| Entry |
|
|---|
| Name |
alkaline phosphatase;
alkaline phosphomonoesterase;
phosphomonoesterase;
glycerophosphatase;
alkaline phosphohydrolase;
alkaline phenyl phosphatase;
orthophosphoric-monoester phosphohydrolase (alkaline optimum) |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
|---|
| Sysname |
phosphate-monoester phosphohydrolase (alkaline optimum) |
|---|
| Reaction(IUBMB) |
a phosphate monoester + H2O = an alcohol + phosphate [RN:R00626] |
|---|
| Reaction(KEGG) |
R00626 > R03024;
(other) R01010 R04620
 |
|---|
| Substrate |
phosphate monoester [CPD:C01153];
H2O [CPD:C00001] |
|---|
| Product |
alcohol [CPD:C00069];
phosphate [CPD:C00009] |
|---|
| Comment |
Wide specificity. Also catalyses transphosphorylations. The human
placental enzyme is a zinc protein. Some enzymes hydrolyse
diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase) |
|---|
| Pathway |
PATH: ec00361 gamma-Hexachlorocyclohexane degradation
PATH: ec00790 Folate biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01077 alkaline phosphatase |
|---|
| Genes |
HSA: 248(ALPI) 249(ALPL) 250(ALPP) 251(ALPPL2)
PTR: 470679(ALPPL2) 740585(ALPI)
MCC: 717809(ALPL)
MMU: 11647(Alpl) 11648(Akp3) 11650(Alppl2) 76768(Alpi)
RNO: 24197(Alpi) 25586(Alpl) 64621(Akp3)
CFA: 403548(ALPL) 403736(ALPI)
BTA: 100125266 280993(ALPI) 280994(ALPL)
ECB: 100058275 100064555 100064588
MDO: 100022318 100026689 100031702
OAA: 100089749
GGA: 396317(ALPL) 424936(ALPI)
TGU: 100228856
XLA: 100036885 380589(alpl)
XTR: 100144722(alpi.2)
DRE: 393982(alp) 541539(alpi) 564254 574009
SPU: 577089 578161 580300 584498
DME: Dmel_CG10592 Dmel_CG10827 Dmel_CG1462(Aph-4) Dmel_CG16771
Dmel_CG1809 Dmel_CG3264 Dmel_CG3290 Dmel_CG3292 Dmel_CG5150
Dmel_CG5361 Dmel_CG5656 Dmel_CG8105 Dmel_CG8147
DPO: Dpse_GA10582 Dpse_GA13119 Dpse_GA14786 Dpse_GA17037
Dpse_GA17199 Dpse_GA20828 Dpse_GA20850
AGA: AgaP_AGAP010596
AAG: AaeL_AAEL000931
AME: 410530 551687
TCA: 663929
NVE: NEMVE_v1g162264
OLU: OSTLU_26163
SCE: YDR481C(PHO8)
AGO: AGOS_AGL260W
KLA: KLLA0E12859g
DHA: DEHA0B14828g
PIC: PICST_43722(PHO82) PICST_82654(PHO8)
CGR: CAGL0H07359g
YLI: YALI0F16709g
SPO: SPBC14F5.13c
NCR: NCU08997
MGR: MGG_05299 MGG_07763
ANI: AN4516.2
AFM: AFUA_2G03110 AFUA_6G08710
AOR: AO090023000621 AO090120000280
ANG: An07g07520
UMA: UM03579.1 UM04114.1
DDI: DDB_0231570(alp)
ECO: b0383(phoA)
ECJ: JW0374(phoA)
ECD: ECDH10B_0340(phoA)
EBW: BWG_0267(phoA)
ECE: Z0479(phoA)
ECS: ECs0433
ECF: ECH74115_0457(phoA)
ETW: ECSP_0445(phoA)
ECG: E2348C_0319(phoA)
ECC: c0490(phoA)
ECI: UTI89_C0402(phoA)
ECP: ECP_0442
ECV: APECO1_1625(phoA)
ECW: EcE24377A_0410(phoA)
ECX: EcHS_A0451(phoA)
ECM: EcSMS35_0413(phoA)
ECY: ECSE_0404
ECL: EcolC_3249
ECQ: ECED1_0406(phoA)
ECR: ECIAI1_0382(phoA)
ECT: ECIAI39_0298(phoA)
ECZ: ECS88_0377(phoA)
EUM: ECUMN_0421(phoA)
ELF: LF82_1656(phoA)
EBL: B21_00334(phoA)
EBD: ECBD_3281
EBR: ECB_00330(phoA)
EFE: EFER_2640(phoA)
YPE: YPO2298(phoA)
YPK: y2130(phoA)
YPM: YP_2083(phoA)
YPA: YPA_1647
YPN: YPN_1759
YPG: YpAngola_A2291
YPP: YPDSF_0845
YPS: YPTB2220(phoA)
YPI: YpsIP31758_1835
YPY: YPK_1946
YPB: YPTS_2298
YEN: YE2068(phoA)
SFL: SF0230(phoA)
SFX: S0252(phoA)
SFV: SFV_0346(phoA)
SSN: SSON_0358(phoA)
SBO: SBO_0278(phoA)
ECA: ECA4130
ETA: ETA_14380(phoA)
PLU: plu4256(phoA)
PAY: PAU_00480(phoA)
ENT: Ent638_0854
KPN: KPN_00327(phoA)
KPE: KPK_4359(phoA)
KPU: KP1_1186(phoA)
CKO: CKO_02788
SPE: Spro_1528
PMR: PMI2500(phoA)
EIC: NT01EI_3263
DDA: Dd703_3809
APJ: APJL_0747
APA: APP7_0789
XFA: XF0657
XFT: PD1515(phoA)
XFM: Xfasm12_1655
XFN: XfasM23_1602
XCC: XCC2597(phoA)
XCB: XC_1519
XCV: XCV2913(phoA) XCV4265(phoD1)
XAC: XAC2759(phoA)
XOO: XOO3296(phoA)
XOM: XOO_3119
SML: Smlt3463 Smlt4232(phoA)
VPA: VP1262 VPA1073
PPR: PBPRB0359
PAE: PA3296(phoA)
PAU: PA14_21410(phoA)
PAP: PSPA7_1828(phoA)
PAG: PLES_17701(phoA)
PSP: PSPPH_0910(phoD)
CJA: CJA_1403
ACB: A1S_2677
ABM: ABSDF0801
ABY: ABAYE0811
ABB: ABBFA_000797
SON: SO_0737.1 SO_0806 SO_0830
SDN: Sden_2976 Sden_3287
SFR: Sfri_0541 Sfri_2542 Sfri_2543 Sfri_3596
SAZ: Sama_0502 Sama_0573 Sama_2924
SBL: Sbal_0651 Sbal_3529 Sbal_3691 Sbal_3692
SBM: Shew185_0664 Shew185_0665 Shew185_0807 Shew185_3654
SBN: Sbal195_0695 Sbal195_0696 Sbal195_0839 Sbal195_3777
SBP: Sbal223_0686 Sbal223_0832 Sbal223_3587
SLO: Shew_0832 Shew_1157 Shew_1158 Shew_3226
SPC: Sputcn32_3163 Sputcn32_3184
SSE: Ssed_0910 Ssed_1249 Ssed_1250 Ssed_3974
SPL: Spea_0820 Spea_1144 Spea_1145
SHE: Shewmr4_0688 Shewmr4_3312 Shewmr4_3369 Shewmr4_3370
SHM: Shewmr7_0583 Shewmr7_0584 Shewmr7_0641 Shewmr7_3334
SHN: Shewana3_3446 Shewana3_3482 Shewana3_3539 Shewana3_3540
SHW: Sputw3181_0759 Sputw3181_0780
SHL: Shal_0874
SWD: Swoo_0959 Swoo_1350
SWP: swp_1292 swp_3844
ILO: IL2011(phoA) IL2176
CPS: CPS_1963 CPS_3932 CPS_3933
PHA: PSHAa1860(phoD) PSHAa2976 PSHAa2977 PSHAb0500
PAT: Patl_1216
SDE: Sde_0655
MAQ: Maqu_3609
PIN: Ping_2627 Ping_3408 Ping_3409
TTU: TERTU_0659 TERTU_4022
MCA: MCA2187
AEH: Mlg_1869
HHA: Hhal_0736
HCH: HCH_01191 HCH_05826
AHA: AHA_2791 AHA_2792
ASA: ASA_1538(phoA2) ASA_1539(phoA1)
TAU: Tola_3056
DNO: DNO_0105
CVI: CV_1513(phoA2) CV_1514(phoA1)
RSO: RSc0097 RSc0098
RPI: Rpic_3653 Rpic_3654
RPF: Rpic12D_3330 Rpic12D_3331
REH: H16_A2182 H16_A2183
RME: Rmet_4084 Rmet_4085
BMA: BMA0106
BMV: BMASAVP1_A3073 BMASAVP1_A3074
BML: BMA10229_A2020 BMA10229_A2021
BMN: BMA10247_2265 BMA10247_2266
BPS: BPSL0360 BPSL0361
BPM: BURPS1710b_0567 BURPS1710b_0568(phoA2)
BPL: BURPS1106A_0404 BURPS1106A_0405
BPD: BURPS668_0384 BURPS668_0385
BTE: BTH_I0332 BTH_I0333
BUR: Bcep18194_B2852 Bcep18194_B2853
PNU: Pnuc_1592
PNA: Pnap_1209
AAV: Aave_1411
AJS: Ajs_3582
DAC: Daci_4037 Daci_5568
DIA: Dtpsy_2905
VAP: Vapar_5658
LCH: Lcho_3609
EBA: ebA362
AZO: azo3855
DAR: Daro_3229
MFA: Mfla_0451 Mfla_1206
SUN: SUN_0543
GUR: Gura_2889
GLO: Glov_0596
PCA: Pcar_0512
PPD: Ppro_1376
DDE: Dde_1216
DMA: DMR_08520
BBA: Bd3653(ybaA)
DAT: HRM2_01880(phoA)
ADE: Adeh_0981 Adeh_0982
ACP: A2cp1_1041
PLA: Plav_0979
RET: RHE_CH01592(ypch00553) RHE_CH04099(phoA)
REC: RHECIAT_CH0004389(phoA)
RLE: RL4713
BME: BMEI0790 BMEII0655
BMF: BAB1_1222
BMB: BruAb1_1205(phoA)
BMC: BAbS19_I11380
BMS: BR1200(phoA)
BMT: BSUIS_A1248(phoA)
BOV: BOV_1163(phoA)
BCS: BCAN_A1222(phoA)
RPA: RPA0391
RPB: RPB_0089
RPC: RPC_0030
RPD: RPD_0714
RPE: RPE_0033 RPE_3453
RPT: Rpal_0396
MET: M446_6455
CCR: CC_0455
CCS: CCNA_00487
CAK: Caul_0348
MMR: Mmar10_2404
HNE: HNE_1260(phoD1) HNE_3483 HNE_3501(phoD2)
HBA: Hbal_0960
ZMO: ZMO0938
ELI: ELI_11965 ELI_12380
GOX: GOX0675
RRU: Rru_A1289
RCE: RC1_2391(phoD)
BSU: BSU05740(phoB) BSU09410(phoA)
BHA: BH0874
BAN: BA3001 BA4574
BAR: GBAA3001 GBAA4574
BAA: BA_3509 BA_5016
BAT: BAS2789 BAS4244
BAH: BAMEG_1604 BAMEG_4611
BAI: BAA_3054 BAA_4593
BCE: BC2986 BC4343
BCA: BCE_3038 BCE_4427
BCZ: BCZK2719(phoB) BCZK4093
BCR: BCAH187_A4478
BCB: BCB4264_A4466
BCU: BCAH820_2999 BCAH820_4426
BCG: BCG9842_B0771
BCQ: BCQ_2818(phoB)
BCX: BCA_3071
BCY: Bcer98_3069
BTK: BT9727_2738(phoB) BT9727_4082
BTL: BALH_2686 BALH_3935
BLI: BL01381(phoB)
BLD: BLi02565(phoB)
BCL: ABC0731 ABC3952(phoB)
BAY: RBAM_009670(phoA)
BPU: BPUM_0896(phoA)
OIH: OB1029 OB2407
GKA: GK2701
GTN: GTNG_0171 GTNG_2628
GWC: GWCH70_1480
GYC: GYMC61_0816
SAU: SA2420(phoB)
SAV: SAV2627(phoB)
SAM: MW2547(phoB)
SAS: SAS2513
SAC: SACOL2648
SAB: SAB2386 SAB2502(phoB)
SAA: SAUSA300_2561(phoB)
SAO: SAOUHSC_02958
SAJ: SaurJH9_2650
SAH: SaurJH1_2706
SAE: NWMN_2526(phoB)
SEP: SE2197
SER: SERP2208
SHA: SH0401(phoB)
SSP: SSP0592
LSP: Bsph_0475
ESI: Exig_2710
MCL: MCCL_0790(phoB)
BBE: BBR47_01730
PJD: Pjdr2_1059
LLC: LACR_0747
LLM: llmg_1854(apl)
LSL: LSL_1322
EFA: EF2973(phoZ)
CTC: CTC00659
CCE: Ccel_0930
AOE: Clos_0143
ATE: Athe_2754
DSY: DSY4404
DHD: Dhaf_0924
HMO: HM1_2777
CSC: Csac_2767
MSM: MSMEG_1012 MSMEG_2292
MVA: Mvan_3577
MAB: MAB_0087c
CGL: NCgl2185(cgl2265) NCgl2371(cgl2457)
CGB: cg2485(phoD) cg2700(phoB)
CGT: cgR_2137 cgR_2360
CEF: CE1217 CE2165
CJK: jk0107(phoD)
NFA: nfa36460
RER: RER_19780(phoA)
SCO: SCO0828(SCF43A.18) SCO2068(SC4A10.01)
SMA: SAV_6139(phoD1)
ART: Arth_3573 Arth_4197 Arth_4297 Arth_4466
NCA: Noca_3819
KRA: Krad_0180 Krad_4547
STP: Strop_0765 Strop_2394
BAD: BAD_1548
RXY: Rxyl_0447
LIL: LA4246
LIC: LIC13397(phoD)
BTH: BT_3708
BFR: BF0480
BFS: BF0425
BVU: BVU_1493
PGI: PG0890
SRU: SRU_0238 SRU_2450
RMR: Rmar_1241
FJO: Fjoh_3187 Fjoh_3249
COC: Coch_0399
AMU: Amuc_0870
RBA: RB1934 RB3532 RB5778(phoA) RB5813(phoD) RB88(phoD)
SYW: SYNW0196
CYA: CYA_0781 CYA_2506(phoD)
CYB: CYB_0684(phoD) CYB_1198
GVI: gll0363 gll0567
PMB: A9601_18341(dedA)
PMC: P9515_18131(dedA)
PMF: P9303_01771(dedA)
PMG: P9301_18161(dedA)
PME: NATL1_11501 NATL1_20761(dedA)
CCH: Cag_0406 Cag_0787
CPH: Cpha266_2693
CPB: Cphamn1_0512
CLI: Clim_2447
PVI: Cvib_1725
PLT: Plut_2085
PPH: Ppha_1700
PAA: Paes_2225
CTS: Ctha_1961
RRS: RoseRS_1990
RCA: Rcas_3268
CAU: Caur_2536
CHL: Chy400_2737
DRA: DR_B0046(phoB)
DGE: Dgeo_2364
TTH: TT_P0024
TTJ: TTHB067
TMA: TM0156
TPT: Tpet_0770
TLE: Tlet_0141 Tlet_1583
TRQ: TRQ2_0793
TNA: CTN_0532
TME: Tmel_1137
TAF: THA_825
FNO: Fnod_0754
KOL: Kole_1359
DTH: DICTH_0398
DTU: Dtur_0524
TYE: THEYE_A1782
TTR: Tter_2306
MAC: MA4354(phoA)
MBA: Mbar_A1231
MMA: MM_0572
HAL: VNG6301G(aph)
PAB: PAB2366(phoA)
PFU: PF1004
 |
|---|
| Structures |
PDB: 1AJA 1AJB 1AJC 1AJD 1ALH 1ALI 1ALJ 1ALK 1ANI 1ANJ
1B8J 1ED8 1ED9 1ELX 1ELY 1ELZ 1EW2 1EW8 1EW9 1HJK
1HQA 1K7H 1KH4 1KH5 1KH7 1KH9 1KHJ 1KHK 1KHL 1KHN
1SHN 1SHQ 1URA 1URB 1Y6V 1Y7A 1ZEB 1ZED 1ZEF 2ANH
2G9Y 2GA3 2GLQ 2IUC 2W0Y 2W5V 2W5W 2W5X 3BDF 3BDG
3BDH 3CMR 3DPC 3DYC 3E2D |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13890304]
ENGSTROM L.
Studies on calf-intestinal alkaline phosphatase. I. Chromatographic
purification, microheterogeneity and some other properties of the
purified enzyme.
Biochim. Biophys. Acta. 52 (1961) 36-48.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4970479]
Harkness DR.
Studies on human placental alkaline phosphatase. II. Kinetic
properties and studies on the apoenzyme.
Arch. Biochem. Biophys. 126 (1968) 513-23.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:14269306]
MALAMY MH, HORECKER BL.
PURIFICATION AND CRYSTALLIZATION OF THE ALKALINE PHOSPHATASE OF
ESCHERICHIA COLI.
Biochemistry. 3 (1964) 1893-7.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13115375]
MORTON RK.
Alkaline phosphatase of milk. 2. Purification of the enzyme.
Biochem. J. 55 (1953) 795-800.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
|
5
Stadtman, T.C.
Alkaline phosphatases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 5, Academic Press, New York, 1961, p. 55-71. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.1
IUBMB Enzyme Nomenclature: 3.1.3.1
ExPASy - ENZYME nomenclature database: 3.1.3.1
BRENDA, the Enzyme Database: 3.1.3.1
CAS: 9001-78-9 |
|---|
