| Entry |
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| Name |
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphatase;
branched-chain oxo-acid dehydrogenase phosphatase;
branched-chain 2-keto acid dehydrogenase phosphatase;
branched-chain alpha-keto acid dehydrogenase phosphatase;
BCKDH;
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase;
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
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| Sysname |
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]-phosphate phosphohydrolase
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| Reaction(IUBMB) |
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O = [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate
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| Reaction(KEGG) |
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| Substrate |
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate [CPD: C01308];
H2O [CPD: C00001]
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| Product |
[3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] [CPD: C04726];
phosphate [CPD: C00009]
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| Comment |
A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate dehydrogenase complex. Simultaneously dephosphorylates and activates EC 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring), that has been inactivated by phosphorylation.
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| Reference |
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| Authors |
Fatania HR, Patston PA, Randle PJ. |
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| Title |
Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase. |
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| Journal |
FEBS. Lett. 158 (1983) 234-8. |
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| Organism |
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| Reference |
|
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| Authors |
Reed LJ, Damuni Z, Merryfield ML. |
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| Title |
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation. |
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| Journal |
Curr. Top. Cell. Regul. 27 (1985) 41-9. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 87244-20-0 88086-29-7 |
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