| Entry |
|
|---|
| Name |
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
|---|
| Sysname |
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase |
|---|
| Reaction(IUBMB) |
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate
+ phosphate [RN:R03393] |
|---|
| Reaction(KEGG) |
R03393;
(other) R03427
 |
|---|
| Substrate |
1D-myo-inositol 1,4-bisphosphate [CPD:C01220];
H2O [CPD:C00001] |
|---|
| Product |
1D-myo-inositol 4-phosphate [CPD:C03546];
phosphate [CPD:C00009] |
|---|
| Comment |
The enzyme acts on inositol 1,4-bisphosphate and inositol
1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar
Vmax values for both substrates, but with a five-times higher
affinity for the bisphosphate. Does not act on inositol 1-phosphate,
inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. |
|---|
| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
|---|
| Orthology |
KO: K01107 inositol polyphosphate 1-phosphatase |
|---|
| Genes |
HSA: 3628(INPP1)
PTR: 460106(INPP1)
MCC: 703301(INPP1)
MMU: 16329(Inpp1)
RNO: 316376(Inpp1)
CFA: 478842(INPP1)
BTA: 281869(INPP1)
ECB: 100054603
MDO: 100028793
XLA: 398838
XTR: 100144649(inpp1)
DRE: 555899
DME: Dmel_CG3028(Ipp)
DPO: Dpse_GA15747
AGA: AgaP_AGAP001047
AME: 409853
TCA: 656805
NVE: NEMVE_v1g171762
TAD: TRIADDRAFT_22251
ATH: AT5G63980(SAL1)
TBR: Tb927.8.7170
 |
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| Structures |
PDB: 1INP 1JP4 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6309146]
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
Changes in the levels of inositol phosphates after agonist-dependent
hydrolysis of membrane phosphoinositides.
Biochem. J. 212 (1983) 473-82.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:3029066]
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
The metabolism of tris- and tetraphosphates of inositol by
5-phosphomonoesterase and 3-kinase enzymes.
J. Biol. Chem. 262 (1987) 2146-9.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:2824473]
Inhorn RC, Majerus PW.
Inositol polyphosphate 1-phosphatase from calf brain. Purification
and inhibition by Li+, Ca2+, and Mn2+.
J. Biol. Chem. 262 (1987) 15946-52.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.57
IUBMB Enzyme Nomenclature: 3.1.3.57
ExPASy - ENZYME nomenclature database: 3.1.3.57
BRENDA, the Enzyme Database: 3.1.3.57
CAS: 111070-17-8 111694-13-4 |
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