KEGG   ENZYME: 3.1.2.4Help
Entry
EC 3.1.2.4                  Enzyme                                 
Name
3-hydroxyisobutyryl-CoA hydrolase;
3-hydroxy-isobutyryl CoA hydrolase;
HIB CoA deacylase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
3-hydroxy-2-methylpropanoyl-CoA hydrolase
Reaction(IUBMB)
3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate [RN:R03352]
Reaction(KEGG)
Substrate
3-hydroxy-2-methylpropanoyl-CoA [CPD:C04047];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
3-hydroxy-2-methylpropanoate [CPD:C01188]
Comment
Also hydrolyses 3-hydroxypropanoyl-CoA.
Pathway
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Metabolic pathways
Orthology
K05605  
3-hydroxyisobutyryl-CoA hydrolase
Genes
HSA: 
26275(HIBCH)
PTR: 
459828(HIBCH)
PPS: 
100967492(HIBCH)
GGO: 
101128664(HIBCH)
PON: 
100174446(HIBCH)
MCC: 
MMU: 
227095(Hibch)
RNO: 
301384(Hibch)
CFA: 
607040(HIBCH)
AML: 
FCA: 
101081824(HIBCH)
BTA: 
535883(HIBCH)
SSC: 
100514687
ECB: 
100069399(HIBCH)
MDO: 
100028760
SHR: 
100932348(HIBCH)
OAA: 
100084964
GGA: 
423979(HIBCH)
MGP: 
100544087
TGU: 
100227137(HIBCH)
ACS: 
100557019
XLA: 
100037216(hibch)
XTR: 
548942(hibch)
DRE: 
798364(hibch)
TRU: 
101062000
OLA: 
101159781
BFO: 
BRAFLDRAFT_270056
CIN: 
100177147
SPU: 
586315
DME: 
Dmel_CG5044
DPO: 
Dpse_GA18617
DAN: 
Dana_GF23000
DER: 
Dere_GG16921
DPE: 
Dper_GL13727
DSE: 
Dsec_GM24227
DSI: 
Dsim_GD19018
DWI: 
Dwil_GK11777
DYA: 
Dyak_GE24304
DGR: 
Dgri_GH16630
DMO: 
Dmoj_GI22035
DVI: 
Dvir_GJ10482
AGA: 
AgaP_AGAP004097
AAG: 
AaeL_AAEL010008
CQU: 
CpipJ_CPIJ012030
AME: 
412796
NVI: 
100121990(NV13588)
TCA: 
657314
API: 
100165582
PHU: 
Phum_PHUM285470
ISC: 
IscW_ISCW010016
CEL: 
CELE_F09F7.4(F09F7.4)
CBR: 
CBG24044
BMY: 
Bm1_41250
TSP: 
Tsp_02189
NVE: 
NEMVE_v1g158887
HMG: 
100212624
TAD: 
TRIADDRAFT_30551
AQU: 
100641036
ATH: 
AT1G06550 AT2G30650 AT2G30660 AT3G60510 AT4G31810 AT5G65940(CHY1)
ALY: 
ARALYDRAFT_481983 ARALYDRAFT_486525 ARALYDRAFT_491556 ARALYDRAFT_668778 ARALYDRAFT_678274 ARALYDRAFT_920141(CHY1)
GMX: 
100170729 100790810 100801676 100808892 100818188
MTR: 
MTR_1g014040 MTR_8g005990
CSV: 
101212576 101215537 101222552 101224412 101226422
RCU: 
RCOM_0659450 RCOM_0696050 RCOM_0920900 RCOM_1609370
POP: 
POPTR_1110019 POPTR_261344 POPTR_551227 POPTR_586337 POPTR_732647 POPTR_787000 POPTR_880124 POPTR_929715
VVI: 
100245360 100253979 100254744 100256133 100257773 100260736 100263739 100266026
OSA: 
4324637 4349332 4351929
DOSA: 
Os01t0752200-01(Os01g0752200) Os10t0552900-01(Os10g0552900) Os12t0264500-02(Os12g0264500)
BDI: 
100825286 100839535 100845202
SBI: 
SORBI_01g028410(SORBIDRAFT_01g028410) SORBI_01g029600(SORBIDRAFT_01g029600) SORBI_03g034770(SORBIDRAFT_03g034770)
ZMA: 
100283469 100283686 100283920
SMO: 
SELMODRAFT_116261 SELMODRAFT_148584 SELMODRAFT_86180
PPP: 
PHYPADRAFT_130534 PHYPADRAFT_188612 PHYPADRAFT_199427 PHYPADRAFT_203056
VCN: 
VOLCADRAFT_31665
SCE: 
YDR036C(EHD3)
AGO: 
AGOS_AGR024C
ERC: 
Ecym_2647
KLA: 
KLLA0F18678g
LTH: 
KLTH0C07304g
PPA: 
PAS_chr3_0937
VPO: 
Kpol_251p6
ZRO: 
ZYRO0F01254g
CGR: 
CAGL0K11968g
NCS: 
NCAS_0A10580(NCAS0A10580)
NDI: 
NDAI_0A05710(NDAI0A05710)
TPF: 
TPHA_0M01100(TPHA0M01100)
TBL: 
TBLA_0E02580(TBLA0E02580)
TDL: 
TDEL_0D03540(TDEL0D03540)
KAF: 
KAFR_0A01030(KAFR0A01030)
DHA: 
DEHA2G12342g
PIC: 
PICST_32846(EHO3)
PGU: 
PGUG_04316
LEL: 
LELG_01545
CAL: 
CaO19.10547(EHD3) CaO19.3029(EHD3)
CTP: 
CTRG_04796
CDU: 
CD36_03120
COT: 
CORT_0B09780
YLI: 
YALI0D06215g
CLU: 
CLUG_04032
NCR: 
NCU03777
SMP: 
SMAC_02624
PAN: 
PODANSg9014
TTT: 
THITE_2108432
MTM: 
MYCTH_2302228
MGR: 
MGG_04012
FGR: 
FG07019.1
NHE: 
NECHADRAFT_49136
VAL: 
VDBG_07520
SSL: 
SS1G_03253
BFU: 
BC1G_06802
ANI: 
AN6844.2
NFI: 
NFIA_074380
AFM: 
AFUA_5G12790
AOR: 
AOR_1_732094(AO090120000413)
ANG: 
ANI_1_1594124(An14g06290)
AFV: 
AFLA_093960
ACT: 
ACLA_015920
PCS: 
Pc21g08400
CIM: 
CIMG_09279
CPW: 
CPC735_016760
PBL: 
PAAG_02554
URE: 
UREG_05014
ABE: 
ARB_03372
TVE: 
TRV_02881
PNO: 
SNOG_10252
PTE: 
PTT_16835
ZTR: 
MYCGRDRAFT_103402
TML: 
GSTUM_00007620001
SPO: 
SPBC2D10.09
CNE: 
CNA02940
CNB: 
CNBA2830
CGI: 
CGB_B3420C
LBC: 
LACBIDRAFT_292320
CCI: 
CC1G_01111
SCM: 
SCHCODRAFT_255886
UMA: 
UM03071.1
MGL: 
MGL_0355
PGR: 
PGTG_07395
MBR: 
MONBRDRAFT_33402
NGR: 
NAEGRDRAFT_2273
DDI: 
DDB_G0267536(hibch)
DPP: 
DICPUDRAFT_33863
PFA: 
PFL1940w
PFD: 
PFDG_00281
PFH: 
PFHG_02270
PYO: 
PY02220
PBE: 
PB001039.02.0
PKN: 
PKH_145800
PVX: 
PVX_100950
PCY: 
PCYB_146570
TBR: 
Tb11.01.8200
TCR: 
511529.160
LMA: 
LMJF_32_3680
LIF: 
LINJ_32_3830
LDO: 
LDBPK_323830
LMI: 
LMXM_31_3680
LBZ: 
LBRM_32_3920
PTI: 
PHATRDRAFT_54528
TPS: 
THAPSDRAFT_261905
PIF: 
PITG_02112
 » show all
Taxonomy
Reference
1  [PMID:13457352]
  Authors
RENDINA G, COON MJ.
  Title
Enzymatic hydrolysis of the coenzyme a thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids.
  Journal
J. Biol. Chem. 225 (1957) 523-34.
  Organism
Sus scofa [GN:ssc], Neurospora crassa [GN:ncr], Tetrahymena pyriformis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-88-1
DBGET integrated database retrieval system