| Entry |
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| Name |
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase;
MMPSepSecS;
SepSecS;
SLA/LP;
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase;
O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
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| Class |
Transferases;
Transferring selenium-containing groups;
Selenotransferases
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| Sysname |
selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase
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| Reaction(IUBMB) |
O-phospho-L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate [RN: R08224]
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| Reaction(KEGG) |
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| Substrate |
O-phospho-L-seryl-tRNASec;
selenophosphate [CPD: C05172]
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| Product |
L-selenocysteinyl-tRNA(Sec) [CPD: C06482];
phosphate [CPD: C00009]
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| Comment |
A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.
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| Pathway |
| Selenocompound metabolism | | Aminoacyl-tRNA biosynthesis |
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| Orthology |
| O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | CRE: | | VCN: | | OLU: | | OTA: | | CME: | | NGR: | | DDI: | | DPP: | | PFA: | | PFD: | | PFH: | | PYO: | | PCB: | | PBE: | | PKN: | | PVX: | | PCY: | | TGO: | | TET: | | PTM: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | PTI: | | TPS: | | PIF: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MAE: | | MVN: | | MVO: | | MOK: | | MKA: | |
» show all
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| Reference |
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| Authors |
Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M |
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| Title |
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. |
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| Journal |
Science. 325 (2009) 321-5. |
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| Organism |
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| Reference |
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| Authors |
Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Soll D, Nureki O |
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| Title |
Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation. |
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| Journal |
Nucleic. Acids. Res. 36 (2008) 1187-99. |
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| Organism |
Methanococcus maripaludis |
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| Reference |
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| Authors |
Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Soll D, Schneider A |
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| Title |
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes. |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 5088-92. |
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| Organism |
Trypanosoma brucei [GN: tbr] |
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| Reference |
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| Authors |
Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D |
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| Title |
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea. |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 18923-7. |
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| Organism |
Methanococcus maripaludis |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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