| Entry |
|
|---|
| Name |
gluconolactonase;
lactonase;
aldonolactonase;
glucono-delta-lactonase;
gulonolactonase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
 |
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| Sysname |
D-glucono-1,5-lactone lactonohydrolase |
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| Reaction(IUBMB) |
D-glucono-1,5-lactone + H2O = D-gluconate [RN:R01519] |
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| Reaction(KEGG) |
R01519;
(other) R02933 R03751 R04785
 |
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| Substrate |
D-glucono-1,5-lactone [CPD:C00198];
H2O [CPD:C00001] |
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| Product |
D-gluconate [CPD:C00257] |
|---|
| Comment |
Acts on a wide range of hexose-1,5-lactones. The hydrolysis of
L-gulono-1,5-lactone was previously listed separately. |
|---|
| Pathway |
PATH: ec00030 Pentose phosphate pathway
PATH: ec00053 Ascorbate and aldarate metabolism
PATH: ec00930 Caprolactam degradation
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01053 gluconolactonase |
|---|
| Genes |
PIC: PICST_28583(CGR1)
NCR: NCU01866
MGR: MGG_05984 MGG_09681
ANI: AN8977.2
AFM: AFUA_1G08990 AFUA_1G11330
AOR: AO090701000487
ANG: An10g00900
UMA: UM05603.1
TBR: Tb11.02.4200
TCR: 503713.30 503945.40
LMA: LmjF26.2700
PCT: PC1_3691
ETA: ETA_33580
ENT: Ent638_3078
KPN: KPN_03982
KPE: KPK_0112
KPU: KP1_5335
SPE: Spro_3932
HSO: HS_0766
PMU: PM1248
MSU: MS0684
APL: APL_1565
XFA: XF1297
XFT: PD0548
XFM: Xfasm12_0622
XFN: XfasM23_0573
XCC: XCC3591(GNL) XCC4113(gnl)
XCB: XC_0553 XC_4205
XCA: xccb100_0569(gnl1) xccb100_4320(gnl3)
XCV: XCV0577(gnl) XCV4353(gnl1)
XAC: XAC0548(GNL) XAC4248(gnl)
XOO: XOO4276(gnl)
XOM: XOO_4033
PST: PSPTO_1345(gnl) PSPTO_2470
PSB: Psyr_0764 Psyr_2235
PSP: PSPPH_2952
PFO: Pfl01_2803 Pfl01_3453 Pfl01_4143
PSA: PST_1621(gnl)
ACI: ACIAD2819
PAT: Patl_2641
CSA: Csal_2779
RSO: RS05371(RSp0824)
RPI: Rpic_3985
RPF: Rpic12D_4098
REU: Reut_B4613
REH: H16_A3012(gnl1) H16_B0345(gnl2) H16_B1441(gnl3)
BMA: BMAA0036
BMV: BMASAVP1_1190
BML: BMA10229_1474
BMN: BMA10247_A0046
BPS: BPSS0035
BPM: BURPS1710b_A1542
BPL: BURPS1106A_A0044
BPD: BURPS668_A0058
BCN: Bcen_5466
BCH: Bcen2424_5396
BXE: Bxe_B0611 Bxe_C0908 Bxe_C0969
BPH: Bphy_4442 Bphy_5161
BPY: Bphyt_4278
BBR: BB1048
BPT: Bpet2682
POL: Bpro_4512
AAV: Aave_2596
AJS: Ajs_0165 Ajs_1999
VEI: Veis_1531 Veis_3148
DAC: Daci_0257
VAP: Vapar_3342
HAR: HEAR0216
LCH: Lcho_1111
AZO: azo2341(gnl)
SCL: sce8236(gnl2)
PUB: SAR11_0777(gnl)
MLO: mll4328
MES: Meso_3770
PLA: Plav_2454
SME: SM_b20453 SMa0196
SMD: Smed_5316
ATU: Atu4029
ATC: AGR_L_1647
RET: RHE_CH00852(ypch00282) RHE_CH03704(ypch01327)
RHE_PC00140(ypc00076) RHE_PF00485(ypf00253)
REC: RHECIAT_CH0003978
RLE: RL0914 RL4240 pRL100387 pRL120288
RLT: Rleg2_3486 Rleg2_5734
RLG: Rleg_3774 Rleg_4647
RHI: NGR_b22240(gnl)
BME: BMEI1997
OAN: Oant_3913
BJA: bll2817 bll2956 blr6437
BRA: BRADO1816 BRADO2487 BRADO2582 BRADO3863 BRADO4769 BRADO5762
BRADO6760
BBT: BBta_2136 BBta_2832 BBta_2929 BBta_4803 BBta_6274 BBta_6492
RPA: RPA3624
RPE: RPE_2028
XAU: Xaut_4321
MEX: Mext_0612
MDI: METDI0591(gnl)
MRD: Mrad2831_5439
MET: M446_0609
MPO: Mpop_0588 Mpop_1059
MCH: Mchl_0623
CCR: CC_1224
CCS: CCNA_01282
SIL: SPO2559(gnl) SPOA0241
RDE: RD1_0868(gnl) RD1_3716(gnl)
MMR: Mmar10_2728
ZMO: ZMO1649
SWI: Swit_2303
GOX: GOX1375 GOX1381
ACR: Acry_2591 Acry_2596
RCE: RC1_3591(gnl)
MSM: MSMEG_1274
MMC: Mmcs_2018
MJL: Mjls_2001
SCO: SCO0524(SCF11.04)
AAU: AAur_0566(gnl)
BCV: Bcav_0231
ACE: Acel_0604
KRA: Krad_1491
SEN: SACE_3449 SACE_3789(gnl)
STP: Strop_0658
SAQ: Sare_0633
ABA: Acid345_0646
ACA: ACP_0195(gnl)
SUS: Acid_2801 Acid_3317 Acid_3430 Acid_4422 Acid_4513 Acid_7716
CHU: CHU_3561(pgl)
DFE: Dfer_2426
OTE: Oter_4181
RBA: RB1022 RB12740(gnl) RB3234 RB5577(gnl)
SYG: sync_0856 sync_1920
SYR: SynRCC307_1922
SYX: SynWH7803_0722
NPU: Npun_F1780
RRS: RoseRS_2498
RCA: Rcas_2848
PTO: PTO0907
 |
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| Structures |
PDB: 3CH7 3CSS 3DR2 3E7F 3EB9 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:14353869]
BRODIE AF, LIPMANN F.
Identification of a gluconolactonase.
J. Biol. Chem. 212 (1955) 677-85.
Saccharomyces cerevisiae [GN:sce] |
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Reference
Authors
Title
Journal
|
2
Bublitz, C. and Lehninger, A.L.
The role of aldonolactonase in the conversion of L-gulonate to
L-ascorbate.
Biochim. Biophys. Acta 47 (1961) 288-297. |
|---|
Reference
Authors
Title
Journal
|
3
Suzuki, K., Kawada, M. and Shimazono, N.
Soluble lactonase. Identity of lactonase I and aldonolactonase with
gluconolactonase.
J. Biochem. (Tokyo) 49 (1961) 448-449. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.1.17
IUBMB Enzyme Nomenclature: 3.1.1.17
ExPASy - ENZYME nomenclature database: 3.1.1.17
BRENDA, the Enzyme Database: 3.1.1.17
CAS: 9012-73-1 |
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