| Entry |
|
| Name |
[heparan sulfate]-glucosamine N-sulfotransferase;
heparin N-sulfotransferase;
3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase;
PAPS:N-desulfoheparin sulfotransferase;
PAPS:DSH sulfotransferase;
N-HSST;
N-heparan sulfate sulfotransferase;
heparan sulfate N-deacetylase/N-sulfotransferase;
heparan sulfate 2-N-sulfotransferase;
heparan sulfate N-sulfotransferase;
heparan sulfate sulfotransferase;
N-desulfoheparin sulfotransferase;
desulfoheparin sulfotransferase;
3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase;
heparitin sulfotransferase;
3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase
|
| Class |
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
 |
| Sysname |
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase
|
| Reaction(IUBMB) |
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
|
| Reaction(KEGG) |
|
| Substrate |
3'-phosphoadenylyl sulfate [CPD: C00053];
[heparan sulfate]-glucosamine [CPD: C17141]
|
| Product |
adenosine 3',5'-bisphosphate [CPD: C00054];
[heparan sulfate]-N-sulfoglucosamine [CPD: C17142]
|
| Comment |
The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.
|
| Reference |
1 |
| Authors |
Suzuki, S., Trenn, R.H. and Strominger, J.L. |
| Title |
Separation of specific mucopolysaccharide sulfotransferases. |
| Journal |
Biochim. Biophys. Acta 50 (1961) 169-174. |
| Reference |
|
| Authors |
Eisenman RA, Balasubramanian AS, Marx W. |
| Title |
3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction. |
| Journal |
Arch. Biochem. Biophys. 119 (1967) 387-97. |
| Organism |
|
| Reference |
|
| Authors |
Johnson AH, Baker JR. |
| Title |
The enzymatic sulphation of heparan sulphate by hen's uterus. |
| Journal |
Biochim. Biophys. Acta. 320 (1973) 341-51. |
| Organism |
|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9026-75-9 |