KEGG   ENZYME: 3.1.2.6Help
Entry
EC 3.1.2.6                  Enzyme                                 
Name hydroxyacylglutathione hydrolase;
glyoxalase II;
S-2-hydroxylacylglutathione hydrolase;
hydroxyacylglutathione hydrolase;
acetoacetylglutathione hydrolase
Class Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname S-(2-hydroxyacyl)glutathione hydrolase
Reaction(IUBMB) S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy
carboxylate [RN:R04090]
Reaction(KEGG) R04090 > R01736
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Substrate S-(2-hydroxyacyl)glutathione [CPD:C03899];
H2O [CPD:C00001]
Product glutathione [CPD:C00051];
2-hydroxy carboxylate [CPD:C02929]
Comment Also hydrolyses S-acetoacetylglutathione, but more slowly.
Pathway PATH: ec00620  Pyruvate metabolism
Orthology KO: K01069  hydroxyacylglutathione hydrolase
Genes HSA: 3029(HAGH) 84264(HAGHL)
PTR: 453828(HAGH) 745423(HAGHL)
MCC: 697846(HAGHL) 703206(HAGH)
MMU: 14651(Hagh) 68977(Haghl)
RNO: 24439(Hagh)
CFA: 479888(HAGH) 490087(HAGHL)
BTA: 509274(HAGH) 511836(HAGHL)
ECB: 100067135 100067912
MDO: 100010784 100017202
GGA: 416536(HAGHL) 416537(HAGH)
TGU: 100190196
XLA: 734940(hagh) 779396(haghl)
XTR: 100145102 100216043(hagh)
DRE: 336977(hagh)
SPU: 578596 581514
DME: Dmel_CG4365
DPO: Dpse_GA18136
AGA: AgaP_AGAP000416
AAG: AaeL_AAEL009462
AME: 551059
TCA: 661166
CEL: Y17G7B.3
BMY: Bm1_40000
NVE: NEMVE_v1g149502 NEMVE_v1g84777
TAD: TRIADDRAFT_20939
OSA: 4332736(Os03g0332400)
OLU: OSTLU_6889 OSTLU_6929
CME: CMT117C
SCE: YDR272W(GLO2) YOR040W(GLO4)
AGO: AGOS_ACR084C
DHA: DEHA0B02178g
PIC: PICST_31656(GLO2)
CGR: CAGL0I00924g
YLI: YALI0D06974g
SPO: SPAC824.07 SPCC13B11.03c
NCR: NCU03749
MGR: MGG_12300
ANI: AN6840.2
AFM: AFUA_5G12840
AOR: AO090120000408
ANG: An14g06340
CNE: CND02510
UMA: UM00589.1
DDI: DDB_0230988(gloB1)
EHI: EHI_068560
PFA: PFD0311w PFL0285w
TAN: TA21365
TPV: TP01_0292
TET: TTHERM_00052170 TTHERM_00120980 TTHERM_00361730 TTHERM_01467280
TBR: Tb927.4.1350 Tb927.6.1080
TCR: 507603.230 509429.290
LMA: LmjF12.0220
TVA: TVAG_019300 TVAG_243530
ECO: b0212(gloB)
ECJ: JW0202(gloB)
ECD: ECDH10B_0193(gloB)
EBW: BWG_0199(gloB)
ECE: Z0236(gloB)
ECS: ECs0208
ECF: ECH74115_0224(gloB)
ETW: ECSP_0211(gloB)
ECG: E2348C_0212(gloB)
ECC: c0249(gloB)
ECI: UTI89_C0231(gloB)
ECP: ECP_0218
ECV: APECO1_1778(gloB)
ECW: EcE24377A_0217(gloB)
ECX: EcHS_A0216(gloB)
ECM: EcSMS35_0226(gloB)
ECY: ECSE_0208
ECL: EcolC_3453
ECK: EC55989_0211(gloB)
ECQ: ECED1_0217(gloB)
ECR: ECIAI1_0220(gloB)
ECT: ECIAI39_0437(gloB)
ECZ: ECS88_0227(gloB)
EUM: ECUMN_0209(gloB)
ELF: LF82_0862(gloB)
EBL: B21_00210(gloB)
EBD: ECBD_3412
EBR: ECB_00205(gloB)
EFE: EFER_0241(gloB)
STY: STY0282(gloB)
STT: t2604(gloB)
SPT: SPA2508(gloB)
SEK: SSPA2339
SPQ: SPAB_03353
SEI: SPC_0271(gloB)
SEC: SC0257(gloB)
SEH: SeHA_C0299(gloB)
SEE: SNSL254_A0286(gloB)
SEW: SeSA_A0291(gloB)
SEA: SeAg_B0305(gloB)
SED: SeD_A0284(gloB)
SEG: SG0259(gloB)
SET: SEN0263(gloB)
SES: SARI_02741
STM: STM0261(gloB)
YPE: YPO1079(gloB)
YPK: y3097(gloB)
YPM: YP_2770(gloB3)
YPA: YPA_0557
YPN: YPN_2919
YPG: YpAngola_A2685
YPP: YPDSF_1633
YPS: YPTB2967(gloB)
YPI: YpsIP31758_1052
YPY: YPK_1106
YPB: YPTS_3085
YEN: YE0919(gloB)
SFL: SF0198(gloB)
SFX: S0206(gloB)
SFV: SFV_0196(gloB)
SSN: SSON_0226(gloB)
SBO: SBO_0201(gloB)
SBC: SbBS512_E0208(gloB)
SDY: SDY_0231(gloB)
ECA: ECA3342(gloB)
PCT: PC1_3138
PWA: Pecwa_1141
ETA: ETA_26370(gloB)
PLU: plu0940(gloB)
PAY: PAU_00858(gloB)
BUC: BU246(gloB)
BAS: BUsg238(gloB)
BAB: bbp228(gloB)
BAP: BUAP5A_242(gloB)
BAU: BUAPTUC7_244(gloB)
WBR: WGLp067(gloB)
SGL: SG0589
ENT: Ent638_0746
ESA: ESA_03127
KPN: KPN_00227(gloB)
KPE: KPK_4507(gloB)
KPU: KP1_1071(gloB)
CKO: CKO_02971
SPE: Spro_0909
PMR: PMI0225(gloB)
EIC: NT01EI_3196
ETR: ETAE_2826(gloB)
BFL: Bfl223(gloB)
BPN: BPEN_230(gloB)
HDE: HDEF_2129(gloB)
DDA: Dd703_2841
DZE: Dd1591_1007
HIN: HI1274
HIT: NTHI1896(gloB)
HIQ: CGSHiGG_01615
HDU: HD1197(gloB)
HAP: HAPS_1262(gloB)
HSO: HS_0809(gloB)
HSM: HSM_1278
PMU: PM0685
MSU: MS0946(gloB)
APL: APL_0415(gloB)
APJ: APJL_0439(gloB)
APA: APP7_0439
ASU: Asuc_1187
AAP: NT05HA_0407
AAT: D11S_1165
XFA: XF2160
XFT: PD1220(gloB)
XFM: Xfasm12_1364
XFN: XfasM23_1299
XCC: XCC0985(gloB)
XCB: XC_3258
XCA: xccb100_3373(gloB)
XCV: XCV1087(gloB)
XAC: XAC1087(gloB)
XOO: XOO1039(gloB)
XOM: XOO_0938
XOP: PXO_02471
SML: Smlt0995
SMT: Smal_0842
VCH: VC2236
VCO: VC0395_A1828
VVU: VV1_1883
VVY: VV0153 VV2532
VPA: VP2295
VHA: VIBHAR_03213
VSP: VS_2329
VFI: VF_1938
VFM: VFMJ11_2073(gloB)
VSA: VSAL_I2401
PPR: PBPRA2920
PAE: PA1813
PAU: PA14_41080
PAP: PSPA7_3483(gloB)
PAG: PLES_35141
PPU: PP_4144(gloB)
PPF: Pput_1721
PPG: PputGB1_3716
PPW: PputW619_3469
PST: PSPTO_3714
PSB: Psyr_1761
PSP: PSPPH_1710
PFL: PFL_3299
PFO: Pfl01_2184
PEN: PSEEN3561
PMY: Pmen_2064
PSA: PST_2254(gloB)
PAR: Psyc_1038
PCR: Pcryo_1432 Pcryo_1778
PRW: PsycPRwf_1411
ACI: ACIAD2452
ACB: A1S_1708 A1S_2194
ABM: ABSDF1508 ABSDF1937
ABY: ABAYE1362 ABAYE1940
ABC: ACICU_02394
ABN: AB57_2530(gloB)
ABB: ABBFA_001272(gloB)
SON: SO_2563
SDN: Sden_2021
SFR: Sfri_2207
SAZ: Sama_1884
SBL: Sbal_1996
SBM: Shew185_2011
SBN: Sbal195_2059
SBP: Sbal223_2327
SLO: Shew_2114
SPC: Sputcn32_1776
SSE: Ssed_1989
SPL: Spea_2406
SHE: Shewmr4_2161
SHM: Shewmr7_2238
SHN: Shewana3_2369
SHW: Sputw3181_2249
SHL: Shal_1871
SWD: Swoo_2611
SWP: swp_2298
ILO: IL1697(gloB)
CPS: CPS_1999
PHA: PSHAa1401 PSHAa1966(gloB)
PAT: Patl_1895
SDE: Sde_2023
MAQ: Maqu_1536
AMC: MADE_01981
PIN: Ping_0498
CBU: CBU_0314
CBS: COXBURSA331_A0422
CBD: CBUD_1765
CBG: CbuG_1690
CBC: CbuK_0511
LPN: lpg1295
LPF: lpl1257(gloB)
LPP: lpp1258(gloB)
LPC: LPC_0719(gloB)
MCA: MCA0343
FTU: FTT_1405c(gloB)
FTF: FTF1405c(gloB)
FTW: FTW_0483
FTL: FTL_0657
FTH: FTH_0660(gloB)
FTA: FTA_0693
FTM: FTM_0616(gloB)
FTN: FTN_1370(gloB)
FPH: Fphi_1316
TCX: Tcr_0926 Tcr_0932
NOC: Noc_1532 Noc_1713 Noc_1750 Noc_2007
AEH: Mlg_1994
HHA: Hhal_1587
HCH: HCH_02525
CSA: Csal_1944
ABO: ABO_1336(blaB)
MMW: Mmwyl1_1702
AHA: AHA_1567
ASA: ASA_2790(gloB)
DNO: DNO_0993
AFE: Lferr_0446 Lferr_0561
AFR: AFE_0269 AFE_0397
BCI: BCI_0475(gloB)
RMA: Rmag_0328 Rmag_0826
VOK: COSY_0753
KKO: Kkor_1932
NMA: NMA0444
NME: NMB1997(gloB)
NMC: NMC1973
NMN: NMCC_0208(golB)
NGO: NGO1187
NGK: NGK_1974
CVI: CV_1254(gloB)
RSO: RSc1515(gloB)
RPI: Rpic_2039 Rpic_2530
RPF: Rpic12D_1731 Rpic12D_2116
REU: Reut_A2187 Reut_A3334
REH: H16_A1980 H16_A2209 H16_A2464(gloB2) H16_A3582(gloB3) H16_A3623
RME: Rmet_2206 Rmet_3484
CTI: RALTA_A1995(gloB) RALTA_A3078
BMA: BMA0765(gloB)
BMV: BMASAVP1_A1275(gloB)
BML: BMA10229_A0594(gloB)
BMN: BMA10247_0558(gloB)
BPS: BPSL1344
BPM: BURPS1710b_0044(glob1) BURPS1710b_1602(gloB) BURPS1710b_2664
BPL: BURPS1106A_1498
BPD: BURPS668_1468
BPR: GBP346_A1502(gloB)
BTE: BTH_I2788
BVI: Bcep1808_1240
BUR: Bcep18194_A3388 Bcep18194_A4429 Bcep18194_A5043 Bcep18194_B0182
BCN: Bcen_0806
BCH: Bcen2424_1287
BCM: Bcenmc03_1258
BCJ: BCAL1257
BAM: Bamb_0199 Bamb_1164
BAC: BamMC406_1176
BMU: Bmul_2033
BMJ: BMULJ_01210(gloB)
BXE: Bxe_A1253
BPH: Bphy_0870
BPY: Bphyt_2871
PNU: Pnuc_1022
PNE: Pnec_0843
BPE: BP3213(gloB)
BPA: BPP3836(gloB)
BBR: BB4280(gloB)
BPT: Bpet0630(gloB)
BAV: BAV2936(gloB)
RFR: Rfer_1462
POL: Bpro_2055
PNA: Pnap_1678 Pnap_2821
AAV: Aave_2651
AJS: Ajs_1743
VEI: Veis_0591
DAC: Daci_4897
DIA: Dtpsy_1975
VAP: Vapar_2338
MPT: Mpe_A0934 Mpe_A2529
HAR: HEAR0917 HEAR2321
MMS: mma_1210(gloB)
LCH: Lcho_1972
NEU: NE0138
NET: Neut_2178
NMU: Nmul_A1621
EBA: ebA6461
AZO: azo1208(gloB1) azo2057(gloB2) azo3379
DAR: Daro_1595
TMZ: Tmz1t_2291
TBD: Tbd_1665
MFA: Mfla_1481 Mfla_1733
APP: CAP2UW1_3928
HPA: HPAG1_0798
PCA: Pcar_3076
BBA: Bd2204(gloB) Bd3549
ADE: Adeh_1984
ACP: A2cp1_1979
AFW: Anae109_1866
ANK: AnaeK_1894
MXA: MXAN_0179 MXAN_2490
SAT: SYN_01158 SYN_01287 SYN_02709
PUB: SAR11_0219(gloB) SAR11_1229
MLO: mlr3546
MES: Meso_3080
PLA: Plav_1578
SME: SMc00708(gloB)
SMD: Smed_2552
ATU: Atu3614(gloB)
ATC: AGR_L_2423
ARA: Arad_4219(gloB)
AVI: Avi_4036(gloB)
RET: RHE_CH01013(ypch00334) RHE_CH03013(ypch01051) RHE_CH03812(gloB)
REC: RHECIAT_CH0004083(gloB)
RLE: RL1093 RL3458 RL4340(gloB)
RLT: Rleg2_3582
BME: BMEI0129 BMEI0496 BMEI1432 BMEII0771
BMF: BAB1_1936 BAB2_0739
BMB: BruAb1_1912
BMC: BAbS19_I18160
BMS: BR1936
BMT: BSUIS_A1776(gloB)
BOV: BOV_1863(gloB)
BCS: BCAN_A1980(gloB)
OAN: Oant_0923
BJA: blr0222(gloB)
BRA: BRADO0567
BBT: BBta_7609
RPA: RPA0610
RPB: RPB_0069
RPC: RPC_0508
RPD: RPD_0093
RPE: RPE_0164 RPE_0233 RPE_3980 RPE_4355
RPT: Rpal_0614
NWI: Nwi_0113 Nwi_0373 Nwi_0890 Nwi_2895
NHA: Nham_0466
OCA: OCAR_4102(gloB)
BHE: BH16640(gloB)
BQU: BQ13520(gloB)
BTR: Btr_2686(gloB)
XAU: Xaut_2019
AZC: AZC_0224
MEX: Mext_2510
MDI: METDI3238
MRD: Mrad2831_0917
MET: M446_2063
MPO: Mpop_2438
MCH: Mchl_2733
MNO: Mnod_0448
BID: Bind_0430
MSL: Msil_1898
CCR: CC_0519
CCS: CCNA_00553
CAK: Caul_0378
PZU: PHZ_c0434
SIL: SPO3168
SIT: TM1040_2091
RSP: RSP_0204 RSP_2294(gloB)
RSH: Rsph17029_0969
RSQ: Rsph17025_2206
RSK: RSKD131_0615
JAN: Jann_1042
RDE: RD1_2249 RD1_3539(gloB)
PDE: Pden_1772 Pden_3813
DSH: Dshi_2691
MMR: Mmar10_2381
HNE: HNE_3406
ZMO: ZMO0759
NAR: Saro_1321
SAL: Sala_0684
SWI: Swit_1986 Swit_2505 Swit_2798
ELI: ELI_07510
GOX: GOX0280 GOX2647
GBE: GbCGDNIH1_0453
ACR: Acry_1778
GDI: GDI_3306
GDJ: Gdia_3064
RRU: Rru_A1522 Rru_A3270
MAG: amb4192
MGM: Mmc1_1222 Mmc1_1657
BAN: BA2538
BAR: GBAA2538
BAA: BA_3036
BAT: BAS2361
BCE: BC3511
BCZ: BCZK2277(gloB)
BCB: BCB4264_A3523
BCU: BCAH820_2552
BCG: BCG9842_B1732
BTK: BT9727_2319(gloB)
BTL: BALH_2284 BALH_2913(gloB)
BWE: BcerKBAB4_2338
BLI: BL02060
BLD: BLi02785
BAY: RBAM_019750
GKA: GK2088
AFL: Aflv_0284
SAB: SAB0031
SAA: SAUSA300_0086
ESI: Exig_0337
EAT: EAT1b_2529
SPZ: M5005_Spy_0533
SPH: MGAS10270_Spy0528
SPI: MGAS10750_Spy0552
SPJ: MGAS2096_Spy0545
SPK: MGAS9429_Spy0524
SPF: SpyM51330
SPA: M6_Spy0554
SPB: M28_Spy0512
SAK: SAK_0673
SGO: SGO_1438
CTC: CTC02196
MTU: Rv0634c
MTC: MT0662
MRA: MRA_0643
MTF: TBFG_10645
MTB: TBMG_00643(TBMG_00643.1)
MBO: Mb0651c
MBB: BCG_0681c
MBT: JTY_0651
MLE: ML1912
MLB: MLBr_01912
MPA: MAP4104c
MAV: MAV_3461 MAV_4532
MSM: MSMEG_1334 MSMEG_5385
MUL: MUL_0715(gloB) MUL_1731
MVA: Mvan_1228 Mvan_1830 Mvan_2589
MGI: Mflv_5123
MMC: Mmcs_0914 Mmcs_2284 Mmcs_5312
MKM: Mkms_0931
MJL: Mjls_0942 Mjls_2323
MMI: MMAR_0965(gloB)
CGT: cgR_0071
NFA: nfa16980
RHA: RHA1_ro06806 RHA1_ro06903
AAU: AAur_pTC10230 AAur_pTC20184
FRA: Francci3_1241
FRE: Franean1_2264
FAL: FRAAL1967
SEN: SACE_3148 SACE_4442 SACE_4489
PCU: pc0942
LIL: LA2116(gloB)
LBJ: LBJ_1894
LBL: LBL_1390
LBI: LEPBI_I1900 LEPBI_I2630
LBF: LBF_1845 LBF_2549
CHU: CHU_1354
FNU: FN1162
RBA: RB11227
SYN: sll1019(HAGH1) slr1259
SYW: SYNW1543
SYC: syc0152_d syc0605_d
SYF: Synpcc7942_0937 Synpcc7942_1403
SYD: Syncc9605_0966
SYE: Syncc9902_0879
SYG: sync_1941
SYR: SynRCC307_0839(gloB)
SYX: SynWH7803_0694(gloB)
SYP: SYNPCC7002_A1864(gloB) SYNPCC7002_A2866
CYA: CYA_1132 CYA_1720
CYB: CYB_0151 CYB_1927
TEL: tll1639 tlr1626
CYT: cce_1190
CYP: PCC8801_2445
CYC: PCC7424_4875
GVI: gll3339
ANA: all0580 alr3904
AVA: Ava_0328 Ava_1793
PMA: Pro0561(gloB)
PMM: PMM0559
PMT: PMT1194
PMN: PMN2A_1889
PMI: PMT9312_0559
PMB: A9601_06151
PMC: P9515_06231
PMF: P9303_08221
PMG: P9301_05851
PMH: P9215_06401(gloB)
PMJ: P9211_05621
PME: NATL1_06141
TER: Tery_3786
CTE: CT2045
CCH: Cag_0125
CPH: Cpha266_0179
PVI: Cvib_1640
PLT: Plut_1997
DEH: cbdb_A762
CAU: Caur_3896
CAG: Cagg_0047
CHL: Chy400_4213
DGE: Dgeo_2681
TTJ: TTHA0837
MAC: MA2320
MBA: Mbar_A2729
MMA: MM_2931
MEM: Memar_2326
HWA: HQ1377A HQ2288A HQ3137A
NPH: NP2670A NP3944A NP4032A
PAB: PAB0703
RCI: RCIX2738
HBU: Hbut_0320
Taxonomy
Structures PDB: 1QH3  1QH5  1XM8  2GCU  2P18  2P1E  2Q42  2QED  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13032160]
RACKER E.
Spectrophotometric measurements of the metabolic formation and
degradation of thiol esters and enediol compounds.
Biochim. Biophys. Acta. 9 (1952) 577-8.
Saccharomyces cerevisiae [GN:sce]
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:4200890]
Uotila L.
Preparation and assay of glutathione thiol esters. Survey of human
liver glutathione thiol esterases.
Biochemistry. 12 (1973) 3938-43.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:4745654]
Uotila L.
Purification and characterization of S-2-hydroxyacylglutathione
hydrolase (glyoxalase II) from human liver.
Biochemistry. 12 (1973) 3944-51.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 3.1.2.6
IUBMB Enzyme Nomenclature: 3.1.2.6
ExPASy - ENZYME nomenclature database: 3.1.2.6
BRENDA, the Enzyme Database: 3.1.2.6
CAS: 9025-90-5
DBGET integrated database retrieval system