KEGG   ENZYME: 3.1.3.57Help
Entry
EC 3.1.3.57                 Enzyme                                 

Name
inositol-1,4-bisphosphate 1-phosphatase;
inositol-polyphosphate 1-phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
Reaction(IUBMB)
1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate [RN:R03393]
Reaction(KEGG)
R03393;
(other) R03427
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Substrate
1D-myo-inositol 1,4-bisphosphate [CPD:C01220];
H2O [CPD:C00001]
Product
1D-myo-inositol 4-phosphate [CPD:C03546];
phosphate [CPD:C00009]
Comment
The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.
History
EC 3.1.3.57 created 1989, modified 2002
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K01107  
inositol polyphosphate 1-phosphatase
K15422  
3'(2'), 5'-bisphosphate nucleotidase / inositol polyphosphate 1-phosphatase
Genes
HSA: 
3628(INPP1)
PTR: 
460106(INPP1)
PPS: 
100967835(INPP1)
GGO: 
101129850(INPP1)
PON: 
100461697(INPP1)
MCC: 
703301(INPP1)
MCF: 
MMU: 
16329(Inpp1)
RNO: 
316376(Inpp1)
CGE: 
100755639(Inpp1)
HGL: 
101724306(Inpp1)
TUP: 
102481098(INPP1)
CFA: 
478842(INPP1)
AML: 
100473008(INPP1)
FCA: 
101082081(INPP1)
PTG: 
102951036(INPP1)
BTA: 
281869(INPP1)
BOM: 
102276134(INPP1)
PHD: 
102330251(INPP1)
CHX: 
102176832(INPP1)
OAS: 
101110908(INPP1)
SSC: 
100514878(INPP1)
CFR: 
102520689(INPP1)
BACU: 
103020750(INPP1)
LVE: 
103071146(INPP1)
ECB: 
100054603(INPP1)
MYB: 
102245840(INPP1)
MYD: 
102766936(INPP1)
PALE: 
102885459(INPP1)
MDO: 
100028793(INPP1)
SHR: 
100914455(INPP1)
OAA: 
103169187(INPP1)
PHI: 
FPG: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
398838(inpp1)
XTR: 
100144649(inpp1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103176536(inpp1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
ISC: 
SMM: 
NVE: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
CSV: 
POP: 
POPTR_0005s06490g(POPTRDRAFT_818252) POPTR_0007s04240g(POPTRDRAFT_832240)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os12t0183200-00(Os12g0183200) Os12t0183300-01(Os12g0183300)
OBR: 
BDI: 
SBI: 
SORBI_08g005190(SORBIDRAFT_08g005190) SORBI_08g005200(SORBIDRAFT_08g005200)
ZMA: 
100276170(cl14808_1) 542492(dnp1)
SITA: 
ATR: 
s00017p00255870(AMTR_s00017p00255870)
SMO: 
PPP: 
CRE: 
VCN: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
CCP: 
DDI: 
DPP: 
DFA: 
ACAN: 
TBR: 
Tb927.8.7170(Tb08.10K10.600)
LBZ: 
 » show all
Taxonomy
Reference
1  [PMID:6309146]
  Authors
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF.
  Title
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
  Journal
Biochem. J. 212 (1983) 473-82.
  Organism
Rattus norvegicus
Reference
2  [PMID:3029066]
  Authors
Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW.
  Title
The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
  Journal
J. Biol. Chem. 262 (1987) 2146-9.
  Organism
Rattus norvegicus
Reference
3  [PMID:2824473]
  Authors
Inhorn RC, Majerus PW.
  Title
Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
  Journal
J. Biol. Chem. 262 (1987) 15946-52.
  Organism
Bos taurus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
111070-17-8 111694-13-4

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