KEGG   ENZYME: 2.8.2.8Help
Entry
EC 2.8.2.8                  Enzyme                                 

Name
[heparan sulfate]-glucosamine N-sulfotransferase;
heparin N-sulfotransferase;
3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase;
PAPS:N-desulfoheparin sulfotransferase;
PAPS:DSH sulfotransferase;
N-HSST;
N-heparan sulfate sulfotransferase;
heparan sulfate N-deacetylase/N-sulfotransferase;
heparan sulfate 2-N-sulfotransferase;
heparan sulfate N-sulfotransferase;
heparan sulfate sulfotransferase;
N-desulfoheparin sulfotransferase;
desulfoheparin sulfotransferase;
3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase;
heparitin sulfotransferase;
3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
BRITE hierarchy
Sysname
3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
Reaction(KEGG)
(other) R02122
Show
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
[heparan sulfate]-glucosamine [CPD:C17141]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[heparan sulfate]-N-sulfoglucosamine [CPD:C17142]
Comment
The enzyme also catalyses the sulfation of chondroitin 4-sulfate and dermatan sulfate, but to a much more limited extent.
History
EC 2.8.2.8 created 1972, modified 2001 (EC 2.8.2.12 created 1972, incorporated 2001)
Reference
1
  Authors
Suzuki, S., Trenn, R.H. and Strominger, J.L.
  Title
Separation of specific mucopolysaccharide sulfotransferases.
  Journal
Biochim. Biophys. Acta 50 (1961) 169-174.
Reference
2  [PMID:4964017]
  Authors
Eisenman RA, Balasubramanian AS, Marx W.
  Title
3'-Phosphoadenylylsulfate:N-desulfoheparin sulfotransferase associated with a postmicrosomal particulate mastocytoma fraction.
  Journal
Arch. Biochem. Biophys. 119 (1967) 387-97.
  Organism
Mus musculus
Reference
3  [PMID:4270798]
  Authors
Johnson AH, Baker JR.
  Title
The enzymatic sulphation of heparan sulphate by hen's uterus.
  Journal
Biochim. Biophys. Acta. 320 (1973) 341-51.
  Organism
Gallus gallus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-75-9

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