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Entry
EC 2.7.8.23                 Enzyme                                 

Name
carboxyvinyl-carboxyphosphonate phosphorylmutase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)
Reaction(IUBMB)
1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2 [RN:R05165]
Reaction(KEGG)
R05165;
(other) R08868 R08869
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Substrate
1-carboxyvinyl carboxyphosphonate [CPD:C06367]
Product
3-(hydrohydroxyphosphoryl)pyruvate [CPD:C06368];
CO2 [CPD:C00011]
Comment
Catalyses the transfer and decarboxylation of the carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being a 3-valent group), in the formation of an unusual C-P bond that is involved in the biosynthesis of the antibiotic bialaphos.
History
EC 2.7.8.23 created 1999
Orthology
K01003  
carboxyvinyl-carboxyphosphonate phosphorylmutase
Genes
AFM: 
PAE: 
PAU: 
PAP: 
PAG: 
PDK: 
PPU: 
PPG: 
PPW: 
PST: 
PSB: 
PSP: 
PFL: 
PFO: 
PEN: 
PSA: 
PST_3733(bcpA)
AVN: 
SBL: 
CSA: 
MMW: 
CVI: 
REU: 
RME: 
Rmet_4291(prpB)
BUR: 
BXE: 
BPY: 
BUG: 
BGE: 
BGF: 
BPE: 
BPA: 
BBR: 
BPT: 
AJS: 
DIA: 
AAA: 
VEI: 
DEL: 
VPE: 
CTT: 
ADN: 
ADK: 
HAR: 
MMS: 
mma_3487(prpB)
MES: 
PLA: 
RLE: 
BJA: 
BRA: 
BBT: 
RPA: 
RPB: 
RPC: 
RPD: 
RPE: 
RPT: 
SNO: 
MNO: 
RVA: 
RDE: 
PDE: 
KVU: 
ACR: 
APT: 
RRU: 
RCE: 
RC1_3804(prpB)
BLI: 
BL00563(yqiQ)
BLD: 
BLi04096(yqiQ)
BHA: 
BAN: 
BA_2350(yqiQ)
BAR: 
GBAA_2350(yqiQ)
BAT: 
BCE: 
BCX: 
BCA_2419(prpB)
BTK: 
BTL: 
BCL: 
BPU: 
BPUM_1846(yqiQ)
OIH: 
LSP: 
AAC: 
MSM: 
MUL: 
MVA: 
MMC: 
MKM: 
MJL: 
CGT: 
RHA: 
SRT: 
ICA: 
NCA: 
FRA: 
SEN: 
LIL: 
LA_1416(prpB)
LIC: 
SYG: 
SYR: 
MHD: 
NPH: 
NP4432A(prpB_2) NP6212A(prpB_1)
TAC: 
TVO: 
PTO: 
APE: 
SSO: 
SSO2587(prpB)
STO: 
SAI: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
MSE: 
MCN: 
PAI: 
PIS: 
PCL: 
PAS: 
CMA: 
TUZ: 
VDI: 
VMO: 
ASC: 
 » show all
Taxonomy
Reference
1  [PMID:1330557]
  Authors
Pollack SJ, Freeman S, Pompliano DL, Knowles JR.
  Title
Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.
  Journal
Eur. J. Biochem. 209 (1992) 735-43.
  Sequence
[up:P11435]
Reference
2  [PMID:3611020]
  Authors
Anzai H, Murakami T, Imai S, Satoh A, Nagaoka K, Thompson CJ.
  Title
Transcriptional regulation of bialaphos biosynthesis in Streptomyces hygroscopicus.
  Journal
J. Bacteriol. 169 (1987) 3482-8.
  Sequence
[up:P11435]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
122799-57-9

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