KEGG   ENZYME: 2.9.1.2Help
Entry
EC 2.9.1.2                  Enzyme                                 

Name
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase;
MMPSepSecS;
SepSecS;
SLA/LP;
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase;
O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
Class
Transferases;
Transferring selenium-containing groups;
Selenotransferases
BRITE hierarchy
Sysname
selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase
Reaction(IUBMB)
O-phospho-L-seryl-tRNASec + selenophosphate = L-selenocysteinyl-tRNASec + phosphate [RN:R08224]
Reaction(KEGG)
Substrate
O-phospho-L-seryl-tRNASec;
selenophosphate [CPD:C05172]
Product
L-selenocysteinyl-tRNA(Sec) [CPD:C06482];
phosphate [CPD:C00009]
Comment
A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.
History
EC 2.9.1.2 created 2009
Pathway
Selenocompound metabolism
Aminoacyl-tRNA biosynthesis
Orthology
K03341  
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
Genes
HSA: 
51091(SEPSECS)
PTR: 
461145(SEPSECS)
PPS: 
100992368(SEPSECS)
GGO: 
101136598(SEPSECS)
PON: 
100172631(SEPSECS)
MCC: 
693433(SLA/LP)
MCF: 
102132029(SEPSECS)
MMU: 
211006(Sepsecs)
RNO: 
679383(Sepsecs)
CGE: 
100768289(Sepsecs)
HGL: 
101700995(Sepsecs)
TUP: 
102475263(SEPSECS)
CFA: 
488852(SEPSECS)
AML: 
FCA: 
101081043(SEPSECS)
PTG: 
102960465(SEPSECS)
BTA: 
518874(SEPSECS)
BOM: 
102277118(SEPSECS)
PHD: 
102344893(SEPSECS)
CHX: 
102170038(SEPSECS)
SSC: 
CFR: 
102508284(SEPSECS)
BACU: 
103004348(SEPSECS)
LVE: 
103075038(SEPSECS)
ECB: 
100067546(SEPSECS)
MYB: 
102249462(SEPSECS)
MYD: 
102770020(SEPSECS)
PALE: 
102878761(SEPSECS)
MDO: 
100011061(SEPSECS)
SHR: 
100929347(SEPSECS)
GGA: 
422808(SEPSECS)
MGP: 
100541247(SEPSECS)
TGU: 
100229507(SEPSECS)
FAB: 
101807497(SEPSECS)
PHI: 
102111984(SEPSECS)
APLA: 
101805269(SEPSECS)
FPG: 
101923091(SEPSECS)
FCH: 
102046928(SEPSECS)
CLV: 
102084644(SEPSECS)
ASN: 
102371649(SEPSECS)
AMJ: 
102573860(SEPSECS)
PSS: 
102445712(SEPSECS)
CMY: 
102944820(SEPSECS)
ACS: 
100565997(sepsecs)
PBI: 
103065916(SEPSECS)
XLA: 
100101304(sepsecs)
XTR: 
448354(sepsecs)
DRE: 
393123(sepsecs)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102364035(SEPSECS)
CMK: 
103175827(sepsecs)
CIN: 
SPU: 
575747(sepsecs)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
552745(GB10166)
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG09712(Cbr-secs-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
VCN: 
OLU: 
OTA: 
MIS: 
MICPUN_56124(SEPSECS)
MPP: 
BPG: 
CSL: 
CVR: 
CME: 
GSL: 
DDI: 
DDB_G0280197(sepsecs)
DPP: 
DFA: 
DFA_01728(sepsecs)
ACAN: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
PIF: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MKA: 
 » show all
Taxonomy
Reference
1  [PMID:19608919]
  Authors
Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M
  Title
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
  Journal
Science. 325 (2009) 321-5.
  Organism
Homo sapiens
  Sequence
[hsa:51091]
Reference
2  [PMID:18158303]
  Authors
Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Soll D, Nureki O
  Title
Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation.
  Journal
Nucleic. Acids. Res. 36 (2008) 1187-99.
  Organism
Methanococcus maripaludis
  Sequence
[mmp:MMP0595]
Reference
3  [PMID:19279205]
  Authors
Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Soll D, Schneider A
  Title
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 5088-92.
  Organism
Trypanosoma brucei
Reference
4  [PMID:17142313]
  Authors
Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D
  Title
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and  archaea.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 18923-7.
  Organism
Homo sapiens, Methanococcus maripaludis, Methanocaldococcus jannaschii
  Sequence
[hsa:51091] [mmp:MMP0595] [mja:MJ_0610]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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