| Entry |
|
|---|
| Name |
3-oxoacid CoA-transferase;
3-oxoacid coenzyme A-transferase;
3-ketoacid CoA-transferase;
3-ketoacid coenzyme A transferase;
3-oxo-CoA transferase;
3-oxoacid CoA dehydrogenase;
acetoacetate succinyl-CoA transferase;
acetoacetyl coenzyme A-succinic thiophorase;
succinyl coenzyme A-acetoacetyl coenzyme A-transferase;
succinyl-CoA transferase |
|---|
| Class |
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
 |
|---|
| Sysname |
succinyl-CoA:3-oxo-acid CoA-transferase |
|---|
| Reaction(IUBMB) |
succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA
[RN:R01780] |
|---|
| Reaction(KEGG) |
R01780 > R00410
 |
|---|
| Substrate |
succinyl-CoA [CPD:C00091];
3-oxo acid [CPD:C01656] |
|---|
| Product |
succinate [CPD:C00042];
3-oxoacyl-CoA [CPD:C00264] |
|---|
| Comment |
Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate,
3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors;
malonyl-CoA can act instead of succinyl-CoA. |
|---|
| Pathway |
PATH: ec00072 Synthesis and degradation of ketone bodies
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec00650 Butanoate metabolism |
|---|
| Orthology |
KO: K01028 3-oxoacid CoA-transferase subunit A
KO: K01029 3-oxoacid CoA-transferase subunit B |
|---|
| Genes |
HSA: 5019(OXCT1) 64064(OXCT2)
PTR: 737468(OXCT1)
MCC: 696642(OXCT1)
MMU: 353371(Oxct2b) 64059(Oxct2a) 67041(Oxct1)
RNO: 366463(Oxct2a) 690163(Oxct1)
CFA: 479347(OXCT1)
BTA: 100137808(OXCT2) 504655(OXCT2) 535804(OXCT1)
SSC: 396978(OXCT1)
ECB: 100054330 100065846
MDO: 100018163
OAA: 100081839
GGA: 427190(OXCT1)
TGU: 100226133
XLA: 398820
XTR: 493307(oxct1)
DRE: 442923(oxct1a)
CIN: 100180566
SPU: 589818
DME: Dmel_CG1140
DPO: Dpse_GA10977
DAN: Dana_GF24850
DER: Dere_GG14840
DPE: Dper_GL22911
DSE: Dsec_GM14463
DSI: Dsim_GD13661
DYA: Dyak_GE21204
DGR: Dgri_GH14994
DMO: Dmoj_GI13155
AGA: AgaP_AGAP006096
AAG: AaeL_AAEL011137
CQU: CpipJ_CPIJ011934
AME: 409157
NVI: 100122534
TCA: 657047
API: 100159806
ISC: IscW_ISCW002707
CEL: C05C10.3
CBR: CBG00970
NVE: NEMVE_v1g180278
HMG: 100209501
TAD: TRIADDRAFT_64132
DHA: DEHA0F25058g
PIC: PICST_33142(OCA3)
LEL: LELG_02460
CAL: CaO19.2281(OCA99)
CTP: CTRG_01733
CDU: CD36_21510
YLI: YALI0F26587g
NCR: NCU06881 NCU08145
PAN: PODANSg1663 PODANSg1949
MGR: MGG_11480
FGR: FG02146.1 FG06342.1
ANI: AN5669.2 AN9394.2
AFM: AFUA_3G04030 AFUA_6G12250
AOR: AO090009000195 AO090124000071
ANG: An01g00200 An06g01370
AFV: AFLA_052610 AFLA_089310
PCS: Pc14g00590 Pc22g03940
NFI: NFIA_006320 NFIA_058220
CIM: CIMG_01784
URE: UREG_05484
SSL: SS1G_07467 SS1G_12031
BFU: BC1G_05154
CNE: CNL05860
CNB: CNBI0970
LBC: LACBIDRAFT_324861
UMA: UM02667.1
MGL: MGL_0383
MBR: MONBRDRAFT_35053
DDI: DDB_0235256(oxct1)
TET: TTHERM_00147510 TTHERM_00442180
PTM: GSPATT00021628001 GSPATT00027503001 GSPATT00032205001
TBR: Tb11.02.0290
TCR: 504153.360 506301.50
LMA: LmjF30.1940 LmjF33.2340
LIF: LinJ30.0330 LinJ30.2260
LBZ: LbrM33_V2.2630
PTI: PHATRDRAFT_23365(SKT1)
TPS: THAPSDRAFT_31777(OCT1)
ECW: EcE24377A_1669 EcE24377A_1670(pcaI)
ECR: ECIAI1_1490(scoB) ECIAI1_1491(scoA)
KPN: KPN_02053 KPN_02054
KPE: KPK_2277 KPK_2278
KPU: KP1_3129 KP1_3130
SPE: Spro_0590 Spro_0591
DDA: Dd703_1375
XCC: XCC0627(ipsI) XCC0628(ipsJ)
XCB: XC_3606 XC_3607
XCA: xccb100_3727(wxcJ) xccb100_3728(wxcI)
XCV: XCV3701(wxcJ) XCV3702(wxcI)
XAC: XAC3577(ipsJ) XAC3578(ipsI)
XOO: XOO0798(ipsI) XOO0799(ipsJ)
XOM: XOO_0726 XOO_0727
XOP: PXO_03175(lpsI) PXO_03176(lpsJ)
SML: Smlt0655(lpsI) Smlt0656(lpsJ)
SMT: Smal_0517 Smal_0518
PAE: PA1999(dhcA) PA2000(dhcB)
PAU: PA14_38640(scoB) PA14_38660(scoA)
PAP: PSPA7_3294 PSPA7_3295
PAG: PLES_33231 PLES_33241
PPU: PP_3122 PP_3123
PPF: Pput_2593 Pput_2594
PPG: PputGB1_2734 PputGB1_2735
PPW: PputW619_2431 PputW619_2432
PST: PSPTO_3455 PSPTO_3456
PSB: Psyr_3237 Psyr_3238
PSP: PSPPH_3156(dxnG) PSPPH_3157(dxnH)
PFL: PFL_2322 PFL_2323
PFO: Pfl01_2075 Pfl01_2076
PFS: PFLU2151(scoB) PFLU2152(scoA)
PEN: PSEEN2464(lpsI) PSEEN2465(lpsJ)
PMY: Pmen_1139 Pmen_1140
PSA: PST_3218 PST_3219
AVN: Avin_17560 Avin_17570 Avin_51600 Avin_51610
PAR: Psyc_1429 Psyc_1430(lpsI)
PCR: Pcryo_1593 Pcryo_1594
PRW: PsycPRwf_1705 PsycPRwf_1706
ACI: ACIAD2513(atoD)
ACB: A1S_1731 A1S_1732
ABY: ABAYE1913(atoD) ABAYE1914(atoA)
ABC: ACICU_01769 ACICU_01770
ABN: AB57_1962 AB57_1963
ABB: ABBFA_001761 ABBFA_001762
SON: SO_1891 SO_1892(atoD)
SDN: Sden_2251 Sden_2252
SFR: Sfri_2732 Sfri_2733
SAZ: Sama_0518 Sama_0519 Sama_1356 Sama_1357
SBL: Sbal_2833 Sbal_2834
SBM: Shew185_2851 Shew185_2852
SBN: Sbal195_2978 Sbal195_2979
SBP: Sbal223_1524 Sbal223_1525
SLO: Shew_2575 Shew_2576
SPC: Sputcn32_1713 Sputcn32_1714
SSE: Ssed_1452 Ssed_1453
SPL: Spea_2803 Spea_2804
SHE: Shewmr4_2327 Shewmr4_2328 Shewmr4_3291 Shewmr4_3292
SHM: Shewmr7_0655 Shewmr7_0656 Shewmr7_2399 Shewmr7_2400
SHN: Shewana3_1666 Shewana3_1667 Shewana3_3467 Shewana3_3468
SHW: Sputw3181_2311 Sputw3181_2312
SHL: Shal_2908 Shal_2909
SWD: Swoo_3228 Swoo_3229
SWP: swp_3449 swp_3450
CPS: CPS_1597(dxnH) CPS_1598(dxnG)
PHA: PSHAa1446(atoA) PSHAa1447 PSHAa2942 PSHAa2943
PAT: Patl_1619 Patl_1620
AMC: MADE_01940 MADE_01941
MMW: Mmwyl1_3054 Mmwyl1_3055
KKO: Kkor_1053 Kkor_1054
RSO: RSc1570(lpsI) RSc1571(lpsJ)
RPI: Rpic_1982 Rpic_1983
RPF: Rpic12D_1652 Rpic12D_1653
REU: Reut_A1269 Reut_A1270 Reut_B4483
REH: H16_A1331 H16_A1332
RME: Rmet_1153 Rmet_1154
CTI: RALTA_A1252(atoD1) RALTA_A1253(atoA1)
BMA: BMA1107 BMA1108
BMV: BMASAVP1_A1549 BMASAVP1_A1550
BML: BMA10229_A0212 BMA10229_A0213
BMN: BMA10247_0951 BMA10247_0952
BPS: BPSL1954(scoB) BPSL1955(scoA)
BPM: BURPS1710b_1877(scoA) BURPS1710b_1878(scoB)
BPL: BURPS1106A_1725 BURPS1106A_1726
BPD: BURPS668_1699 BURPS668_1700
BPR: GBP346_A1746 GBP346_A1747
BTE: BTH_I2607 BTH_I2608
BVI: Bcep1808_1430 Bcep1808_1431
BUR: Bcep18194_A4610 Bcep18194_A4611
BCN: Bcen_0983 Bcen_0984
BCH: Bcen2424_1465 Bcen2424_1466
BCM: Bcenmc03_1443 Bcenmc03_1444
BCJ: BCAL1472(scoA) BCAL1473(scoB)
BAM: Bamb_1350 Bamb_1351
BAC: BamMC406_1390 BamMC406_1391
BMU: Bmul_1783 Bmul_1784
BMJ: BMULJ_01455(scoA) BMULJ_01456(scoB)
BXE: Bxe_A1366 Bxe_A1367 Bxe_C0572 Bxe_C0573
BPH: Bphy_1562 Bphy_1563
BPY: Bphyt_2760 Bphyt_2761
BGL: bglu_1g21560 bglu_1g21570
PNU: Pnuc_0825 Pnuc_0826
PNE: Pnec_1013 Pnec_1014
BPE: BP2400
BPA: BPP0358(scoB) BPP0359(scoA) BPP3265 BPP3266
BBR: BB0361(scoB) BB0362(scoA) BB3716 BB3717
BPT: Bpet1173(scoA) Bpet1174(scoB) Bpet1425 Bpet1426 Bpet1789(lpsI)
Bpet1790(lpsJ1) Bpet4180(lpsJ2)
BAV: BAV1154(lpsI) BAV1155(lpsJ)
RFR: Rfer_2634 Rfer_2635
POL: Bpro_1905 Bpro_1906
PNA: Pnap_2657 Pnap_2658
AAV: Aave_3126 Aave_3127
AJS: Ajs_1961 Ajs_1962
VEI: Veis_2607 Veis_2608
DAC: Daci_4265 Daci_4266
DIA: Dtpsy_1762 Dtpsy_1763
VAP: Vapar_3261 Vapar_3262
CTT: CtCNB1_2185 CtCNB1_2187
MPT: Mpe_A1456 Mpe_A1457
HAR: HEAR1806(atoA) HEAR1807(lpsI)
MMS: mma_1481(scoA) mma_1482(scoB)
LCH: Lcho_1983 Lcho_1984 Lcho_2491
EBA: ebA4718(kctA) ebA4719(kctB)
DAR: Daro_1021
HPY: HP0691 HP0692
HPJ: jhp0636(scoB) jhp0637(scoA)
HPA: HPAG1_0676 HPAG1_0677
HPS: HPSH_03395 HPSH_03400
HPG: HPG27_647 HPG27_648
HPP: HPP12_0702(scoA) HPP12_0703(scoB)
HPB: HELPY_0681(scoB) HELPY_0682(scoA)
HAC: Hac_0956(scoB) Hac_0957(scoA)
GME: Gmet_3296 Gmet_3297
GUR: Gura_4355 Gura_4356
BBA: Bd2096 Bd2097
ADE: Adeh_2363 Adeh_2364
ACP: A2cp1_1595 A2cp1_1596
AFW: Anae109_1505 Anae109_1506
ANK: AnaeK_1500 AnaeK_1501
MXA: MXAN_3789 MXAN_3790
SCL: sce5784(scoA) sce5785(scoB)
HOH: Hoch_4552 Hoch_4553
SFU: Sfum_2290
RCM: A1E_01865 A1E_01870 A1E_01875
RCO: RC0904 RC0905 RC0906(scoB)
RFE: RF_0373(scoB) RF_0374(scoA)
RAK: A1C_04615 A1C_04625
RRI: A1G_04995 A1G_05000
RRJ: RrIowa_1076 RrIowa_1077
RMS: RMA_0937(scoA) RMA_0938(scoB)
RAF: RAF_ORF0820(scoA) RAF_ORF0821(scoB)
RBE: RBE_1007(scoB)
RBO: A1I_03605 A1I_03610
AVI: Avi_5436(pcaI) Avi_5437(pcaJ) Avi_7413
BJA: bll7092(pcaJ) bll7093(pcaI)
BRA: BRADO1223(atoD) BRADO1224(atoA)
RPA: RPA4155 RPA4156
RPB: RPB_1458 RPB_1459
RPC: RPC_0638 RPC_3949 RPC_3950
RPD: RPD_1434 RPD_1435
RPE: RPE_4077 RPE_4078
RPT: Rpal_4634 Rpal_4635
NWI: Nwi_1010 Nwi_1011
NHA: Nham_1246 Nham_1247
OCA: OCAR_5116 OCAR_5117
XAU: Xaut_2349 Xaut_2350
MEX: Mext_2919 Mext_2920
MEA: Mex_1p3124(atoD) Mex_1p3125(atoA)
MDI: METDI3687(atoD) METDI3688(atoA)
MRD: Mrad2831_5000 Mrad2831_5001
MET: M446_1572 M446_5856 M446_5857
MPO: Mpop_3043 Mpop_3044
MCH: Mchl_3145 Mchl_3146
MNO: Mnod_2278 Mnod_6364 Mnod_6365
BID: Bind_1141 Bind_1142 Bind_3274
MSL: Msil_1856 Msil_2969 Msil_2970
CCR: CC_0206 CC_2405 CC_2406
CCS: CCNA_00206 CCNA_00207 CCNA_02488 CCNA_02489
CAK: Caul_3847 Caul_3848 Caul_4700 Caul_4701
PZU: PHZ_c0319(pcaI) PHZ_c0320(msrA)
SIL: SPO3082(dxnG)
SIT: TM1040_2340 TM1040_2341
RSP: RSP_1914
RSH: Rsph17029_0563 Rsph17029_0564
RSQ: Rsph17025_3108 Rsph17025_3109
RSK: RSKD131_0223 RSKD131_0224
JAN: Jann_1009
RDE: RD1_2130(dxnG)
PDE: Pden_4683 Pden_4684
DSH: Dshi_1134 Dshi_1136
MMR: Mmar10_1476 Mmar10_1477
HNE: HNE_2893(dxnH) HNE_2894(dxnG)
HBA: Hbal_1594 Hbal_1595
NAR: Saro_0566 Saro_0568 Saro_3823 Saro_3824
SAL: Sala_2123 Sala_2124
SWI: Swit_0958 Swit_0959 Swit_4164 Swit_4165 Swit_4888 Swit_4889
Swit_5023 Swit_5064
ELI: ELI_14300 ELI_14310
ACR: Acry_2257 Acry_2258
RRU: Rru_A1471
RCE: RC1_2504 RC1_2505
BSU: BSU38980(scoB) BSU38990(scoA)
BCL: ABC4024(scoE) ABC4025(scoA)
BAY: RBAM_018210(scoB) RBAM_018220(scoA)
SSP: SSP2199 SSP2200
LSP: Bsph_0799 Bsph_0800
ESI: Exig_1172 Exig_1173
BBE: BBR47_49540(scoA) BBR47_49550(scoB)
AAC: Aaci_2059 Aaci_2060
SPZ: M5005_Spy_0121
SPI: MGAS10750_Spy0126
SPB: M28_Spy0119
SOZ: Spy49_0125
CDC: CD196_2519(ctfB)
CDL: CDR20291_2566(ctfB)
CBA: CLB_2791
CBH: CLC_2724
CBY: CLM_3219
CBL: CLK_2239
CBK: CLL_A2132
CBB: CLD_1722
CBT: CLH_1916
CBF: CLI_2898
CBE: Cbei_2653 Cbei_3834
AMT: Amet_4246
AOE: Clos_2360
NTH: Nther_1909
MTU: Rv2503c(scoB) Rv2504c(scoA)
MTC: MT2578(scoB) MT2579(scoA)
MRA: MRA_2529(scoB) MRA_2530(scoA)
MTF: TBFG_12525 TBFG_12526
MTB: TBMG_01467(TBMG_01467.1) TBMG_01468(TBMG_01468.1)
MBO: Mb2531c(scoB) Mb2532c(scoA)
MBB: BCG_2523c(scoB) BCG_2524c(scoA)
MBT: JTY_2517(scoB) JTY_2518(scoA)
MPA: MAP3861(scoB)
MAV: MAV_4786
MSM: MSMEG_1898 MSMEG_1899
MUL: MUL_3781(scoB) MUL_3782(scoA)
MVA: Mvan_4892 Mvan_4893
MGI: Mflv_1349 Mflv_1350
MMC: Mmcs_1368 Mmcs_1369
MKM: Mkms_1386 Mkms_1387
MJL: Mjls_1402 Mjls_1403
MMI: MMAR_3850(scoB) MMAR_3851(scoA)
CGL: NCgl2306(cgl2389) NCgl2307(cgl2390)
CGB: cg2622(scoB) cg2623(scoA)
CGT: cgR_2271 cgR_2272
CEF: CE0326 CE1268 CE1269 CE2292 CE2293
CJK: jk1544(scoB) jk1545(scoA)
RHA: RHA1_ro01333(pcaJ1) RHA1_ro01334(pcaI) RHA1_ro03780(pcaJ2)
RHA1_ro03781(pcaI1) RHA1_ro03893(pcaJ3) RHA1_ro03894(pcaI2)
RER: RER_12080 RER_12090 RER_52840(pcaJ) RER_52850(pcaI)
ROP: ROP_10490(pcaJ) ROP_10500(pcaI) ROP_37630(scoB) ROP_37640(scoA)
GBR: Gbro_4163 Gbro_4164
SCO: SCO6702(pcaJ) SCO6703(pcaI)
SMA: SAV_1700(scoA) SAV_1701(scoB)
SGR: SGR_1191 SGR_1192
ART: Arth_0490 Arth_0491 Arth_1388 Arth_1389
AAU: AAur_0471 AAur_0472 AAur_1531 AAur_1532
ACH: Achl_0647 Achl_0649 Achl_1406 Achl_1407
RSA: RSal33209_0553 RSal33209_0554
KRH: KRH_02340(scoA) KRH_02350(scoB)
MLU: Mlut_07610 Mlut_07620
BCV: Bcav_3846 Bcav_3847
KSE: Ksed_08490 Ksed_08500
XCE: Xcel_2105 Xcel_2106
NCA: Noca_0330 Noca_0331
TCU: Tcur_2343 Tcur_2344
FRA: Francci3_2503 Francci3_2504
FRE: Franean1_4284 Franean1_4285
FAL: FRAAL2504(atoA) FRAAL2505(atoD) FRAAL3148(scoA) FRAAL3149(atoA)
KRA: Krad_2883
SVI: Svir_07030 Svir_07040 Svir_18930 Svir_18940
CAI: Caci_4891 Caci_4892 Caci_7913
LIL: LA1424(scoA)
ABA: Acid345_1163 Acid345_1164
ACA: ACP_0927 ACP_0929(dxnH)
PGN: PGN_1171
CPI: Cpin_6962 Cpin_6963
PHE: Phep_2917 Phep_2918
GFO: GFO_3238(scoB) GFO_3240(scoA)
FJO: Fjoh_0887 Fjoh_0888
FPS: FP0026(atoD) FP0030(atoA)
FBA: FIC_00873 FIC_00876
RBI: RB2501_06415 RB2501_06425
DRA: DR_A0054 DR_A0067 DR_A0068
DGE: Dgeo_0808 Dgeo_0809 Dgeo_1306
DDR: Deide_14840 Deide_14850 Deide_17100 Deide_1p01290
TLE: Tlet_1555
TME: Tmel_1135
TAF: THA_1441
FNO: Fnod_0211
PMO: Pmob_1076
KOL: Kole_0596
NPH: NP6032A NP6034A
 |
|---|
| Structures |
PDB: 1M3E 1O9L 1OOY 1OOZ 1OPE 2NRB 2NRC 3CDK 3DLX |
|---|
Reference
Authors
Title
Journal
|
1
Hersh, L.B. and Jencks, W.P.
Coenzyme A transferase. Kinetics and exchange reactions.
J. Biol. Chem. 242 (1967) 3468-3480. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13115439]
LYNEN F, OCHOA S.
Enzymes of fatty acid metabolism.
Biochim. Biophys. Acta. 12 (1953) 299-314.
Clostridiurn kluyveri |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13769479]
MENON GK, STERN JR.
Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl
coenzyme A.
J. Biol. Chem. 235 (1960) 3393-8.
Sus scofa [GN:ssc] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13345795]
STERN JR, COON MJ, DEL CAMPILLO A, SCHNEIDER MC.
Enzymes of fatty acid metabolism. IV. Preparation and properties
of coenzyme A transferase.
J. Biol. Chem. 221 (1956) 15-31.
Sus scofa [GN:ssc] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.8.3.5
IUBMB Enzyme Nomenclature: 2.8.3.5
ExPASy - ENZYME nomenclature database: 2.8.3.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.8.3.5
BRENDA, the Enzyme Database: 2.8.3.5
CAS: 9027-43-4 |
|---|
