KEGG   ENZYME: 3.1.3.53Help
Entry
EC 3.1.3.53                 Enzyme                                 

Name
[myosin-light-chain] phosphatase;
myosin light chain kinase phosphatase;
myosin phosphatase;
myosin phosphatase;
protein phosphatase 2A;
myosin-light-chain-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
[myosin-light-chain]-phosphate phosphohydrolase
Reaction(IUBMB)
[myosin light-chain] phosphate + H2O = [myosin light-chain] + phosphate [RN:R03151]
Reaction(KEGG)
Substrate
myosin light-chain phosphate [CPD:C03875];
H2O [CPD:C00001]
Product
[myosin light-chain];
phosphate [CPD:C00009]
Comment
The enzyme is composed of three subunits. The holoenzyme dephosphorylates myosin light chains and EC 2.7.11.18, myosin-light-chain kinase, but not myosin; the catalytic subunit acts on all three substrates.
History
EC 3.1.3.53 created 1986
Reference
1  [PMID:6304072]
  Authors
Pato MD, Adelstein RS.
  Title
Purification and characterization of a multisubunit phosphatase from turkey gizzard smooth muscle. The effect of calmodulin binding to myosin light chain kinase on dephosphorylation.
  Journal
J. Biol. Chem. 258 (1983) 7047-54.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
60241-39-6

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