KEGG ENZYME: 3.1.1.32

KEGG

ENZYME: 3.1.1.32

Help

Entry

EC 3.1.1.32 Enzyme

Name

phospholipase A1

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

BRITE hierarchy

Sysname

phosphatidylcholine 1-acylhydrolase

Reaction(IUBMB)

phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate [RN:R01314]

Reaction(KEGG)

R01314 > R01316;
(other) R02054 R04034 R07860

Show

Substrate

phosphatidylcholine [CPD:C00157];
H2O [CPD:C00001]

Product

2-acylglycerophosphocholine;
carboxylate [CPD:C00060]

Comment

This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A2. Requires Ca2+.

Pathway

ec00564	Glycerophospholipid metabolism
ec00592	alpha-Linolenic acid metabolism
ec01100	Metabolic pathways

Orthology

K01058	phospholipase A1
K16817	HRAS-like suppressor 3
K16818	phospholipase A1

Genes

HSA:	11145(PLA2G16)
PTR:	451279(PLA2G16)
PPS:	100977983(PLA2G16)
GGO:	101139742(PLA2G16)
PON:	100190820(PLA2G16)
MCC:	722178(PLA2G16)
MMU:	225845(Pla2g16)
RNO:	24913(Pla2g16)
CFA:	476045(PLA2G16)
AML:	100476627
FCA:	101090719(PLA2G16)
BTA:	506802(PLA2G16)
SSC:	100512584(PLA2G16)
ECB:	100049811
SHR:	100932477(PLA2G16)
OAA:	100083387
ACS:	100562853
TRU:	101061653
OLA:	101157546
ATH:	AT2G44810(DAD1)
ALY:	ARALYDRAFT_322142
GMX:	100816744 100817287
MTR:	MTR_7g081620
CSV:	101220804
RCU:	RCOM_1607830
POP:	POPTR_755075 POPTR_918082
VVI:	100242763
DOSA:	Os11t0146600-00(Os11g0146600)
SBI:	SORBI_05g002750(SORBIDRAFT_05g002750)
ECO:	b3821(pldA)
ECJ:	Y75_p3357(pldA)
ECD:	ECDH10B_4012(pldA)
EBW:	BWG_3499(pldA)
ECOK:	ECMDS42_3261(pldA)
ECE:	Z5342(pldA)
ECS:	ECs4751
ECF:	ECH74115_5262(pldA)
ETW:	ECSP_4876(pldA)
ELX:	CDCO157_4489
EOJ:	ECO26_4764(pldA)
EOI:	ECO111_4649(pldA)
EOH:	ECO103_4342(pldA)
ECG:	E2348C_4121(pldA)
EOK:	G2583_4621(pldA)
ELR:	ECO55CA74_22150
ECC:	c4742(pldA)
ECP:	ECP_4015
ECI:	UTI89_C4384(pldA)
ECV:	APECO1_2655(pldA)
ECX:	EcHS_A4045(pldA)
ECW:	EcE24377A_4342(pldA)
ECM:	EcSMS35_4188(pldA)
ECY:	ECSE_4109
ECR:	ECIAI1_4014(pldA)
ECQ:	ECED1_4506(pldA)
ECK:	EC55989_4298(pldA)
ECT:	ECIAI39_3188(pldA)
EOC:	CE10_4471(pldA)
EUM:	ECUMN_4347(pldA)
ECZ:	ECS88_4247(pldA)
ELO:	EC042_4201(pldA)
ELN:	NRG857_18965
ELH:	ETEC_4099
ESE:	ECSF_3660
ESO:	O3O_00585
ESM:	O3M_24670
ESL:	O3K_24750
ECL:	EcolC_4187
EBR:	ECB_03700(pldA)
EBD:	ECBD_4217
EKO:	EKO11_4536
EKF:	KO11_04120(pldA)
EAB:	ECABU_c43030(pldA)
EDH:	EcDH1_4158
EDJ:	ECDH1ME8569_3700(pldA)
EIH:	ECOK1_4271(pldA)
ENA:	ECNA114_4112(pldA)
ELU:	UM146_19240
EUN:	UMNK88_4634
ELW:	ECW_m4123(pldA)
ELL:	WFL_20110(pldA)
ELC:	i14_4336(pldA)
ELD:	i02_4336(pldA)
ELP:	P12B_c3945(pldA)
EBL:	ECD_03700(pldA)
EBE:	B21_03649(pldA)
ELF:	LF82_1669(pldA)
ECOA:	APECO78_22935
EFE:	EFER_3681(pldA)
EBT:	EBL_c37680(pldA)
STY:	STY3602(pldA)
STT:	t3340(pldA)
SEX:	STBHUCCB_35290
STM:	STM3957(pldA)
SEO:	STM14_4760(pldA)
SEV:	STMMW_39281
SEY:	SL1344_3911(pldA)
SEM:	STMDT12_C41060
SEJ:	STMUK_3942(pldA)
SEB:	STM474_4135(pldA)
SEF:	UMN798_4296(pldA)
SETU:	STU288_19945
SPT:	SPA3798(pldA)
SEK:	SSPA3536
SPQ:	SPAB_04910
SEI:	SPC_4064(pldA)
SEC:	SC3856(pldA)
SEH:	SeHA_C4284
SHB:	SU5_066
SEE:	SNSL254_A4237
SEW:	SeSA_A4165
SEA:	SeAg_B4186
SED:	SeD_A4344
SEG:	SG3494(pldA)
SEL:	SPUL_3475(pldA)
SET:	SEN3752(pldA)
SENJ:	CFSAN001992_13900
SES:	SARI_03700
SBG:	SBG_3491(pldA)
YPE:	YPO3834(pldA)
YPK:	y0396(pldA)
YPA:	YPA_0188
YPN:	YPN_0130
YPM:	YP_3214(pldA)
YPP:	YPDSF_3451
YPG:	YpAngola_A0554
YPZ:	YPZ3_3389(pldA)
YPT:	A1122_06670
YPD:	YPD4_3380(pldA)
YPX:	YPD8_3381(pldA)
YPS:	YPTB0201(pldA)
YPI:	YpsIP31758_0217
YPY:	YPK_3999
YPB:	YPTS_0216
YEN:	YE0203(pldA)
YEP:	YE105_C0203
YEY:	Y11_34021
SFL:	SF3899(pldA)
SFX:	S3856(pldA)
SFV:	SFV_3677(pldA)
SFE:	SFxv_4250(pldA)
SSN:	SSON_3995(pldA)
SSJ:	SSON53_22950
SBO:	SBO_3833(pldA)
SBC:	SbBS512_E4288(pldA)
SDY:	SDY_3922(pldA)
ECA:	ECA4173(pldA)
PCT:	PC1_3965
PCC:	PCC21_039510
PWA:	Pecwa_4155
PEC:	W5S_4312
ETA:	ETA_02220(pldA)
EPY:	EpC_02100(pldA)
EPR:	EPYR_00220(pldA)
EAM:	EAMY_0197(pldA3)
EAY:	EAM_0190(pldA)
EBI:	EbC_02200(pldA)
ERJ:	EJP617_14080(pldA)
SGL:	SG2338
ENT:	Ent638_3975
ENC:	ECL_04974
ENO:	ECENHK_21285
ECLO:	ENC_01900
ESC:	Entcl_4216
EEC:	EcWSU1_04360(pldA)
ENL:	A3UG_22070
EAS:	Entas_4258
EAE:	EAE_07930
EAR:	ST548_p4644
ESA:	ESA_03739
CSK:	ES15_3670(pldA)
CSZ:	CSSP291_17315
CTU:	CTU_02520(pldA)
KPN:	KPN_04316(pldA)
KPU:	KP1_0177(pldA)
KPM:	KPHS_01620
KPP:	A79E_4871
KPE:	KPK_5362(pldA)
KPO:	KPN2242_24580
KVA:	Kvar_4916
KOX:	KOX_07705
CKO:	CKO_00160
CRO:	ROD_39331(pldA)
SPE:	Spro_0192
SRR:	SerAS9_0153
SRS:	SerAS12_0153
SRA:	SerAS13_0152
SMAF:	D781_0166
SMW:	SMWW4_v1c02000(pldA)
PMR:	PMI3344(pldA)
EIC:	NT01EI_0121
ETR:	ETAE_0130(pldA)
ETD:	ETAF_0102
ETC:	ETAC_00500
HDE:	HDEF_1313(pldA)
DDA:	Dd703_0241
DDC:	Dd586_3863
DDD:	Dda3937_00307(pldA)
DZE:	Dd1591_0192
PAM:	PANA_0176(pldA)
PLF:	PANA5342_4251(pldA)
PAJ:	PAJ_3336(pldA)
PAQ:	PAGR_g4102
PVA:	Pvag_3413(pldA)
PAO:	Pat9b_0168
RAH:	Rahaq_4234
RAQ:	Rahaq2_4342
RAA:	Q7S_21530
PSI:	S70_11815
ROR:	RORB6_17800
EBF:	D782_4333
PMU:	PM1426
PMV:	PMCN06_1685(pldA)
PUL:	NT08PM_1740
PMP:	Pmu_16780(pldA)
GAN:	UMN179_01529
XCC:	XCC1420
XCB:	XC_2818
XCA:	xccb100_2878(pldA)
XCV:	XCV1520(pldA)
XCP:	XCR_1692
XAC:	XAC1463
XAX:	XACM_1452(pldA)
XAO:	XAC29_07380
XOO:	XOO2334
XOM:	XOO_2214
XOR:	XOC_3017
XAL:	XALc_1129(pldA)
XCI:	XCAW_02880(pldA)
SML:	Smlt3218
SMT:	Smal_2651
BUJ:	BurJV3_2668
SMZ:	SMD_2796
PSU:	Psesu_1754
PSD:	DSC_09655
FAU:	Fraau_0736
RHD:	R2APBS1_2671
VVU:	VV1_2799
VVY:	VV1466
VVM:	VVMO6_01752
VPA:	VP1260 VPA0788
VPB:	VPBB_A0729
VHA:	VIBHAR_02036 VIBHAR_02841
VEX:	VEA_000246
VFU:	vfu_B01358
VFI:	VF_1556(pldA)
VFM:	VFMJ11_1652
VSA:	VSAL_I1995
PPR:	PBPRA1301
CJA:	CJA_2715
PAR:	Psyc_0231(pldA)
PCR:	Pcryo_0260
PRW:	PsycPRwf_2026
ACI:	ACIAD1354
ACD:	AOLE_08230
ACB:	A1S_1919
ABY:	ABAYE1646
ABC:	ACICU_02030
ABN:	AB57_2255
ABB:	ABBFA_001533
ABX:	ABK1_2497
ABZ:	ABZJ_02212
ABR:	ABTJ_01679
ABD:	ABTW07_2242
ABH:	M3Q_2377
ABAD:	ABD1_19410
ACC:	BDGL_001400(pldA)
MCT:	MCR_1385
SDN:	Sden_0955
SFR:	Sfri_3189
SAZ:	Sama_2893
SBL:	Sbal_3410
SBM:	Shew185_0926
SBN:	Sbal195_0960
SBP:	Sbal223_0952
SBT:	Sbal678_0987
SBS:	Sbal117_3550
SBB:	Sbal175_0956
SLO:	Shew_0671
SPC:	Sputcn32_3045
SHP:	Sput200_3154
SSE:	Ssed_0681
SPL:	Spea_0661 Spea_2290
SHE:	Shewmr4_3074
SHM:	Shewmr7_0898
SHN:	Shewana3_0861
SHW:	Sputw3181_0900
SHL:	Shal_2004 Shal_3535
SWD:	Swoo_0786
SWP:	swp_4060
SVO:	SVI_3510(pldA)
ILO:	IL2489
CPS:	CPS_1960(pldA)
PHA:	PSHAa0175(pldA)
PAT:	Patl_2081
PSM:	PSM_A0193(pldA)
MAQ:	Maqu_0459 Maqu_0625
MHC:	MARHY0367
MAD:	HP15_210
MBS:	MRBBS_0471
AMC:	MADE_1005285 MADE_1012790
AMAC:	MASE_12760
AMB:	AMBAS45_13295
AMG:	AMEC673_13075
AMK:	AMBLS11_12780
AMAA:	amad1_13690
ALT:	ambt_04025 ambt_18045
GAG:	Glaag_2180
GNI:	GNIT_1039(pldA)
GPS:	C427_0773
PIN:	Ping_3493
FBL:	Fbal_2460
CBU:	CBU_0489
CBS:	COXBURSA331_A0598
CBD:	CBUD_1587
CBG:	CbuG_1524
CBC:	CbuK_1371
TCX:	Tcr_0489
MEJ:	Q7A_509
MEC:	Q7C_2104
CYQ:	Q91_2165
TVI:	Thivi_1372
HNA:	Hneap_1437
HCH:	HCH_01113 HCH_05407
CSA:	Csal_1446
HEL:	HELO_2044(pldA)
ABO:	ABO_2104(pldA)
ADI:	B5T_00921(pldA)
KKO:	Kkor_0588
MMW:	Mmwyl1_3291
MME:	Marme_1309
MPC:	Mar181_0942
TOL:	TOL_2367
SAGA:	M5M_11110
NMA:	NMA2021
NME:	NMB0464
NMP:	NMBB_391
NMH:	NMBH4476_0457
NMN:	NMCC_1678
NMT:	NMV_0510
NMI:	NMO_1578
NMD:	NMBG2136_1636
NMM:	NMBM01240149_1626
NMS:	NMBM01240355_0472
NMW:	NMAA_1476
NMZ:	NMBNZ0533_1787(pldA)
NGO:	NGO1492
NGK:	NGK_1764
NGT:	NGTW08_1388
NLA:	NLA_5020(pldA)
LHK:	LHK_00790
PSE:	NH8B_0720
RFR:	Rfer_0525
POL:	Bpro_4284
PNA:	Pnap_0350
AAV:	Aave_4476
AJS:	Ajs_3867
DIA:	Dtpsy_3140
AAA:	Acav_4372
ACK:	C380_21610
VEI:	Veis_0598
DAC:	Daci_0552
DEL:	DelCs14_0496
VAP:	Vapar_0719
VPE:	Varpa_0738
CTT:	CtCNB1_0398
ADN:	Alide_3926
ADK:	Alide2_4271
RTA:	Rta_04060
MPT:	Mpe_A3505
CFU:	CFU_1369(pldA)
RGE:	RGE_10060(pldA)
DAR:	Daro_2090
TBD:	Tbd_0096
MEH:	M301_0416
GCA:	Galf_2495
HPY:	HP0499
HEO:	C694_02565
HPA:	HPAG1_0475
HPS:	HPSH_04420
HHP:	HPSH112_04550
HHQ:	HPSH169_02570
HHR:	HPSH417_02380
HPP:	HPP12_0507(pldA)
HPL:	HPB8_684(pldA)
HPC:	HPPC_02460
HCA:	HPPC18_02380
HPM:	HPSJM_02500
HPE:	HPELS_04365
HPO:	HMPREF4655_21105(pldA)
HPI:	hp908_0497
HPQ:	hp2017_0478
HPW:	hp2018_0480
HEF:	HPF16_0854(pldA)
HPF:	HPF30_0822(pldA)
HEQ:	HPF32_0480(pldA) HPF32_0481(pldA)
HEX:	HPF57_0530(pldA) HPF57_0531(pldA)
HPT:	HPSAT_04265
HPZ:	HPKB_0838
HPX:	HMPREF0462_0920(pldA)
HEN:	HPSNT_02570
HPH:	HPLT_02470
HPN:	HPIN_04400
HEP:	HPPN120_02425
HEU:	HPPN135_02450
HES:	HPSA_02410
HCN:	HPB14_04215
HEY:	MWE_1025
HER:	C695_02565
HEI:	C730_02565
HPYA:	HPAKL117_02500
HPYO:	HPOK113_0483
HPYL:	HPOK310_0826 HPOK310_0827
HHE:	HH0853(pldA)
HAC:	Hac_0820(pldA)
HFE:	HFELIS_02840
HBI:	HBZC1_15560
HCE:	HCW_03880
HCM:	HCD_01535
HCP:	HCN_1709(pldA)
HCB:	HCBAA847_1946(pldA)
WSU:	WS0018(PLDA)
TDN:	Suden_0016
SUA:	Saut_1409
SKU:	Sulku_2659
CJE:	Cj1351(pldA)
CJB:	BN148_1351(pldA)
CJJ:	CJJ81176_1350(pldA)
CJU:	C8J_1267(pldA)
CJN:	ICDCCJ_1283
CJI:	CJSA_1286(pldA)
CJM:	CJM1_1309(pldA)
CJS:	CJS3_1446(pldA)
CJP:	A911_06565
CJR:	CJE1540(pldA)
CFF:	CFF8240_0197
CCV:	CCV52592_0610
CHA:	CHAB381_0126
CCO:	CCC13826_2191
ABU:	Abu_0861(pldA)
ABT:	ABED_0784
ANT:	Arnit_2161
ARC:	ABLL_1084
SDL:	Sdel_2263
SBA:	Sulba_2527
GLO:	Glov_3432
DPR:	Despr_1842
DAT:	HRM2_10340(pldA)
PDI:	BDI_0074
OSP:	Odosp_0397
TFO:	BFO_2191
SHG:	Sph21_4465
CMR:	Cycma_4200
CHU:	CHU_0769(pldA)
FAE:	FAES_2810(pldA)
GFO:	GFO_0043
FJO:	Fjoh_4607
COC:	Coch_2175
CCM:	Ccan_17890
ZPR:	ZPR_0295
CAO:	Celal_3085
KDI:	Krodi_2626
LAN:	Lacal_2817
ZGA:	zobellia_3566(pldA)
ASL:	Aeqsu_1958
PTQ:	P700755_000039

Taxonomy

Reference

1 [PMID:5657461]

Authors

Gatt S.

Title

Purification and properties of phospholipase A-1 from rat and calf brain.

Journal

Biochim. Biophys. Acta. 159 (1968) 304-16.

Organism

Rattus norvegicus [GN:rno], Bos taurus [GN:bta]

Reference

2 [PMID:4946924]

Authors

Scandella CJ, Kornberg A.

Title

A membrane-bound phospholipase A1 purified from Escherichia coli.

Journal

Biochemistry. 10 (1971) 4447-56.

Organism

Escherichia coli [GN:eco]

Reference

3 [PMID:6252969]

Authors

van den Bosch H.

Title

Intracellular phospholipases A.

Journal

Biochim. Biophys. Acta. 604 (1980) 191-246.

Organism

Escherichia coli [GN:eco], Mycobacterium phlei

Reference

4 [PMID:4858811]

Authors

van den Bosch H, Aarsman AJ, van Deenen LL.

Title

Isolation and properties of a phospholipase A1 activity from beef pancreas.

Journal

Biochim. Biophys. Acta. 348 (1974) 197-209.

Organism

Bos taurus [GN:bta]

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

CAS:

9043-29-2

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (11)   
   KEGG PATHWAY (11)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (29)   
   KEGG ENZYME (2)   
   KEGG REACTION (12)   
   KEGG RPAIR (11)   
   KEGG RCLASS (4)   
Genome (3)   
   KEGG GENOME (3)   
Gene (5296)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (479)   
   KEGG DGENES (5)   
   KEGG EGENES (3)   
   KEGG MGENES (4806)   
Protein sequence (1469)   
   UniProt (721)   
   PRF (30)   
   RefSeq(pep) (703)   
   PDBSTR (12)   
   PMD (3)   
DNA sequence (1138)   
   RefSeq(nuc) (703)   
   GenBank (217)   
   EMBL (218)   
3D Structure (8)   
   PDB (8)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
Literature (4)   
   PubMed (4)   
Enzyme (4)   
   BRENDA (1)   
   EXPASY-ENZYME (1)   
   EXPLORENZ (1)   
   IUBMB (1)   
All databases (7977)   

Download RDF

DBGET integrated database retrieval system