KEGG   ENZYME: 2.8.2.17Help
Entry
EC 2.8.2.17                 Enzyme                                 

Name
chondroitin 6-sulfotransferase;
chondroitin 6-O-sulfotransferase;
3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase;
terminal 6-sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate [RN:R02181]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
chondroitin [CPD:C00401]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
chondroitin 6'-sulfate [CPD:C00635]
Comment
The sulfation is at the 6-position of N-acetylgalactosamine residues of chondroitin. Not identical with EC 2.8.2.5 chondroitin 4-sulfotransferase.
History
EC 2.8.2.17 created 1986
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K01020  
chondroitin 6-sulfotransferase 3
K04743  
chondroitin 6-sulfotransferase 7
Genes
HSA: 
56548(CHST7) 9469(CHST3)
PTR: 
466290(CHST3)
PPS: 
100985655(CHST3) 100985832(CHST7)
GGO: 
101125111(CHST7) 101148104(CHST3)
PON: 
100435256(CHST7) 100436913(CHST3)
NLE: 
100594042(CHST3) 100596547(CHST7)
MCC: 
704906(CHST7) 709333(CHST3)
MCF: 
102131107(CHST7) 102145369(CHST3)
CJC: 
100390135(CHST7) 100398765(CHST3)
MMU: 
53374(Chst3) 60322(Chst7)
RNO: 
302302(Chst7) 84468(Chst3)
CGE: 
100758880(Chst3) 103163077(Chst7)
HGL: 
TUP: 
102490707(CHST7) 102497293(CHST3)
CFA: 
100855759(CHST3) 491852(CHST7)
AML: 
UMR: 
103668018(CHST3)
FCA: 
101080828(CHST3) 101089584(CHST7)
BTA: 
506758(CHST3) 540357(CHST7)
BOM: 
102276566(CHST7) 102287289(CHST3)
PHD: 
102338556(CHST3)
CHX: 
102172247(CHST7) 102175464(CHST3)
OAS: 
101112877(CHST3) 101119189(CHST7)
SSC: 
100151968(CHST3) 100521649(CHST7)
CFR: 
102517861(CHST3)
BACU: 
103011675(CHST3)
LVE: 
103072942(CHST3) 103085120(CHST7)
ECB: 
100063554(CHST3)
MYD: 
102767857(CHST3)
PALE: 
102888749(CHST3) 102897895(CHST7)
MDO: 
100010061(CHST3) 100011790(CHST7)
SHR: 
OAA: 
100077797(CHST3)
GGA: 
396018(CHST3)
MGP: 
TGU: 
FAB: 
101816190(CHST3) 101817310(CHST7)
PHI: 
102100321(CHST3) 102107465(CHST7)
FPG: 
101917853(CHST3)
FCH: 
102056929(CHST3)
CLV: 
102093446(CHST3)
ASN: 
102372386(CHST3)
AMJ: 
102564934(CHST7) 102571152(CHST3)
PSS: 
102446589(CHST3)
CMY: 
102935727(CHST3)
ACS: 
100568098(chst3) 103278315(chst7)
PBI: 
XLA: 
734885(chst7)
XTR: 
100379720(chst7) 100492673(chst3)
DRE: 
556800(chst3b) 559721(chst3a) 563748
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103177115(chst7) 103182392(chst3)
BFO: 
LGI: 
 » show all
Taxonomy
Reference
1  [PMID:6957247]
  Authors
Habuchi O, Miyashita N.
  Title
Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage.
  Journal
Biochim. Biophys. Acta. 717 (1982) 414-21.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37292-93-6

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