| Entry |
|
|---|
| Name |
succinyl-CoA:(R)-benzylsuccinate CoA-transferase;
benzylsuccinate CoA-transferase |
|---|
| Class |
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
 |
|---|
| Sysname |
succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase |
|---|
| Reaction(IUBMB) |
succinyl-CoA + (R)-2-benzylsuccinate = succinate +
(R)-2-benzylsuccinyl-CoA [RN:R05588] |
|---|
| Reaction(KEGG) |
R05588
 |
|---|
| Substrate |
succinyl-CoA [CPD:C00091];
(R)-2-benzylsuccinate [CPD:C09816] |
|---|
| Product |
succinate [CPD:C00042];
(R)-2-benzylsuccinyl-CoA [CPD:C09817] |
|---|
| Comment |
Involved in anaerobic catabolism of toluene and is a strictly
toluene-induced enzyme that catalyses the reversible regio- and
enantio-selective synthesis of (R)-2-benzylsuccinyl-CoA. The enzyme
from Thauera aromatica is inactive when (R)-benzylsuccinate is
replaced by (S)-benzylsuccinate. |
|---|
| Pathway |
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K07543 benzylsuccinate CoA-transferase BbsE subunit
KO: K07544 benzylsuccinate CoA-transferase BbsF subunit |
|---|
| Genes |
BBR: BB4333(bbsE) BB4334(bbsF)
VEI: Veis_4269 Veis_4270
EBA: c2A311(bbsF) c2A312(bbsE)
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11418570]
Leutwein C, Heider J.
Succinyl-CoA:(R)-benzylsuccinate CoA-transferase: an enzyme of the
anaerobic toluene catabolic pathway in denitrifying bacteria.
J. Bacteriol. 183 (2001) 4288-95.
Thauera aromatica |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:10589736]
Leutwein C, Heider J.
Anaerobic toluene-catabolic pathway in denitrifying Thauera
aromatica: activation and beta-oxidation of the first intermediate,
(R)-(+)-benzylsuccinate.
Microbiology. 145 ( Pt 11) (1999) 3265-71.
Thauera aromatica |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:10629170]
Leuthner B, Heider J.
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon
codes for enzymes of beta oxidation of the intermediate
benzylsuccinate.
J. Bacteriol. 182 (2000) 272-7.
Thauera aromatica |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:11749953]
Heider J.
A new family of CoA-transferases.
FEBS. Lett. 509 (2001) 345-9.
Thauera aromatica |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.8.3.15
IUBMB Enzyme Nomenclature: 2.8.3.15
ExPASy - ENZYME nomenclature database: 2.8.3.15
BRENDA, the Enzyme Database: 2.8.3.15
CAS: 260966-56-1 |
|---|
