| Entry |
|
|---|
| Name |
phosphoinositide 5-phosphatase;
type II inositol polyphosphate 5-phosphatase;
triphosphoinositide phosphatase;
IP3 phosphatase;
PtdIns(4,5)P2 phosphatase;
triphosphoinositide phosphomonoesterase;
diphosphoinositide phosphatase;
inositol 1,4,5-triphosphate 5-phosphomonoesterase;
inositol triphosphate 5-phosphomonoesterase;
phosphatidylinositol-bisphosphatase;
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase;
phosphatidylinositol 4,5-bisphosphate phosphatase;
polyphosphoinositol lipid 5-phosphatase;
phosphatidyl-inositol-bisphosphate phosphatase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
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| Sysname |
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase |
|---|
| Reaction(IUBMB) |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O =
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate [RN:R04404] |
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| Reaction(KEGG) |
R04404
 |
|---|
| Substrate |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [CPD:C04637];
H2O [CPD:C00001] |
|---|
| Product |
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277];
phosphate [CPD:C00009] |
|---|
| Comment |
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3
and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with
differing abilities to catalyse two or more of the four reactions
listed. They are thought to use inositol lipids rather than inositol
phosphates as substrates in vivo. All of them can use either or both
of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main
property that distinguishes them from EC 3.1.3.56,
inositol-polyphosphate 5-phosphatase. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K01099 phosphatidylinositol-bisphosphatase |
|---|
| Genes |
HSA: 3633(INPP5B) 4952(OCRL) 56623(INPP5E) 8867(SYNJ1) 8871(SYNJ2)
PTR: 456767(INPP5B) 473959(SYNJ1) 748603(PMPCA)
MCC: 705639 710121
MMU: 104015(Synj1) 20975(Synj2) 320634(Ocrl) 64436(Inpp5e)
RNO: 317576(Ocrl) 84018(Synj2) 85238(Synj1)
CFA: 478403(SYNJ1) 484052(SYNJ2) 492123(OCRL) 607443(INPP5E)
BTA: 282087(SYNJ1) 506349(INPP5E) 518435(SYNJ2) 535844(OCRL)
538291(INPP5B)
ECB: 100052605(SYNJ1) 100054559 100059144(OCRL) 100059716(SYNJ2)
100068731
MDO: 100016332 100021521 100032343
OAA: 100074182 100083729 100087165 100092732
GGA: 417135(INPP5E) 418498(SYNJ1) 419609(INPP5B) 422136(OCRL)
TGU: 100218296 100219842 100220826 100227989 100228100
DRE: 337236(synj1) 777716
BFO: BRAFLDRAFT_120737
CIN: 100177344 100177642 100180050
SPU: 592337 592451
DME: Dmel_CG10426
DPE: Dper_GL18219
AGA: AgaP_AGAP005139 AgaP_AGAP010556 AgaP_AGAP012175
AAG: AaeL_AAEL001367 AaeL_AAEL003143 AaeL_AAEL011417
CQU: CpipJ_CPIJ002194 CpipJ_CPIJ002259 CpipJ_CPIJ010212
AME: 409136 411705 412731
NVI: 100121409 100123980
TCA: 658061 659292 661520
API: 100159919 100160196 100160684
ISC: IscW_ISCW000015 IscW_ISCW017778
CBR: CBG01799 CBG03815
BMY: Bm1_02165 Bm1_40105 Bm1_48265
SMM: Smp_064190 Smp_159670 Smp_166990
NVE: NEMVE_v1g164307 NEMVE_v1g174916 NEMVE_v1g215928
HMG: 100210418 100215015
TAD: TRIADDRAFT_29738 TRIADDRAFT_32656 TRIADDRAFT_53207
MBR: MONBRDRAFT_22078 MONBRDRAFT_28797
DDI: DDB_0191151(Dd5P4)
EHI: EHI_153490
EDI: EDI_093680
TET: TTHERM_00035480 TTHERM_00079570 TTHERM_00621470
PTI: PHATRDRAFT_573
TPS: THAPSDRAFT_2555
 |
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| Structures |
PDB: 1UFW 1W80 2DNR 2KIE 2QV2 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4284485]
Dawson RM, Thompson W.
The triphosphoinositide phosphomonoesterase of brain tissue.
Biochem. J. 91 (1964) 244-50.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:6271223]
Roach PD, Palmer FB.
Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate
phosphatase.
Biochim. Biophys. Acta. 661 (1981) 323-33.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
|
3
Woscholski, R. and Parker, P.J.
Inositol phosphatases: constructive destruction of phosphoinositides
and inositol phosphates.
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of
Phosphoinositides, Oxford, 2000, p. 320-338. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.36
IUBMB Enzyme Nomenclature: 3.1.3.36
ExPASy - ENZYME nomenclature database: 3.1.3.36
BRENDA, the Enzyme Database: 3.1.3.36
CAS: 9036-01-5 |
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