KEGG   ENZYME: 2.7.8.27Help
Entry
EC 2.7.8.27                 Enzyme                                 

Name
sphingomyelin synthase;
SM synthase;
SMS1;
SMS2
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
BRITE hierarchy
Sysname
ceramide:phosphatidylcholine cholinephosphotransferase
Reaction(IUBMB)
a ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol [RN:R08969]
Reaction(KEGG)
Substrate
ceramide [CPD:C00195];
phosphatidylcholine [CPD:C00157]
Product
sphingomyelin [CPD:C00550];
1,2-diacyl-sn-glycerol [CPD:C00641]
Comment
The reaction can occur in both directions [3]. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism [4]. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types [4]. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin [2].
History
EC 2.7.8.27 created 2006
Pathway
Sphingolipid metabolism
Metabolic pathways
Orthology
K04714  
shingomyelin synthase
Genes
HSA: 
166929(SGMS2) 259230(SGMS1)
PTR: 
100613097(SGMS2) 450460(SGMS1)
PPS: 
100983907(SGMS1) 100993903(SGMS2)
GGO: 
101138449(SGMS2) 101138874(SGMS1)
PON: 
100444992(SGMS1) 100446194(SGMS2)
NLE: 
100593842(SGMS2) 100601656(SGMS1)
MCC: 
695947(SGMS2) 704027(SGMS1)
MCF: 
101867034(SGMS2) 102126212(SGMS1)
CJC: 
100391389(SGMS1) 100400486(SGMS2)
MMU: 
208449(Sgms1) 74442(Sgms2)
RNO: 
310849(Sgms2) 353229(Sgms1)
CGE: 
100760913(Sgms2) 100766719(Sgms1)
HGL: 
101710267(Sgms1) 101712715(Sgms2)
TUP: 
102484900(SGMS2) 102485341(SGMS1)
CFA: 
477582(SGMS1) 478505(SGMS2)
AML: 
UMR: 
103661724(SGMS2) 103661995(SGMS1)
FCA: 
101088574(SGMS2) 101090897(SGMS1)
PTG: 
102957023(SGMS1) 102970893(SGMS2)
BTA: 
520954(SGMS2) 533538(SGMS1)
BOM: 
102268543(SGMS2) 102269418(SGMS1)
PHD: 
102315273(SGMS1) 102342407(SGMS2)
CHX: 
102184583(SGMS1) 102187660(SGMS2)
OAS: 
101118575(SGMS1) 101123121(SGMS2)
SSC: 
100037303(SGMS1) 100518796(SGMS2)
CFR: 
102508365(SGMS1) 102509917(SGMS2)
BACU: 
103014494(SGMS1) 103016480(SGMS2)
LVE: 
103070270(SGMS2) 103073289(SGMS1)
ECB: 
100062484(SGMS1) 100072971(SGMS2)
MYB: 
102255621(SGMS1) 102257109(SGMS2)
MYD: 
102752902(SGMS1) 102771993(SGMS2)
PALE: 
102883450(SGMS1) 102886439(SGMS2)
MDO: 
100011020(SGMS2) 100013212(SGMS1)
SHR: 
100928230(SGMS1) 100933601(SGMS2)
OAA: 
GGA: 
378907(SGMS1) 422529(SGMS2)
MGP: 
APLA: 
101791169(SGMS2) 101798673(SGMS1)
TGU: 
100218763(SGMS2) 100229900(SGMS1)
FAB: 
101816191(SGMS1) 101821395(SGMS2)
PHI: 
102106139(SGMS1) 102109103(SGMS2)
FPG: 
101912331(SGMS2) 101914270(SGMS1)
FCH: 
102046789(SGMS2) 102050714(SGMS1)
CLV: 
102093540(SGMS2) 102093853(SGMS1)
ASN: 
102384963(SGMS2) 102386662(SGMS1)
AMJ: 
102560347(SGMS1) 102561422(SGMS2)
PSS: 
102457944(SGMS2) 102458830(SGMS1)
CMY: 
102929744(SGMS2) 102942050(SGMS1)
ACS: 
100553259(sgms1) 100556412(sgms2)
PBI: 
XLA: 
414566(sgms1)
XTR: 
493559(sgms1) 496853(sgms2)
DRE: 
556193(sgms2) 566563(sgms1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103180856(sgms1) 103187947(sgms2)
BFO: 
CIN: 
AGA: 
AAG: 
CQU: 
AME: 
408766(GB20079)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG06147(Cbr-sms-1) CBG08086(Cbr-sms-2) CBG11695(Cbr-sms-3)
BMY: 
LOA: 
TSP: 
PPP: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:4817756]
  Authors
Ullman MD, Radin NS.
  Title
The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver.
  Journal
J. Biol. Chem. 249 (1974) 1506-12.
Reference
2  [PMID:7093220]
  Authors
Voelker DR, Kennedy EP.
  Title
Cellular and enzymic synthesis of sphingomyelin.
  Journal
Biochemistry. 21 (1982) 2753-9.
Reference
3  [PMID:14685263]
  Authors
Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC.
  Title
Identification of a family of animal sphingomyelin synthases.
  Journal
EMBO. J. 23 (2004) 33-44.
  Sequence
Reference
4  [PMID:16905542]
  Authors
Tafesse FG, Ternes P, Holthuis JC.
  Title
The multigenic sphingomyelin synthase family.
  Journal
J. Biol. Chem. 281 (2006) 29421-5.
Reference
5  [PMID:14976195]
  Authors
Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T.
  Title
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells.
  Journal
J. Biol. Chem. 279 (2004) 18688-93.
  Sequence
[hsa:259230]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
58703-97-2

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