KEGG   ENZYME: 2.8.2.5Help
Entry
EC 2.8.2.5                  Enzyme                                 

Name
chondroitin 4-sulfotransferase;
chondroitin sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate [RN:R02180]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
chondroitin [CPD:C00401]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
chondroitin 4'-sulfate [CPD:C00634]
Comment
The sulfation takes place at the 4-position of N-acetyl-galactosamine residues of chondroitin. Not identical with EC 2.8.2.17 chondroitin 6-sulfotransferase.
History
EC 2.8.2.5 created 1965, modified 1986
Pathway
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K01017  
chondroitin 4-sulfotransferase 11
K04742  
chondroitin 4-sulfotransferase 12
K07779  
chondroitin 4-sulfotransferase 13
Genes
HSA: 
166012(CHST13) 50515(CHST11) 55501(CHST12)
PTR: 
467113(CHST11) 471065(CHST13) 472270(CHST12)
PPS: 
100971795(CHST13) 100975988(CHST11) 100977359(CHST12)
GGO: 
101133837(CHST11) 101139277(CHST13) 101144960(CHST12)
PON: 
100441016(CHST13) 100456373(CHST12) 100457862(CHST11)
MCC: 
700690(CHST11) 713591(CHST12) 716548(CHST13)
MCF: 
102121463(CHST12) 102142576(CHST13) 102145281(CHST11)
MMU: 
58250(Chst11) 59031(Chst12) 71797(Chst13)
RNO: 
304322(Chst12) 314694(Chst11) 500257(Chst13)
CGE: 
100762689(Chst12) 100771243(Chst13) 100771304(Chst11)
HGL: 
101699086 101700717(Chst12) 101703999(Chst13)
TUP: 
102472415(CHST12) 102500906(CHST11)
CFA: 
481299(CHST11) 484618(CHST13) 609635(CHST12)
AML: 
FCA: 
101085731(CHST11) 101086274(CHST12) 101093089(CHST13)
PTG: 
102956639(CHST11) 102962488(CHST12)
BTA: 
513030(CHST12) 523460(CHST13) 528860(CHST11)
BOM: 
102266002(CHST11) 102284925(CHST12)
PHD: 
102324187(CHST12) 102343636(CHST11)
CHX: 
102168320(CHST12) 102184407(CHST11)
SSC: 
100157186(CHST11) 100519444(CHST13) 100524793(CHST12)
CFR: 
BACU: 
103001272(CHST12)
LVE: 
103089407(CHST12)
ECB: 
100059762(CHST12) 100067989(CHST11)
MYB: 
102256866(CHST11) 102261451(CHST12)
MYD: 
102763992(CHST11) 102765213(CHST12)
PALE: 
102887006(CHST11) 102893899(CHST13) 102897939(CHST12)
MDO: 
SHR: 
100914185(CHST12) 100921711(CHST11)
OAA: 
100076609(CHST11) 100082901(CHST12) 100088952
GGA: 
100857771 416032(CHST13) 416469(CHST12) 418081(CHST11)
MGP: 
TGU: 
100222220(CHST12) 100225306(CHST11) 100228818
FAB: 
101806996(CHST11) 101808164 101816778(CHST12)
PHI: 
102103855(CHST12) 102109237 102110718(CHST11)
APLA: 
101796810(CHST12) 101802330(CHST11)
FPG: 
101910612(CHST12) 101924047(CHST11)
FCH: 
102058489(CHST12)
CLV: 
102089116(CHST12)
ASN: 
102379722(CHST12)
AMJ: 
PSS: 
102449023(CHST11) 102463513(CHST12)
CMY: 
102932531(CHST12) 102942919(CHST11)
ACS: 
PBI: 
XLA: 
380581(chst11) 496355(chst12) 734260(chst13)
XTR: 
100125190(chst11) 493458(chst13) 548703(chst12)
DRE: 
404232(chst11) 407076(chst12a) 565671(wu:fb44a12)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102347601(CHST12)
CMK: 
BFO: 
SPU: 
AGA: 
AAG: 
AME: 
550998(GB10157)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
NVE: 
HMG: 
 » show all
Taxonomy
Reference
1  [PMID:6957247]
  Authors
Habuchi O, Miyashita N.
  Title
Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage.
  Journal
Biochim. Biophys. Acta. 717 (1982) 414-21.
  Organism
Gallus gallus
Reference
2  [PMID:6130977]
  Authors
Nakanishi Y, Otsu K, Suzuki S.
  Title
Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine.
  Journal
FEBS. Lett. 151 (1983) 15-8.
  Organism
Gallus gallus
Reference
3  [PMID:6787041]
  Authors
Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S.
  Title
A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate.
  Journal
J. Biol. Chem. 256 (1981) 5443-9.
  Organism
Gallus gallus
Reference
4  [PMID:13835879]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. I. Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides.
  Journal
J. Biol. Chem. 235 (1960) 257-66.
  Organism
Gallus gallus
Reference
5  [PMID:13835880]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. II. Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors.
  Journal
J. Biol. Chem. 235 (1960) 267-73.
  Organism
Gallus gallus
Reference
6  [PMID:13835881]
  Authors
SUZUKI S, STROMINGER JL.
  Title
Enzymatic sulfation of mucopolysaccharides in hen oviduct. III. Mechanism of sulfation of chondrotin and chondrotin sulfate A.
  Journal
J. Biol. Chem. 235 (1960) 274-6.
  Organism
Gallus gallus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
83589-04-2

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