| Entry |
|
|---|
| Name |
lysophospholipase;
lecithinase B;
lysolecithinase;
phospholipase B;
lysophosphatidase;
lecitholipase;
phosphatidase B;
lysophosphatidylcholine hydrolase;
lysophospholipase A1;
lysophopholipase L2;
lysophospholipase transacylase;
neuropathy target esterase;
NTE;
NTE-LysoPLA;
NTE-lysophospholipase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
 |
|---|
| Sysname |
2-lysophosphatidylcholine acylhydrolase |
|---|
| Reaction(IUBMB) |
2-lysophosphatidylcholine + H2O = glycerophosphocholine + a
carboxylate [RN:R07291] |
|---|
| Reaction(KEGG) |
R07291;
(other) R01309 R02744 R02746 R02747 R03416 R03417
 |
|---|
| Substrate |
2-lysophosphatidylcholine [CPD:C04230];
H2O [CPD:C00001] |
|---|
| Product |
glycerophosphocholine [CPD:C00670];
carboxylate [CPD:C00060] |
|---|
| Pathway |
PATH: ec00564 Glycerophospholipid metabolism |
|---|
| Orthology |
KO: K01048 lysophospholipase
KO: K06128 lysophospholipase I
KO: K06129 lysophospholipase III
KO: K06130 lysophospholipase II
KO: K10804 acyl-CoA thioesterase I
KO: K13278 60kDa lysophospholipase
KO: K13333 lysophospholipase
KO: K13334 eosinophil lysophospholipase (galectin-10) |
|---|
| Genes |
HSA: 10434(LYPLA1) 11313(LYPLA2) 1178(CLC) 23659(PLA2G15)
374569(ASPG)
PTR: 453196(ASPG) 454188(PLA2G15) 464177(LYPLA1) 749332(LYPLA2)
MCC: 693700(LYPLA1) 699418 702619(PLA2G15) 719074
MMU: 104816(Aspg) 18777(Lypla1) 192654(Pla2g15) 26394(Lypla2)
RNO: 246266(Aspg) 25514(Lypla1) 361401(Pla2g15) 83510(Lypla2)
CFA: 403403(PLA2G15) 487374(LYPLA2) 609018(LYPLA1) 612664
BTA: 282271(PLA2G15) 505486(ASPG) 539992(LYPLA1) 784764(LYPLA2)
SSC: 100152491
ECB: 100053908 100071559
MDO: 100020616 100022408 100022867
OAA: 100077550
GGA: 419685(LYPLA2) 768530(LYPLA3) 772201
TGU: 100221749 100224059 100225756 100228600
XLA: 379246(MGC52664) 734415
XTR: 100145621 394905
DRE: 100124594 335008(pla2g15) 393722
BFO: BRAFLDRAFT_230181
CIN: 100178412
SPU: 588190
DME: Dmel_CG18815 Dmel_CG31683 Dmel_CG6428
DPO: Dpse_GA15093 Dpse_GA15103 Dpse_GA19585
DAN: Dana_GF19463(Dana_lyso)
DER: Dere_GG18566
DPE: Dper_GL14545
DSE: Dsec_GM12708
DSI: Dsim_GD18651
DYA: Dyak_GE16877
DGR: Dgri_GH24648
DMO: Dmoj_GI21703
AGA: AgaP_AGAP002397 AgaP_AGAP008990
AAG: AaeL_AAEL002796 AaeL_AAEL009539 AaeL_AAEL013170
CQU: CpipJ_CPIJ008683
AME: 409201 551548 552091
NVI: 100115096
TCA: 654991 657690 659399
API: 100164179
CEL: C27A7.5(asparaginase) M05B5.4
CBR: CBG21934 CBG23394
BMY: Bm1_48320 Bm1_50405
SMM: Smp_153810
NVE: NEMVE_v1g192479 NEMVE_v1g230518 NEMVE_v1g83566
HMG: 100215832
TAD: TRIADDRAFT_30040
OSA: 4337344(Os04g0669500)
OLU: OSTLU_32853
SCE: YMR006C(PLB2) YMR008C(PLB1) YOL011W(PLB3)
KLA: KLLA0C05940g
LTH: KLTH0C10670g
DHA: DEHA0E05522g
PIC: PICST_48846(PLB6) PICST_81360(PLB4) PICST_82807(PLB1)
PPA: PAS_chr4_0153
VPO: Kpol_1037p12
LEL: LELG_05352
ZRO: ZYRO0C07238g
CAL: CaO19.689(PLB1)
CTP: CTRG_01230 CTRG_02894 CTRG_05889
CDU: CD36_16240 CD36_34860 CD36_62110(PLB1) CD36_62120(PLB2)
CGR: CAGL0J11748g CAGL0J11770g
YLI: YALI0E16060g
SPO: SPAC1786.02 SPAC1A6.03c SPAC1A6.04c(plb1) SPAC977.09c
SPCC1450.09c
NCR: NCU03141 NCU03768
PAN: PODANSg5850 PODANSg9008
MGR: MGG_04017 MGG_07287
FGR: FG02073.1 FG03875.1 FG07410.1
ANI: AN1675.2
AFM: AFUA_3G14680 AFUA_4G08720 AFUA_5G01340 AFUA_5G02930
AOR: AO090023000685 AO090102000492 AO090701000473
ANG: An04g03590 An09g01240 An09g04950
AFV: AFLA_005640 AFLA_059410 AFLA_110960
PCS: Pc18g02900(plb1) Pc21g16610
NFI: NFIA_039170 NFIA_040760 NFIA_062570 NFIA_107440
CIM: CIMG_06486 CIMG_08300
URE: UREG_02479 UREG_03935
SSL: SS1G_04530 SS1G_06458
BFU: BC1G_00376 BC1G_05610
CNE: CNF02430 CNM00920
CNB: CNBM0810
LBC: LACBIDRAFT_244034
UMA: UM00130.1 UM01007.1 UM01035.1
MGL: MGL_2589
DDI: DDB_0234150
TET: TTHERM_00483700
PTM: GSPATT00024733001
TBR: Tb927.8.6390
TCR: 511907.50
LMA: LmjF24.1840
ECO: b0494(tesA) b3825(pldB)
ECJ: JW0483(tesA) JW5584(pldB)
ECD: ECDH10B_0451(tesA) ECDH10B_4016(pldB)
EBW: BWG_0375(tesA) BWG_3503(pldB)
ECE: Z0647(tesA) Z5346(pldB)
ECS: ECs0558 ECs4755
ECF: ECH74115_0598(tesA) ECH74115_5266(pldB)
ETW: ECSP_0571(tesA) ECSP_4880(pldB)
ECG: E2348C_0433(tesA) E2348C_4126(pldB)
ECC: c0615(tesA) c4747(pldB)
ECI: UTI89_C0529(tesA) UTI89_C4389(pldB)
ECP: ECP_0560 ECP_4019
ECV: APECO1_1515(tesA) APECO1_2651(pldB)
ECW: EcE24377A_0533(tesA) EcE24377A_4346(pldB)
ECX: EcHS_A0574(tesA) EcHS_A4049(pldB)
ECM: EcSMS35_0543(tesA) EcSMS35_4192(pldB)
ECY: ECSE_0520 ECSE_4113
ECL: EcolC_3122 EcolC_4183
ECK: EC55989_0507(tesA) EC55989_4302(pldB)
ECQ: ECED1_0521(tesA) ECED1_4510(pldB)
ECR: ECIAI1_0497(tesA) ECIAI1_4020(pldB)
ECT: ECIAI39_3184(pldB)
ECZ: ECS88_0499(tesA) ECS88_4253(pldB)
EUM: ECUMN_0541(tesA) ECUMN_4351(pldB)
ELF: LF82_1670(pldB) LF82_2242(tesA)
EBL: B21_00450(tesA) B21_03653(pldB)
EBD: ECBD_3162 ECBD_4213
EBR: ECB_00445(tesA) ECB_03704(pldB)
EOH: ECO103_0470(tesA) ECO103_4338(pldB)
EOI: ECO111_0529(tesA) ECO111_4653(pldB)
EOJ: ECO26_0529(tesA) ECO26_4760(pldB)
EFE: EFER_0552(tesA) EFER_3675(pldB)
STY: STY0552(tesA) STY3598(pldB)
STT: t2353(tesA) t3336(pldB)
SPT: SPA2216(tesA) SPA3802(pldB)
SEK: SSPA2060 SSPA3540
SPQ: SPAB_03059 SPAB_04914
SEI: SPC_0521(tesA) SPC_4068(pldB)
SEC: SC0547(tesA) SC3860(pldB)
SEH: SeHA_C0615 SeHA_C4288(pldB)
SEE: SNSL254_A0561 SNSL254_A4241(pldB)
SEW: SeSA_A0571 SeSA_A4169(pldB)
SEA: SeAg_B0554 SeAg_B4190(pldB)
SED: SeD_A0556 SeD_A4348(pldB)
SEG: SG0517(tesA) SG3490(pldB)
SET: SEN0487(tesA) SEN3756(pldB)
SES: SARI_02427 SARI_03696
STM: STM0506(tesA) STM3961(pldB)
YPE: YPO3080(tesA) YPO3830(pldB)
YPK: y0400(pldB) y1099(tesA)
YPM: YP_0844(tesA) YP_3218(pldB2)
YPA: YPA_0192 YPA_2575
YPN: YPN_0134 YPN_1009
YPG: YpAngola_A0558(pldB) YpAngola_A1271
YPP: YPDSF_2718 YPDSF_3447
YPS: YPTB0205(pldB) YPTB1028(tesA)
YPI: YpsIP31758_0221(pldB) YpsIP31758_3021
YPY: YPK_3159 YPK_3995
YPB: YPTS_0220 YPTS_1076
YEN: YE0207(pldB) YE3055(apeA)
SFL: SF3903(pldB)
SFX: S3852(pldB)
SFV: SFV_3673(pldB)
SSN: SSON_0484(tesA) SSON_3999(pldB)
SBO: SBO_0397(tesA) SBO_3837(pldB)
SBC: SbBS512_E0429(tesA) SbBS512_E4292(pldB)
SDY: SDY_0404(tesA) SDY_3918(pldB)
ECA: ECA1222(tesA) ECA4169(pldB)
PCT: PC1_1122 PC1_3961
PWA: Pecwa_3193 Pecwa_4151
ETA: ETA_02250(pldB) ETA_24460(tesA)
PLU: plu3818(tesA) plu4619(pldB)
PAY: PAU_00982(tesA) PAU_04110(pldB)
ENT: Ent638_0968 Ent638_3971
ESA: ESA_02772 ESA_03735
CTU: Ctu_02560(pldB) Ctu_11000(tesA)
KPN: KPN_00472(tesA) KPN_04321(pldB)
KPE: KPK_4208(tesA) KPK_5357(pldB)
KPU: KP1_0182(pldB) KP1_1352(tesA)
CKO: CKO_00166 CKO_02646
SPE: Spro_0196 Spro_1157
PMR: PMI2167(tesA) PMI3346(pldB)
EIC: NT01EI_3015 NT01EI_3719
ETR: ETAE_2704 ETAE_3343
DDA: Dd703_0245 Dd703_1054
DDC: Dd586_1095 Dd586_3859
DZE: Dd1591_0196 Dd1591_3005
HIN: HI0645(pldB)
HIT: NTHI0764(pldB)
HIP: CGSHiEE_08985
HSO: HS_0775(pldB)
HSM: HSM_1242
PMU: PM1631(pldB)
MSU: MS0004(pldB)
ASU: Asuc_0277
XCC: XCC0778(tesA)
XCB: XC_3453
XCA: xccb100_3574(tesA)
XCV: XCV0886
XAC: XAC0833(tesA)
XOO: XOO3764(tesA)
XOM: XOO_3553
XOP: PXO_04660
SML: Smlt0800
SMT: Smal_0651
VCH: VC0135 VCA0783
VCO: VC0395_0724 VC0395_A2385(lypA)
VCM: VCM66_0135(lypA) VCM66_A0742
VCJ: VCD_000539 VCD_001594
VVU: VV1_1137 VV2_0266
VVY: VV0096 VVA0773
VPA: VP2974 VPA0872
VHA: VIBHAR_00300 VIBHAR_05801
VSP: VS_3037 VS_II0759
VEX: VEA_000168
VFI: VF_2481(pldB) VF_A1044(tesA)
VFM: VFMJ11_2604 VFMJ11_A1165
VSA: VSAL_I2931 VSAL_II0285
PPR: PBPRA0137 PBPRA2816 PBPRB1931
PAE: PA2856(tesA)
PAU: PA14_27160(tesA)
PAP: PSPA7_2298(tesA)
PAG: PLES_22081(tesA)
PPU: PP_2318
PPF: Pput_3451
PPG: PputGB1_1920
PPW: PputW619_1760
PST: PSPTO_2268
PSB: Psyr_2068
PSP: PSPPH_2039
PFL: PFL_4278
PFO: Pfl01_4014
PFS: PFLU1699
PEN: PSEEN1886
PMY: Pmen_2558
PSA: PST_2020(tesA)
CJA: CJA_1615(tesA)
AVN: Avin_23070
ACI: ACIAD1057(tesA)
ACB: A1S_0985
ABM: ABSDF2417(tesA)
ABY: ABAYE2808(tesA)
ABC: ACICU_00946
ABN: AB57_1064
ABB: ABBFA_002625
SON: SO_2928 SO_4733(lypA)
SDN: Sden_2368 Sden_3669
SFR: Sfri_0039 Sfri_2568
SAZ: Sama_0083 Sama_1485
SBL: Sbal_0044 Sbal_2688
SBM: Shew185_2709 Shew185_4354
SBN: Sbal195_2785 Sbal195_4496
SBP: Sbal223_1678 Sbal223_4299
SLO: Shew_2403 Shew_3723
SPC: Sputcn32_2392 Sputcn32_3916
SSE: Ssed_0088 Ssed_1696
SPL: Spea_0094 Spea_1660
SHE: Shewmr4_1478 Shewmr4_3914
SHM: Shewmr7_1543 Shewmr7_4006
SHN: Shewana3_1537 Shewana3_4119
SHW: Sputw3181_0036 Sputw3181_1616
SHL: Shal_2605 Shal_4228
SWD: Swoo_2898
SWP: swp_1940 swp_5081
ILO: IL1768(tesA) IL2432(pldB)
CPS: CPS_2308 CPS_4384(pldB)
PHA: PSHAa0373 PSHAa1880(apeA)
PAT: Patl_0989 Patl_2914
SDE: Sde_3444
MAQ: Maqu_1044
AMC: MADE_02304
PIN: Ping_2959 Ping_3290
TTU: TERTU_1706
MCA: MCA1401
TCX: Tcr_0549
NOC: Noc_0429
AEH: Mlg_2409
HHA: Hhal_2068
TGR: Tgr7_2116
HNA: Hneap_0010
HCH: HCH_01539(pldB) HCH_04953(tesA)
CSA: Csal_2620
ABO: ABO_1400(tesA)
MMW: Mmwyl1_2207
AHA: AHA_0036 AHA_3489
ASA: ASA_0032(lypA) ASA_0828(tesA)
TAU: Tola_0872
KKO: Kkor_0790
CVI: CV_3735(tesA)
LHK: LHK_02196(tesA)
RSO: RSc1717
RPI: Rpic_1863
RPF: Rpic12D_1530
REU: Reut_A1384
REH: H16_A1500 H16_A3666(pldB)
RME: Rmet_1881
CTI: RALTA_A1439(tesA)
BMA: BMA1451(tesA)
BMV: BMASAVP1_A1944
BML: BMA10229_A3360(tesA)
BMN: BMA10247_1219
BPS: BPSL1411
BPM: BURPS1710b_2468(tesA)
BPL: BURPS1106A_2349
BPD: BURPS668_2311
BPR: GBP346_A2419
BTE: BTH_I2130
BVI: Bcep1808_1851
BUR: Bcep18194_A5220
BCN: Bcen_6160
BCH: Bcen2424_1919
BCM: Bcenmc03_1942
BCJ: BCAL1992
BAM: Bamb_1907
BAC: BamMC406_1837
BMU: Bmul_1355
BMJ: BMULJ_01888
BXE: Bxe_A2289
BPH: Bphy_1017
BPY: Bphyt_1912
BGL: bglu_1g13570
PNU: Pnuc_0938
PNE: Pnec_0904
BPE: BP1733(tesA)
BPA: BPP3043(tesA)
BBR: BB3006(tesA)
BPT: Bpet2220(tesA)
BAV: BAV1968
RFR: Rfer_2424
POL: Bpro_3031
PNA: Pnap_1888
AAV: Aave_3020
AJS: Ajs_2271
VEI: Veis_3412
DAC: Daci_4035
DIA: Dtpsy_1603
VAP: Vapar_2205
CTT: CtCNB1_2946
MPT: Mpe_A1815
HAR: HEAR1747(tesA)
MMS: mma_1538(tesA2)
LCH: Lcho_1901
NEU: NE1455
EBA: ebA6814
AZO: azo1666(tesA1)
TMZ: Tmz1t_2242
TBD: Tbd_0686
MFA: Mfla_1250
MMB: Mmol_1286
MEI: Msip34_1746
APP: CAP2UW1_3262
DAT: HRM2_23650
MLO: mlr3034
MES: Meso_2747
PLA: Plav_1981
SME: SMc04041(pldB)
ATU: Atu3886(pldB)
ATC: AGR_L_1924
RET: RHE_CH02875(ypch00991) RHE_CH03572(pldB)
REC: RHECIAT_CH0003826(pldB)
RLE: RL4090
RLG: Rleg_3621
BME: BMEI0552 BMEII0047
BMF: BAB2_0045
BMB: BruAb2_0046
BMS: BRA0046
BOV: BOV_A0044
OAN: Oant_4281
BJA: bll7739(pldB)
BRA: BRADO0400(tesA) BRADO6235
BBT: BBta_0389(tesA) BBta_1374
RPA: RPA0888
RPB: RPB_4534
RPC: RPC_0764
RPD: RPD_0871
RPE: RPE_0686
NWI: Nwi_2951
NHA: Nham_1140
BHE: BH07290
BQU: BQ05220
BTR: Btr_1334
MEX: Mext_4557
MEA: Mex_1p5006
MDI: METDI5607
MRD: Mrad2831_1114
MET: M446_0411
MPO: Mpop_5072
MCH: Mchl_5017
MNO: Mnod_1727
CCR: CC_2253
SIL: SPO1414
SIT: TM1040_0570
RSP: RSP_2418(pldB)
RSH: Rsph17029_1082
RSQ: Rsph17025_1563
JAN: Jann_3314
RDE: RD1_1819(pldB)
PDE: Pden_1831
DSH: Dshi_0780
HNE: HNE_0098
NAR: Saro_1082
ELI: ELI_01535
BSU: BSU30510(ytpA)
BAN: BA5009
BAR: GBAA5009
BAA: BA_5429
BAT: BAS4654
BCE: BC1788 BC4753
BCA: BCE_4904
BCZ: BCZK4510
BCY: Bcer98_3430
BTK: BT9727_4492
BTL: BALH_4334
BWE: BcerKBAB4_4586
BCL: ABC1422 ABC2876
AFL: Aflv_0417
SAB: SAB1163
LSP: Bsph_4249
AAC: Aaci_0725
LLC: LACR_1660
LLM: llmg_0935
LCB: LCABL_12170
LRL: LC705_01092
CAC: CAC2246
CPE: CPE0944(pldB)
CPF: CPF_1188
CTC: CTC00812
DSY: DSY0424
MMY: MSC_0837(pldB)
MMO: MMOB3850(pldB)
RHA: RHA1_ro02357
PAC: PPA0594
SVI: Svir_06860
LIL: LA3604
ACA: ACP_0896
PHE: Phep_1599
OTE: Oter_0074
RBA: RB668(pldB) RB6876
CTS: Ctha_1767
HAU: Haur_4800
 |
|---|
| Structures |
PDB: 1G86 1HDK 1IVN 1J00 1JRL 1LCL 1QKQ 1U8U 1V2G 2G07
2G08 2G09 2G0A |
|---|
Reference
Authors
Title
Journal
|
1
Abe, M., Ohno, K. and Sato, R.
Possible identity of lysolecithin acyl-hydrolase with
lysolecithin-lysolecithin acyl-transferase in rat-lung soluble
fraction.
Biochim. Biophys. Acta 369 (1974) 361-370. |
|---|
Reference
Authors
Title
Journal
|
2
Contardi, A. and Ercoli, A.
The enzymic cleavage of lecithin and lysolecithin.
Biochem. Z. 261 (1933) 275-302. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13607409]
DAWSON RM.
Studies on the hydrolysis of lecithin by a Penicillium notatum
phospholipase B preparation.
Biochem. J. 70 (1958) 559-70.
Penicillium notatum |
|---|
Reference
Authors
Title
Journal
|
4
Fairbairn, D.
The preparation and properties of a lysophospholipase from
Penicillium notatum.
J. Biol. Chem. 173 (1948) 705-714. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:13032127]
SHAPIRO B.
Purification and properties of a lysolecithinase from pancreas.
Biochem. J. 53 (1953) 663-6.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:4693514]
van den Bosch H, Aarsman AJ, de Jong JG, van Deenem LL.
Studies on lysophospholipases. I. Purification and some properties
of a lysophospholipase from beef pancreas.
Biochim. Biophys. Acta. 296 (1973) 94-104.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:7278668]
van den Bosch H, Vianen GM, van Heusden GP.
Lysophospholipase--transacylase from rat lung.
Methods. Enzymol. 71 Pt C (1981) 513-21.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
8 [PMID:11927584]
van Tienhoven M, Atkins J, Li Y, Glynn P.
Human neuropathy target esterase catalyzes hydrolysis of membrane
lipids.
J. Biol. Chem. 277 (2002) 20942-8.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
9 [PMID:12805562]
Quistad GB, Barlow C, Winrow CJ, Sparks SE, Casida JE.
Evidence that mouse brain neuropathy target esterase is a
lysophospholipase.
Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7983-7.
Mus musculus [GN:mmu] |
|---|
Reference
Authors
Title
Journal
Organism
|
10 [PMID:9576844]
Lush MJ, Li Y, Read DJ, Willis AC, Glynn P.
Neuropathy target esterase and a homologous Drosophila
neurodegeneration-associated mutant protein contain a novel domain
conserved from bacteria to man.
Biochem. J. 332 ( Pt 1) (1998) 1-4.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
11 [PMID:12640454]
Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C.
Loss of neuropathy target esterase in mice links organophosphate
exposure to hyperactivity.
Nat. Genet. 33 (2003) 477-85.
Mus musculus [GN:mmu] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.1.5
IUBMB Enzyme Nomenclature: 3.1.1.5
ExPASy - ENZYME nomenclature database: 3.1.1.5
BRENDA, the Enzyme Database: 3.1.1.5
CAS: 9001-85-8 |
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