KEGG   ENZYME: 3.1.3.4Help
Entry
EC 3.1.3.4                  Enzyme                                 
Name
phosphatidate phosphatase;
phosphatic acid phosphatase;
acid phosphatidyl phosphatase;
phosphatic acid phosphohydrolase;
PAP, Lipin
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
diacylglycerol-3-phosphate phosphohydrolase
Reaction(IUBMB)
a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate [RN:R02239]
Reaction(KEGG)
Substrate
1,2-diacylglycerol 3-phosphate;
H2O [CPD:C00001]
Product
1,2-diacyl-sn-glycerol [CPD:C00641];
phosphate [CPD:C00009]
Comment
This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signalling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.
Pathway
Glycerolipid metabolism
Glycerophospholipid metabolism
Ether lipid metabolism
Sphingolipid metabolism
Metabolic pathways
Orthology
K01080  
phosphatidate phosphatase
K15728  
phosphatidate phosphatase LPIN
Genes
HSA: 
23175(LPIN1) 64900(LPIN3) 8611(PPAP2A) 8612(PPAP2C) 8613(PPAP2B) 9663(LPIN2)
PTR: 
455317(LPIN2) 455525(PPAP2C) 456884(PPAP2B) 458255(LPIN3) 459036(LPIN1) 461869(PPAP2A)
PPS: 
100967268(LPIN3) 100971417(LPIN1) 100975594(PPAP2B) 100975798(PPAP2C) 100977018(LPIN2) 100987060(PPAP2A)
GGO: 
PON: 
100442989(PPAP2C) 100448168(PPAP2A) 100451550(LPIN2) 100455097(PPAP2B) 100458857(LPIN1)
MCC: 
MMU: 
101056416 14245(Lpin1) 19012(Ppap2a) 50784(Ppap2c) 64898(Lpin2) 64899(Lpin3) 67916(Ppap2b)
RNO: 
192270(Ppap2b) 246115(Ppap2c) 313977(Lpin1) 316737(Lpin2) 362261(Lpin3) 64369(Ppap2a)
CFA: 
100856443 475670(LPIN1) 479557(PPAP2B) 485876(LPIN3) 607640(LPIN2) 607962(PPAP2A)
AML: 
FCA: 
101085623(LPIN1) 101087178(LPIN2) 101088547(PPAP2A) 101088986(PPAP2C) 101095760(PPAP2B) 101096222(LPIN3)
BTA: 
504545(PPAP2C) 514448(LPIN2) 521637(LPIN3) 537224(LPIN1) 617172(PPAP2A) 617707(PPAP2B)
SSC: 
100170771(LPIN3) 100170845(LPIN1) 100187579(LPIN2) 100233200(PPAP2C) 100512419 100515451
ECB: 
100049896 100051300(LPIN2) 100055753(LPIN3) 100062257 100072273(LPIN1) 100147309
MDO: 
100012110(LPIN2) 100025143 100031858 100032239 100032678
SHR: 
100919385(LPIN2) 100921659 100922599(LPIN3) 100926398(PPAP2B) 100927244 100934490(PPAP2A)
OAA: 
100073354(LPIN1) 100077278(LPIN2) 100078592 100083232 100084258 100090109
GGA: 
100858471 421059(LPIN2) 421945(LPIN1) 424666(PPAP2B) 427138(PPAP2A)
MGP: 
100539289(LPIN1) 100547177 100551046 100551396
TGU: 
100220959(PPAP2A) 100227047(PPAP2B) 100230735(LPIN2) 100231657(LPIN1)
ACS: 
100552130 100552631 100557280 100559740(lpin3) 100562132 100562534 100566027(lpin2)
XLA: 
398816(lpin2) 443763(ppap2c) 444206 447215(ppap2b-b) 447319(ppap2b-a) 735106(ppap2a)
XTR: 
100135382 394722(ppap2c) 496488(ppap2a) 549612(ppap2b) 779950(lpin1) 779972(lpin2)
DRE: 
335485(ppap2c) 557680(ppap2b) 558422(lipin2) 559124(ppap2b) 560638 563806 569053 794598 799099(lpin1)
TRU: 
101065874 101070467 101070779 101072572 101075847 101076308 101077623 101079363
OLA: 
101159828 101161835 101166135 101166433 101168661 101172508 101173452
BFO: 
BRAFLDRAFT_209457 BRAFLDRAFT_83499
CIN: 
100177985 100183801
SPU: 
576030 582841 756707
DME: 
Dmel_CG11425 Dmel_CG11426 Dmel_CG11437 Dmel_CG11438 Dmel_CG11440(laza) Dmel_CG12746 Dmel_CG8709(Lpin) Dmel_CG8804(wun) Dmel_CG8805(wun2)
DPO: 
Dpse_GA10998 Dpse_GA10999 Dpse_GA11004 Dpse_GA11005 Dpse_GA11006 Dpse_GA21271 Dpse_GA21332 Dpse_GA24835
DAN: 
Dana_GF10978 Dana_GF10979 Dana_GF10980 Dana_GF10981 Dana_GF11207 Dana_GF11822 Dana_GF13080 Dana_GF23463
DER: 
Dere_GG10557 Dere_GG10671 Dere_GG13182 Dere_GG16256 Dere_GG16257 Dere_GG16258 Dere_GG16259 Dere_GG23436
DPE: 
Dper_GL16886 Dper_GL17376 Dper_GL17588 Dper_GL23143 Dper_GL23154 Dper_GL23165 Dper_GL23176 Dper_GL23307
DSE: 
Dsec_GM20603 Dsec_GM20717 Dsec_GM21120 Dsec_GM22093 Dsec_GM22445 Dsec_GM22446 Dsec_GM22448 Dsec_GM22449
DSI: 
Dsim_GD10076 Dsim_GD10183 Dsim_GD10653 Dsim_GD12067 Dsim_GD15029 Dsim_GD15030 Dsim_GD15031 Dsim_GD15032
DWI: 
Dwil_GK16759 Dwil_GK16760 Dwil_GK16761 Dwil_GK16762 Dwil_GK17452 Dwil_GK21557 Dwil_GK21745 Dwil_GK23042
DYA: 
Dyak_GE19275 Dyak_GE19505 Dyak_GE19506 Dyak_GE19507 Dyak_GE19508 Dyak_GE22302 Dyak_GE23017 Dyak_GE23018 Dyak_GE23019 Dyak_GE23020 Dyak_GE23267
DGR: 
Dgri_GH14815 Dgri_GH16692 Dgri_GH16693 Dgri_GH16694 Dgri_GH16696 Dgri_GH19981 Dgri_GH20575 Dgri_GH21309
DMO: 
Dmoj_GI11380 Dmoj_GI11381 Dmoj_GI11383 Dmoj_GI11384 Dmoj_GI13921 Dmoj_GI19743 Dmoj_GI19768 Dmoj_GI20267
DVI: 
Dvir_GJ11635 Dvir_GJ11637 Dvir_GJ11638 Dvir_GJ11639 Dvir_GJ13711 Dvir_GJ18026 Dvir_GJ18273 Dvir_GJ20221
AGA: 
AgaP_AGAP007636 AgaP_AGAP012445
AAG: 
AaeL_AAEL005175 AaeL_AAEL007322
CQU: 
CpipJ_CPIJ000134 CpipJ_CPIJ002060 CpipJ_CPIJ012565
AME: 
410201 724942 727078
NVI: 
100115448(NV12088) 100121847(NV16393)
TCA: 
659825 664486
API: 
100162988 100164616(Ppap2a) 100165537
PHU: 
Phum_PHUM389600 Phum_PHUM407130 Phum_PHUM593970
ISC: 
IscW_ISCW006345 IscW_ISCW015634
CEL: 
CELE_F53C3.13
CBR: 
CBG11512 CBG18435
BMY: 
Bm1_52625
TSP: 
Tsp_03778 Tsp_06576
SMM: 
Smp_085240.1 Smp_085240.2 Smp_147940.2 Smp_171720
NVE: 
NEMVE_v1g129610 NEMVE_v1g216577 NEMVE_v1g42019 NEMVE_v1g93314
HMG: 
100214900
TAD: 
TRIADDRAFT_64077 TRIADDRAFT_64321
AQU: 
100632908 100635939
ATH: 
AT3G09560 AT5G42870(PAH2)
ALY: 
ARALYDRAFT_317759 ARALYDRAFT_494731
GMX: 
100780784 100795884 100796839 100798304 100811824
MTR: 
MTR_1g019740 MTR_3g101590 MTR_7g100370
CSV: 
101209025 101221733 101230766
RCU: 
RCOM_1590970 RCOM_1590980
POP: 
POPTR_667714
VVI: 
100255086 100266011
OSA: 
4350917
DOSA: 
Os05t0462400-01(Os05g0462400) Os11t0615000-01(Os11g0615000)
BDI: 
100835099
SBI: 
SORBI_05g024490(SORBIDRAFT_05g024490) SORBI_09g022740(SORBIDRAFT_09g022740)
ZMA: 
100279857
SMO: 
SELMODRAFT_115253 SELMODRAFT_132576
PPP: 
PHYPADRAFT_162139 PHYPADRAFT_64260
CRE: 
CHLREDRAFT_99951
VCN: 
VOLCADRAFT_32171
OLU: 
OSTLU_19583
OTA: 
Ot07g00640
CME: 
CMN061C
SCE: 
YMR165C(PAH1)
AGO: 
AGOS_AFL195W
ERC: 
Ecym_5631
KLA: 
KLLA0D09867g
LTH: 
KLTH0F09812g
PPA: 
PAS_chr3_0512
VPO: 
Kpol_1043p19
ZRO: 
ZYRO0A07370g
CGR: 
CAGL0F07689g
NCS: 
NCAS_0D00920(NCAS0D00920)
NDI: 
NDAI_0H03210(NDAI0H03210)
TPF: 
TPHA_0C03670(TPHA0C03670)
TBL: 
TBLA_0B07260(TBLA0B07260)
TDL: 
TDEL_0G02750(TDEL0G02750)
KAF: 
KAFR_0B04860(KAFR0B04860)
DHA: 
DEHA2D04268g
PIC: 
PICST_81508(SMP2)
PGU: 
PGUG_04971
LEL: 
LELG_01127
CAL: 
CaO19.1462(SMP2) CaO19.9037(SMP2)
CTP: 
CTRG_01246
CDU: 
CD36_16400
COT: 
CORT_0A13480
YLI: 
YALI0D27016g
CLU: 
CLUG_01747
NCR: 
NCU03137
SMP: 
SMAC_02868
PAN: 
PODANSg5853
TTT: 
THITE_2113595
MTM: 
MYCTH_2296156
MGR: 
MGG_01311
FGR: 
FG00866.1
NHE: 
NECHADRAFT_57597
VAL: 
VDBG_07233
SSL: 
SS1G_06175
BFU: 
BC1G_13009
ANI: 
AN0802.2
NFI: 
NFIA_010810
AFM: 
AFUA_1G14610
AOR: 
AOR_1_848154(AO090003000481)
ANG: 
ANI_1_1712014(An01g12610)
AFV: 
AFLA_033350
ACT: 
ACLA_020820
PCS: 
Pc16g14070
CIM: 
CIMG_03243
CPW: 
CPC735_009330
PBL: 
PAAG_05401
URE: 
UREG_07094
ABE: 
ARB_00030
TVE: 
TRV_02756
AJE: 
HCAG_02361
PNO: 
SNOG_14260
PTE: 
PTT_10187
ZTR: 
MYCGRDRAFT_41117
TML: 
GSTUM_00001674001
SPO: 
SPAC1952.13(ned1)
CNE: 
CND05230
CNB: 
CNBD1100
CGI: 
CGB_I1600W
LBC: 
LACBIDRAFT_231619
CCI: 
CC1G_01386
SCM: 
SCHCODRAFT_72030
UMA: 
UM03463.1
MGL: 
MGL_2511
PGR: 
PGTG_12070
NCE: 
NCER_101930
MBR: 
MONBRDRAFT_33582
NGR: 
NAEGRDRAFT_66400 NAEGRDRAFT_68337
DDI: 
DDB_G0271730
DPP: 
DICPUDRAFT_33329
PFA: 
PFC0150w
PFD: 
PFDG_02348
PFH: 
PFHG_02384
PYO: 
PY01351
PCB: 
PC000057.00.0 PC000129.00.0
PBE: 
PB001069.03.0
PKN: 
PKH_083700
PVX: 
PVX_119285
PCY: 
PCYB_084600
TAN: 
TA08565
TPV: 
TP04_0460
BBO: 
BBOV_II001270(18.m06095)
CPV: 
cgd3_3210
CHO: 
Chro.30366
TGO: 
TGME49_030690 TGME49_047360
TET: 
TTHERM_00189270
PTM: 
GSPATT00038553001
TBR: 
Tb10.389.0020 Tb10.61.2970 Tb927.7.5450(Tb07.10C21.580)
TCR: 
509153.60 511277.370
LMA: 
LMJF_06_0830 LMJF_18_0440
LIF: 
LINJ_06_0860
LDO: 
LDBPK_060860
LMI: 
LMXM_06_0830
LBZ: 
LBRM_06_0800
TVA: 
TVAG_041100
PIF: 
PITG_08460
FTW: 
FTW_0252
FTL: 
FTL_1728
FTH: 
FTH_1667
 » show all
Taxonomy
Reference
1  [PMID:13475370]
  Authors
SMITH SW, WEISS SB, KENNEDY EP.
  Title
The enzymatic dephosphorylation of phosphatidic acids.
  Journal
J. Biol. Chem. 228 (1957) 915-22.
  Organism
Rattus norvegicus [GN:rno], Cavia porcellus
Reference
2  [PMID:18812320]
  Authors
Carman GM, Han GS
  Title
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
  Journal
J. Biol. Chem. 284 (2009) 2593-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-77-8
DBGET integrated database retrieval system