| Entry |
|
| Name |
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
| Sysname |
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
|
| Reaction(IUBMB) |
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN: R03393]
|
| Reaction(KEGG) |
|
| Substrate |
1D-myo-inositol 1,4-bisphosphate [CPD: C01220];
H2O [CPD: C00001]
|
| Product |
1D-myo-inositol 4-phosphate [CPD: C03546];
phosphate [CPD: C00009]
|
| Comment |
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
|
| Pathway |
| Inositol phosphate metabolism | | Metabolic pathways |
|
| Orthology |
| inositol polyphosphate 1-phosphatase | | 3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase |
|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | ISC: | | SMM: | | NVE: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | CSV: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | CRE: | | VCN: | | TBR: | | LBZ: | | » show all
 |
| Reference |
|
| Authors |
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF. |
| Title |
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. |
| Journal |
Biochem. J. 212 (1983) 473-82. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW. |
| Title |
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes. |
| Journal |
J. Biol. Chem. 262 (1987) 2146-9. |
| Organism |
Rattus norvegicus [GN: rno] |
| Reference |
|
| Authors |
Inhorn RC, Majerus PW. |
| Title |
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+. |
| Journal |
J. Biol. Chem. 262 (1987) 15946-52. |
| Organism |
|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 111070-17-8 111694-13-4 |