KEGG   ENZYME: 2.8.1.9Help
Entry
EC 2.8.1.9                  Enzyme                                 

Name
molybdenum cofactor sulfurtransferase;
molybdenum cofactor sulfurase;
ABA3;
HMCS;
MoCo sulfurase;
MoCo sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
L-cysteine:molybdenum cofactor sulfurtransferase
Reaction(IUBMB)
molybdenum cofactor + L-cysteine + 2 H+ = thio-molybdenum cofactor + L-alanine + H2O
Substrate
molybdenum cofactor [CPD:C18237];
L-cysteine [CPD:C00097];
H+ [CPD:C00080]
Product
thio-molybdenum cofactor;
L-alanine [CPD:C00041];
H2O [CPD:C00001]
Comment
Contains pyridoxal phosphate. Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide. The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes. In prokaryotes the reaction is catalysed by two enzymes: cysteine desulfurase (EC 2.8.1.7), which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
History
EC 2.8.1.9 created 2011
Orthology
K15631  
molybdenum cofactor sulfurtransferase
Genes
HSA: 
55034(MOCOS)
PTR: 
455379(MOCOS)
PPS: 
100980622(MOCOS)
GGO: 
101144098(MOCOS)
PON: 
100437474(MOCOS)
NLE: 
100603055(MOCOS)
MCC: 
715633(MOCOS)
MCF: 
102120844(MOCOS)
CJC: 
100394299(MOCOS)
MMU: 
68591(Mocos)
RNO: 
361300(Mocos)
CGE: 
103158571(Mocos)
HGL: 
101714313(Mocos)
TUP: 
102477563(MOCOS)
CFA: 
490482(MOCOS)
AML: 
UMR: 
103665067(MOCOS)
FCA: 
101098093(MOCOS)
PTG: 
102960562(MOCOS)
BTA: 
281226(MOCOS)
BOM: 
102271668(MOCOS)
PHD: 
102325177(MOCOS)
CHX: 
102184109(MOCOS)
OAS: 
101115591(MOCOS)
SSC: 
100621611(MOCOS)
CFR: 
102519803(MOCOS)
BACU: 
103013287(MOCOS)
LVE: 
103077536(MOCOS)
ECB: 
100067480(MOCOS)
MYB: 
102247364(MOCOS)
MYD: 
102753138(MOCOS)
PALE: 
102880788(MOCOS)
MDO: 
100013356(MOCOS)
SHR: 
100930485(MOCOS)
OAA: 
100075210(MOCOS)
GGA: 
420964(MOCOS)
MGP: 
100545875(MOCOS)
APLA: 
101790101(MOCOS)
TGU: 
100221503(MOCOS)
FAB: 
PHI: 
102107851(MOCOS)
FPG: 
101916617(MOCOS)
FCH: 
CLV: 
102094081(MOCOS)
ASN: 
102371402(MOCOS)
AMJ: 
102570986(MOCOS)
PSS: 
102456094(MOCOS)
CMY: 
ACS: 
PBI: 
XTR: 
DRE: 
100331902(mocos)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103181183(mocos)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AgaP_AGAP000555(MOCOS_ANOGA)
AAG: 
CQU: 
AME: 
411261(GB18250)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CBR: 
TSP: 
HRO: 
LGI: 
NVE: 
TAD: 
AQU: 
ATH: 
AT1G16540(ABA3)
ALY: 
CRB: 
EUS: 
CIT: 
102577967(ABA3)
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0007s08330g(POPTRDRAFT_719124)
VVI: 
SLY: 
543832(FLACCA)
SOT: 
DOSA: 
Os06t0670000-01(Os06g0670000)
OBR: 
BDI: 
SBI: 
SORBI_10g026910(SORBIDRAFT_10g026910)
SITA: 
PDA: 
ATR: 
s00032p00122530(AMTR_s00032p00122530)
SMO: 
PPP: 
CRE: 
VCN: 
BPG: 
MIS: 
CSL: 
CVR: 
GSL: 
CCP: 
PPA: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1090144(AO090023000633)
ANG: 
ANI_1_1786184(An04g03890)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
PFP: 
DDI: 
DPP: 
DFA: 
DFA_00843(mocos)
ACAN: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:11553608]
  Authors
Bittner F, Oreb M, Mendel RR
  Title
ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana.
  Journal
J. Biol. Chem. 276 (2001) 40381-4.
  Sequence
[ath:AT1G16540]
Reference
2  [PMID:15561708]
  Authors
Heidenreich T, Wollers S, Mendel RR, Bittner F
  Title
Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
  Journal
J. Biol. Chem. 280 (2005) 4213-8.
  Sequence
[ath:AT1G16540]
Reference
3  [PMID:18258600]
  Authors
Wollers S, Heidenreich T, Zarepour M, Zachmann D, Kraft C, Zhao Y, Mendel RR, Bittner F
  Title
Binding of sulfurated molybdenum cofactor to the C-terminal domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration.
  Journal
J. Biol. Chem. 283 (2008) 9642-50.
  Sequence
[ath:AT1G16540]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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