KEGG   ENZYME: 2.8.2.20Help
Entry
EC 2.8.2.20                 Enzyme                                 

Name
protein-tyrosine sulfotransferase;
tyrosylprotein sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate [RN:R02586]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
protein tyrosine [CPD:C00585]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
protein tyrosine-O-sulfate [CPD:C03721]
Comment
The tyrosine residues of some specific proteins of rat pheochromocytoma cells act as acceptors.
History
EC 2.8.2.20 created 1986
Orthology
K01021  
protein-tyrosine sulfotransferase
Genes
HSA: 
8459(TPST2) 8460(TPST1)
PTR: 
458726(TPST2) 472398(TPST1)
PPS: 
100981666(TPST2) 100995854(TPST1)
GGO: 
101139944(TPST2) 101146881(TPST1)
PON: 
100454434(TPST1) 100457197(TPST2)
NLE: 
100602727(TPST1) 100606069(TPST2)
MCC: 
696626(TPST1) 715338
MCF: 
101865653(TPST2) 102139969(TPST1)
CJC: 
100402781(TPST2) 100415662(TPST1)
MMU: 
22021(Tpst1) 22022(Tpst2)
RNO: 
288617(Tpst1) 288719(Tpst2)
CGE: 
100757649(Tpst1) 100771893(Tpst2)
NGI: 
103738944(Tpst1) 103746732(Tpst2)
HGL: 
101711599(Tpst1) 101717396(Tpst2)
OCU: 
100338693(TPST2) 100345464(TPST1)
TUP: 
102478726(TPST2) 102479475(TPST1)
CFA: 
486332(TPST2) 489788(TPST1)
AML: 
UMR: 
103659261(TPST2) 103670182(TPST1)
FCA: 
101091155(TPST2) 101101278(TPST1)
PTG: 
102958179(TPST2) 102963176(TPST1)
BTA: 
513004(TPST1) 540183(TPST2)
BOM: 
102276807(TPST1) 102284382(TPST2)
PHD: 
102325548(TPST2) 102337614(TPST1)
CHX: 
102182899(TPST2) 102187284(TPST1)
OAS: 
101104858(TPST2) 101110019(TPST1)
SSC: 
100154448(TPST2) 100517581(TPST1)
CFR: 
102503921(TPST2) 102509002(TPST1)
BACU: 
103003690(TPST2) 103015335(TPST1)
LVE: 
103074713(TPST2) 103089525(TPST1)
ECB: 
100059398(TPST2) 100061873(TPST1)
MYB: 
MYD: 
102762909(TPST2) 102771855(TPST1)
PALE: 
102880813(TPST2) 102882492(TPST1)
MDO: 
100009937(TPST1) 100011282(TPST2)
SHR: 
100915171(TPST1)
OAA: 
100075156(TPST2) 100081244(TPST1)
GGA: 
416910(TPST2) 417546(TPST1)
MGP: 
APLA: 
101791156(TPST2) 101791667(TPST1)
TGU: 
100224714(TPST2) 100227687(TPST1) 100231926(TPST1)
FAB: 
101808873(TPST1) 101812318(TPST2)
PHI: 
102103318(TPST1) 102109477(TPST2)
FPG: 
101912194(TPST2) 101919555(TPST1)
FCH: 
102054159(TPST1) 102058320(TPST2)
CLV: 
102086711(TPST1) 102091967(TPST2)
ASN: 
102381170(TPST1) 102385474(TPST2)
AMJ: 
102560068(TPST2) 102566332(TPST1)
PSS: 
102453626(TPST1) 102460081(TPST2)
CMY: 
102932566(TPST1) 102946687(TPST2)
PBI: 
103047966(TPST2) 103063767(TPST1)
XLA: 
444016(tpst1) 495291(tpst2)
XTR: 
549785(tpst2) 595028(tpst1)
DRE: 
30677(tpst1) 393171(tpst1l)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102364059(TPST2) 102364758(TPST1)
CMK: 
103180643(tpst1) 103189950(tpst2)
BFO: 
CIN: 
SPU: 
DME: 
Dmel_CG32632(Tango13)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
552278(Tango13)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
AQU: 
ALI: 
 » show all
Taxonomy
Reference
1  [PMID:6577005]
  Authors
Lee RW, Huttner WB.
  Title
Tyrosine-O-sulfated proteins of PC12 pheochromocytoma cells and their sulfation by a tyrosylprotein sulfotransferase.
  Journal
J. Biol. Chem. 258 (1983) 11326-34.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
87588-33-8

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