| Entry |
|
|---|
| Name |
pyruvate, water dikinase;
phosphoenolpyruvate synthase;
pyruvate-water dikinase (phosphorylating);
PEP synthetase;
phosphoenolpyruvate synthase;
phoephoenolpyruvate synthetase;
phosphoenolpyruvic synthase;
phosphopyruvate synthetase |
|---|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with paired acceptors
 |
|---|
| Sysname |
ATP:pyruvate, water phosphotransferase |
|---|
| Reaction(IUBMB) |
ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate
[RN:R00199] |
|---|
| Reaction(KEGG) |
R00199
 |
|---|
| Substrate |
ATP [CPD:C00002];
pyruvate [CPD:C00022];
H2O [CPD:C00001] |
|---|
| Product |
AMP [CPD:C00020];
phosphoenolpyruvate [CPD:C00074];
phosphate [CPD:C00009] |
|---|
| Cofactor |
Manganese [CPD:C00034] |
|---|
| Comment |
A manganese protein. |
|---|
| Pathway |
PATH: ec00620 Pyruvate metabolism
PATH: ec00720 Reductive carboxylate cycle (CO2 fixation) |
|---|
| Orthology |
KO: K01007 pyruvate, water dikinase |
|---|
| Genes |
BFO: BRAFLDRAFT_121021
ISC: IscW_ISCW012519 IscW_ISCW023042
CEL: T21C9.6
CBR: CBG09648
CME: CMF012C
PAN: PODANSg867
FGR: FG10445.1
ANI: AN5843.2
AFM: AFUA_5G14790
ECO: b1702(pps)
ECJ: JW1692(pps)
ECD: ECDH10B_1838(pps)
EBW: BWG_1516(pps)
ECE: Z2731(ppsA)
ECS: ECs2409
ECF: ECH74115_2419(ppsA)
ETW: ECSP_2269(pps)
ECG: E2348C_1787(pps)
ECC: c2098(ppsA)
ECI: UTI89_C1895(ppsA)
ECP: ECP_1649
ECV: APECO1_778(pps)
ECW: EcE24377A_1919(ppsA)
ECX: EcHS_A1781(ppsA)
ECM: EcSMS35_1489(ppsA)
ECY: ECSE_1826
ECL: EcolC_1929
ECK: EC55989_1870(pps)
ECQ: ECED1_1904(pps)
ECR: ECIAI1_1756(pps)
ECT: ECIAI39_1351(pps)
ECZ: ECS88_1753(pps)
EUM: ECUMN_1992(pps)
ELF: LF82_1709(pps)
EBL: B21_01660(ppsA)
EBD: ECBD_1944
EBR: ECB_01671(ppsA)
EOH: ECO103_1846(pps)
EOI: ECO111_2172(pps)
EOJ: ECO26_2431(pps)
EFE: EFER_1362(pps)
STY: STY1761(ppsA)
STT: t1230(ppsA)
SPT: SPA1494(ppsA)
SEK: SSPA1386
SPQ: SPAB_01985
SEI: SPC_2381(ppsA)
SEC: SC1368(pps)
SEH: SeHA_C1479(ppsA)
SEE: SNSL254_A1461(ppsA)
SEW: SeSA_A1445(ppsA)
SEA: SeAg_B1823(ppsA)
SED: SeD_A1995(ppsA)
SEG: SG1767(pps)
SET: SEN1695(pps)
SES: SARI_01619
STM: STM1349(pps)
YPE: YPO2409(ppsA)
YPK: y1930(ppsA)
YPM: YP_2196(ppsA)
YPA: YPA_1753
YPN: YPN_1863
YPG: YpAngola_A2600(ppsA)
YPP: YPDSF_0740
YPS: YPTB2318(ppsA)
YPI: YpsIP31758_1737(ppsA)
YPY: YPK_1843
YPB: YPTS_2393
YEN: YE2176(pps)
SFL: SF1528(ppsA)
SFX: S1646(ppsA)
SFV: SFV_1522(ppsA)
SSN: SSON_1457(ppsA)
SBO: SBO_1427(ppsA)
SBC: SbBS512_E1905(ppsA)
SDY: SDY_1794(ppsA)
ECA: ECA1853(ppsA)
PCT: PC1_2456
PWA: Pecwa_2758
ETA: ETA_18240(ppsA)
PLU: plu2628(ppsA) plu4508
PAY: PAU_01902(ppsA) PAU_04011(ppsA)
SGL: SG1429
ENT: Ent638_1745
ESA: ESA_02102
CTU: Ctu_18640(ppsA)
KPN: KPN_02160(ppsA)
KPE: KPK_2159(ppsA)
KPU: KP1_3261(ppsA)
CKO: CKO_01725
SPE: Spro_2174
PMR: PMI1421(ppsA)
EIC: NT01EI_1916
ETR: ETAE_1789(ppsA)
DDA: Dd703_1657
DDC: Dd586_1650
DZE: Dd1591_1689
XFA: XF1259
XFT: PD0524
XFM: Xfasm12_0593
XFN: XfasM23_0548
XCC: XCC2166(ppsA)
XCB: XC_1952
XCA: xccb100_2015(ppsA)
XCV: XCV2202(ppsA)
XAC: XAC2041(ppsA)
XOO: XOO2211(ppsA)
XOM: XOO_2079
XOP: PXO_00922(ppsA)
SML: Smlt2975(pps)
SMT: Smal_2422
VCH: VCA0987
VCO: VC0395_0251(ppsA)
VCM: VCM66_A0946(ppsA)
VCJ: VCD_000351
VVU: VV2_0005
VVY: VVA0514
VPA: VPA0372
VHA: VIBHAR_06517
VSP: VS_1407 VS_II1225
VEX: VEA_000648
VFI: VF_1242
VFM: VFMJ11_1325
VSA: VSAL_I1726
PPR: PBPRA1751
PAE: PA1770(ppsA)
PAU: PA14_41670(ppsA)
PAP: PSPA7_3536(ppsA)
PAG: PLES_35591(ppsA)
PPU: PP_2082(ppsA)
PPF: Pput_3658
PPG: PputGB1_1593
PPW: PputW619_1600
PST: PSPTO_2292(ppsA)
PSB: Psyr_2090
PSP: PSPPH_2061(ppsA)
PFL: PFL_1869(ppsA)
PFO: Pfl01_1770
PFS: PFLU4620
PEN: PSEEN1742(ppsA)
PMY: Pmen_2085
PSA: PST_2039(ppsA)
AVN: Avin_23280(ppsA)
PAR: Psyc_1335(ppsA)
PCR: Pcryo_1034
PRW: PsycPRwf_0949
ACI: ACIAD2423(ppsA)
ACB: A1S_2164
ABM: ABSDF1577(ppsA)
ABY: ABAYE1391(ppsA)
ABC: ACICU_02367
ABN: AB57_2501(ppsA)
ABB: ABBFA_001300(ppsA)
SON: SO_2644(ppsA)
SDN: Sden_2009
SFR: Sfri_2297
SAZ: Sama_2072
SBL: Sbal_2488
SBM: Shew185_2481
SBN: Sbal195_2601
SBP: Sbal223_1863
SLO: Shew_1549
SPC: Sputcn32_2243
SSE: Ssed_1871
SPL: Spea_2549
SHE: Shewmr4_1592
SHN: Shewana3_1736
SHW: Sputw3181_1765
SHL: Shal_1705
SWD: Swoo_2715
SWP: swp_1851
ILO: IL1316(ppsA)
CPS: CPS_3011(ppsA)
PHA: PSHAb0557(ppsA)
PAT: Patl_1744
MAQ: Maqu_1883
AMC: MADE_02382
LPN: lpg0805
LPF: lpl0838(ppsA)
LPP: lpp0867(ppsA)
LPC: LPC_2490
TCX: Tcr_1186
NOC: Noc_1446
AEH: Mlg_1890
HHA: Hhal_0220
TGR: Tgr7_2934
HNA: Hneap_1363
HCH: HCH_02123(ppsA) HCH_06026
CSA: Csal_2062
ABO: ABO_1427(ppsA)
MMW: Mmwyl1_1405
AHA: AHA_2691(ppsA)
ASA: ASA_2544(ppsA)
TAU: Tola_1318 Tola_1891
DNO: DNO_0630(ppsA)
AFE: Lferr_1493 Lferr_2043
AFR: AFE_1816(ppsA) AFE_2412
KKO: Kkor_1420
NMA: NMA0826(ppsA)
NME: NMB0618(ppsA)
NMC: NMC0561(ppsA)
NMN: NMCC_0566(ppsA)
NMI: NMO_0504(ppsA)
NGO: NGO0200
NGK: NGK_0330
CVI: CV_3709(ppsA)
LHK: LHK_02665(ppsA)
RSO: RSc1421(ppsA)
RPI: Rpic_1298 Rpic_3805 Rpic_4390
RPF: Rpic12D_1362 Rpic12D_3918 Rpic12D_4522
REU: Reut_A1162 Reut_A1864
REH: H16_A2038(ppsA)
RME: Rmet_1453
CTI: RALTA_A1674(pps)
BMA: BMA1535(ppsA)
BMV: BMASAVP1_A2035(ppsA)
BML: BMA10229_A3277(ppsA)
BMN: BMA10247_1306(ppsA)
BPS: BPSL2140(ppsA)
BPM: BURPS1710b_2561(ppsA)
BPL: BURPS1106A_2470(ppsA)
BPD: BURPS668_2415(ppsA)
BPR: GBP346_A2540(ppsA)
BTE: BTH_I2046(ppsA)
BVI: Bcep1808_1908
BUR: Bcep18194_A5312
BCN: Bcen_6075
BCH: Bcen2424_2002
BCM: Bcenmc03_2022
BCJ: BCAL2074(ppsA)
BAM: Bamb_2035
BAC: BamMC406_1904
BMU: Bmul_1274 Bmul_5940
BMJ: BMULJ_01973(ppsA) BMULJ_05585(ppsA)
BXE: Bxe_A1699
BPH: Bphy_1099 Bphy_1321
BPY: Bphyt_2438
BGL: bglu_1g12900
PNU: Pnuc_1433
BPE: BP1436(ppsA)
BPA: BPP1544(ppsA)
BBR: BB2622(ppsA)
BPT: Bpet2518(ppsA)
BAV: BAV1751(ppsA)
RFR: Rfer_2191
POL: Bpro_2757 Bpro_3042
PNA: Pnap_2081 Pnap_2399
AAV: Aave_1382
AJS: Ajs_2164 Ajs_2879
VEI: Veis_2050
DAC: Daci_5064
DIA: Dtpsy_2366
VAP: Vapar_1816
CTT: CtCNB1_1187
MPT: Mpe_A1521
HAR: HEAR1352(pps)
MMS: mma_2041(ppsA)
LCH: Lcho_2833
NEU: NE2359(ppsA) NE2366(ppsA)
NET: Neut_0868
NMU: Nmul_A0998 Nmul_A1613
EBA: ebA5781(ppsA) ebA5830(pps)
AZO: azo2167(ppsA1) azo2486(ppsA2)
DAR: Daro_1768
TBD: Tbd_0618
MFA: Mfla_2203
MMB: Mmol_1348
MEI: Msip34_2218
HPY: HP0121
HPJ: jhp0111(ppsA)
HPA: HPAG1_0120
HPS: HPSH_00605
HPG: HPG27_111
HPP: HPP12_0121(ppsA)
HPB: HELPY_0120(pps)
HHE: HH1824(ppsA)
HAC: Hac_1459(ppsA)
WSU: WS0826
SDL: Sdel_0972
NIS: NIS_0923(ppsA)
SUN: SUN_1214(ppsA)
NAM: NAMH_0766(ppsA)
GSU: GSU0803(ppsA)
GME: Gmet_0770
GUR: Gura_1291
PCA: Pcar_2435(ppsA)
PPD: Ppro_2845
DVU: DVU1833 DVU2739 DVU3214 DVU3237
DVL: Dvul_0151 Dvul_0174 Dvul_0567 Dvul_1329 Dvul_2815
DVM: DvMF_0416 DvMF_1987 DvMF_1990 DvMF_2339
DDE: Dde_0604 Dde_2080
DDS: Ddes_1552 Ddes_1565 Ddes_1568 Ddes_1644
DMA: DMR_28090 DMR_35020 DMR_37260 DMR_42440
DSA: Desal_2037 Desal_2198
LIP: LI0025(ppsA)
DBA: Dbac_0212 Dbac_0874 Dbac_1886 Dbac_1988 Dbac_2044 Dbac_2045
Dbac_2917
DRT: Dret_0098 Dret_0691 Dret_0704 Dret_1010
BBA: Bd3153(ppsA)
DOL: Dole_1355
DAL: Dalk_5266
DAT: HRM2_22950(ppsA5) HRM2_38170(ppsA7) HRM2_42990(ppsA8)
HRM2_46050(ppsA9)
MXA: MXAN_6800(ppsA)
SCL: sce4177(ppsA1) sce4570(ppsA2) sce7847(ppsA3)
HOH: Hoch_3241
SAT: SYN_01243 SYN_02383 SYN_02966
SFU: Sfum_0630 Sfum_0634 Sfum_0649 Sfum_2666
BJA: blr4655(ppsA)
BRA: BRADO1573(pps)
BBT: BBta_1604 BBta_1605 BBta_6481(pps)
PZU: PHZ_c0457(ppsA) PHZ_p0195
RCE: RC1_3562(ppsA)
BSU: BSU18830(pps)
BAN: BA3116(ppsA)
BAR: GBAA3116(ppsA)
BAA: BA_3618
BAT: BAS2899
BAH: BAMEG_1494(ppsA)
BAI: BAA_3165(ppsA)
BCE: BC3087
BCA: BCE_3137(ppsA)
BCZ: BCZK2825(ppsA)
BCR: BCAH187_A3140(ppsA)
BCB: BCB4264_A3108
BCU: BCAH820_3119(ppsA)
BCG: BCG9842_B2130(ppsA)
BCQ: BCQ_2926(ppsA)
BCX: BCA_3175(ppsA)
BTK: BT9727_2868(ppsA)
BTL: BALH_2779(ppsA) BALH_2780
BWE: BcerKBAB4_2894
BLI: BL01065 BL01998(pps) BL05212
BLD: BLi00634 BLi02172(pps) BLi02241
BAY: RBAM_008480 RBAM_017370(pps) RBAM_032330(yvkC)
BPU: BPUM_3151(ppsA)
GYM: GYMC10_3473
LMO: lmo0411
LMF: LMOf2365_0430
LMH: LMHCC_2227
LMC: Lm4b_00434
LIN: lin0432
BBE: BBR47_38090(pps)
PJD: Pjdr2_3179
SSA: SSA_1012 SSA_1016
SGO: SGO_0936 SGO_0940(ppsA)
LPL: lp_1912(pps)
LPJ: JDM1_1607(pps)
CAC: CAC0534(pps)
CDF: CD0582
CDC: CD196_0526
CDL: CDR20291_0509
CBO: CBO2582
CBA: CLB_2523
CBH: CLC_2454
CBY: CLM_2889
CBL: CLK_1967
CBB: CLD_1983
CBI: CLJ_B2812
CBF: CLI_2645
CBE: Cbei_2063 Cbei_2066 Cbei_3516 Cbei_3859
CKL: CKL_0066(ppsA) CKL_3749
CKR: CKR_0052 CKR_3312
CCE: Ccel_2388
AMT: Amet_1525 Amet_1914
VPR: Vpar_1061
DSY: DSY2123(pps) DSY3072 DSY3730(pps) DSY4219(pps)
DHD: Dhaf_1117 Dhaf_1622 Dhaf_3294 Dhaf_4241
DRM: Dred_2466
DAE: Dtox_2649 Dtox_2728 Dtox_3057 Dtox_3844
PTH: PTH_2376(ppsA) PTH_2377
ADG: Adeg_1730
NTH: Nther_0751
HOR: Hore_12720
MSM: MSMEG_3934
MVA: Mvan_1818 Mvan_2632 Mvan_4106
MGI: Mflv_0493 Mflv_4990
MMC: Mmcs_3406
MKM: Mkms_3469
MJL: Mjls_3417
MMI: MMAR_3410
CGB: cg0642
CGT: cgR_0664 cgR_0665
CEF: CE0560
RER: RER_33970(ppsA)
ROP: ROP_24310 ROP_24980
SCO: SCO5896(redH)
SGR: SGR_6947
ART: Arth_0339 Arth_0384 Arth_0474 Arth_1972 Arth_1995 Arth_1996
Arth_2857
AAU: AAur_0411 AAur_1894(ppsA) AAur_4105
ACH: Achl_0121 Achl_0605 Achl_2080 Achl_3615
BCV: Bcav_0076
KSE: Ksed_23630
XCE: Xcel_2432
NCA: Noca_1185
TCU: Tcur_0540 Tcur_4777
SRO: Sros_0682 Sros_1894 Sros_4939 Sros_5147
FRA: Francci3_2689
FRE: Franean1_6941
NML: Namu_0620 Namu_1713
KRA: Krad_2434
SEN: SACE_0388 SACE_2459 SACE_2483 SACE_7324(ppsII)
SAQ: Sare_3009 Sare_4547
RXY: Rxyl_1574 Rxyl_3073
TDE: TDE0349
SRU: SRU_1138(ppsA)
CHU: CHU_2293
DFE: Dfer_0644
CPI: Cpin_0173 Cpin_2960
PHE: Phep_3585
STR: Sterm_1949 Sterm_3580
MIN: Minf_0020(ppsA)
SYN: slr0301(ppsA)
SYC: syc0756_d(ppsA)
SYF: Synpcc7942_0781
SYP: SYNPCC7002_A0250(ppsA)
CYA: CYA_0741(ppsA)
CYB: CYB_1115(ppsA)
TEL: tll0583 tlr0765
MAR: MAE_02620 MAE_17590 MAE_17610
CYT: cce_1632 cce_2775 cce_4692(ppsA)
CYP: PCC8801_0607 PCC8801_3257 PCC8801_3944
CYC: PCC7424_1835 PCC7424_1972 PCC7424_2777 PCC7424_3966
CYN: Cyan7425_2010 Cyan7425_2277 Cyan7425_4726
CYH: Cyan8802_0623 Cyan8802_2864 Cyan8802_3993
GVI: gll1985 glr2690
ANA: all0635 all2509 alr3146 alr3147 alr3397
NPU: Npun_F0017 Npun_F1309 Npun_R6166
AVA: Ava_0441 Ava_3388 Ava_3841 Ava_4569
TER: Tery_0910 Tery_4209
AMR: AM1_0440(ppsA) AM1_2347 AM1_D0156(ppsA)
DET: DET0554(ppsA)
DEH: cbdb_A529(ppsA)
DEB: DehaBAV1_0529
DEV: DhcVS_494
HAU: Haur_1951
TRO: trd_1681 trd_A0070 trd_A0075 trd_A0779(ppsA) trd_A0780
DRA: DR_1727
DGE: Dgeo_0621
DDR: Deide_17060(ppsA)
TTH: TTC1136
TTJ: TTHA1500
AAE: aq_2142(ppsA)
HYA: HY04AAS1_1583
SUL: SYO3AOP1_1054
SAF: SULAZ_0672(ppsA)
PMX: PERMA_0568(ppsA)
TYE: THEYE_A0726
MJA: MJ0542
MFE: Mefer_0788
MVU: Metvu_0945
MMP: MMP1094(ppsA)
MMQ: MmarC5_0490
MMX: MmarC6_1573
MMZ: MmarC7_0346
MAE: Maeo_0271
MVN: Mevan_0419
MAC: MA2458(ppsA) MA2667(ppsA) MA3408(ppsA)
MBA: Mbar_A2223 Mbar_A3094 Mbar_A3264
MMA: MM_2723
MBU: Mbur_0799
MTP: Mthe_1637
MHU: Mhun_2610
MLA: Mlab_1544
MEM: Memar_1849
MBN: Mboo_0034 Mboo_2165
MPL: Mpal_1433 Mpal_2079
MPD: MCP_0254 MCP_0398(ppsA-1) MCP_1266(ppsA-2) MCP_1482
MTH: MTH1118
MST: Msp_0328(ppsA)
MSI: Msm_0988
MKA: MK0252(ppsA)
AFU: AF0710(ppsA)
HAL: VNG0330G(ppsA)
HSL: OE1500R(ppsA)
HMA: rrnAC1795(ppsA)
HWA: HQ1570A(ppsA1) HQ2024A(ppsA2)
NPH: NP1196A(ppsA)
HLA: Hlac_0508 Hlac_0592
HMU: Hmuk_2997
PTO: PTO1519
PHO: PH0092
PAB: PAB0057(ppsA)
PFU: PF0043
TKO: TK1292
TON: TON_0311
TGA: TGAM_1043(ppsA)
TSI: TSIB_0271 TSIB_1635
RCI: RCIX1188(ppsA-1) RCIX1540(ppsA-2)
APE: APE_0026 APE_0028 APE_0650.1(ppsA)
SMR: Smar_0141
IHO: Igni_1113
DKA: DKAM_0631
SSO: SSO0883(ppsA-1)
STO: ST1235
SAI: Saci_1417
SIS: LS215_1423
SIA: M1425_1336
SIM: M1627_1386
SID: M164_1318
SIY: YG5714_1330
SIN: YN1551_1527
MSE: Msed_0431 Msed_1694
PAI: PAE2423
PIS: Pisl_1888
PCL: Pcal_0313
PAS: Pars_0510 Pars_1445
TNE: Tneu_1204
TPE: Tpen_0588
KCR: Kcr_0060
 |
|---|
| Structures |
PDB: 2OLS |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4319237]
Berman KM, Cohn M.
Phosphoenolpyruvate synthetase of Escherichia coli. Purification,
some properties, and the role of divalent metal ions.
J. Biol. Chem. 245 (1970) 5309-18.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4319238]
Berman KM, Cohn M.
Phosphoenolpyruvate synthetase. Partial reactions studied with
adenosine triphosphate analogues and the inorganic phosphate-H2 18O
exchange reaction.
J. Biol. Chem. 245 (1970) 5319-25.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5322808]
Cooper RA, Kornberg HL.
Net formation of phosphoenolpyruvate from pyruvate by Escherichia
coli.
Biochim. Biophys. Acta. 104 (1965) 618-20.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
|
4
Cooper, R.A. and Kornberg, H.L.
Phosphoenolpyruvate synthetase.
Methods Enzymol. 13 (1969) 309-314. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.9.2
IUBMB Enzyme Nomenclature: 2.7.9.2
ExPASy - ENZYME nomenclature database: 2.7.9.2
BRENDA, the Enzyme Database: 2.7.9.2
CAS: 9013-09-6 |
|---|
