| Entry |
|
|---|
| Name |
1,4-lactonase;
gamma-lactonase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
 |
|---|
| Sysname |
1,4-lactone hydroxyacylhydrolase |
|---|
| Reaction(IUBMB) |
a 1,4-lactone + H2O = a 4-hydroxyacid [RN:R03708] |
|---|
| Reaction(KEGG) |
R03708 > R02933 R03034
 |
|---|
| Substrate |
1,4-lactone [CPD:C01770];
H2O [CPD:C00001] |
|---|
| Product |
4-hydroxyacid [CPD:C01991] |
|---|
| Cofactor |
Calcium [CPD:C00076] |
|---|
| Comment |
The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It
does not hydrolyse simple aliphatic esters, acetylcholine, sugar
lactones or substituted aliphatic lactones, e.g.
3-hydroxy-4-butyrolactone; requires Ca2+. |
|---|
| Pathway |
PATH: ec00052 Galactose metabolism
PATH: ec00053 Ascorbate and aldarate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Structures |
PDB: 2DG0 2DG1 2DSO |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4958984]
Fishbein WN, Bessman SP.
Purification and properties of an enzyme in human blood and rat
liver microsomes catalyzing the formation and hydrolysis of
gamma-lactones. I. Tissue localization, stoichiometry, specificity,
distinction from esterase.
J. Biol. Chem. 241 (1966) 4835-41.
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4958985]
Fishbein WN, Bessman SP.
Purification and properties of an enzyme in human blood and rat
liver microsomes catalyzing the formation and hydrolysis of
gamma-lactones. II. Metal ion effects, kinetics, and equilibra.
J. Biol. Chem. 241 (1966) 4842-7.
Homo sapiens [GN:hsa], Rattus norvegicus [GN:rno] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.1.25
IUBMB Enzyme Nomenclature: 3.1.1.25
ExPASy - ENZYME nomenclature database: 3.1.1.25
BRENDA, the Enzyme Database: 3.1.1.25
CAS: 37278-38-9 |
|---|
