KEGG   ENZYME: 3.1.3.43Help
Entry
EC 3.1.3.43                 Enzyme                                 

Name
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase;
pyruvate dehydrogenase phosphatase;
phosphopyruvate dehydrogenase phosphatase;
[pyruvate dehydrogenase (lipoamide)]-phosphatase;
[pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
[pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase
Reaction(IUBMB)
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate [RN:R03450]
Reaction(KEGG)
Substrate
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD:C01293];
H2O [CPD:C00001]
Product
[pyruvate dehydrogenase (acetyl-transferring)] [CPD:C01256];
phosphate [CPD:C00009]
Comment
A mitochondrial enzyme associated with EC 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring), in the pyruvate dehydrogenase complex.
History
EC 3.1.3.43 created 1978
Orthology
K01102  
pyruvate dehydrogenase phosphatase
Genes
HSA: 
54704(PDP1) 57546(PDP2)
PTR: 
454147(PDP2) 472819(PDP1)
PPS: 
100972380(PDP1) 100981913(PDP2)
GGO: 
101139788(PDP2) 101144604(PDP1)
PON: 
100172698(PDP2) 100174041(PDP1)
MCC: 
694851(PDP2) 699172(PDP1)
MCF: 
MMU: 
381511(Pdp1) 382051(Pdp2)
RNO: 
246311(Pdp2) 54705(Pdp1)
CGE: 
100761381(Pdp1) 100762846(Pdp2)
HGL: 
101700253(Pdp2) 101724432(Pdp1)
TUP: 
102472878(PDP2) 102484694(PDP1)
CFA: 
477941(PDP1) 489771(PDP2)
AML: 
100471099(PDP2) 100472720(PDP1)
FCA: 
101082975(PDP1) 101095536(PDP2)
PTG: 
102951980(PDP2) 102967311(PDP1)
BTA: 
100299267(PDP2) 280891(PDP1)
BOM: 
102282548(PDP1) 102287532(PDP2)
PHD: 
102330294(PDP2) 102334297(PDP1)
CHX: 
102176634(PDP2) 102188063(PDP1)
SSC: 
100153002(PDP1) 100623511(PDP2)
CFR: 
102515819(PDP1) 102518428(PDP2)
BACU: 
103017011(PDP1) 103019943(PDP2)
LVE: 
103079949(PDP2) 103083852(PDP1)
ECB: 
100051376(PDP1) 100065629(PDP2)
MYB: 
MYD: 
102754418(PDP1) 102759039(PDP2)
PALE: 
102890859(PDP1) 102891688(PDP2)
MDO: 
100019207(PDP2) 100029761(PDP1)
SHR: 
100923400(PDP1) 100929377(PDP2)
OAA: 
GGA: 
427550(PDP2) 428372(PDP1)
MGP: 
TGU: 
100222486(PDP2) 100225941(PDP1)
FAB: 
101806939(PDP1) 101818130(PDP2)
PHI: 
102110428(PDP2) 102113607(PDP1)
APLA: 
101791170(PDP2) 101794102(PDP1)
FPG: 
101914907(PDP1) 101920971(PDP2)
FCH: 
102048165(PDP1) 102058009(PDP2)
CLV: 
102096463(PDP2) 102097264(PDP1)
ASN: 
102370616(PDP1) 102384447(PDP2)
AMJ: 
102558735(PDP2) 102562869(PDP1)
PSS: 
102453190(PDP1) 102455495(PDP2)
CMY: 
102936038(PDP2) 102937543(PDP1)
ACS: 
100553198(pdp2) 100560050(pdp1)
PBI: 
103048021(PDP1) 103067358(PDP2)
XLA: 
447514(pdp1) 779268(pdp2)
XTR: 
100489227(pdp2) 779724(pdp1)
DRE: 
558728(pdp1) 562650 58149(pdp2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
413080(Pdp)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0976700-01(Os01g0976700) Os02t0685600-01(Os02g0685600) Os03t0832400-01(Os03g0832400) Os07t0114000-01(Os07g0114000)
OBR: 
BDI: 
SBI: 
SORBI_01g002450(SORBIDRAFT_01g002450) SORBI_01g030180(SORBIDRAFT_01g030180) SORBI_01g047830(SORBIDRAFT_01g047830) SORBI_06g026510(SORBIDRAFT_06g026510) SORBI_09g001340(SORBIDRAFT_09g001340)
ZMA: 
SITA: 
ATR: 
s00001p00136050(AMTR_s00001p00136050) s00003p00098390(AMTR_s00003p00098390) s00032p00171590(AMTR_s00032p00171590) s00044p00096750(AMTR_s00044p00096750) s00045p00196960(AMTR_s00045p00196960)
SMO: 
PPP: 
CME: 
SCE: 
YOR090C(PTC5)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B06730(NCAS0B06730)
NDI: 
NDAI_0B04060(NDAI0B04060)
TPF: 
TPHA_0P00960(TPHA0P00960)
TBL: 
TBLA_0B01830(TBLA0B01830)
TDL: 
TDEL_0C04670(TDEL0C04670)
KAF: 
KAFR_0J01860(KAFR0J01860)
DHA: 
PIC: 
PGU: 
LEL: 
SPAA: 
CAL: 
CTP: 
CDU: 
COT: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_796114(AO090701000434) AOR_1_854164(AO090001000488)
ANG: 
ANI_1_2172024(An02g00580) ANI_1_788164(An18g05890)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
ZTR: 
PFJ: 
BCOM: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
MBR: 
PYO: 
PCB: 
PBE: 
TGO: 
PIF: 
NGD: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:4401694]
  Authors
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ.
  Title
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
  Journal
Arch. Biochem. Biophys. 148 (1972) 327-42.
  Organism
Bos taurus
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr. Top. Cell. Regul. 27 (1985) 41-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-70-5

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