KEGG   ENZYME: 3.1.3.57Help
Entry
EC 3.1.3.57                 Enzyme                                 
Name
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Reaction(IUBMB)
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:R03393]
Reaction(KEGG)
R03393;
(other) R03427
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Substrate
1D-myo-inositol 1,4-bisphosphate [CPD:C01220];
H2O [CPD:C00001]
Product
1D-myo-inositol 4-phosphate [CPD:C03546];
phosphate [CPD:C00009]
Comment
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01107  
inositol polyphosphate 1-phosphatase
K15422  
3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase
Genes
HSA: 
3628(INPP1)
PTR: 
460106(INPP1)
PPS: 
100967835(INPP1)
GGO: 
101129850(INPP1)
PON: 
100461697(INPP1)
MCC: 
703301(INPP1)
MMU: 
16329(Inpp1)
RNO: 
316376(Inpp1)
CFA: 
478842(INPP1)
AML: 
100473008(INPP1)
FCA: 
101082081(INPP1)
BTA: 
281869(INPP1)
SSC: 
100514878(INPP1)
ECB: 
100054603(INPP1)
MDO: 
100028793
SHR: 
100914455(INPP1)
ACS: 
100556887
XLA: 
398838(inpp1)
XTR: 
100144649(inpp1)
DRE: 
555899
TRU: 
101068265
OLA: 
101154772
BFO: 
BRAFLDRAFT_251702
CIN: 
100182945
SPU: 
584178
DME: 
Dmel_CG3028(Ipp)
DPO: 
Dpse_GA15747
DAN: 
Dana_GF16228
DER: 
Dere_GG19895
DPE: 
Dper_GL24229
DSE: 
Dsec_GM24144
DSI: 
Dsim_GD18939
DWI: 
Dwil_GK22680
DYA: 
Dyak_GE26306
DGR: 
Dgri_GH14420
DMO: 
Dmoj_GI10045
DVI: 
Dvir_GJ22570
AGA: 
AgaP_AGAP001047
CQU: 
CpipJ_CPIJ015548
AME: 
409853(Ipp)
NVI: 
100122810(NV11510)
TCA: 
656805
API: 
100162683
ISC: 
IscW_ISCW016506
SMM: 
Smp_017520
NVE: 
NEMVE_v1g171762
TAD: 
TRIADDRAFT_22251
AQU: 
100633510
ATH: 
AT5G09290 AT5G63980(SAL1) AT5G63990 AT5G64000(SAL2)
ALY: 
ARALYDRAFT_487739 ARALYDRAFT_496591 ARALYDRAFT_496593 ARALYDRAFT_496594
GMX: 
100796038 100817415
CSV: 
101204881
POP: 
POPTR_818252 POPTR_832240
VVI: 
100244767
OSA: 
4351685 4351686
DOSA: 
Os12t0183200-00(Os12g0183200)
BDI: 
100844934
SBI: 
SORBI_08g005190(SORBIDRAFT_08g005190) SORBI_08g005200(SORBIDRAFT_08g005200)
ZMA: 
100276170(cl14808_1) 542492(dnp1)
SMO: 
SELMODRAFT_234473
PPP: 
PHYPADRAFT_130451
CRE: 
CHLREDRAFT_146533
VCN: 
VOLCADRAFT_65837
TBR: 
Tb927.8.7170(Tb08.10K10.600)
LBZ: 
LBRM_31_3290
 » show all
Taxonomy
Reference
1  [PMID:6309146]
  Authors
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
  Title
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
  Journal
Biochem. J. 212 (1983) 473-82.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:3029066]
  Authors
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
  Title
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
  Journal
J. Biol. Chem. 262 (1987) 2146-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:2824473]
  Authors
Inhorn RC, Majerus PW.
  Title
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
  Journal
J. Biol. Chem. 262 (1987) 15946-52.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
111070-17-8 111694-13-4
DBGET integrated database retrieval system