KEGG   ENZYME: 3.1.3.43Help
Entry
EC 3.1.3.43                 Enzyme                                 
Name
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase;
pyruvate dehydrogenase phosphatase;
phosphopyruvate dehydrogenase phosphatase;
[pyruvate dehydrogenase (lipoamide)]-phosphatase;
[pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
[pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase
Reaction(IUBMB)
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate [RN:R03450]
Reaction(KEGG)
Substrate
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD:C01293];
H2O [CPD:C00001]
Product
[pyruvate dehydrogenase (acetyl-transferring)] [CPD:C01256];
phosphate [CPD:C00009]
Comment
A mitochondrial enzyme associated with EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring), in the pyruvate dehydrogenase complex.
Orthology
K01102  
pyruvate dehydrogenase phosphatase
Genes
HSA: 
54704(PDP1) 57546(PDP2)
PTR: 
454147(PDP2) 472819(PDP1)
PPS: 
100972380(PDP1) 100981913(PDP2)
GGO: 
101139788(PDP2) 101144604(PDP1)
PON: 
100172698(PDP2) 100174041(PDP1)
MCC: 
694851(PDP2) 699172(PDP1)
MMU: 
381511(Pdp1) 382051(Pdp2)
RNO: 
246311(Pdp2) 54705(Pdp1)
CFA: 
477941(PDP1) 489771(PDP2)
AML: 
100471099(PDP2) 100472720(PDP1)
FCA: 
101082975(PDP1) 101095536(PDP2)
BTA: 
100299267(PDP2) 280891(PDP1)
SSC: 
100153002 100623511(PDP2)
ECB: 
100051376 100065629(PDP2)
MDO: 
100019207 100029761
SHR: 
100923400(PDP1) 100929377(PDP2)
OAA: 
100090454(PDP2) 100091977
GGA: 
427550(PDP2) 428372(PDP1)
MGP: 
100544457 100545056(PDP1)
TGU: 
100222486(PDP2) 100225941(PDP1)
ACS: 
100553198(pdp2) 100560050(pdp1)
XLA: 
447514(pdp1)
XTR: 
100489227 779724(pdp1)
DRE: 
558728(pdp1) 58149(pdp2)
TRU: 
101070199
OLA: 
101157692 101169140
BFO: 
BRAFLDRAFT_278942
SPU: 
584018
ISC: 
IscW_ISCW014874
CBR: 
CBG12191
BMY: 
Bm1_55415
NVE: 
NEMVE_v1g100712 NEMVE_v1g228005
HMG: 
100213261
AQU: 
100636527
TET: 
TTHERM_00703440 TTHERM_00942970 TTHERM_01243430
 » show all
Taxonomy
Reference
1  [PMID:4401694]
  Authors
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ.
  Title
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
  Journal
Arch. Biochem. Biophys. 148 (1972) 327-42.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr. Top. Cell. Regul. 27 (1985) 41-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-70-5
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