| Entry |
|
|---|
| Name |
S-formylglutathione hydrolase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
 |
|---|
| Sysname |
S-formylglutathione hydrolase |
|---|
| Reaction(IUBMB) |
S-formylglutathione + H2O = glutathione + formate [RN:R00527] |
|---|
| Reaction(KEGG) |
R00527
 |
|---|
| Substrate |
S-formylglutathione [CPD:C01031];
H2O [CPD:C00001] |
|---|
| Product |
glutathione [CPD:C00051];
formate [CPD:C00058] |
|---|
| Comment |
Also hydrolyses S-acetylglutathione, but more slowly. |
|---|
| Pathway |
PATH: ec00680 Methane metabolism |
|---|
| Orthology |
KO: K01070 S-formylglutathione hydrolase |
|---|
| Genes |
ATH: AT2G41530(SFGH)
MXA: MXAN_7093(fghA)
BRA: BRADO5460(fghA)
BBT: BBta_5942(fghA)
RSP: RSP_0852(fghA)
RDE: RD1_0888
HNE: HNE_0555(fghA)
 |
|---|
| Structures |
PDB: 3C6B 3FCX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4200890]
Uotila L.
Preparation and assay of glutathione thiol esters. Survey of human
liver glutathione thiol esterases.
Biochemistry. 12 (1973) 3938-43.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4436331]
Uotila L, Koivusalo M.
Purification and properties of S-formylglutathione hydrolase from
human liver.
J. Biol. Chem. 249 (1974) 7664-72.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:8892832]
Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH.
S-formylglutathione hydrolase of Paracoccus denitrificans is
homologous to human esterase D: a universal pathway for formaldehyde
detoxification?
J. Bacteriol. 178 (1996) 6296-9.
Homo sapiens [GN:hsa] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.2.12
IUBMB Enzyme Nomenclature: 3.1.2.12
ExPASy - ENZYME nomenclature database: 3.1.2.12
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.2.12
BRENDA, the Enzyme Database: 3.1.2.12
CAS: 83380-83-0 |
|---|
