540)
AFV: 
AFLA_100970
ACT: 
ACLA_034760
PCS: 
Pc20g02950
CIM: 
CIMG_00395
CPW: 
CPC735_058150
URE: 
UREG_00448
ABE: 
ARB_07328
TVE: 
TRV_04770
PNO: 
SNOG_00237
PTE: 
PTT_17559
TML: 
GSTUM_00008250001
SPO: 
SPAC6F12.09(rdp1)
CNE: 
CNG01230
CNB: 
CNBG3560
LBC: 
LACBIDRAFT_315790(RDR16201)
DDI: 
DDB_G0291249(rrpB)
EHI: 
EHI_139420(171.t00022)
EDI: 
EDI_284080
TET: 
TTHERM_00853150
PTM: 
GSPATT00024768001
GLA: 
GL50803_102515
BUR: 
Bcep18194_A6181
 » show all
Taxonomy
Reference
1
  Authors
August, J.T., Cooper, S., Shapiro, L. and Zinder, N.D.
  Title
RNA phage induced RNA polymerase.
  Journal
Cold Spring Harbour Symp. Quant. Biol. 28 (1963) 95-97.
Reference
2
  Authors
Haruna, J., Nozu, K., Ohtaka, Y. and Spiegelman, S.
  Title
An RNA "Replicase" induced by and selective for a viral RNA: isolation and properties.
  Journal
Proc. Natl. Acad. Sci. USA 50 (1963) 905-911.
Reference
3
  Authors
Weismann, C., Simon, L. and Ochoa, S.
  Title
Induction by an RNA phage of an enzyme catalyzing incorporation of ribonucleotides into ribonucleic acid.
  Journal
Proc. Natl. Acad. Sci. USA 49 (1963) 407-414.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-28-2
DBGET integrated database retrieval system