| Entry |
|
|---|
| Name |
acetylcholinesterase;
true cholinesterase;
choline esterase I;
cholinesterase;
acetylthiocholinesterase;
acetylcholine hydrolase;
acetyl.beta-methylcholinesterase;
AcCholE |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
 |
|---|
| Sysname |
acetylcholine acetylhydrolase |
|---|
| Reaction(IUBMB) |
acetylcholine + H2O = choline + acetate [RN:R01026] |
|---|
| Reaction(KEGG) |
R01026
 |
|---|
| Substrate |
acetylcholine [CPD:C01996];
H2O [CPD:C00001] |
|---|
| Product |
choline [CPD:C00114];
acetate [CPD:C00033] |
|---|
| Inhibitor |
Tacrine [CPD:C01453] |
|---|
| Comment |
Acts on a variety of acetic esters; also catalyses
transacetylations. |
|---|
| Pathway |
PATH: ec00564 Glycerophospholipid metabolism |
|---|
| Orthology |
KO: K01049 acetylcholinesterase |
|---|
| Genes |
HSA: 43(ACHE)
MCC: 713370(ACHE)
MMU: 11423(Ache)
RNO: 83817(Ache)
CFA: 489828(ACHE)
BTA: 540446(ACHE)
ECB: 100069149
MDO: 100017989
GGA: 396388(ACHE)
DRE: 114549(ache)
CIN: 100169895(ache)
SPU: 576746
DME: Dmel_CG17907(Ace)
DPO: Dpse_GA14718
AGA: AgaP_AGAP000466
AAG: AaeL_AAEL012141
AME: 406104(Ache)
TCA: 659368
CEL: W09B12.1(ace-1) Y44E3A.2(ace-2) Y48B6A.7(ace-4)
NVE: NEMVE_v1g171912
AFM: AFUA_7G01710
MSM: MSMEG_1432
 |
|---|
| Structures |
PDB: 1ACJ 1ACL 1AMN 1AX9 1B41 1C2B 1C2O 1CFJ 1DX4 1DX6
1E3Q 1E66 1EA5 1EEA 1EVE 1F8U 1FSS 1GPK 1GPN 1GQR
1GQS 1H22 1H23 1HBJ 1J06 1J07 1JJB 1MAA 1MAH 1N5M
1N5R 1OCE 1ODC 1Q83 1Q84 1QID 1QIE 1QIF 1QIG 1QIH
1QII 1QIJ 1QIK 1QIM 1QO9 1QON 1QTI 1SOM 1U65 1UT6
1VOT 1VXO 1VXR 1VZJ 1W4L 1W6R 1W75 1W76 1ZGB 1ZGC
2ACE 2ACK 2BAG 2C0P 2C0Q 2C4H 2C58 2C5F 2C5G 2CEK
2CKM 2CMF 2DFP 2GYU 2GYV 2GYW 2H9Y 2HA0 2HA2 2HA3
2HA4 2HA5 2HA6 2HA7 2J3D 2J3Q 2J4F 2JEY 2JEZ 2JF0
2JGE 2JGF 2JGG 2JGH 2JGI 2JGJ 2JGK 2JGL 2JGM 2V96
2V97 2V98 2VA9 2VJA 2VJB 2VJC 2VJD 2VQ6 2VT6 2VT7
2W6C 2WFZ 2WG0 2WG1 2WHP 2WHQ 2WHR 2WLS 2WU3 2WU4
3DL4 3DL7 3I6M 3I6Z |
|---|
Reference
Authors
Title
Journal
|
1
Augustinsson, K.-B.
Cholinesterases. A study in comparative enzymology.
Acta Physiol. Scand. 15, Suppl. 2 (1948) |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13522650]
BERGMANN F, RIMON S, SEGAL R.
Effect of pH on the activity of eel esterase towards different
substrates.
Biochem. J. 68 (1958) 493-9.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:5073758]
Ciliv G, Ozand PT.
Human erythrocyte acetylcholinesterase purification, properties and
kinetic behavior.
Biochim. Biophys. Acta. 284 (1972) 136-56.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:5238989]
Leuzinger W, Baker AL, Cauvin E.
Acetylcholinesterase. II. Crystallization, absorption spectra,
isoionic point.
Proc. Natl. Acad. Sci. U. S. A. 59 (1968) 620-3.
Electrophorus electricus |
|---|
Reference
Authors
Title
Journal
|
5 [PMID:14885021]
NACHMANSOHN D, WILSON IB.
The enzymic hydrolysis and synthesis of acetylcholine.
Adv. Enzymol. Relat. Subj. Biochem. 12 (1951) 259-339. |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:14377597]
ZITTLE CA, DELLAMONICA ES, CUSTER JH, KRIKORIAN R.
Purification of human red cell acetylcholinesterase by
electrophoresis, ultracentrifugation and gradient extraction.
Arch. Biochem. 56 (1955) 469-75.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.1.7
IUBMB Enzyme Nomenclature: 3.1.1.7
ExPASy - ENZYME nomenclature database: 3.1.1.7
BRENDA, the Enzyme Database: 3.1.1.7
CAS: 9000-81-1 |
|---|
