KEGG   ENZYME: 3.1.2.22Help
Entry
EC 3.1.2.22                 Enzyme                                 
Name palmitoyl[protein] hydrolase;
palmitoyl-protein thioesterase;
palmitoyl-(protein) hydrolase
Class Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname palmitoyl[protein] hydrolase
Reaction(IUBMB) palmitoyl[protein] + H2O = palmitate + protein [RN:R01705]
Reaction(KEGG) R01705 > R08602;
(other) R01274
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Substrate palmitoyl[protein];
H2O [CPD:C00001]
Product palmitate [CPD:C00249];
protein [CPD:C00017]
Comment Specific for long-chain thioesters of fatty acids. Hydrolyses fatty
acids from S-acylated cysteine residues in proteins, palmitoyl
cysteine and palmitoyl-CoA.
Pathway PATH: ec00062  Fatty acid elongation in mitochondria
PATH: ec01100  Metabolic pathways
Orthology KO: K01074  palmitoyl-protein thioesterase
Genes HSA: 5538(PPT1) 9374(PPT2)
PTR: 456789(PPT1) 462580(PPT2)
MCC: 693377(PPT1)
MMU: 19063(Ppt1) 54397(Ppt2)
RNO: 29411(Ppt1) 54398(Ppt2)
CFA: 474856(PPT2) 475316(PPT1)
BTA: 281421(PPT1) 516797(PPT2)
SSC: 100144537(SBAB-649D6.5)
ECB: 100051483 100068301
MDO: 100024015 100032080
OAA: 100077897 100078347
GGA: 419681(PPT1)
TGU: 100190233
XLA: 100037210 379689 444228
XTR: 100101696(ppt2) 448650(ppt1)
DRE: 100126133(ppt2) 100150238 393135 393657 405845 406648(ppt1)
     619258
BFO: BRAFLDRAFT_128749 BRAFLDRAFT_276374
CIN: 100177362 100183454
SPU: 586868 587708
DME: Dmel_CG12108(Ppt1) Dmel_CG4851
DPO: Dpse_GA11401 Dpse_GA18478
DAN: Dana_GF14769 Dana_GF19174
DER: Dere_GG19029 Dere_GG23717
DPE: Dper_GL13042 Dper_GL19554
DSE: Dsec_GM18996 Dsec_GM21149
DSI: Dsim_GD16099 Dsim_GD23774
DYA: Dyak_GE17436 Dyak_GE18522
DGR: Dgri_GH13391 Dgri_GH24517
DMO: Dmoj_GI15083 Dmoj_GI20683
AGA: AgaP_AGAP001058 AgaP_AGAP009695
AAG: AaeL_AAEL001235 AaeL_AAEL007828 AaeL_AAEL015038
CQU: CpipJ_CPIJ001043 CpipJ_CPIJ002498
AME: 408426 551664
NVI: 100119223(Ppt2) 100119614
TCA: 658084 659956
API: 100163656 100164869
ISC: IscW_ISCW016977
CEL: F44C4.5(ppt-1)
CBR: CBG18981
BMY: Bm1_51565
SMM: Smp_142970
NVE: NEMVE_v1g136346 NEMVE_v1g187212
HMG: 100204442 100211752
TAD: TRIADDRAFT_25162 TRIADDRAFT_28251
ATH: AT4G17470
POP: POPTR_1073630 POPTR_1109716 POPTR_755068
RCU: RCOM_0006400 RCOM_1608620
VVI: 100241128
OSA: 4331284(Os03g0101100)
SBI: SORBI_01g050600(SORBIDRAFT_01g050600)
PPP: PHYPADRAFT_129823 PHYPADRAFT_183116
CRE: CHLREDRAFT_131913
DHA: DEHA0F08899g
PIC: PICST_83712
PPA: PAS_chr2-2_0107
LEL: LELG_01936
CAL: CaO19.540(PPT2)
CTP: CTRG_00395
CDU: CD36_29840
YLI: YALI0F14135g
NCR: NCU06530
PAN: PODANSg1551
MGR: MGG_04920
FGR: FG04980.1
ANI: AN2497.2
AFM: AFUA_3G14060
AOR: AO090012000721
ANG: An09g04580
AFV: AFLA_019760
PCS: Pc13g15530
NFI: NFIA_063220
CIM: CIMG_00103
URE: UREG_00211
SSL: SS1G_07558
CNE: CNA00890
CNB: CNBA0860
UMA: UM05641.1
MGL: MGL_1417
MBR: MONBRDRAFT_29102
DDI: DDB_0233890(ppt1) DDB_0233891(ppt2)
TET: TTHERM_00591650
PTM: GSPATT00008973001
PTI: PHATR_10454
Taxonomy
Structures PDB: 1EH5  1EI9  1EXW  1PJA  3GRO  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:7651163]
Camp LA, Hofmann SL.
Assay and isolation of palmitoyl-protein thioesterase from bovine
brain using palmitoylated H-Ras as substrate.
Methods. Enzymol. 250 (1995) 336-47.
Bos taurus [GN:bta]
Reference
  Authors
  Title


  Journal
  Organism
 2  [PMID:8786130]
Schriner JE, Yi W, Hofmann SL.
cDNA and genomic cloning of human palmitoyl-protein thioesterase
(PPT), the enzyme defective in infantile neuronal ceroid
lipofuscinosis.
Genomics. 34 (1996) 317-22.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title
  Journal
  Organism
 3  [PMID:8663305]
Verkruyse LA, Hofmann SL.
Lysosomal targeting of palmitoyl-protein thioesterase.
J. Biol. Chem. 271 (1996) 15831-6.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 3.1.2.22
IUBMB Enzyme Nomenclature: 3.1.2.22
ExPASy - ENZYME nomenclature database: 3.1.2.22
BRENDA, the Enzyme Database: 3.1.2.22
CAS: 150605-49-5
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