| Entry |
|
|---|
| Name |
phosphoserine phosphatase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
|---|
| Sysname |
O-phosphoserine phosphohydrolase |
|---|
| Reaction(IUBMB) |
O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate
[RN:R00582 R02853] |
|---|
| Reaction(KEGG) |
R00582 R02853
 |
|---|
| Substrate |
O-phospho-L-serine [CPD:C01005];
O-phospho-D-serine;
H2O [CPD:C00001] |
|---|
| Product |
L-serine [CPD:C00065];
D-serine [CPD:C00740];
phosphate [CPD:C00009] |
|---|
| Pathway |
PATH: ec00260 Glycine, serine and threonine metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01079 phosphoserine phosphatase
KO: K02203 phosphoserine / homoserine phosphotransferase
KO: K05518 negative regulator of sigma-B (phosphoserine
phosphatase) |
|---|
| Genes |
HSA: 5723(PSPH)
PTR: 463420(PSPH)
MCC: 715687
MMU: 100678(Psph)
RNO: 304429(Psph)
CFA: 489783(PSPH)
BTA: 533630(PSPH)
ECB: 100061297
MDO: 100010308
TGU: 100228134
XLA: 446328(psph)
DRE: 606663
CIN: 100178245
DME: Dmel_CG3705(aay)
DPO: Dpse_GA17627
DAN: Dana_GF10695
AGA: AgaP_AGAP012247
AAG: AaeL_AAEL001100
AME: 412674
TCA: 659777
API: 100158884(Acypi000304)
CEL: Y62E10A.13
CBR: CBG01775
BMY: Bm1_49380
NVE: NEMVE_v1g209120
TAD: TRIADDRAFT_49601
ATH: AT1G18640(PSP)
POP: POPTR_569934
OSA: 4350964(Os11g0629500) 4352281(Os12g0502400)
PPP: PHYPADRAFT_134750
CRE: CHLREDRAFT_194322(PSP1)
OLU: OSTLU_16249
CME: CMI086C
SCE: YGR208W(SER2)
AGO: AGOS_ACL130C
KLA: KLLA0E16423g
DHA: DEHA0G04455g
PIC: PICST_40365(PSP1)
VPO: Kpol_1050p43
CAL: CaO19.13260(SER2)
CGR: CAGL0K00825g
YLI: YALI0B20438g
SPO: SPBC3H7.07c
NCR: NCU02004
PAN: PODANSg4469
MGR: MGG_03661
FGR: FG08529.1
AFM: AFUA_3G06550
AOR: AO090020000345
ANG: An11g09770
NFI: NFIA_070710
SSL: SS1G_04321
BFU: BC1G_12230
MBR: MONBRDRAFT_16456
DDI: DDB_0230054(serB)
PTI: PHATRDRAFT_19244(PSP)
TPS: THAPSDRAFT_32137
ECO: b4388(serB)
ECJ: JW4351(serB)
ECD: ECDH10B_4546(serB)
EBW: BWG_4080(serB)
ECE: Z5989(serB)
ECS: ECs5346(serB)
ECF: ECH74115_5902(serB)
ETW: ECSP_5470(serB)
ECG: E2348C_4686(serB)
ECC: c5473(serB)
ECI: UTI89_C5159(serB)
ECP: ECP_4772(serB)
ECV: APECO1_1993(serB)
ECW: EcE24377A_4987(serB)
ECX: EcHS_A4623(serB)
ECM: EcSMS35_4937(serB)
ECY: ECSE_4663(serB)
ECL: EcolC_3668(serB)
ECK: EC55989_5050(serB)
ECQ: ECED1_5259(serB)
ECR: ECIAI1_4611(serB)
ECT: ECIAI39_4920(serB)
ECZ: ECS88_5069(serB)
EUM: ECUMN_5012(serB)
ELF: LF82_2116(serB)
EBL: B21_04229(serB)
EBD: ECBD_3632
EBR: ECB_04264(serB)
EOH: ECO103_5249(serB)
EOI: ECO111_5249(serB)
EOJ: ECO26_5594(serB)
EFE: EFER_4485(serB)
STY: STY4925(serB)
STT: t4617(serB)
SPT: SPA4388(serB)
SEK: SSPA4073(serB)
SPQ: SPAB_05756(serB)
SEI: SPC_4711(serB)
SEC: SC4423(serB)
SEH: SeHA_C4988(serB)
SEE: SNSL254_A4936(serB)
SEW: SeSA_A4829(serB)
SEA: SeAg_B4902(serB)
SED: SeD_A4990(serB)
SEG: SG4400(serB)
SET: SEN4334(serB)
SES: SARI_03005(serB)
STM: STM4578(serB)
YPE: YPO0442(serB)
YPK: y3738(serB)
YPM: YP_3740(serB)
YPA: YPA_3842(serB)
YPN: YPN_0313(serB)
YPG: YpAngola_A0826(serB)
YPP: YPDSF_3192(serB)
YPS: YPTB0586(serB)
YPI: YpsIP31758_3493(serB)
YPY: YPK_3622(serB)
YPB: YPTS_0608(serB)
YEN: YE0578(serB)
SFL: SF4420(serB)
SFX: S4691(serB)
SFV: SFV_4422(serB)
SSN: SSON_4538(serB)
SBO: SBO_4451(serB)
SBC: SbBS512_E4935(serB)
SDY: SDY_4649(serB)
ECA: ECA0465(serB)
PCT: PC1_0450
ETA: ETA_06720(serB)
PLU: plu0551(serB)
PAY: PAU_00520(serB)
SGL: SG0398(serB)
ENT: Ent638_0547(serB)
ESA: ESA_03364(serB)
KPN: KPN_04843(serB)
KPE: KPK_4771(serB)
KPU: KP1_0804(serB)
CKO: CKO_03400(serB)
SPE: Spro_0666(serB)
PMR: PMI2507(serB)
EIC: NT01EI_0618
ETR: ETAE_0539(serB)
DDA: Dd703_1255 Dd703_3469
DZE: Dd1591_3588
HIN: HI1033(serB)
HIT: NTHI1192(serB)
HIP: CGSHiEE_06895(serB)
HIQ: CGSHiGG_08785(serB)
HSO: HS_0687(serB)
HSM: HSM_1098(serB)
PMU: PM1657(serB)
MSU: MS1758(serB)
APL: APL_1230(serB)
APJ: APJL_1241(serB)
APA: APP7_1279
ASU: Asuc_2112(serB)
AAP: NT05HA_2341
AAT: D11S_1919
VCH: VC2345(serB)
VCO: VC0395_A1924(serB)
VVU: VV1_1730(serB)
VVY: VV2674(serB)
VPA: VP2431(serB)
VHA: VIBHAR_03372(serB)
VSP: VS_2458(serB)
VFI: VF_0509(serB)
VFM: VFMJ11_0511(serB)
VSA: VSAL_I0624(serB)
PPR: PBPRA0635(serB)
PAE: PA1757(thrH) PA4960
PAU: PA14_41830(thrH) PA14_65560(serB)
PAP: PSPA7_3550(thrH) PSPA7_5689
PAG: PLES_35721(thrH) PLES_53461
PPU: PP_4909(serB)
PPF: Pput_4785
PPG: PputGB1_4962
PPW: PputW619_4701
PST: PSPTO_2281 PSPTO_4957
PSB: Psyr_0557 Psyr_2079(thrH)
PSP: PSPPH_0550 PSPPH_2050(thrH)
PFL: PFL_0551 PFL_1855(thrH)
PFO: Pfl01_0506 Pfl01_1758(thrH)
PFS: PFLU0504 PFLU4641
PEN: PSEEN4962(serB)
PMY: Pmen_0618 Pmen_2544(thrH)
PSA: PST_2028(thrH) PST_3805(serB)
CJA: CJA_2041(thrH) CJA_2960
AVN: Avin_07410(serB)
PAR: Psyc_1857(serB)
PCR: Pcryo_2146
PRW: PsycPRwf_2184
ACI: ACIAD0834(thrH) ACIAD3567(serB)
ACB: A1S_2774(thrH) A1S_3386
ABM: ABSDF0688(thrH) ABSDF3575(serB)
ABY: ABAYE0098(serB) ABAYE0710(thrH)
ABC: ACICU_03024(thrH) ACICU_03586
ABN: AB57_3275(thrH) AB57_3836
ABB: ABBFA_000097(serB) ABBFA_000693(thrH)
SON: SO_1223(serB)
SDN: Sden_1032
SFR: Sfri_1007
SAZ: Sama_0978
SBL: Sbal_3222
SBM: Shew185_3223
SBN: Sbal195_3361
SBP: Sbal223_1145
SLO: Shew_2810
SPC: Sputcn32_2817
SSE: Ssed_3373
SHE: Shewmr4_1042
SHM: Shewmr7_1107
SHN: Shewana3_1046
SHW: Sputw3181_1194
ILO: IL1876(serB_2)
CPS: CPS_1107(serB)
PHA: PSHAa0661(serB)
PAT: Patl_1278
SDE: Sde_1075 Sde_1670(thrH)
MAQ: Maqu_1581(thrH) Maqu_2786
PIN: Ping_2446
TTU: TERTU_0663 TERTU_1745(thrH)
CBU: CBU_1730
MCA: MCA1267(serB)
FTH: FTH_1390
FTN: FTN_0742(serB)
TCX: Tcr_1620
NOC: Noc_0206 Noc_2504
AEH: Mlg_1629(thrH) Mlg_2041
HHA: Hhal_1390(thrH) Hhal_1598
HCH: HCH_02661(thrH) HCH_05403(serB)
CSA: Csal_2542
ABO: ABO_1436(thrH) ABO_2442(serB)
MMW: Mmwyl1_1310
AHA: AHA_3685
ASA: ASA_3650(serB)
AFE: Lferr_0538
AFR: AFE_0368(serB)
RMA: Rmag_0271
VOK: COSY_0257(serB)
NMA: NMA1179
NME: NMB0981(serB)
NMC: NMC0961(serB)
NGO: NGO1468
CVI: CV_3516(serB)
LHK: LHK_01051(serB)
RSO: RSc1640(serB)
RPI: Rpic_1906
RPF: Rpic12D_1577
REU: Reut_A1357
REH: H16_A1452(serB1) H16_A3080(serB2) H16_B1164(serB3)
RME: Rmet_1368
BMA: BMA0338 BMA1313(serB)
BMV: BMASAVP1_A0637 BMASAVP1_A1802(serB)
BML: BMA10229_A0094(serB) BMA10229_A2471
BMN: BMA10247_0085 BMA10247_1073(serB)
BPS: BPSL0834 BPSL1543
BPM: BURPS1710b_1041 BURPS1710b_2322(serB)
BPL: BURPS1106A_0881 BURPS1106A_2194(serB)
BPD: BURPS668_0878 BURPS668_2157(serB)
BTE: BTH_I0700 BTH_I2264
BVI: Bcep1808_1709
BUR: Bcep18194_A5077
BCN: Bcen_6301
BCH: Bcen2424_1778
BCM: Bcenmc03_1803
BAM: Bamb_1718
BXE: Bxe_A2331
PNU: Pnuc_0928
BPE: BP0863(serB)
BPA: BPP3368(serB)
BBR: BB3819(serB)
BPT: Bpet1373(thrH)
RFR: Rfer_0818(thrH) Rfer_1329
POL: Bpro_2720
PNA: Pnap_2554
AAV: Aave_1576
AJS: Ajs_3159
VEI: Veis_4883
MPT: Mpe_A1568
HAR: HEAR1915
NEU: NE0439(serB)
NET: Neut_0597
NMU: Nmul_A0636
EBA: ebA3466(thrH) ebA6034(serB)
AZO: azo1668(serB) azo3743(thrH)
DAR: Daro_0057(thrH) Daro_1962
TMZ: Tmz1t_0583
TBD: Tbd_2011
MFA: Mfla_1890
MMB: Mmol_0675
APP: CAP2UW1_3895
HPA: HPAG1_0637
HPB: HELPY_0719(serB)
HHE: HH0078(serB)
HAC: Hac_0485(serB) Hac_1062(serB)
WSU: WS2081(serB)
TDN: Suden_1665
CJE: Cj0282c(serB)
CJR: CJE0330(serB)
CJJ: CJJ81176_0308(serB)
CJU: C8J_0258(serB)
CJD: JJD26997_1689(serB)
CFF: CFF8240_0333(serB)
CCV: CCV52592_1659(serB)
CHA: CHAB381_1307(serB)
CCO: CCC13826_1582(serB)
CLA: Cla_1367(serB)
ABU: Abu_0221(serB)
NIS: NIS_1308
SUN: SUN_0642
NAM: NAMH_1111(serB)
PCA: Pcar_2283(serB)
DMA: DMR_33050(serB)
DSA: Desal_0115
DBA: Dbac_3017
DRT: Dret_0264
DOL: Dole_0290(thrH)
DAL: Dalk_0712(thrH)
DAT: HRM2_13550 HRM2_42260(serB)
AFW: Anae109_2053(thrH)
MXA: MXAN_1089(serB) MXAN_1530
SCL: sce0663(serB)
SAT: SYN_02182
MLO: mlr1449
MES: Meso_1744
PLA: Plav_2462
SME: SMc01494(serB)
SMD: Smed_2012
ATU: Atu2040(serB)
ATC: AGR_C_3697(serB)
ARA: Arad_2903(serB)
AVI: Avi_1112 Avi_2809(serB)
RET: RHE_CH02794(serB)
REC: RHECIAT_CH0002937(serB)
RLE: RL3250(serB)
RLT: Rleg2_2538
RLG: Rleg_2797
RHI: NGR_c20220(serB)
BME: BMEI0615
BMF: BAB1_1410
BMB: BruAb1_1387(serB)
BMC: BAbS19_I13180
BMS: BR1391(serB)
BMT: BSUIS_A1442(serB)
BOV: BOV_1348(serB)
BCS: BCAN_A1423(serB)
BMR: BMI_I1402(serB)
OAN: Oant_1800
BJA: blr6505(serB)
BRA: BRADO5568(serB)
BBT: BBta_6089(serB)
RPA: RPA2029(serB)
RPB: RPB_3347
RPC: RPC_3257
RPD: RPD_2096
RPE: RPE_2185
RPT: Rpal_2240
NWI: Nwi_2345
NHA: Nham_2724
OCA: OCAR_5282(serB)
XAU: Xaut_1660
AZC: AZC_2574(serB)
MEX: Mext_2655
MEA: Mex_1p2848
MDI: METDI3414
MRD: Mrad2831_4531
MET: M446_6188
MPO: Mpop_2777
MCH: Mchl_2882
MNO: Mnod_6707
BID: Bind_3139
MSL: Msil_1756
CCR: CC_2097
CCS: CCNA_02182
CAK: Caul_3347
PZU: PHZ_c0875(serB)
SIL: SPO2363(serB-1) SPO3353(serB-2)
SIT: TM1040_3019
RSP: RSP_1350(serB)
RSH: Rsph17029_0018
RSQ: Rsph17025_0008
RSK: RSKD131_2748
JAN: Jann_0252
RDE: RD1_0195(serB)
PDE: Pden_0812
DSH: Dshi_3316(serB)
HNE: HNE_0453(serB)
ZMO: ZMO1137
NAR: Saro_2259
SAL: Sala_1468
SWI: Swit_0607
ELI: ELI_05525
GOX: GOX1085
GBE: GbCGDNIH1_1483
ACR: Acry_2835
GDI: GDI_0020(serB)
GDJ: Gdia_1777
RRU: Rru_A0465
RCE: RC1_1979(serB)
MAG: amb3479
BSU: BSU04740(rsbX)
BHA: BH0530(rsbX)
BLI: BL02209(rsbX)
BLD: BLi00561(rsbX)
BCL: ABC0817(rsbX)
OIH: OB0631
LMO: lmo0896(rsbX)
LMF: LMOf2365_0915
LIN: lin0895(rsbX)
LWE: lwe0878(rsbX)
LLA: L0085(serB)
LLC: LACR_0621
LLM: llmg_0567(serB)
SPR: spr1033(serB-truncation)
SAG: SAG0625(serB)
SAN: gbs0605
SAK: SAK_0710(serB)
SMU: SMU.1269(serB)
STC: str1519(serB)
STL: stu1519(serB)
STE: STER_1478
SSA: SSA_0508 SSA_0882(serB)
SSU: SSU05_1508
SSV: SSU98_1518
SGO: SGO_1430(serB)
CPF: CPF_1375
CPR: CPR_1188
CTC: CTC00969 CTC01739
CNO: NT01CX_0181
CDF: CD0241
SWO: Swol_0642
DSY: DSY1404
HMO: HM1_2542(serB)
EEL: EUBELI_20125
ERE: EUBREC_2971
TTE: TTE2448(serB)
MTU: Rv0505c(serB1) Rv2483c(plsC) Rv3042c(serB2)
MTC: MT0526 MT3127(serB)
MRA: MRA_0513(serB1) MRA_2508(plsC) MRA_3074(serB2)
MTF: TBFG_13058
MTB: TBMG_00927(TBMG_00927.1)
MBO: Mb0517c(serB1) Mb2508c(plsC) Mb3068c(serB2)
MBB: BCG_0548c(serB1) BCG_2501c(plsC) BCG_3066c(serB2)
MBT: JTY_3061(serB2)
MLE: ML1727
MLB: MLBr_01727
MPA: MAP3090c(serB2) MAP3997c(serB)
MAV: MAV_0431 MAV_1687 MAV_3907(serB) MAV_4645
MSM: MSMEG_0949 MSMEG_1041(serB) MSMEG_2321(serB)
MUL: MUL_1888(serB2) MUL_4577(serB1)
MVA: Mvan_0843 Mvan_2083
MGI: Mflv_0069 Mflv_4276
MAB: MAB_3388c MAB_3995
MMC: Mmcs_0674 Mmcs_1853 Mmcs_5506
MKM: Mkms_0687 Mkms_1900 Mkms_5907
MJL: Mjls_0667 Mjls_1834
MMI: MMAR_1652(serB2)
CGL: NCgl0294(cgl0299) NCgl0400(cgl0415) NCgl2436(cgl2522)
CGB: cg0495 cg2779(serB)
CGT: cgR_0486
CEF: CE0434 CE2417
CDI: DIP1863
CJK: jk0483(serB)
CUR: cur_1477
CAR: cauri_2107(serB)
CKP: ckrop_1407
NFA: nfa42930(serB) nfa51730
RHA: RHA1_ro02056 RHA1_ro05647 RHA1_ro06447(serB)
RER: RER_23580(serB)
ROP: ROP_65000(serB)
GBR: Gbro_3280
SCO: SCO1808(SCI28.02)
SMA: SAV_6470(serB2)
SGR: SGR_5689
LXX: Lxx11750(serB)
CMI: CMM_0549(serB1) CMM_1720(serB2)
ART: Arth_2123 Arth_3299
AAU: AAur_2124(serB) AAur_3296
ACH: Achl_1874
RSA: RSal33209_2096 RSal33209_2715
KRH: KRH_12440(serB)
MLU: Mlut_11600
BCV: Bcav_2319
PAC: PPA2051
NCA: Noca_2574
TFU: Tfu_0136
TCU: Tcur_4820
SRO: Sros_0500
FRA: Francci3_0481
FAL: FRAAL0979(serB)
NML: Namu_1688
KRA: Krad_2903
SEN: SACE_1188(serB) SACE_6952(serB)
SVI: Svir_29300
AMI: Amir_0990
STP: Strop_0348
CAI: Caci_2310
BLO: BL1792(serB)
BAD: BAD_0545(serB)
SHI: Shel_24420
ELE: Elen_1446
LIL: LA2145(serB)
LIC: LIC11775(serB)
LBJ: LBJ_1868(serB)
LBL: LBL_1416(serB)
LBI: LEPBI_I0832(serB)
LBF: LBF_0801(serB)
ABA: Acid345_2803
ACA: ACP_3085(serB)
BTH: BT_0832
BFR: BF2300
BFS: BF2389
BVU: BVU_3158
PGI: PG0653(serB)
PGN: PGN_0692
PDI: BDI_1107
FJO: Fjoh_1712
FSU: Fisuc_2349
FNU: FN0091 FN0892
OTE: Oter_3725(thrH)
RBA: RB8037(serB)
AVA: Ava_3723
CTE: CT0173(serB)
CPC: Cpar_1870
CCH: Cag_0409
CPH: Cpha266_0250
CPB: Cphamn1_0341
CLI: Clim_0216
PVI: Cvib_1591
PLT: Plut_1948
PPH: Ppha_2664
PAA: Paes_0314
CTS: Ctha_0041
RRS: RoseRS_3902(thrH)
RCA: Rcas_3211(thrH)
MJA: MJ1594
MFE: Mefer_0829
MMP: MMP0541(serB)
MMQ: MmarC5_1066
MMX: MmarC6_0351
MMZ: MmarC7_1560
MAE: Maeo_1052
MVN: Mevan_1695
MAC: MA0678 MA4428 MA4429(serB)
MBA: Mbar_A1093 Mbar_A1094
MMA: MM_1106 MM_1107 MM_1833
MBU: Mbur_0935 Mbur_0936
MTP: Mthe_1682
MHU: Mhun_0943
MLA: Mlab_0742
MEM: Memar_1450
MBN: Mboo_1403
MTH: MTH1626
MST: Msp_1096
MSI: Msm_0719
MKA: MK0121(serB)
AFU: AF2031 AF2138(serB)
HAL: VNG2423G(serB)
HMA: pNG7333(serB2) rrnAC1820 rrnAC2717(serB1)
HWA: HQ1044A(serB)
NPH: NP0274A(serB) NP4058A
HLA: Hlac_0452 Hlac_2730
TAC: Ta0936
TVO: TVN1082
PTO: PTO0700 PTO0776 PTO1365
PAB: PAB1207
PFU: PF1921
TKO: TK0052
TON: TON_1175
TGA: TGAM_0997(serB)
TSI: TSIB_1092
RCI: RCIX1733(serB-1) RCIX1735(serB-2)
APE: APE_0683
IHO: Igni_0242 Igni_0986
HBU: Hbut_0391
PAI: PAE2017
PIS: Pisl_1830
PCL: Pcal_1016
PAS: Pars_2080
TNE: Tneu_1288
NMR: Nmar_0666
KCR: Kcr_1154
 |
|---|
| Structures |
PDB: 1F5S 1J97 1L7M 1L7N 1L7O 1L7P 1L8L 1L8O 1NNL 2J6Y
2J6Z 2J70 2OM6 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13654276]
BORKENHAGEN LF, KENNEDY EP.
The enzymatic exchange of L-serine with O-phospho-L-serine catalyzed
by a specific phosphatase.
J. Biol. Chem. 234 (1959) 849-53.
Rattus norvegicus [GN:rno], Gallus gallus [GN:gga] |
|---|
Reference
Authors
Title
Journal
|
2
Byrne, W.L.
Glucose-6-phosphatase and phosphoserine phosphatase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 5, Academic Press, New York, 1961, p. 73-78. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13610904]
NEUHAUS FC, BYRNE WL.
Metabolism of phosphoserine. II. Purification and properties of
O-phosphoserine phosphatase.
J. Biol. Chem. 234 (1959) 113-21.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.3
IUBMB Enzyme Nomenclature: 3.1.3.3
ExPASy - ENZYME nomenclature database: 3.1.3.3
BRENDA, the Enzyme Database: 3.1.3.3
CAS: 9025-73-4 |
|---|
